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2019 CTOS Annual MeetingNovember 13-16, 2019Tokyo, Japan2019 CTOS President 2019 CTOS Program CommitteeAkira Kawai, MD Robin Jones, MD Takafumi Ueda, MD - Program Co-Chairs Damon Reed, MD Judith Bovee, MD

Dear Colleagues,We are delighted to invite you to join us in Tokyo for the 24th Annual Meeting of theConnective Tissue Oncology Society, November 13-16, 2019. The meeting will be held at the Hilton Tokyo.The Annual Meeting continues to grow in attendance as well as the number of abstracts submitted. We will build on the excellent meeting in Rome last year. This year’s meeting will provide the ideal venue for debate and connecting with old friends. This is the rst time the meeting has been in Japan and we would like this to be an opportunity to have further collaboration between ‘East and West’. There will be a special session for mentoring young researchers. CTOS is unique in bringing to together an international community of scientists, clinicians, patients and families. Desmoplastic small round cell sarcoma is the “Sarcoma of the Year” and there will be a special session focusing on the challenges of diagnosing and treating this rare subtype. In addition, there will be a number of focused sessions with a multi-disciplinary theme, incorporating new data from basic science to outcomes research. We also eagerly await the Herman Suit Lecture which will be delivered by Jay Wunder and the Nina Axelrad Lecture by Richard Gorlick. There will also be the opportunity to enjoy the amazing history and culture of Tokyo, we are delighted to provide complimentary tours of the city. The Gala Reception will be at the traditional Japanese beautiful garden of Happo En.We look forward to seeing you in Tokyo!2019 CTOS President 2019 CTOS Program CommitteeAkira Kawai, MD Robin Jones, MD Takafumi Ueda, MD - Program Co-Chairs Damon Reed, MD Judith Bovee, MD CTOS Annual MeetingNovember 13-16, 2019Tokyo, JapanRegister for the Meeting Early Registration Deadline: September 6, 2019 Questions Contact Barbara Rapp ctos@ctos.org1CTOS 2019 Board of Directors Akira Kawai, MD, PresidentKirsten Sundby Hall, MD, PhD, Vice PresidentRick Haas, MD, SecretaryWilliam Tap, MD, TreasurerDavid Thomas, FRCP, PhD, Immediate Past PresidentAndrea Hayes Jordan, MDCarol Swallow, MDPaolo G. Casali, MDRoberta Maestro, MDDamon Reed, MDAbha Gupta, MD, MSc, FRCPCDavid Kirsch, MD, PhDElizabeth Demicco, MD, PhDKevin Jones, MDEugenie Kleinerman, MDSilvia Stacchiotti, MDBarbara RappExecutive DirectorSubmit an Abstract Deadline: June 21, 2019 ©Tokyo Convention & Visitors Bureau

2019 Preliminary Meeting ScheduleNote: Schedule is subject to change.Nurses’ Program – Thursday, November 14, 8:00 - 16:30Wednesday, November 13, 2019Thursday November 14, 2018Friday November 15, 2019Saturday November 16, 20196:00Registration Opens Registration Opens Registration OpensSUNRISE IN TOKYO–MENTORING PROGRAM SUNRISE IN TOKYO–MENTORING PROGRAM SUNRISE IN TOKYO–MENTORING PROGRAM7:008:009:00Coffee & Posters10:00Coffee & Posters Coffee & Posters11:00Young Investigator Awards12:0013:0014:0015:00Coffee & Posters Coffee & Posters Coffee & Posters16:0017:0018:0019:00Welcome ReceptionRegistration and Poster Set-UpLunchCoffee & PostersCoffee & PostersSESSION 4 Bone SarcomasSESSION 6 West Meets EastIn the Management of SarcomasSESSION 5Radiation OncologyLunchSESSION 7 GISTHERMAN SUIT LECTUREJay WunderSESSION 8Retroperitoneal andPelvic SarcomasSARCLunchSESSION 10 Soft Tissue SarcomaSESSION 11 Challenges in MPNST and NF1CTOSBusinessMeetingCoffee & PostersNina Axelrad LectureRichard GorlickSESSION 9Pediatric SarcomasGala 18:30 - 22:30SESSION 1Sarcoma of the Year DSRCTSESSION 2Clinical Trials and Precision Medicine In SarcomasSESSION 3 The New WHO Classification System; Clinical Implications and Global PerspectivesPoster Viewing Reception2

2019 CTOS Annual MeetingNovember 13-16, 2019Tokyo, JapanMeeting RegistrationYou will receive an email conrmation of your registration once payment has been received. If you have not received a written conrmation prior to your departure for the meeting, please contact Barbara Rapp at email: ctos@ctos.org for details. Reservations and costs incurred by the registrant, such as airline and hotel expenses, are the responsibility of the registrant. Annual Meeting Early Registration FeesMember Physician US $500.00Non-Member Physician US $700.00Member Resident/Fellow/Student (graduate, undergraduate and medical) US $325.00*Non Member Resident/Fellow/Student (graduate, undergraduate and medical) US $375.00*Member Allied Healthcare Professional US $325.00Non Member Allied Healthcare Professional US $375.00Nurse US $325.00Friday Night Gala Guest US $200.00Fees after September 6Member Physician US $525.00 US $625.00Non-Member Physician US $800.00 US $900.00Member Resident/Fellow/Student US $375.00* US $425.00*Non Member Resident/Fellow/Student US $425.00* US $475.00*Member Allied Healthcare Professional US $375.00 US $425.00Non Member Allied Healthcare Professional US $425.00 US $475.00Nurse US $325.00 US $325.00 Friday Night Gala Guest US $200.00 US $200.00Registration fees include Welcome Reception, Friday Gala Event, lunches and all breaks. Breakfast is only included for Hilton Tokyo guests.*To receive discounted fees, a letter conrming residency must be emailed to Jennifer@ctos.org or provided onsite at the meeting. If no proof of residency is received, the difference of the full non-member rate will be applied to the registration transaction.HotelAccommodationsMake your hotel reservations at the Hilton Tokyo Hotel where the meeting will take place. Hotel Rooms are limited so book your rooms as soon as possible! The Hilton Tokyo overlooks Shinjuku Central Park and the Shinjuku Skyscraper District. Elegantly decorated rooms await. A breakfast buffet with Western food and a range of Japanese dishes is included in the room rate. The Hilton is directly connected to Tochomae Subway Station. Shinjuku Train Station is a pleasant 15-minute walk away, or a 5-minute ride in the hotel’s free shuttle. Visit Hilton Tokyo online to explore all that is offered.3Register TodayRegister Today©Tokyo Convention & Visitors BureauConnective Tissue Oncology SocietyP.O. Box 320574Alexandria, VA 22320Phone: 301-502-7371 Email: ctos@ctos.orgRegisterHere©Tokyo Convention & Visitors BureauOnsite FeeBeginning Nov. 13

Complimentary Tokyo City ToursTokyo Metropolitan Government will provide complimentary bus tours with an English-speaking guide for conference registrants and their guests to enjoy the most popular sightseeing areas in Tokyo. Departure/Arrival: Hilton Tokyo Duration: approx. 3.5-4 hours for a half day tour Fare: Free Registration: Registration will commence in early September via a link at ctos.org. Schedule:Date AM (9:00-12:30) PM (13:30-17:00)Nov. 12 (Tuesday) River Cruise & Hama-rikyu Japanese Gardens (20ppl)Nov. 13 (Wednesday) Meiji Jingu Shrine & Harajuku Shopping (40 ppl)Nov. 14 (Thursday) TOKYO SKYTREE® (40 ppl) & Solamachi Shopping Nov. 15 (Friday) Edo Tokyo Museum & Asakusa (40 ppl)Nov 16 (Saturday) River Cruise & Hama-rikyu Japanese Gardens (40 ppl)First-come, rst served. Tour itineraries are subject to change.Tour HighlightsRiver Cruise & Hama-rikyu Japanese Gardens This half-hour boat cruise down the Sumida River travels under some 14 bridges spanning Tokyo’s main river, showing the capital’s famous landmarks along the way. The cityscape of Tokyo seen from the river is refreshing to the eye. The cruise will arrive at the majestic Hamarikyu Gardens, located along the Tokyo Waterfront. Visitors can enjoy a walk in the beautifully preserved garden which the family of the ruling Tokugawa Shogun owned from 17th to mid- 19th century, and used for hunting with falcons.Autumn leaves can be enjoyed in Tokyo from late November to December. The reection of the colorful trees on the waters of the ponds are spectacular, making this a beautiful viewing spot. Together with the autumn leaves, enjoy the sculpted beauty of this vast Japanese garden in the middle of the city.Meiji Jingu Shrine & Harajuku Shopping See the the iconic and bustling Shibuya scramble intersection from the bus window, be-fore heading to Meiji Jingu Shrine. The Meiji Jingu Shrine, a Shinto shrine dedicated to Emperor Meiji and his wife Empress Shoken, was established in 1920. Over 100,000 trees were donated by people all over Japan at the time of the shrine’s establishment, creating the extensive forest and garden that can be seen today. Meiji Jingu Shrine is also the place where Japanese people honor life events, such as births and weddings. If you are lucky, you may encounter a happy bride dressed in a white Kimono with her groom. After a pleasant stroll around Meiji Jingu Shrine, you can head towards Harajuku and Omotesando district. This area is one of the most fashionable streets in Tokyo today. 4

TOKYO SKYTREE® & Solamachi Shopping Senso-ji Temple in Asakusa, the oldest temple in Tokyo founded in 628 AD, is visited by about 30 million worshippers a year from different parts of Japan and abroad. Kaminarimon is one of the must see sites for visitors to Tokyo. See the large red lantern and impressive gate from the bus before heading to TOKYO SKYTREE®. TOKYO SKYTREE® is the capital city’s latest icon, and the world’s tallest broadcasting tower (634m high). Located in Sumida ward, where Edo (the ancient name for Tokyo) culture thrives to this day. The elevator moving at a top speed of Tokyo City Tours, continued600m per minute will take visitors to the glass-enclosed ob-servation deck 350m above ground, where you can see 360 degrees across Tokyo. Many of the famous features of theTokyo cityscape, including Rainbow Bridge and Mt. Fuji in the distance on a clear day, can be enjoyed from the observation deck. The 300-odd shops and restaurants at the foot of the tower collectively known as Tokyo Solamachi strive to embrace new trends but at the same time, capture the feeling of this area of Tokyo from days of yore.Edo Tokyo Museum & Asakusa Edo-Tokyo Museum introduces the history and culture of Edo (the ancient name for Tokyo). It also fascinates visitors with stories of the city’s past. You can take a look at a traditional theatre and scenes from everyday life that will transport you back in time to the Edo-period (1603-1868). This museum presents visitors with a unique opportunity to compare and contrast old Edo with modern Tokyo, so you can appreciate how Tokyo has transformed over the years. After learning the history of Tokyo at the museum, the next stop will be the Sensoji Temple at Asakusa. It is one of the most popular tourist destinations in Tokyo, known for Sensoji, a Buddhist temple built in the 7th century. The temple is best approached through the Kaminarimon (Thunder Gate) and Nakamise-Dori, a street lined with merchants that have been providing visitors with old-fashioned, local snacks and souvenirs for centuries. If you venture off into other alleys, you will nd small eateries serving traditional fare.CTOS Annual MeetingNovember 13-16, 2019Tokyo, JapanRegister Today!5