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BASIC SCIENCEFOCUS FORUMWednesday-ThursdayOCTOBER 12 – 13, 2022Tampa Convention Center - Ballroom D Tampa, FloridaANNUAL MEETINGTAMPA, FLORIDA OCTOBER 12 – 15, 2022#OTA2022 Schedule and presenters are subject to change.10.75 AMA PRA Category I Credits™
OTA MemberOn/Before9/11/22OTA MemberAfter9/11/22Non-MemberOn/Before9/11/22Non-MemberAfter9/11/22Course Fee: $ 250 $ 350 $ 350 $ 450Early Bird Registration Until September 11.OVERVIEW The 2022 Basic Science Focus Forum Course (BSFF) is directed towards orthopaedic surgeons with an interest in the basic science of orthopaedic trauma and how it relates to or impacts their practice. Basic science researchers will also obtain valuable knowledge about translational opportunities and how their research has the potential to change orthopaediccare. This course will involve 5 main symposia specicallydesignedto‘bridgethegap’between basic science and clinical practice, in addition to approximately 32 original research papers from the cutting edge of basic science research. The attendees of the BSFF program will also have the opportunity to join together with the attendees at the International Trauma Care Forum for a special joint symposium. This combined session has proved to be a great collaboration and a chance to discuss ideas with our international colleagues. Upon successful completion of this course, participants will be able to: üUpdate their knowledge in the basic science of orthopaedic traumaüUnderstand the different animal models available for investigation in orthopaedic traumaüDemonstrate knowledge of the latest evidence and basic science perspectives around amputations and prostheticsüExplore the latest research on geriatric trauma from a basic science and clinical perspectiveüUnderstand the biomechanics of fracture healing and how this can help you optimize xation constructsüExplore the latest research around immune modulation and response to traumaüExplore basic science and International Perspectives on distal femur fractures. Academic orthopaedic surgeons, community surgeons with an interest in clinically relevant basic science, basic and clinicalresearchers,residentsandfellowswillbenetmostfrom this Basic Science Focus Forum. #OTA2022 | @otatrauma | @otatrauma | ota.org 2SYMPOSIA – Combined Session with International Trauma Forum: Distal Femur Fractures: Basic Science and International Perspectives– Immune Modulation of Fracture Healing and Response to Polytrauma– Amputation and Prosthetics: The Latest Advances and Basic Science Perspectives – SRI Collaborative Session: Animal Models – Other Symposia Topics Include: Geriatric Trauma; Biomechanics of Fracture HealingBASIC SCIENCE FOCUS FORUMBASIC SCIENCE COMMITTEE Aaron Nauth, MD ChairAndrew R. Evans, MD, FACSJustin Haller, MDMichael W. Hast, PhDChristopher Lee, MD Saam Morshed, MD, PhDEmil H. Schemitsch, MDAndrew Trenholm, MDJohn J. Wixted, MD
Register today at ota.org.BASIC SCIENCE FOCUS FORUM 7:30 AM - 7:35 AM Aaron Nauth, MD7:35 AM - SYMPOSIUM I8:40 AM Moderators: Saam Morshed, MD Chelsea Bahney, PhD7:35 AM Overview Saam Morshed, MD7:40 AM Post-Traumatic OA: Current Models and Translational Relevance Justin Haller, MD7:50 AM Fracture Related Infection: Preclinical Models to Assess Emerging Therapies Joseph C. Wenke, PhD8:00 AM Animal Models for Non-union and Delayed Fracture Healing After Multiple Trauma Augustine Saiz Jr., MD8:10 AM From Mouse to Human: Choosing the Correct Animal Model to Facilitate Clinical Translation Thomas Schaer, VMD8:20 AM Discussion8:40 AM - PAPER SESSION I9:35 AM - Moderators: Saam Morshed, MD Chelsea Bahney, PhD8:40 AM PAPER 1 Probiotics and Microbiota: Can They Modulate Fracture Healing? Yufa Wang; Aouod Agenor, MD; Cari Whyne, PhD; Allison J. Clement, MSc; Adam Hopfgartner, MSc; Diane Nam, MD8:46 AM PAPER 2 Facilitated Fracture Repair via Noninvasive Localized Cold Therapy Matthew Zakaria, BS, MSc; Yazan Honjol, BA, MD; Jose Luis Ramirez Garcia Luna, MD, MSc; Lucy Luo, MD; Daniela Vieira, MSc; Rachel Monk; Nicole Gamburg, BS; Géraldine Merle; Edward J. Harvey, MD, MSc8:52 AM PAPER 3 DistinctInammatoryNetworksare Associated with Organ Dysfunction in Orthopaedic Trauma Patients Greg E. Gaski, MD, FAAOS; Ruben Zamora, PhD; Katherine Frey, MPH, PhD; Krista M. Brown, MS; Eric Elster; Scott D. Steenburg, MD; Kuladeep Reddy Sudini, PhD; Laurence Kempton, MD, FAAOS; Reza Firoozabadi, MD, FAAOS; Joshua Layne Gary, MD, FAAOS; Stephen James Warner, MD, PhD; William T. Obremskey, MD, MPH; Robert V. O’Toole, MD, FAAOS; Arun Aneja, MD, PhD; Susan Catherine Jane Collins, MSc; Renan C. Castillo, MD; Timothy R. Billar, MD; Yoram Vodovotz, PhD; Todd Owen McKinley, MD, FAAOS; METRC
BASIC SCIENCE FOCUS FORUM 8:58 AM PAPER 4 BMP-2 is Superior to PDGF for Bone Defect Healing in a Small Animal Model Matthew Raleigh, MD; Stéphane Gagnon, MSc; Hilary Felice, MD; Charles Godbout, PhD; Emil H. Schemitsch, MD, FAAOS; Aaron Nauth, MD9:04 AM Discussion9:10 AM PAPER 5 Targeted Delivery of GSK-3ß Inhibitor Loaded Nanoparticles for Fracture Healing in a Murine Nonunion Model Brittany Haws, MD; Baixue Xiao; John P. Ketz, MD, FAAOS; Danielle Benoit PhD9:16 AM PAPER 6 Post Traumatic Lipidomic Course In Occult Hypoperfusion: An Analysis In a Standardized Porcine Polytrauma Model Yohei Kumabe, MD; Yannik Kalbas, MD; Sascha Halvachizadeh, MD; Thorsten Hornemann, PhD; Paolo Cinelli, PhD; Hans-Christoph Pape, MD; Roman Pfeifer, MD #OTA2022 | @otatrauma | @otatrauma | ota.org 49:22 AM PAPER 7 Production of Bioengineered Oriented 3D-PLGA/aCaP Scaffolds for Improving the Treatment of a Critical Size Defects Sascha Halvachizadeh, MD; Yannik Kalbas, MD; Yohei Kumabe, MD; Hans-Christoph Pape, MD; Paolo Cinelli, PhD9:28 AM Discussion9:35 AM - Morning Break9:50 AM9:50 AM - SYMPOSIUM II10:55 AM Moderators: Jack Wixted, MD Andrew Evans, MD9:50 AM What a Long Strange Trip It’s Been. Osseointegration, Then and Now Rickard Branemark, MD, PhD10:15 AM Osseointegration: Is It Ready for Prime Time? Complications, Challenges, and Successes Kevin Tetsworth, MD10:40 AM Establishing an Osseointegration Program in the US Stephen Quinnan, MD10:55 AM - 11:50 AM Moderators: Jack Wixted, MD Andrew Evans, MD10:55 AM PAPER 8 TheEfcacyofEndothelialProgenitorCell Therapy Combined with Local Antibiotics in a Rat Critical-Size Defect Model Ikran Ali, BS; Stéphane Gagnon, MSc; Kalter Hali, MSc; Graeme Hoit, MD; Richard Magony, BS; Emil H. Schemitsch, MD, FAAOS; Aaron Nauth, MD
BASIC SCIENCE FOCUS FORUMRegister today at ota.org.5 11:01 AM PAPER 9 Silver Carboxylate-TiO2/Polydimethyl SiloxaneisaSafeandEfcacious AntimicrobialwithSignicantWound Care Potential Dioscaris R. Garcia, PhD; Neel Vishwanath, BS; Sai Siddharth Allu, BA; Drew James Clippert; Elia J. Jouffroy, BS; Colin D. Whitaker BA; James Minwoo Hong; Valentin Antoci, MD, PhD; Christopher T. Born, MD, FAAOS11:07 AM PAPER 10 Methods of Disinfection of Grossly Contaminated Devitalized Bone for Retained Use in Open Fractures: An in vitro Study Aleksey Dvorzhinskiy, MD; Kathleen Meyers, MS; William M. Ricci, MD, FAAOS; David Leonard Helfet, MD, FAAOS; Alberto V. Carli, MD, MSc; Xu Yang, MD; Mathias P. G. Bostrom, MD, FAAOS; David Wellman, MD, FAAOS11:13 AM Discussion11:19 AM PAPER 11 Patients with Acute or Impending Pathological Fractures Demonstrate Platelet-Mediated Hypercoagulability and High Venous Thromboembolism Rates Lisa Yamaura, MSc; Leslie Skeith; Michael Monument, MD, MSc; Andrew Dodd, MD; Paul James Duffy, MD; Robert Korley, MD; Ryan Martin, MD; Prism Schneider, MD, PhD11:25 AM PAPER 12 ImplantMaterialsAffectBiolmFormation David Kerr, MD; Megan Zheng; Thorsten M. Seyler MD, PhD11:31 AM PAPER 13 Computed Tomography Provides Effective Detection of Traumatic Arthrotomies of the Elbow Jacob Jackowski, MD; Alexandra Cancio-Bello; Elizabeth Wellings, MD; Jonathan D. Barlow MD, MS; Krystin Hidden, MD; Brandon J. Yuan, MD, FAAOS11:37 AM PAPER 14 Prolonged Post-operative Hypercoagulability Occurs in Patients with Metastatic Bone Disease Lisa Yamaura, MSc; Leslie Skeith; Michael Monument, MD, MSc; Andrew Dodd, MD; Paul James Duffy, MD; Robert Korley, MD; Ryan Martin, MD; Prism Schneider, MD, PhD11:43 AM Discussion11:50 AM Proceed to Ballroom C12:00 PM - 12:50 PM Sponsored by Addressing Complex Distal Radius Fractures Complex and comminuted distal radius fractures pose unique challenges for orthopaedic surgeons. This presentation reviews those challenges as well as Biologics, bridge plating and volar plating options. Box Lunch Provided by OTA (Lunch hour 11:55 AM - 12:55 PM)12:55 PM Return to Ballroom D
BASIC SCIENCE FOCUS FORUM #OTA2022 | @otatrauma | @otatrauma | ota.org 6 1:00 PM - SYMPOSIUM III2:00 PM Moderators: Emil Schemitsch, MD Christopher Lee, MD1:00 PM Overview Christopher Lee, MD1:02 PM Preoperative: Is Fracture Healing Different in the Elderly, and How Can It Be Optimized? Stephen Kates, MD1:10 PM Intraoperative: Are We Getting this Right? How to Assess Reduction Matt Graves, MD1:18 PM Postoperative: Preventative Management to Reduce Subsequent Fractures Kyle Jeray, MD1:26 PM Multidisciplinary Orthogeriatric Care Roger Lee, MD1:34 PM Atypical Femur Fractures: How to Optimize Treatment Reza Firoozabadi, MD1:42 PM Discussion 2:00 PM - 2:50 PM Moderators: Emil Schemitsch, MD Christopher Lee, MD2:00 PM PAPER 15 CollagenXBiomarkerCorrelatesto CanonicalBoneTurnoverMarkersDuring Fracture Healing and Distinguishes Sex-Related Differences in Soft Callus Formation Zachary Mark Working, MD, FAAOS; Kelsey O’Hara, BS; Anna Laura Nelson, MS; Ryan Coghlan; Lucas Scott Marchand, MD; SoaBzovsky,MSc;SheilaSprague,PhD; Nathan N. O’Hara, PhD; Gerard Slobogean, MD, MPH; Chelsea S. Bahney, PhD2:06 PM PAPER 16 Biological Activity of Human Induced Membranes: Differences Between Anatomical Sites are More Important than Time Interval Between Stages Vaida Glatt, PhD; Anna Woloszyk; Kevin Tetsworth, MD2:12 PM PAPER 17 Collagen X Longitudinal Fracture BiomarkerSuggestsStagedFixationin Tibial Plateau Fractures Delays Rate of Endochondral Repair Zachary Mark Working, MD, FAAOS; Danielle Peterson, MD; Michelle Lawson, MD; Kelsey O’Hara, BS; Ryan Coghlan; Matthew T. Provencher, MD, MBA; Darin M. Friess, MD, FAAOS; Brian Johnstone, PhD; Theodore Miclau, MD, FAAOS; Chelsea S. Bahney, PhD2:18 PM Discussion2:24 PM PAPER 18 Local Environment Changes Driving Progression to Non-union Michalis Panteli, MD; James Vun, MBCHB, MRCSED; Robert Michael West, DPHIL (OXON), MSc; Elena Jones, PhD; Ippokratis Pountos; Peter Giannoudis MD, BS2:30 PM PAPER 19 How Many Patients Do We Need? Simple ClassicationtoUseInStudyPlanning Meghan Wally, PhD, MSPH; Rachel Seymour, PhD; Tamar Roomian, MPH, MS; Christine Churchill, BA; Nikkole Marie Haines, MD; Joseph R. Hsu, MD, FAAOS; Michael J. Bosse, MD, FAAOS; Madhav A. Karunakar, MD, FAAOS; EMIT2:36 PM PAPER 20 Edaravone-Based Intervention In Spinal Cord Injury Amar Chandra Sharma PhD; Rajeshwar Nath Srivastava, MS2:42 PM Discussion2:50 PM - Afternoon Break3:05 PM
BASIC SCIENCE FOCUS FORUM,Register today at ota.org.73:05 PM - SYMPOSIUM IV4:05 PM Moderators: Michael Hast, PhD Justin Haller, MD3:05 PM Overview Justin Haller, MD3:10 PM Smart Fracture Plate for Monitoring Callus Stiffness Michael Archdeacon, MD3:20 PM Actively Controlling Fixation Stability to Optimize and Accelerate Bone Healing Vaida Glatt, PhD3:30 PM FractSim Software for Visualization of 3D Fracture Fixation Biomechanics Greg Lewis, PhD3:40 PM Where Might We Go from Here? Jaimo Ahn, MD, PhD3:50 PM Discussion4:05 PM - 4:55 PM Moderators: Michael Hast, PhD Justin Haller, MD4:05 PM PAPER 21 A Wireless Intramuscular Near-Infrared Spectroscopy Device Detects Muscle Oxygenation Changes in Swine Model of Leg Compartment Syndrome Amanda Westman, PhD; Hexia Guo; Yameng Xu, MS; Wubin Bai, PhD; Wei Ouyang, PhD; William R. Moritz, MD; Lauren Jacobson MD; Yang Weng; Hao Zang MS; Changsheng Wu; Ziying Hu, PhD; Shuo Li, PhD; Di Lu, PhD; Hany Mohamed Arafa, MS; Matthew Macewan, PhD; Lauren Maccormick Tatman, MD; John A. Rogers, PhD; Mitchel Andrew Pet4:11 PM PAPER 22 DualVersusLateralLockedPlatingin Elderly Cadaveric Bicondylar Tibial Plateau Fractures: Does Medial Comminution Matter? Dencel Armando García Vélez, MEd; Paraskevi Marousa Limberatos; Krishna Vangipuram Suresh, BS; J. Gary Bledsoe, PhD; Mikel Headford, DO; Thomas Revak, DO, FAAOS4:17 PM PAPER 23 Optimal Placement of Calcaneal Pin for AnkleExternalFixator Tyler Daniel Ragsdale, MD; Brandon Paul McMaster, BS; Daemeon A. Nicolaou, MD, FAAOS4:23 PM Discussion4:29 PM PAPER 24 Medial Column Screw Supplementation ofLateralLockingPlateforDistalFemur Fractures: A Biomechanical Study Joseph David Henningsen, MD; Kyle S. Mobley, MD; Michael Regensburger; Joshua David Perrin, MS; Scott W. Huff, MD; Andrew Froehle, PhD; Jennifer Jerele, MD, FAAOS; Michael J. Prayson, MD, FAAOS4:35 PM PAPER 25 Bringing Balance to the Force: Lateral LockingPlateScrewConguration Alternatives for Comminuted Distal Femur Fractures with Major Bone Loss Deniz Erbulut, PhD; Kevin Tetsworth, MD; Nicholas Green, BS; Caroline Grant4:41 PM PAPER 26 Simulation-Enabled Measurement of Interfragmentary Strain in Distal Femur Fracture Fixation Ajith Malige, MD; Andrew Jordan Kantzos, MD; Jordan Inacio, BS; Hannah L. Dailey, PhD; Chinenye O. Nwachuku, MD, FAAOS4:47 PM Discussion4:55 PM Adjourn for the Day
BASIC SCIENCE FOCUS FORUM #OTA2022 | @otatrauma | @otatrauma | ota.org 8 8:25 AM - 8:30 AM Aaron Nauth, MD8:30 AM - SYMPOSIUM V9:35 AM Moderators: Andrew Evans, MD Christopher Lee, MD8:30 AM Overview Christopher Lee, MD8:35 AM Trauma Immunotypes: Do They Affect Outcomes? Todd McKinley, MD8:45 AM Immune Modulation of Fracture Healing Philipp Leucht, MD8:55 AM Time Course of Immune Response and Immunomodulation During Normal and DelayedHealingofMusculoskeletal Wounds Joseph C. Wenke, PhD9:05 AM Immune Cellular and Molecular Contributions to Fracture Healing Peter Giannoudis, MD, FACS9:15 AM Discussion9:35 AM - 10:25 AM Moderators: Andrew Evans, MD Christopher Lee, MD9:35 AM PAPER 27 HighLevelsofSynovialInammatory CytokinesatTimeofArticularFractureare Associated with Poorer Long Term Clinical Outcomes Joshua Daryoush, MD; Zachary M. Olsen, BS; Thomas F. Higgins MD, FAAOS; David Lynn Rothberg, MD, FAAOS; Lucas Scott Marchand, MD; Justin Haller, MD, FAAOS9:41 AM PAPER 28 Calcium/Calmodulin-Dependent Protein Kinase is Elevated in Human Osteoarthritis and its Inhibition Protects Against Chondrocyte Apoptosis and Catabolism Julian Dilley, MD; Xinchun Ding; MargaretBello; Abhijit Seetharam, MD; Jennifer Shutter; Roman Natoli, MD, PhD; Todd Owen McKinley, MD, FAAOS; Uma Sankar, PhD9:47 AM PAPER 29 Smad3 Gene Polymorphisms and Expression In Serum and Cartilage InuencetheRiskofKneeOsteoarthritis Rajeshwar Nath Srivastava, MS; Amar Chandra Sharma, PhD9:53 AM Discussion9:59 AM PAPER 30 The Relationship Between Intra-Articular Fracture Energy and a Patient’s InammatoryResponse Justin Haller, MD, FAAOS; Diane Elizabeth Fink; Hannah Jo Smith, BS; Zachary M. Olsen, BS; Cale Jacobs, PhD; Donald D. Anderson, PhD10:05 AM PAPER 31 High Energy Pilon Fractures Result in SignicantChondrocyteCellDeathon Both the Tibia and Talar Side of Injury Justin Haller, MD, FAAOS; Graham John Dekeyser, MD
The Orthopaedic Trauma Association is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.The Orthopaedic Trauma Association designates this live activity for a maximum of 10.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.BASIC SCIENCE FOCUS FORUMRegister today at ota.org.9 10:11 AM PAPER 32 A Reliable Pre-Clinical Impact Model of Post Traumatic Arthritis in Rabbit Hessam Noori-Dokht; Julian Dilley, MD; Margaret Bello; Abhijit Seetharam, MD; Roman Natoli, MD, PhD; Todd Owen McKinley, MD, FAAOS; Diane Wagner, PhD; Uma Sankar, PhD10:17 AM Discussion10:25 AM - Break / Proceed to West Exhibit Hall 10:45 AM10:45 AM - 12:00 PM Moderators: Aaron Nauth, MD Hans-Christoph Pape, MD10:45 AM Overview Aaron Nauth, MD; Hans-Christoph Pape, MD10:50 AM Distal Femur Fixation: Biomechanical Considerations Peter Augat, PhD11:00 AM Preventing Post-traumatic Arthritis in Articular Injuries: The Latest Basic Science Evidence Justin Haller, MD11:10 AM Managing Non-unions: Biological Options Michael D. McKee, MD, FRCSC11:20 AM Nailing, Plating, or Both: Optimizing Stability Hans-Christoph Pape, MD11:30 AM Distal Femur Fractures: What Factors Determine Outcomes? Richard Jenkinson, MD11:40 AM Discussion12:00 PM Adjourn