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Message 2025BASIC SCIENCE FOCUS FORUMWEDNESDAY157 AMA PRA Category I Credits™Schedule and presenters are subject to change. OTA.ORG |#OTA2025PRE-MEETING PROGRAMCourtesy of Visit Phoenix®NEWin 2025The registration fee for the Basic ScienceFocus Forum (BSFF) is includedas part of Annual Meeting registration. Attendees simply need to select BSFFas their pre-meeting course option when registering for Annual Meeting.
Register today at ota.org 2TARGET AUDIENCE Academic orthopaedic surgeons, community surgeons with an interest in clinically relevant basic science, basic and clinical researchers, PhDs, residents and fellows will benet most from this course.BASIC SCIENCE COMMITTEE Justin Haller, MD ChairDon D. Anderson, PhDShuyang Han, PhDMichael Hast, PhDBrian (Vu) Le, MD John J. Wixted, MD WEDNESDAY, OCTOBER 1511:45 AM – 12:35 PM, ROOM 301D JOINT INTERNATIONAL INDUSTRY LUNCH SESSIONSponsored by: Zimmer BiometBSFF POSTERRECEPTIONCome join your colleagues for light appetizers and drinks while you have the opportunity to view the selected Basic Science posters. At the conclusion of the reception, a winner will be named for the Best Basic Science poster. The 60-minute reception will be immediately following the conclusion of the BSFF program on Wednesday, October 15, to be held in the pre-function space directly outside the BSFF course. Don’t miss this opportunity to connect with peers and appreciate the latest in orthopaedic trauma research.OVERVIEW The 2025 Basic Science Focus Forum (BSFF) course is directed towards orthopaedic surgeons with an interest in the basic science of orthopaedic trauma and how it relates to or impacts their practice. Basic science researchers will also obtain valuable knowledge about translational opportunities and how their research has the potential to change orthopaedic care. This course will involve 3 main symposia specically designed to ‘bridge the gap’ between basic scienceand clinical practice, in addition to 26 original research papers from the cutting edge of basic science research.LEARNING OBJECTIVESUpon successful completion of the 2025 Basic Science Focus Forum, participants will be able to: 1. Explore the mechanisms and treatment of fracture-related infection2. Understand the impacts of the articial intelligence in providing patient care and performing orthopedic research. 3. Explore the expanding eld of orthobiologics in improving patient outcomes and reducing complications.®NEWin 2025
#OTA2025 | FOLLOW OTA ON | ota.org WEDNESDAY, OCTOBER 157:30 AM WELCOME & INTRODUCTION7:35 AM Justin Haller, MD7:35 AM - SYMPOSIUM I8:35 AM ORTHOBIOLOGICS: IN COLLABORATION WITH INTERNATIONAL SECTION OF FRACTURE REPAIR (ISFR) Moderators: Mike Hast, PhD Brian (Vu) Le, MD 7:35 AM Inducing Better Masquelet Membranes with Orthobiologics J. Tracy Watson, MD7:45 AM Hydroxyapatite Coating Mitigates Degradation of Additively Manufactured Magnesium Scaffolds Lauren Priddy, PhD7:55 AM Nature-Inspired Healing: Clinical Potential of Biomimetic Hematoma Scaffold Vaida Glatt, PhD8:05 AM Strategies to Enhance Musculoskeletal Recovery After Traumatic Injury Katie Hixon, PhD8:15 AM Discussion All Faculty 8:35 AM - BSFF PODIUM SESSION I9:37 AM MUSCULOSKELETAL HEALING Moderators: Mike Hast, PhD & Brian (Vu) Le, MD8:35 AM - BSFF PODIUM 18:41 AM Harnessing the Power of Nature: mRNA-Activated Biomimetic Hematoma Scaffold for Volumetric Muscle Loss Regeneration Vaida Glatt, PhD; Joshua Choe MD; William Murphy, PhD8:41 AM - BSFF PODIUM 28:47 AM ∆ Co-Delivery of Mesenchymal Stem Cells and Disordered Peptides Attenuates the InammatoryResponseandImproves Fracture Healing in Polytrauma Augustine M. Saiz, Jr., MD; Mechanistic Polytrauma Working Group8:47 AM - BSFF PODIUM 38:53 AM ∆ Injury-Associated Anemia Attenuates Fracture Healing Victoria Duke, BS; Cynthia Alcazar, BS; Natasha S. McKibben, MD; Zachary M. Working, MD; Nick J. Willett, PhD; Karina Nakayama, PhD8:53 AM - BSFF PODIUM 48:59 AM The Role of Human Hematoma and Soft Callus in Fracture Healing Ting Zheng, PhD; Schimizzi Gregory, MD, PhD; Robert Bilodeau, BS; Ruge Chen, BS; Kathryn A. Barth, MD; Heather Haeberle, MD; Alona Katzir, MD; Klinger E. Craig, MPH; William M. Ricci, MD; Baohong Zhao, PhD8:59 AM Discussion9:09 AM - BSFF PODIUM 59:15 AM Inhibition of CAMKK2 Signaling and ROS Mitigates PTOA After Acute Cartilage Injury Julian E. Dilley, MD; Aaron Nanavaty, BA; Keegan Riggs, BS; Nyssa Qiao, BS; Abhijit Seetharam, MD; Hessam Noori-Dokht, PhD; Diane Wagner, PhD; Roman M. Natoli, MD, PhD; Todd O. McKinley, MD; Uma Sankar, PhD9:15 AM - BSFF PODIUM 69:21 AM IGF1-Integrated Muscle Void Fillers for Interim Support in Volumetric Muscle Loss Andrew Clark, PhD; Claudia Hernandez; Chun-Hui Su, PhD; Roman Natoli, MD, PhD; Todd O. McKinley, MD; Christopher Dearth, PhD; Stephen Goldman, PhDCOURSE AGENDABASIC SCIENCE FOCUS FORUM PHOENIX CONVENTION CENTER, ROOM 222ABC3∆ OTA Grant
9:21 AM - BSFF PODIUM 79:27 AM Collagen X Longitudinal Fracture Biomarker Expression Demonstrates Similar Endochondral Activity in Intra and Extra-articular Fractures Caellagh D. Catley, MD; Catherine E.T. Hutchison, MD; Natasha S. McKibben, MD; Talia Trapalis, BS; Colby Curtis, BS; Dane Brodke, MD; Graham John DeKeyser, MD; Darin Friess, MD; Chelsea S. Bahney, PhD; Zachary M. Working, MD9:27 AM Discussion9:37 AM - Morning Break9:50 AM9:50 AM - SYMPOSIUM II10:50 AM AI: IT’S IN YOUR PHONE, WHY NOT YOUR PRACTICE? Moderators: Don Anderson, PhD Shuyang Han, PhD Krystin Hidden, MD, PhD 9:50 AM OTA AI Task Force: Accomplishments, Insights and Future of AI Within and the OTA Meir Marmor, MD 10:00 AM The Use of AI in Fall Prevention for the Elderly Thurmon Lockhart, PhD 10:10 AM Synergies Between Traditional Computational Modeling and Machine Learning – Towards in Silico Clinical Trials Steven Mell, PhD 10:20 AM Applying AI to Study Intertrochanteric Fracture Fixation Linjun Yang, PhD 10:30 AM DiscussionRegister today at ota.org 410:50 AM - BSFF PODIUM SESSION II11:45 AM POLYTRAUMA Moderators: Don Anderson, PhD Shuyang Han, PhD10:50 AM - BSFF PODIUM 810:56 AM Raman Spectroscopy: Investigating the Predictive Value for Fracture Andrew J. Rodenhouse, MD; Kyle Jerreld, BS; Anthony Yosick, BS; Sashank Lekkala, MS; Andrew Berger, PhD; Hani Awad, PhD; Constantinos Ketonis, MD, PhD10:56 AM - BSFF PODIUM 911:02 AM SystemicLongitudinalImmuneProlingtoNoninvasively Predict Fracture Nonunion Kelly Leguineche, MS; Jena Robinson, BS, CCRP; Lauren Hill, BS, CCRC; Danielle Olson, BS; Raj Karia, MPH; Samantha Nino, MD; Auveen Hajarizadeh, BS; Kimberly Jones, PhD; Roman Natoli, MD, PhD; Philipp Leucht, MD; Todd O. McKinley, MD; Robert Guldberg, PhD11:02 AM - BSFF PODIUM 1011:08 AM Distinct Immunologic Mediators Are Associated with Venous Thromboembo-lism in Polytrauma Patients Prism Schneider, MD, PhD, FRCSC; Peter Quinn, BSc; Renan Castillo, MS; Greg Gaski, MD; Katherine Frey, PhD; Seth Schobel, PhD; Felipe A. Lisboa, MD; Henry Robertson, PhD; Timothey Billiar, MD; Eric Elster, MD; Laurence B. Kempton, MD; Reza Firoozabadi, MD; Joshua Layne Gary, MD; Stephen Warner, MD, PhD; William T. Obremskey, MD, MPH, FIOTA; Robert O’Toole MD; Arun Aneja, MD, PhD; Eric Gann, PhD; Simon Tallowin, PhD; Todd O. McKinley MD; Major Extremity Trauma Research Consortium (METRC)11:08 AM Discussion
WEDNESDAY, OCTOBER 15, 2025BASIC SCIENCE FOCUS FORUM PHOENIX CONVENTION CENTER, ROOM 222ABC12:45 PM - BSFF PODIUM SESSION III1:41 PM NEW TECHNIQUES IN PATIENT CARE Moderators: Dillon O’Neill, MD Zachary Working, MD12:45 PM - BSFF PODIUM 1412:51 PM Implantable Strain Sensors Revealed Higher Strain Thresholds for Robust Fracture Healing Kylie E. Williams, PhD; Farhan Muhib, BSc; Jeffrey A. Weiss, PhD; Robert E. Guldberg, PhD; Ghee Ong, PhD12:51 PM - BSFF PODIUM 1512:57 PM InllArchitectureInuencesBoneGrowthin 3D Printed PCL Scaffolds Hisham Omar, MS; Paulina Bargallo Gonzalez Lugo, BS; RachelBonni,BS;MatthewFainor,BS; Sarah Gullbrand, PhD; Michael Hast, PhD12:57 PM - BSFF PODIUM 161:03 PM Right Femur Fractures: Establishing a Timeline for Returning to Drive Using a Braking Simulator Device Daniel S. Horwitz, MD; Claire E. Hayes, BS; Daniel Hayes, BS; Ahmed N. Mahmoud, MD, PhD; Zane D. Patterson, BS; Joseph P. Carrey, BS; Eric A. Kennedy, PhD1:03 PM Discussion 1:13 PM - BSFF PODIUM 171:19 PM Fixation of B3 Sacral Fractures Utilizing a Novel Compressive Bolt – A Biomechanical Comparison Devin Froerer, MD; Sebastion Jensen; Colin Gregersen, MS; Justin Haller, MD1:19 PM - BSFF PODIUM 181:25 PM Dynamic Interfragmentary Compression Through a Tibial Intramedullary Nail Compared to Backslapping Alone: A Biomechanical Analysis Brittany Haws, MD; Daniel Thompson, MS; Jonathan Yawman, MD; Jana Davis, MD; Nina Suh, MD; James A. Blair, MD, FACS11:18 AM - BSFF PODIUM 1111:24 AM The Effect of Retrograde Nail Tip Location on Proximal Femur Fracture: A Finite Element Study with Validation Gregory R. Roytman, DC, MS; Sarah Elizabeth Rizzo, MD; Jay Moran, MD; Brad J. Yoo, MD; Steven M. Tommasini, PhD; Daniel H. Wiznia, MD; Brianna R. Fram, MD11:24 AM - BSFF PODIUM 1211:30 AM Risk of Nonunion and Revision Surgery with Early Bisphosphonate Use in Proximal Femoral Fractures Mehul Mittal BS; Aruni Areti BS; Aaron Singh BS; Daniel E. Pereira, MD; Pooya Hosseinzadeh, MD; Mahshid Mohseni, MD11:30 AM - BSFF PODIUM 1311:36 AM Increased Platelet Activity Follows Hip Fracture Surgery Compared to Elective Total Hip Arthroplasty Daniyya Chaudhry, PhD Cand; Golpira E. Assadzadeh, PhD; Souvik Maiti, BSc; Jessica Duong, PhD; Robert Korley, MDCM; Paul Duffy, MD; Prism Schneider, MD, PhD, FRCSC11:36 AM Discussion11:45 AM - Lunch in Room 301D 12:45 PM 11:45 AM - JOINT INDUSTRY (Room 301D) 12:35 PM LUNCH SESSION WITH ITCF Sponsored by: Zimmer Biomet ADDRESSING INFECTION AND PERIPROSTHETIC FRACTURE SOLUTIONS ACROSS UPPER AND LOWER EXTREMITY FRACTURES Faculty: James Baker, MD Anil Dutta, MD Infection and periprosthetic fracture treat-ment challenges across both lower and upper extremity fractures and related cases are addressed in this presentation.#OTA2025 | FOLLOW OTA ON | ota.org 5
2:55 PM - BSFF PODIUM SESSION IV3:57 PM INFECTION Moderators: Justin Haller, MD Jack Wixted, MD2:55 PM - BSFF PODIUM 203:01 PM ∆ Halicin Increases Rifampicin Potency and Prevents Resistance Against S. aureus Biolms Allison Wintring, MD; Joash Suryavanshi, MD; Akira Morita, MD, PhD; Roman Natoli, MD, PhD; EdwardGreeneld,PhD3:01 PM - BSFF PODIUM 213:07 PM Temporal Effects on Intraoperative Bacterial Contamination of Surgical Gloves in Non-infection Orthopaedic Trauma Cases Arya Amirhekmat, MD; Julie Shimabukuro, BS; Cassiana Bittencourt, MD; James R. Learned, MD, BA; John A. Scolaro, MD, MA; Philip Lim, MD3:07 PM - BSFF PODIUM 223:13 PM Plasma Metabolomics Discriminates Patients with Fracture-Related Infection from Uninfected Controls Priyanka Ghosh, MD; Lauren Hill, BS; Makenzie Barger, MS; Sarah Malek, DVM, PhD; Roman M. Natoli, MD, PHD3:13 PM - BSFF PODIUM 233:19 PM ∆ Impact of Preoperative Antibiotic Administration on Culture Positivity in Musculoskeletal Infections: A Preclinical Investigation Lauren Luther, MD; Brittney D. Gimz, PhD; Kara Eichelberger, PhD; Stephanie N. Moore-Lotridge, PhD; Michael Quacinella, DO, MPH; Jonathan G. Schoenecker, MD, PhD; James E. Cassat, MD, PhD; William T. Obremskey, MD, MPH, FIOTA1:25 PM - BSFF PODIUM 191:31 PM Nerve to Artery Coaptation for Neuroma Prevention: A Pilot Study Tyler D. Ragsdale, MD; Benjamin Nwadike, MD; J. Tracy Watson, MD1:31 PM Discussion 1:41 PM - Afternoon Break1:55 PM1:55 PM - SYMPOSIUM III2:55 PM FRACTURE RELATED INFECTION: IN COLLABORATION WITH MUSCULOSKELETAL INFECTION SOCIETY (MSIS) Moderators: Justin Haller, MD Jack Wixted, MD 1:55 PM Fluorescence-Guided Debridement Leah Gitajn, MD, MS 2:05 PM Infection Biomarkers and Next Generation Sequencing - Are They Infected? What Are the Pathogens Roman Natoli, MD, PhD 2:15 PM Antibiotic Management of Fracture-Related Infections Laura Certain, MD, PhD 2:25 PM Operative Techniques for Infection Outside My Wheelhouse Richard Yoon, MD, FIOTA 2:35 PM Discussion∆ OTA GrantRegister today at ota.org 6
BSFF POSTER RECEPTION BSFF POSTER 1 Biomechanical Testing of 3D-Printed Implants for the Fixation of OTA Type B Ankle FracturesMyles Dworkin, MD, MPH; Michael Bergen, MD; Eleanor Burstein, MD; Rachel Schilkowsky, MS; Joseph Cusano, MD; Janine Molino, PhD; Brad Blankenhorn, MD, MSBSFF POSTER 2Parallel Trajectory of Cannulated Screws is Biomechanically Advantageous to Diverging Trajectory in Moderate Pauwels Angle Femoral Neck Fractures Cory Hewitt, MD; Raghunandan Nayak, BS; Alyssa Peterson, BS; Rohan Patel, BS; Tomer Korabelnikov, BS; Nathan Deming, BS; Krystyna Gielo-Perczak, PhD; Adam Lindsay, MDBSFF POSTER 3Cell Attachment to Orthopaedic Implants is Affected by Local Fracture Conditions Sarah Romereim, PhD; Hailey Bennett, MD; Matthew Smykowski, BS; Xue Ma, MD, PhD;Joseph Wenke, PhD; Rachel Seymour, PhD; Joseph Hsu, MD; Bailey Fearing, PhD and EMIT3:19 PM Discussion3:29 PM - BSFF PODIUM 243:35 PM BactericidalEfcacyofBacterialLoad ReductionTechniquesAgainstBiolm Peter Mittwede, MD, PhD; Chelsey E. Smith, MD; Patrick F. Bergin, MD; Dillon C. O’Neill, MD3:35 PM - BSFF PODIUM 253:41 PM DecientEpithelialandAdaptive Immunologic Mediators Predict Organ Dysfunction in Patients Treated with Early Total Care (ETC) Greg Gaski, MD; Prism Schneider, MD, PhD, FRCSC; Katherine Frey, PhD; Timothy R. Billiar, MD; Renan Castillo, MS; Robert V. O’Toole, MD; Reza Firoozabadi, MD; William T. Obremskey, MD, MPH, FIOTA; Laurence B. Kempton, MD; Stephen Warner, MD, PHD; Arun Aneja, MD, PhD; Todd O. McKinley, MD; METRC3:41 PM - BSFF PODIUM 263:47 PM Metabolomics After Polytrauma – A Biobank Analysis of 97 Patients Over the Time Course of 10 Days Felix Klingebiel, MD; Christian T. Hübner, MD; Yannik Kalbas, MD; Sascha Halvachizadeh, MD, PhD; Michel Paul Johan Teuben, MD/PhD; Bergita Ganse, MD; Paolo Cinelli, PhD; Hans-Christoph Pape, MD, FIOTA; Roman Pfeifer, MD3:47 PM Discussion3:57 PM Adjourn to Poster Reception3:57 PM - EVERYONE IS INVITED TO ATTEND THE4:57 PM BSFF POSTER RECEPTION (Directly outside the BSFF course room in the pre-function space)WEDNESDAY, OCTOBER 15, 2025BASIC SCIENCE FOCUS FORUM PHOENIX CONVENTION CENTER, ROOM 222ABC7#OTA2025 | FOLLOW OTA ON | ota.org
The Orthopaedic Trauma Association is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.The Orthopaedic Trauma Association designates this live activity for a maximum of 7 AMA PRA Category 1 Credits™. Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME of the American Board of Orthopaedic Surgery’s Maintenance of Certica-tion program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABOS credit. Physicians should claim only the credit commensurate with the extent of their participation in the activity.Register today at ota.org 8BSFF POSTER 4 Association Between Mechanical Alignment of the Knee and Regional Bone Density Patterns in the Distal Femur and Proximal Tibia Craig Klinger, MPH; Douglas Mintz, MD; Robert Bilodeau, BS; William Ricci, MD; Kathryn Barth, MD; Elizabeth Gausden, MD; Ashley Weaver, PhD;Hollis Potter, MD; Derek Hansen, MDBSFF POSTER 5Effects of Halicin on S. aureus Small Colony Variants Allison Wintring, MD; Akira Morita, MD, PhD; Joash Suryavanshi, MD; Roman Natoli, MD, PhD; EdwardGreeneld,PhDBSFF POSTER 6Multi-OmicProlingRevealsDose-dependentImmuneResponse to BMP-2 in Preclinical Critically-sized Defect Fracture Model Lia Strait, PhD Cand; Tyler Guyer, PhD Cand; Kelly Leguineche, PhD Cand; Dylan Gill, BS; Robert Guldberg, PhDBSFF POSTER 7∆ Multifunctional Medical Foam (MF) to Enhance Wound Management In Situ Lynn Pezzanite, DVM, PhD; Nicholas Alfonso, MD; Amelia Stoner, BS; Steven Dow, DVM, PhD;Kirk McGilvray, PhDBSFF POSTER 8Point-of-Care Neutrophil Analysis to Determine Post-Traumatic Neutrophil Cell Surface Receptor Alterations: An International Validation Study Christian Hübner, MD; Roman Pfeifer, MD; Emma de Fraiture, MD; Nathalie Piaz, MS; Paolo Cinelli, PhD; Leo Koenderman, PhD; Falco Hietbrink, PhD; Michel Paul Johan Teuben, MD, PhD; Hans-Christoph Pape, MDBSFF POSTER 9 Simulated Weight-Bearing CT Improves Hindfoot Alignment Assessment and Offers an Alternative to True Weight-Bearing CT Scanners Joon Soo Ha, MBBS; Prism Schneider, MD, PhD; Gareth Rooke, FRACS; Jeremy Kubik, MD; Kimberly Rondeau, BSc; Andrew Dodd, MDBSFF POSTER 10 Accuracy and Precision of Biplanar Videoradiography to Quantify Tibial Fracture Motion After Fixation Stephen Warner, MD, PhD; Conor Smith, PhD; Tomasz Bugajski, PhD; Augustine Saiz, MD; Patrick Kellam, MD; John Munz, MD; Andrew Choo, MD; Timothy Achor, MD; Jonathan Eastman, MD; Payam Zandiyeh, PhD