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SPOTLESS‘Multi-Purpose’ Fibroblast Plasma PenSkin Tightening | Wrinkle Removal | Skin Rejuvenation | Blemish RemovalNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

1. Intro………….….………..32. Strength………………...73. Manual………………....164. Precautions…………...235. Clinical Results……....246. Client Review………...277. Specifications………..288. Related Products……..30Multi-Purpose Fibroblast Plasma Pen for Skin Tightening & Blemish RemovalSafely Vaporizes Skin Cells without Contact, Incision, Scarring & BleedingSimple Use Stable EnergyFine ControlVarious Effects Cost-EfficientTable of ContentsSafe MaterialNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

Plasma is a state of matter that is distinct from solids, liquids, and gases.It is often referred to as the fourth state of matter.This state is created when gas is heated to a point where electrons areknocked free from atoms, forming an ionized gas. It consists of positivelycharged particles (ions) and negatively charged particles (electrons) presentin random motion.SOLID LIQUIDGASPLASMAPlasma is found in over 99% of the visible universe.From neon signs on the streets to the sun and lightning strikes, we aresurrounded by plasma in our daily lives.Such easy accessibility of plasma has encouraged scientists to study andapply it to countless meaningful uses, including making computer chips, rocketpropulsion, cleaning the environment, destroying biological hazards, as well ashealing wounds.NEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.Intro: Plasma EnergyThe Fourth State of MatterIonized Gas Encountered in Daily Life, Found to Heal Wounds

The discovery of the plasma energy’s ability to heal wounds gave rise toa new trend in the aesthetic field – the plasma pen treatment.Spotless is a multi-purpose plasma pen that utilizes the plasmaenergy to treat various skin concerns.When the tip of Spotless approaches a conductor such as a human body,high frequency plasma arc energy is released. This plasma energyvaporizes epidermal cells to accelerate the healing of the skin.Without direct contact with the skin, incision, scarring or bleeding,damage to the skin is minimized, enabling rapid recovery after thetreatment.Plasma energy has various effects including blemish and wrinkleremoval, skin lifting, and skin elasticity enhancement.Intro: Principle of Plasma PenSpotless Emits Plasma Energy to Vaporize Skin CellsNo Contact With Skin for Lower Damage and Rapid RecoverySkin tightens as it healsPlasma arcSpotless tipEpidermisNo contact with skin (conductor)Older Skin Younger SkinSmoother, thicker, and tighter skinCollagenFibroblastElastinHyaluronic acid waterDeep wrinkleEpidermisDermisFatNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

A plasma arc creates controlled light damage to the epidermis.The damage stimulates fibroblast cells which produce more collagen to repair the skin.Collagen continues to generate for 4-6 weeks after treatment, resulting in lifted, younger and smoother skin.Intro: Principle of FibroblastingPlasma Energy Stimulates Fibroblast Cells for New SkinNew Collagen Generated for Healthier and Tighter SkinTip of Plasma PenPlasma ArcCollagen FibroblastEpidermisCarbon CrustTightening EffectCollagen StimulatedFibroblasts StimulatedCollagen IncreasedFibroblasts IncreasedNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.At Treatment Post Treatment 7thDay Post Treatment

Reference: Meyer, P.F. et al. (2017) “Radiofrequency treatment induces fibroblast growth factor 2 expression and subsequently promotes neocollagenesis and neoangiogenesis in the skin tissue,” Lasers in Medical Science, 32(8), pp. 1727–1736. Available at: https://doi.org/10.1007/s10103-017-2238-2. Intro: Research on FibroblastingStudies Have Verified the Advantages of FibroblastingProven to Promote Neocollagenesis and Thicken the DermisYounger SkinOlder SkinElastinCollagenHyaluronic AcidNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

4 Types of TipsFor Diverse ApplicationsStainless 304The Most Widely Used for SafetyStrength: Overview6 Unique Qualities that Make Spotless the Right ChoiceProfessional Treatments in Simple, Cost-Efficient WayNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.Small Size & Ergonomic Grip For Precise ControlStable EnergyWith 24V Power & 60Hz WavelengthCost EfficientFunctionalities Comparable toMedical Laser Machines64 Energy CombinationsFor Professional Treatments

Size of a Board Marker✓ Dimensions (W x D x H): 170 x 35 x 15mm✓ Light body of 53g - easy on the wrist✓ Optimized design through elimination ofsuperfluous details for enhanced user-friendliness103°Shot button positioned on top of the devicewhere the index finger is placed for convenienceExcellent grip facilitated by the perfectlyangled curved design for guaranteed comfort of useRound edges & smooth linesfor a simple yet professional appearanceControl panel facing the practitioner for visualization of energy levels during treatmentsSwitch and power & frequency buttonspositioned on the bottom for easy reach and control by thumbAdaptor connection pointon the back of the deviceStrength: DesignSmall Size & Ergonomic Grip for Precise ControlMinimalist Design for User’s Simplicity and Professional AestheticsNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

Average Laser Machine SpotlessDimensions 750 x 580 x 1370 mm 170 x 35 x 15 mmWeight 80kg 0.053kgPortabilityCan be wheeled within the room, otherwise stationaryPortable everywhere with complementary adaptorNo. of Treatments1-3 treatments4 treatments focusing on over 20+ skin concernsPrice $$$$$$$$$$ $Consumables Yes (Costly) Yes (Affordable)Pre-Heating Required Yes NoPower Consumption High LowEase of Use ★★ ★★★★★Warranty 1 year 1 year + lifetime maintenanceStrength: Cost EfficiencyFunctionalities Comparable to Medical Laser MachinesAt Only 1/20 of the Price for an Average Laser MachineNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

WrinkleCherry HemangiomasAge SpotWartEnergy width and depth can be controlled from 1 to 8 levels depending on the skin concernPOWER FREQUENCYAcne1234567887654321123456788765432112345678 8765432112345678876543211234567887654321Mode 2Mode 4Mode 6 Mode 8Mode 2Mode 4Mode 6Mode 8Strength: Energy Control64 Energy Combinations for Accurate Treatments8 Levels of Power & 8 Levels of Frequency Enable Precise TargetingNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

Shallow MolePower 4-6Deep Spot Power 5-7Frequency 4-6While there are recommended energy levels for different skin concerns, it must be kept in mind that the same skin concern can require different energy levels depending on its degree of severity.For instance, while a light, superficial mole can be removed with 4-6 power level and 1-3 frequency level, they would not suffice for removing a deeper and darker mole.Hence, Spotless has been created to incorporate 8 levels of power and 8 levels of frequency – a unique feature like no other in the world of plasma pens.With 64 energy combinations, Spotless allows precise treatments tailored to the patient’s needs and condition. The energy levels can be easily adjusted according to the size and depth of the skin concern and, ultimately, the practitioner’s judgment.Soft SyringomaPower 1-3Frequency 1-3Frequency 2-4Strength: Energy ControlModify the Energy Based on Severity of the ConcernTailor the Treatment to Suit the Patient’s Needs and ConditionsNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

The emitted plasma energy increases and decreases in a steadycurve of sine waves. The stable wavelength of up to 60Hzdelivers consistent plasma energy, which allows easier controlof the effect on treatment.Skin(Conductor)The plasma energy from Spotless focuses on a wide surface areaon the epidermis layer of the skin, ensuring:✓ Reduced risk of adverse effects from limited damage to deeperlevels of the skin✓ Shorter downtime✓ User-friendliness even for first time usersPower Supply 110–240vFrequency 60Hz, 0.5AVoltage DC 24/1AThe ranges of power supply, frequency and voltagehave been optimized for best performance at thesafest level.Strength: Stable EnergyUp to 24V Power & 60Hz WavelengthIncreased Precision, Consistent Result and Reduced DowntimeFrequencyWavelengthAmplitudeSpotlessPowerNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

The regular tip causes plasma sparks in the skin tissueto vaporize various skin blemishes without side effects.A small plasma spark from the fine tip vaporizes theepidermis at a recognized interval, stimulatingfibroblasts for cell regeneration.The flat tip transfers heat to the deep dermis without pain,promoting collagen production.The fractional tip stimulates the skin surface with numeroussmall arcs without affecting the cellular tissue. A subtlethermal effect also occurs, performing a complex function.Flat TipWide Thermal EnergyRegular TipThick Plasma EnergyFine TipThin Plasma EnergyFractional TipFractional Plasma EnergySimply screw the tip onto themain body within 10 seconds toprepare for your treatment.The gold plating on the tips acts as an indicator for when the tips should be replaced with new ones.Strength: Various Tips4 Tips, 4 Types of Energy, Diverse ApplicationsReusable Tips, Easy to Screw On for Various TreatmentsNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

Numerous studies have proven the safety of Stainless 304 for itsanti-allergy and corrosion-resistant properties when in contact with the skin.Spotless tips have been produced with the Stainless 304 material to ensure harmless effects on the skin and minimize the possibility of adverse reactions.In addition, better cost efficiency compared to the Stainless 316 material ensuresaffordable prices of the tips, which are consumables that need to be repurchased regularly.Special gold plating, also anti-allergic and corrosion-resistant on the skin, provides a premium aesthetic appearance.Reference: Cunat, P.-J. (2000) “Stainless Steel - The Safe Choice,” Environment and Human Health Series. Strength: Safe MaterialStainless 304: The Most Widely Used for SafetyHigh Quality Stainless Tips Ensure Durability and Safety for the SkinTable 3: Stainless steel in prolonged contact with skin and the Ni contact dermatitis issue.NEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

Product NameSpotless Brand ‘B’ Brand ‘F’ Brand ‘P’Product ImageSize 170 x 35 x 15mm 160 x 25 x 25mm 180 x 20 x 20mm 170 x 40 x 23mmWeight 53g 50g 67g 100gEnergy Levels 64 levels (8*8) 16 levels (4*4) 9 9Complementary Tips O O X OTip Price $ $$$ $$ $Warranty12 months + Lifetime Maintenance12 months X 12 monthsConsumer Price $$ $$$$$ $$$$ $$Strength: Comparison DataSpotless: The Best Plasma Pen in the MarketUnbeatable Product Quality for a Significantly Less PriceNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

Manual: BodyInsert a Tip. Connect the Power. Simple as That.How to Operate Spotless Within 30 SecondsInsert a tip onto the device.Connect the power adaptor to the device.Press the on/off button for a few seconds to operate it.Adjust the power and frequency.Press the shot button.Once the power button starts blinking, it is ready for use.Press the shot button to activate plasma energy, and release it to stop.Press the on/off button for a few seconds to switch off.A : Shot ButtonB : On/OffC : PowerD : FrequencyE : Adaptor Connection PointABCDENEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.1.2.3.4.5.6.7.

Wrinkle Removal & Skin RegenerationVarious Effects Including Acne & Wrinkle RemovalBlemish Removal✓ Moles✓ Freckles✓ Milia✓ Age spots✓ Warts✓ Skin tags/lesions✓ Accordion lines ✓ Crow’s feet ✓ Forehead lines✓ Jowl/jawline✓ Marionette lines✓ Nasolabial folds✓ Skin lifting✓ Injectable delivery✓ Pore cleansing✓ Antiaging skin treatment✓ Exfoliation✓ Acne treatment✓ Fine wrinkle treatment✓ Elasticity enhancementSkin Tightening & Elasticity Enhancement✓ Injectable absorption & activation✓ Skin lifting✓ Pore tightening✓ Skin sterilization✓ Elasticity enhancement✓ Fine wrinkle removalManual: TipsChoose Your Tip Depending on the Desired EffectCombine the Tips for a Complete Facial TreatmentNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

Manual: TipsRegular Tip: Thick Plasma EnergyFor All Types of Blemish Removal Treatment3. Press the shot button, and place the regular tip closer to thetargeted area in a continuous moving motion.2. Place the Regular Tip onto Spotless, and set the power andfrequency levels according to the treatment plan.1. Cleanse the skin with a non-alcoholic cleanser, and apply anestheticcream to leave on for 20 minutes.4. After treatment, apply a Beta Mask or regenerating cream to thetreated area to heal the skin.Before AfterNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

Manual: TipsFine Tip: Thin Plasma EnergyFor Optimized Fibroblast Skin Tightening and Wrinkle Removal Treatment3. Use the Scanning Technique or the DOT-BY-DOT Technique ondeep wrinkles and rough skin.2. Set the level of intensity on the device, and get the Fine Tip closer tothe skin. Once closer to the skin, plasma arcs will appear.1. Cleanse the skin with a non-alcoholic cleanser, and apply anestheticcream to leave on for 20 minutes.4. After treatment, apply a Beta Mask or healing cream immediately.FibroblastsCollagenBefore AfterNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

Manual: TipsFractional Tip: Fractional Plasma EnergyFor Collagen Synthesis and Anti-Aging Treatment3. Place the Fractional Tip on the skin, and move in a tapping motionfor 5 minutes each on the forehead, the cheeks, the perioral area, andthe neck.2. Apply Beta Serum or conductor gel to the skin.4. Remove conductor gel if used. For post-care, apply a Beta Maskimmediately to accelerate skin repair.FibroblastsCollagenBefore After1. Cleanse the skin with a non-alcoholic cleanser, and apply anestheticcream to leave on for 20 minutes.1. Cleanse the skin with a non-alcoholic cleanser, and apply anestheticcream to leave on for 20 minutes.NEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

Manual: TipsFlat Tip: Wide Thermal EnergyFor Skin Rejuvenation With Tightening and Lifting Effects3. Place the Flat Tip on the skin, and move in a gliding motion for 5minutes each on the forehead, the cheeks, the perioral area, and theneck.2. Apply Beta Serum or conductor gel to the skin.4. Remove conductor gel if used. For post-care, apply a Beta Maskimmediately to accelerate skin repair.Before AfterFibroblastsCollagen1. Cleanse the skin with a non-alcoholic cleanser, and apply anestheticcream to leave on for 20 minutes.NEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

Apply Beta Serum or conductor gel to the skin.Get the Fractional Tip closer to the skin, and move in a tapping motion for 5 minutes each on the forehead, the cheeks, the perioral area, and the neck.Remove conductor gel if used, and apply Beta Serum to the skin.Replace the Fractional Tip with the Flat Tip.Get the Flat Tip closer to the skin, and move in a gliding motion for 5 minutes on each of the areas previously treated with the Fractional Tip.Once complete, apply a Beta Mask immediately.Manual: TipsMixed Treatment with Fractional and Flat TipsDouble the Effects of Skin Rejuvenation and Anti-Aging TreatmentBeforeFractional TipFibroblastsCollagenFlat TipNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.1.2.3.4.5.6.

Apply a minimum of SPF15 sunblock, and avoid exposure to the sun.Avoid sauna/spa, use of exfoliating products, or botox/dermal fillers.Do not pick the brown/black crusts on the skin surface. The crusts will fall off in a few days.Use ice packs or hydrating face masks like Beta Mask to soothe the skin and reduce swelling.Use skin soothing serum like Beta Serum to prevent the skin from dehydration and peeling.Precautions5 Rules for Maximized BenefitsAccelerate the Healing Process for the Best Spotless Therapy Result2 431 5NEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

Figure 1. Mole RemovalFigure 2. Skin Tag RemovalCandidate Detail Female, 22Area of Concern Skin TagTreatment Type Blemish Removal Used Tip Regular TipNumber of Sessions 1Candidate Detail Female, 31Area of Concern Mole Treatment Type Mole RemovalUsed Tip Regular TipNumber of Sessions 2Before & 8 Days After Treatment Before & 5 Days After Treatment Clinical ResultsExcellent Mole & Skin Tag Removal with Regular TipNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

Candidate Detail Female, 62Area of Concern Sagging SkinTreatment Type Skin TighteningUsed Tip Fractional & Flat TipsNumber of Sessions 1Candidate Detail Female, 46Area of Concern Crow’s FeetTreatment Type Fibroblast TreatmentUsed Tip Fine TipNumber of Sessions 2Clinical ResultsVisibly Reduced Wrinkles and Improved Skin ElasticityBefore & 13 Days After Treatment Before & 4 Days After Treatment Figure 3. Wrinkle RemovalFigure 4. Skin RejuvenationNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

Figure 5. Neck Wrinkle LiftingClinical ResultsAlso Effective for the Neck & Back of the HandsFigure 6. Hand Wrinkle RemovalBefore & 7 Days After Treatment Before & 17 Days After Treatment Candidate Detail Female, 57Area of Concern Back of HandTreatment Type LiftingUsed Tip Fine TipNumber of Sessions 2Candidate Detail Female, 54Area of Concern NeckTreatment Type LiftingUsed Tip Fine TipNumber of Sessions 1NEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

Figure 5 shows pictures taken from Kin Professional’s video review on milia removal treatment using Spotless. Reference:https://www.youtube.com/shorts/37b49O4gIzg“Without using any pressure, gently touch the tip of the milium. The patient may feel a little zap but it isn’t painful.”“The milium instantly vaporizes and the treatment is done.”Figure 7. Spotless on Social MediaClient ReviewCredible Reviews Prove the Effectiveness of SpotlessMilia Removal Treatment with Spotless Conducted by Kin ProfessionalNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

3 Complimentary Tips (2 Regular Tips + 1 Fine Tip)Package BoxManualMain BodyAvailable for Purchase(Fractional Tip, Flat Tip)SpecificationsGet 3 Complimentary Tips Upon Purchase of SpotlessAdaptorOptional TipsNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

Application Wrinkles, Moles, Skin Tags, Milia, Etc.Power Supply 110~240V / 60 Hz. 0.5AVoltage Rating DC 24V, 1ADimensions (W x D x H) 170 x 35 x 15mmWeight (Body + Accessory) 53gContents Main device, Adaptor, 3 Complimentary Tips (2 Regular +1 Fine)Consumables Regular, Fine, Fractional, Flat TipsFunction Power & Frequency Control (8*8 levels)SpotlessSpecificationsQuality Guaranteed with GMP, ISO13485 Certified FacilitiesNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

Neo-Cain CreamHigh-quality anesthetic cream with 10.56% lidocaine✓ Quick & powerful effects✓ Made in strict GMP facilities in South Korea✓ Competitive priceNeo-Pro CreamExceptional numbing with fine emulsion of 5% lido-prilocaine✓ Stronger and safer effects✓ Remarkable dermal protection✓ Especially suitable for patients with sensitive skinRelated Products: Neo Anesthetic CreamsGet Ready with Neo-Cain & Neo-Pro CreamGlobally Used Lidocaine and Prilocaine Without Side-EffectsNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

Beta SerumMaximize the effects of Spotless treatment✓ Skin hydration ✓ Rejuvenation✓ Collagen synthesis Beta MaskExperience professional post-treatment care✓ Cell regeneration✓ Excellent aftercare✓ Outstanding recovery effectsRelated Products: Beta SeriesAmplify the Effect with Beta Serum & MaskHighest Quality Beta-Glucan Provides Outstanding Skin Rejuvenation EffectsNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.

Get Flawless with SPOTLESSAddress: #302~304 E&C Dream Tower, 146, Seonyu-roYeongdeungpo-gu, Seoul, South Korea (07255)Tel: +82-2-583-1348 Fax: +82-2-2038-0848Email: info@neogenesis.co.krWebsite: www.neogenesis.co.krNEOGENESIS Co., Ltd. Copyright ⊙ All Rights Reserved.