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232024BASIC SCIENCE FOCUS FORUM/ISFR JOINT MEETINGOCTOBERMONTRÉAL, QC7 AMA PRA Category I Credits™Schedule and presenters are subject to change.#OTA2024WEDNESDAY
Register today at ota.org 2OTA MemberOn/Before9/23/24OTA MemberAfter9/23/24Non-MemberOn/Before9/23/24Non-MemberAfter9/23/24Course Fee : $ 275 $ 375 $ 375 $ 475Early Bird Registration Until September 23.TARGET AUDIENCE Academic orthopaedic surgeons, community surgeons with an interest in clinically relevant basic science, basic and clinical researchers, PhDs, residents and fellows will benet most from this combined course.BASIC SCIENCE COMMITTEE Justin Haller, MD ChairAndrew Evans, MD Michael Hast, PhD Brian (Vu) Hoan Le, MD Christopher Lee, MDOVERVIEW The 2024 Basic Science Focus Forum (BSFF) andcombined International Section for Fracture Repair (ISFR) course is directed towards orthopaedic surgeons with an interest in the basic science of orthopaedic trauma and how it relates to or impacts their practice. Basic science researchers will also obtain valuable knowledge about translational opportunities and how their research has the potential to change orthopaedic care. This course will involve 3 main symposia specically designed to ‘bridge the gap’ between basic science and clinical practice, in addition to approximately 30 original research papers from the cutting edge of basic science research. This combined course hasproved to be a great collaboration and a chance todiscuss ideas with our international colleagues.LEARNINGOBJECTIVESUpon successful completion of the 2024 BSFF/ISFR Joint Meeting, participants will be able to: 1. Explore the mechanisms and treatment of fracture nonunion2. Understand the impacts of the aging patient on fracture healing and recovery. 3. Understand the impact of trauma on fracture and soft tissue healing.WEDNESDAY, OCTOBER 23, 2024BASIC SCIENCE FOCUS FORUM/ ISFR JOINT MEETING MONTREAL CONVENTION CENTER, ROOMS 512ABCEFGWEDNESDAY, OCTOBER 2311:45 AM – 12:35 PM, ROOM 517A JOINT INTERNATIONAL INDUSTRY LUNCH SESSIONSponsored by: Zimmer BiometPlease note, if you would like to attend the Tuesday session, in addition to Wednesday (cost $355), information and registration are available here.(Wedonly)KEY NOTE ADDRESSDR. ILIZAROV:HIS LIFE, AND HIS METHOD: LEARNING FROM NATURESvetlana Ilizarov, MDSkepticism from the midcentury medical community about the initial clinical results from the Ilizarov unit prompted Ilizarov’s early involvement in basic science research. This propelled further development and eventual recognition of his method. Some of Ilizarov’s original clinical work and research will be presented.
COURSE AGENDABASIC SCIENCE FOCUS FORUM/ ISFR JOINT MEETING MONTREAL CONVENTION CENTER, ROOMS 512ABCEFG3#OTA2024 | FOLLOW OTA ON | ota.org WEDNESDAY, OCTOBER 23 7:30 AM WELCOME & INTRODUCTION7:35 AM Justin Haller, MD7:35 AM - SYMPOSIUM I8:35 AM FRACTURE NONUNION Moderators: Brian (Vu) Le, MD Andrew Evans, MD7:35 AM Culture Positive Nonunion: Now What? Cliff Jones, MD, FIOTA7:45 AM Early Clinical Determination/ Detection of Nonunion Zachary Working, MD 7:55 AM The Biologic Mechanisms for Nonunion Development Georg Duda, PhD8:05 AM Novel Therapeutic Strategies for Nonunions Christopher Evans, PhD8:15 AM Discussion All Faculty 8:35 AM - PODIUM SESSION I9:25 AM NONUNION AND EMERGING TECHNOLOGIES Moderators: Brian (Vu) Le, MD & Andrew Evans, MD8:35 AM - PODIUM 18:39 AM Of Mice and Men: Temporal Comparison ofModiedRadiographicUnionScores for Tibia Fractures (mRUST) between Mouse and Human Femoral Shaft Fractures Treated with Intramedullary Nails (IMNs) Yohan Jang, DO; Luke A. Lopas, MD; Todd O. McKinley, MD; Brian Mullis, MD, FIOTA; David P. Foley, MBA, MD; Christopher Collier, MD; Jiliang Li, PhD; Ziyue Liu, PhD; Melissa Kacena, PhD; Roman Natoli, MD, PhD8:39 AM - PODIUM 28:43 AM Synergistic Coupling of PTH with Cold Therapy to Enhance Fracture Healing Matthew Zakaria, MSc; Michael Grant, PhD; Laura M. Epure; Fackson Mwale; Geraldine Merle, PhD; Edward J. Harvey, MD, FIOTA8:43 AM - PODIUM 38:47 AM Biomarker to Endochondral Phase of Fracture Repair Demonstrates Differences Between Early and Delayed Long Bone Healing Zachary M. Working, MD; Molly E. Czachor; Anna L. Nelson, MS; Kelsey O’Hara, BS; Karalynn Lancaster, BS; Colby Curtis, BS; Ryan Coghlan; Graham J. Dekeyser, MD; Darin M. Friess, MD; Theodore Miclau III, MD, FIOTA; William Horton, MD; Brian Johnstone, PhD; Chelsea S. Bahney, PhD
8:47 AM - PODIUM 48:51 AM Collagen X Fracture Biomarker Suggests Surgical Intervention for Fracture Nonunion Drives Endochondral Bone Response Zachary M. Working MD; Natasha S. McKibben, MD; Molly E. Czachor; Danielle Peterson, MD; Michelle Lawson, MD; Catherine E. Hutchison, MD; Colby Curtis, BS; Karalynn J. Lancaster, BS; Graham J. Dekeyser, MD; Darin M. Friess, MD; Chelsea S. Bahney, PhD8:51 AM Discussion9:00 AM - PODIUM 59:04 AM ∆Immunophenotyping to Characterize Immune Dysregulation in a Delayed Fracture Healing Murine Model Daniel R. Lind; Herbert Kasler, PhD; Marc J. Philippon, MD; Victoria R. Duke; Kohei Yamaura, MD, PhD; Naomasa Fukase, MD; Anna L. Nelson, MS; Matt Huard, BS; Sealy Hambright, PhD; Johnny Huard, PhD; Ralph Marcucio, PhD; Dustin M. Snapper, MD, MS; Chelsea S. Bahney, PhD9:04 AM - PODIUM 69:08 AM Fremanezumab Reduces Pain Behavior in Murine Femoral Fractures Tyler James Margetts, BS; Ashlyn G. Cochran, BSc; Upasana Ganguly, MSc; Sonali J. Karnik, PhD; Rachel J. Blosser MSc; Sarah L. Mostardo, BSc; Nicole Courtney; Kuldeep Yadav, MBBS; Fletcher A. White, MSc, PhD; Roman Natoli, MD, PhD; Jill C. Fehrenbacher, PhD; Melissa Kacena, PhD9:08 AM - PODIUM 79:12 AM Automated Assessment of Post-Fracture Pain in Mice Using Novel Imaging and Machine Learning Tools Jarret Weinrich, PhD; Molly E. Czachor; Charles Lam, BA; Dane Lind; Kazuhito Morioka, MD, PhD; Dustin Snapper, MD, BS; Ralph Marcucio, PhD; Allan Basbaum, PhD; Chelsea S. Bahney, PhD9:12 AM - PODIUM 89:16 AM Reducing Radiation Dose During Plate Fixation Using Depth Camera Augmented Fluoroscopy (DeCAF) Parinaz Ranjbaran, MSc; David J. Stockton, MD, MSc; Antony Hodgson, PhD; Pierre Guy, MD9:16 AM Discussion9:25 AM - Morning Break9:40 AM9:40 AM - SYMPOSIUM II10:50 AM GERIATRIC FRACTURE (IN COLLABORATION WITH FRAGILITY FRACTURE NETWORK) Moderators: Justin Haller, MD Emil Schemitsch, MD, FIOTA 9:40 AM Biology of Aging Philipp Leucht, MD 9:50 AM Fixation of Geriatric Fractures Frede Frihagen, MD 10:00 AM Sarcopenia Gustavo Duque, MD 10:10 AM Importance of Mobility in the Geriatric Patient Richard Yoon, MD, FIOTA 10:20 AM Novel Candidates for Accelerating Geriatric Delayed Healing Susan Bukata, MD 10:30 AM DiscussionRegister today at ota.org 4∆ OTA Grant
WEDNESDAY, OCTOBER 23, 2024BASIC SCIENCE FOCUS FORUM/ ISFR JOINT MEETING MONTREAL CONVENTION CENTER, ROOMS 512ABCEFG5#OTA2024 | FOLLOW OTA ON | ota.org 11:15 AM - PODIUM 1311:19 AM Femoral Neck Prophylaxis with Lateral Femoral Plating: A Biomechanical Study Jacob D. Schultz, MD; Nathaniel Schaffer, MD, PhD; Joseph O. Labrum, MD; Lauren Luther, MD; Emily Beretsky, BS; Sasidhar Uppuganti, MS; Jeffry Nyman, PhD, MS; Phillip M. Mitchell MD 11:19 AM - PODIUM 1411:23 AM A Novel Radiographic Marker to Avoid Dorsal Screw Prominence During Distal Radius Fixation with Volar Locking Plates Kellen Worhacz, MD; Paulo Castaneda, MD; Joseph B. Walker, MD 11:23 AM - PODIUM 1511:27 AM Biomechanics of Femoral Neck System (FNS) in Pauwels Type III Fractures Samarth Mittal, MBBS; Laureb Rao, MD; Kaushik Mukherjee, MD; Apoorva P. Kabra, MBBS; Anoop Chawla, MD; Vivek Trikha, MD 11:27 AM - PODIUM 1611:31 AM Deep Learning for Automated Deformity Correction Planning in the Setting of Prior Arthroplasty Joshua K. Helmkamp, MD; Jay M. Levin, MD; Pranav Manjunath, MS; Bruno N. Valan, MS; Pragya Raghuvanshi, MS; Maria Izzi, BS; Malcolm R. DeBaun, MD; Christian A. Pean, MD; Tim Dunn, PhD; Thorsten M. Seyler, MD, PhD; Mikhail A. Bethell, MS 11:31 AM Discussion11:40 AM - Lunch in Room 517A 12:40 PM 10:50 AM - PODIUM SESSION II11:40 AM GERIATRIC FRACTURE FIXATION Moderators: Justin Haller, MD Emil Schemitsch, MD, FIOTA10:50 AM - PODIUM 910:54 AM Biomechanical Comparison of Cephalomedullary and Reconstruction Nails Used in the Treatment of Subtrochanteric Femur Fractures Jonathan McKeeman, MD, MBA, MS; Samantha N. Weiss, MD; Robert Gomez, MD; Michael Hast, PhD; Chet Friday, BE; Margaret J. Higgins, MD; Douglas W. Lundy, MD, MBA, FIOTA 10:54 AM - PODIUM 1010:58 AM Noninvasively Quantifying In Vivo Distal Femur Fracture Motion William D. Lack, MD; Aerie Grantham, BS; William L. Crutcher, MD; Will Lin, BS; Elmer Vazquez, BS; Joseph L. Davis, BS; Sam S. Nelson, BS; William R. Ledoux, PhD 10:58 AM - PODIUM 1111:02 AM Compression Buttress Screw Fixation for the Treatment of Vertical Femoral Neck Fractures: A Biomechanical Comparison with Traditional Sliding Compression Fixations Hui Sun, MD, PhD; Zhi-Yuan Fan, MD; Lin-Yuan Shu, MD; Matthew C. Sherrier, MD; Wei Zhang, MD, PhD 11:02 AM - PODIUM 12 ∆Evaluating Feasibility of Ultrasound- Guided Insertion of Iliosacral Screws for Pelvic Fracture Fixation Pierre Guy, MD; Prashant Pandey, PhD; Emily K. Bliven, BSME; Kelly A. Lefaivre, MD, MS; Antony Hodgson, PhD 11:06 AM Discussion∆ OTA Grant
Register today at ota.org 612:52 PM - PODIUM 2012:56 PM Can We Identify at What Point in Recovery Somatosensory Reprogramming Occurs in Patients with Chronic Pain After Surgically Treated Lower Extremity Fractures? William M. Charlton, BS; Lucy C. Bowers, BS; Joshua Van Wyngaarden, DPT, PhD; Gregory S. Hawk, PhD; Brian Noehren, PT, PhD; Paul E. Matuszewski, MD 12:56 PM Discussion1:05 PM - PODIUM 211:09 PM The Effect of Emergency Department Saline Lavage on Synovial Fluid Composition Following Human Intra- Articular Ankle Fracture: A Randomized Controlled Trial Keith Whitlock, MD; Samuel G. Lorentz, MD; Nicholas Allen, BS; Alexandra Hunter Aitchison, BS; Steven A. Olson, MD, FIOTA; Samuel Bruce Adams MD 1:09 PM - PODIUM 221:13 PM IL-1 Receptor Antagonist Rescue Chondrocytes from Cellular Death Following Intra-Articular Fractures in a Porcine Pilon Fracture Model Tyler J. Thorne, MD; Willie Dong, BS; Eleanor Sato, MD; Dillon C. O’Neill, MD; Joseph Featherall, MD; Lillia Steffenson, MD; Aaron L. Olsen, DVM, PhD; Justin Haller, MD1:13 PM - PODIUM 231:17 PM Preservation of Osteochondral Autografts for Delayed Reimplantation in a Novel Preclinical Canine Model Gregory J. Della Rocca, MD, PhD, MBA; Aaron M. Stoker, PhD, MS; Chantelle Bozynski, DVM, MSc; Julia V. Nuelle, MD; James L. Cook, DVM, PhD, OTC 1:17 PM Discussion 11:45 AM - JOINT INDUSTRY (Room 517A) 12:35 PM LUNCH SESSION WITH ITCF Sponsored by: Zimmer Biomet TREATING INFECTION IN COMPLEX TRAUMA AND JOINT RECONSTRUCTION CASES Infection poses a challenging clinical obstacle for Trauma and Joint Reconstruction Orthopaedic surgeons. This presentation will review the hurdles posed by infection and available treatment options. Erik Kubiak, MD12:40 PM - PODIUM SESSION III1:25 PM INFECTION AND PTOA Moderators: Zachary Working, MD Michael Hast, PhD12:40 PM - PODIUM 1712:44 PM WITHDRAWN 12:44 PM - PODIUM 1812:48 PM Characterization of a Transtibial Amputation Model of Osseointegrated Implant Infection Bailey Fearing, PhD; Sarah Romereim, PhD; Matthew R. Smykowski, BS; Susan Appt, DVM; Heather Burkart, DVM; Jana M. Davis, MD; Ryan Serbin, MD; Nainisha Chintalapudi, MD; Rachel Seymour, PhD; Joseph R. Hsu, MD 12:48 PM - PODIUM 1912:52 PM ∆Halicin and Aminoglycosides Synergize Against Staphylococcus aureus in Both PlanktonicCulturesandBiolms Joash R. Suryavanshi, MD; Akira Morita, MD, PhD; Shota Higashihira, MD; James E. Slavin, MS; Dalton Walsh, BS; Roman M. Natoli, MD, PhD; EdM.Greeneld,PhD∆ OTA Grant
WEDNESDAY, OCTOBER 23, 2024BASIC SCIENCE FOCUS FORUM/ ISFR JOINT MEETING MONTREAL CONVENTION CENTER, ROOMS 512ABCEFG7#OTA2024 | FOLLOW OTA ON | ota.org 3:30 PM - PODIUM SESSION IV3:30 PM BASIC SCIENCE OF THE POLYTRAUMA PATIENT Moderators: Chris Lee, MD Hans-Christoph Pape, MD, FIOTA3:30 PM - PODIUM 243:34 PM SystemicLipidomicProleChangesAlign with Injury Severity and Predict Outcomes in Polytraumatized Patients Yannik Kalbas, MD; Felix Karl-Ludwig Klingebiel, MD; Sascha Halvachizadeh, MD; Michel P. Johan Teuben, MD, PhD; Roman Pfeifer, Prof., MD; Paolo Cinelli, PhD; Hans-Christoph Pape, MD, FIOTA 3:34 PM - PODIUM 253:38 PM Hypercoagulability and Systemic InammationContributetoVenous Thromboembolism in Orthopaedic Surgery Patients with Metastatic Bone Disease Lisa Yamaura, MSc; Haiyan Hou; Andrew Dodd, MD; Paul J. Duffy, MD; Robert Korley, MD; Shannon Puloski, MD; Leslie Skeith, MD, MHPE; Michael Monument, MD, MSc; Craig Jenne, PhD; Prism Schneider, MD, PhD 3:38 PM - PODIUM 263:42 PM ∆Novel Fracture-Based Porcine Model of Acute Compartment Syndrome Creates Elevated Intracompartmental Pressure Using a Only Simulated Blast Injury Eleanor Sato, MD; Tyler J. Thorne, MD; Willie Dong, BS; Joshua Klonoski, MD, PhD; Aaron L. Olsen, DVM, PhD; Justin Haller, MD; Dillon C. O’Neill, MD 1:25 PM - KEYNOTE ADDRESS 2:10 PM BSFF/ISFR JOINT KEYNOTE LECTURE DR. ILIZAROV: HIS LIFE, AND HIS METHOD: LEARNING FROM NATURE Skepticism from the midcentury medical com-munity about the initial clinical results from the Ilizarov unit prompted Ilizarov’s early involvement in basic science research. This propelled further development and eventual recognition of his method. Some of Ilizarov’s original clinical work and research will be presented. Svetlana Ilizarov, MD2:10 PM - Afternoon Break2:30 PM2:30 PM - SYMPOSIUM III3:30 PM POLYTRAUMA, IN COLLABORATION ESTES Moderators: Chris Lee, MD Hans-Christoph Pape, MD, FIOTA 2:30 PM Soft Tissue Healing in a Polytrauma Patient Arun Aneja, MD 2:40 PM Effects of Traumatic Brain Injury and Bone Healing in Polytrauma Patient Prism Schneider, MD, PhD 2:50 PM Fracture Fixation in Polytrauma Patients Hans-Christoph Pape, MD, FIOTA 3:00 PM TheImpactofInammationand Polytrauma on Bone Healing Melanie Haffner Luntzer, PhD 3:10 PM Value of a Multi-center Serum Data Bank for Trauma Patients Michel Teuben, MD 3:20 PM Discussion∆ OTA Grant
Register today at ota.org 83:42 PM - PODIUM 273:46 PM PCMP as a Barrier for Complex Wounds: Impact on Clinical Outcomes, Bioburden, and Gene Expression in a Canine Model James P. Stannard, MD; Katie Culpepper Mowry, PhD; Rami A. Nasrallah, BS; James L. Cook DVM, PhD, OTC; Chantelle Bozynski, DVM, MSc; Aaron M. Stoker, PhD, MS; Kelly Kimmerling, PhD 3:46 PM Discussion3:55 PM - PODIUM 283:59 PM Developing a Pragmatic Murine Injury Model for Polytrauma Research Taylor Landis, BA; Nathan Lamb, BS; Murad K. Nazzal, BS; Wenwu Zhang, PhD; Larry Chen, BS; Rachel Blosser, MS; Kayla Gates, MD; Nada S. Alakhras, PhD; Michelle Niese, PhD; Aamir Tucker DO; Melissa Kacena, PhD; Mark Kaplan PhD; Todd O. McKinley MD 3:59 PM - PODIUM 294:03 PM ∆Indocyanine Laser Angiography Does Not Predict Early Muscle Injury Severity in a Porcine Open Tibia Fracture Model Joseph Featherall, MD; Tyler J. Thorne, MD; Dillon C. O’Neill, MD; Eleanor Sato, MD; Willie Dong, BS; Justin Haller MD4:03 PM - PODIUM 304:07 PM ∆Intravenous Iron Infusion Mitigates Platelet Exhaustion and Improves Secretory Response to Agonists in Orthopedic Trauma Patients Chih-Jen Yang MD; Danielle Peterson, MD; Natasha S. McKibben, MD; Victoria R. Duke; Catherine E. T. Hutchison, MD; Michaela Geffert, BS; Colby Curtis, BS; Karalynn Lancaster, BS; Talia Trapalis, BS; Dongseok Choi, PhD; Joseph Shatzel; Graham J. Dekeyser, MD; Darin M. Friess, MD; Martin A. Schreiber; Karina Nakayama, PhD; Nick Willett; Zachary M. Working, MD; Joseph Aslan 4:07 PM - PODIUM 314:11 PM ∆Intravenous Iron Therapy Alters the InammatoryCascadeFollowing Orthopaedic Trauma: A Pilot Randomized Controlled Trial Victoria Rose Duke; Danielle Peterson, MD; Natasha S. McKibben, MD; Catherine E. T. Hutchison, MD; Chih-Jen Yang, MD; Colby Curtis, BS; Karalynn Lancaster, BS; Talia Trapalis, BS; Dongseok Choi, PhD; Joseph Shatzel; Graham John Dekeyser, MD; Darin M. Friess, MD; Martin Allan Schreiber; Joseph Aslan; Zachary Mark Working, MD; Karina Nakayama PhD; Nick Willett 4:11 PM Discussion4:20 PM Adjourn4:45 PM - EVERYONE IS INVITED TO ATTEND THE6:00 PM OTA INTERNATIONAL RECEPTION (720 Atrium)∆ OTA Grant
BASIC SCIENCE FOCUS FORUM/ ISFR JOINT MEETING MONTREAL CONVENTION CENTER, ROOMS 512ABCEFG9#OTA2024 | FOLLOW OTA ON | ota.org The Orthopaedic Trauma Association is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.The Orthopaedic Trauma Association designates this live activity for a maximum of 7 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Don’t miss the Combined ITCF/BSFF Symposium on Friday morning in the General Session Room. Must be registered for Annual Meeting to attend.FRIDAY, OCTOBER 25 8:00 AM - BSFF/ITCF (General Session 9:00 AM JOINT SYMPOSIUM Room 210CDGH) CURRENT MANAGEMENT OF FRACTURE-RELATED INFECTIONS Moderators: Justin Haller, MD Hans-Christoph Pape, MD, FIOTA 8:00 AM Overview Justin Haller, MD 8:02 AM Biolms:WhatAreTheyand How We Prevent Them Joseph Wenke, PhD 8:12 AM Infection Prevention and Diagnosis in High Risk Patients Lucas Marchand, MD 8:22 AM Management of Acute Infections After Osteosynthesis Peter V. Giannoudis, MD, PhD 8:32 AM How to Manage Critical Sized Defects in the Setting of Infection John Scolaro, MD 8:42 AM Best Practices for Treating Chronic Fracture Related Infection Hans-Christoph Pape, MD, FIOTA 8:52 AM Discussion - 9:00 AM