Return to flip book view

Wu MengYu Talks Preparing a Scientific Manuscript Eze France 2015 1

Foreword Kate 20 7 8 8 10 2017 KO Kate How to write a scientific masterpiece 2

Ushma S Neills The Journal of Clinical Investigation JCI 2017 IF 13 25 1924 Neills MDPhD Nature Medicine 2 JCI 9 JCI JCI Conversations with Giants in Medicine Scientist mother instigator Kate PubMed 2019 https www youtube com watch v w5Cy2mjBxQw Kate 3

Why Making Papers It s something about Your Big Pictures 4

Reality Impact factor 5

Impossible yesterday difficult today and become routine tomorrow

Pioneering Kate Starzl Kate KO knowledge gap 7

Direction 8 Murano Italy 2015

Unspoken rules 9

Relationship

Mentor KO

Searching and Focus on hot spots Matterhorn Switzerland 2014

Target of research 13

Data Collection 14

Missing data 15

Mimicking Find a nice model to learn

Mimicking and expanding 30 17

best gap Presenting the There s always a of you between what you want and which you can templates mimicking differences Find the literature with extensive review then them Remember making some 18

Remember 1 2 3 4 19

Start to Write 20

Anxiety Kate Pain Gain Reviewer Reviewer Kate 21

Editor in Chief Lack of novelty or importance Errors in methodology or statistics Improper reference citation Structural inconsistency or grammar errors I don t buy it 22

Common reasons for being rejected Lack of novelty or importance Errors in methodology or statistics Improper reference citation Structural or language inconsistency 23

Novelty Importance 24

Novelty or Importance 3 25

Errors in methodology 26

Errors in methodology Reviewer 27

Reference citation Improper 28

Improper reference citation Guideline Reviewer Reviewer references 29

Grammar Errors or Structural inconsistency

Inconsistency Reviewer Reviewer Grammarly 31

Processing a Technical Manuscript Define the problem Assume a solution Measure the effectiveness scientifically Emphasize or lightly write Answer the initial assumption 32

1 Yz 2 X X X X Yz X Yz 3 X Yz 4 5 6 33

Find your Buyers From your list of cited references 34

Targeting the potential buyer 7 Dr Neils 35

Editorin Chief Aim scope Leave information Format Find your Buyers From your list of cited references 36

Journal Info Author instruction Editorial in Chief Cover Letter Register 37

Cover Letter 38

Cover Letter Neils 2019 Cover Letter Cover Letter 4 5 1 2 Neils Abstract reviewer 39

Dr Neils Cover Letter Dear Professor X We are pleased to submit a manuscript by Rentschler et al entitled Notch Signaling Regulates Murine Atrioventricular Conduction and the Formation of Accessory Pathways for consideration by the Journal of Clinical Investigation The authors declare no conflict of interests COI We present the generation of a striking new model of human cardiac ventricular pre excitation commonly referred to as Wolff Parkinson White syndrome WPW and present evidence to support a developmental model to explain the etiology of this disease We believe that this paper will be paradigm shifting 40

Although this relatively common disorder has been appreciated nearly 100 years little is known about etiology One genetic cause has been described for a relatively rare variant of WPW associated a glycogen storage disorder and mouse models of this variant involving PRKAG2 seem to develop pre excitation because of a breakdown of the fibrotic layer of insulation between atria and ventricles This does not mimic the pathology of more common forms of WAW in humans Our work provides a better animal model and a different developmental explanation invoking different genetic pathways While various commentaries over the years have suggested that persistence of embryonic structures could explain features of WPW we know of no prior experimental evidence to support this hypothesis Appropriate referees include Person 1 Institution email Person 2 Institution email Person 3 Institution email We request to exclude person 4 Institution email person 5 Institution email as referees due to COI With regards Jonathan Epstein MD 41

Upload Formats of a Manuscript Cover letter 4 5 paragraphs Main body a Title page Topic Authors and affiliations key words correspondence Title 15 words b Abstract 250 350 words c Introduction Material and methods Results Discussion Conclusions d Reference Reference manager Endnote e Tables f Legends of figures Figures resolution 600 dpi tif Copyright transfer IRB No

My Conclusion Constructing a scientific manuscript is to Ask an important question then answer it FB KO https www drwumengyu com blog 43