June 2025 | Volume 20 | Issue 6 : simplebooklet.com

GLP-1 receptor agonists (RA’s) have surged in popularity as transformative medications for weight loss and the management of metabolic syndrome. By mimicking the action of the glucagon-like peptide-1 (GLP-1) hormone, these drugs enhance insulin secretion, suppress appetite, and improve glucose metabolism, offering significant benefits for individuals with obesity and type 2 diabetes. Their potential impact extends beyond metabolic, with emerging research highlighting potential applications in reducing the risks of dementia and cardiovascular diseases, though which, quite frankly, are closely related to metabolic syndrome. However, despite their promise, GLP-1 receptor agonists are not without drawbacks, including gastrointestinal side effects, high costs, the need for long-term use to sustain benefits, and long-term safety profile assessment, which warrant careful considerationGLP-1 Mechanism of ActionGLP-1 inhibits appetite-promoting neurons via neuropeptide Y (NPY) and agouti-related peptide (AgRP) receptors in the hypothalamus and limbic system; while stimulating satiety-promoting receptors (pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART). Additionally, GLP-1 slows gastric emptying, which enhances postprandial satiety. It also improves glucose control by enhancing glucose-dependent insulin secretion from pancreatic beta-cells, without acting as an insulinagogue, and suppressing glucagon release from alpha-cells. By alleviating beta-cell dysfunction caused by insulin resistance, GLP-1 enhances insulin secretion efficiency and reduces the compensatory hyperinsulinemia that exacerbates insulin resistance.Its therapeutic potential has been harnessed through the rollouts of GLP-1 receptor agonists (GLP-1 RA’s). GLP-1 RA’s, unlike their endogenous counterpart, are modified GLP-1 peptide designed to extend their half-lives for prolonged action (e.g. liraglutide: about 13 hours; semaglutide: about 1 week). However, those very modifications are also the cause of the many drawbacks with GLP-1 RA’s among other challenges. Challenges with GLP-1 Receptor Agonists (RA’s)•The high cost of these medications, coupled with supply shortages, poses significant barriers to access for many patients•Due to the delay of gastric emptying and slowing of gut motility, common adverse effects include nausea, vomiting, and gastrointestinal discomfort, which can limit patient adherence. In fact, GLP-1 RA’s have been shown to be associated with functional bowel diseases like IBS and SIBO[1]•The use of GLP-1 RA’s has also been shown in a systematic review to be associated with significant lean muscle mass loss, which poses long-term risk and impact on the patient’s overall health and quality of life[2]•Approximately 90% of GLP-1 receptors are in the digestive tract, making gut health critical for effective therapy. Prescription GLP-1 medications bypass the gut, targeting the brain directly, which can lead to incomplete metabolic reset and weight regain (20-30%) upon discontinuation[3]These challenges highlight the importance of exploring natural and sustainable strategies to support metabolic health after GLP-1 RA treatment or enhance endogenous GLP-1 activity as a primary approach.Comprehensive Approach to Promoting GLP-1 Activity & MoreIt’s important to note that GLP-1 is not a standalone hormone but part of a cascade that includes other hormones (e.g., ghrelin, insulin, CCK, PYY, PP) and receptors (e.g., bitter receptors). This cascade regulates satiation, reduces hunger, and resets metabolic processes. Therefore, a comprehensive GLP-1 therapy should focus on restoring metabolic balance by improving insulin sensitivity, reducing glucose toxicity, and managing systemic inflammation, rather than solely targeting appetite controls. Natural GLP-1 Promoting IngredientsSeveral natural compounds have demonstrated the ability to promote endogenous appetite-suppressing hormones, including GLP-1, and promote the overall metabolic health, offering complementary or alternative approaches to GLP-1 RAs.Hops (Humulus lupulus) supercritical-CO2 extract, rich in bitter acids such as alpha- and iso-alpha acids (e.g. humulone, xantholhumone, cohumulone, etc.), has emerged as a potent promoter of GLP-1 activity. It’s been clinically shown to boost GLP-1 secretion (6.4-fold rise in post-prandial GLP-1 concentration), slow gastric emptying, and enhance postprandial glycemic control[4]. It also stimulates other satiety-promoting peptide hormones, such as peptide YY (PYY) and cholecystokinin (CCK), which collectively aid in appetite management (Table 1)[4]. Beyond its metabolic benefits, hops exhibits anti-inflammatory properties by selectively targeting inducible cyclooxygenase-2 (COX-2) pathways, reducing the risk of gastrointestinal and cardiovascular toxicity associated with NSAIDs[5].Cinnamon (Cinnamomum cassia) has a long history of use in blood sugar regulation. It enhances insulin sensitivity, promotes cellular glucose uptake, and increases GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) secretions.[6] A crossover trial involving 15 healthy adults found that 3g of cinnamon reduced postprandial serum insulin and elevated GLP-1 levels[7].Berberine is well-studied for its hypoglycemic effects by promoting glucose uptake, improving insulin sensitivity, and increasing GLP-1 secretion[8,9]. Clinical trials have shown that berberine improves metabolic parameters, including insulin sensitivity, lipid profiles, and glycemic control, particularly in individuals with Dr. Joseph Cheng, NDAdvertisementobesity or metabolic syndrome[10,11].Gardenia (Gardenia jasminoides) extract, containing the iridoid glycoside geniposide, has shown promise in increasing GLP-1 secretion and improving beta-cell function[12]. It also inhibits weight gain and improves lipid profiles, glucose tolerance, and insulin resistance[13].Probiotics, particularly Bifidobacteria with their natural habitats in the colon, can promote intestinal GLP-1 secretion and support colonocyte integrity by producing short-chain fatty acids, such as butyrate[14,15].Liver protectants, such as milk thistle, licorice, and n-acetyl-cysteine, are indicated in patients with MFALD (metabolic dysfunction-associated fatty liver disease). Low-Carb Diets & Moderate & High Intensity ExercisesBoth natural and pharmaceutical GLP-1 therapies can be complemented by low-carbohydrate diets and consistent exercise, which provide practical and accessible ways to enhance endogenous GLP-1 secretion. These diets capitalize on the stimulatory effects of dietary fats and proteins on various gut-brain axis peptides, including GLP-1, cholecystokinin (CCK), peptide YY (PYY), oxyntomodulin, and pancreatic polypeptide (PP) (Table 1). This promotes satiety and improves glycemic control. A study comparing a ketogenic diet to high-carbohydrate and high-dextrose diets demonstrated that the ketogenic group exhibited higher fasting and postprandial GLP-1 concentrations alongside lower insulin levels[16].A randomized controlled trial involving 195 diabetic patients, the subjects on GLP-1 with adherent moderate-high intensity exercises yielded the best outcome in terms of abdominal obesity, inflammation (hsCRP), and cardiometabolic risk[17].Final ThoughtsWhile GLP-1 receptor agonists have revolutionized the management of type 2 diabetes and obesity, their limitations necessitate a broader approach to promoting GLP-1 activity. By leveraging dietary strategies, such as low-carbohydrate diets, and natural ingredients like hops, cinnamon, berberine, and gardenia, we can support patients in achieving sustainable metabolic health. These interventions not only enhance endogenous GLP-1 secretion but also address appetite control, glycemic regulation, and weight management, offering a comprehensive and accessible framework for patients transitioning off GLP-1 RAs or seeking non-pharmacological alternatives.[Click here for Full Reference.]Beyond GLP-1 Receptor Agonists A Comprehensive Approach to Promoting GLP-1 Activity & MoreVita Aid Metabolic Health ProtocolGLP-1RAG / Gluco-Metab:For those coming off weekly Semaglutide Injection treatment:•Start the week of the last injection.•Days 1-7: 1 capsule AC 1 hour before the first meal, and 1 capsule AC 1 hour before the biggest meal.•Days 8+: 2 capsules AC 1 hour before the first meal, and 2 capsules AC 1 hour before the biggest meal.For those choosing non-pharmacological alternatives:•Days 1-14: 1 capsule AC 1 hour before the first meal, and 1 capsule AC 1 hour before the biggest meal.•Days 15+: 2 capsules AC 1 hour before the first meal, and 2 capsules AC 1 hour before the biggest meal.May be used in conjunction with Intermittent Fasting to make the process easier (i.e. take 1-2 times during fasting).Continue until the desired weight/body composition/health goal is achieved and taper off if necessary. Bifido-PB30+ DF (Dairy-Free, Bifido-Only Probiotics): 1 capsule CC QDHepatolief (Liver-Protectant for MFALD): 1 cap CC BID. © 2025 Vita Aid Professional Therapeutics Inc. All Right Reserved.P: 1.800.490.1738www.vitaaid.comComprehensive Metabolic Support via GLP-1-Associated Pathways*The statements made herein have not been evaluated by the Food and Drug Administraon. Products are not intended to diagnose, treat, cure, or prevent disease. If you have any concerns about your own health, you should always consult with a physician or healthcare professional.Proudly in Collaboraon with: ✓ Featuring Hops (Supercrical CO2-Extract), Berberine, Cinnamon, and Gardenia ✓ Appete Regulaon by Promong GLP-1 secreon and acvity, with minimal GI side eects* ✓ Supports healthy blood glucose levels and insulin sensivity ✓ Opmizes fat metabolismLearn More:GLP-1RAG Gluco-Metab (Canada)Table 1. An Overview of Appetite-Suppressing Peptide Hormones

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Clinical pearlsCase management/case studiesNaturopathic philosophyPractice building and business managementCurrent trends and issues that affect naturopathic physicians in your areaNews, announcements, and event noticesDevelopment of new techniques or protocolsAbstracts and reviewsDiscussions pertaining to diagnosticsPublic/media relations and networkingUsing technology to make practices more efficient and profitableEducational and grassroots programs that further the naturopathic causeAny other trend, event, or development you believe is pertinent to theprofessionFor more information regarding article submission, or to receive a copy ofsubmission guidelines, please contact editor@ndnr.com or scan the QR code formore information. Opinions expressed in Naturopathic Doctor News & Review do not necessarilyreflect those of this publication and its publishers.Copyright © 2025 Naturopathic Doctor News & Review. All rights reserved. No portionof this publication may be copied, reproduced, or redistributed without express writtenpermission from the publisher. Reprint information is available by contactingpublisher@ndnr.com.Naturopathic Doctor News & Review reserves the right to edit or reject any submittededitorial or advertising. Opinions expressed by contributors and advertisers are notnecessarily the opinions of Naturopathic Doctor News & Review or its principals.Naturopathic Doctor News & Review is published and circulated as an annualsubscription (12 issues) to licensed naturopathic doctors (NDs) and students andgraduates of CNME recognized naturopathic colleges in North America, and certainsuppliers to the profession. Annual subscriptions (12 issues) are available to other healthcare providers and NDs outside of North America: $249 USDINSIDE The Breath of Life: Mastering the Art of ConsciousBreathing08Jennifer Ruthensteiner, NDBreath is more than just a biological necessity. Discoverthe science behind breathwork and its profound impacton health. Explore how ancient practices align withmodern physiology to improve oxygenation, balancethe nervous system, and enhance mental clarity,resilience, and overall vitality.Tauroursodeoxycholic Acid (TUDCA) And Its Protective RoleAgainst NeurodegenerationDevin Miles, ND and Elizabeth Sutherland, NDAn overview of TUDCA’s neuroprotective effects in Alzheimer’s,Parkinson’s, and MS, highlighting its ability to reduce inflammation,prevent cell death, and support brain health through metabolicand immune modulation.Reams’ Analysis in Practice: A Bio-Electric Framework forNaturopathic AssessmentDarrell Misak, NDAn introduction to Reams’ Bio-Electric Analysis as a practical toolfor assessing energy efficiency and guiding personalizednaturopathic care through diet, detox, and supplementation.Hormonal, Neurological & Gut-Brain Restoration in ChronicMigraine: A Case StudyAnna Kolomitseva, NDThis case study explores the complete resolution of chronic,medication-resistant migraines in a 46-year-old female using anaturopathic protocol targeting hormonal, neurological, and gut-brain imbalances. The patient experienced full remission anddiscontinued pharmaceutical treatments within six months.A Naturopathic Approach to Trauma: Engaging the Body’s VitalForceMelissa Sophia Joy, NDA naturopathic exploration of how the divine vital force, whenconsciously activated, can transmute trauma and restore physical,emotional, and energetic health through somatic-spiritual healing.Preventing Alzheimer’s Before It Starts: A Root-Cause Approachfor Genetic ApoE4 RiskStephanie Yang, NDThis case study outlines a personalized and holistic prevention planfor Alzheimer’s disease in a genetically at-risk midlife woman.Through early detection, neuroinflammatory screening, andtargeted interventions, the patient achieved significantimprovements in memory and quality of life. Neurosensory Healing: A Holistic Approach to Stress andEmotional WellbeingRob Streisfeld, NMDThis article explores the integrative use of color, light,aromatherapy, and sound frequencies to improve mental health.Backed by neuroscience and holistic medicine research, thesesensory therapies offer a natural, accessible path to emotionalbalance and stress relief.A Trauma-Informed Mind-Body Approach to Chronic Illness: A Caseof Early-Onset Rheumatoid ArthritisErin Hayford, NDThis case report explores the therapeutic potential of a trauma-informed, mind-body approach in a woman with early-onsetrheumatoid arthritis. By addressing the deeper nervous systemimprints and emotional patterns underlying her illness, the patientexperienced lasting improvement and a transformative shift inidentity and health.Homeopathic Intervention in Neonatal Asphyxia: A Case of RapidNeurologic ImprovementBlake Myers, NDThis case report describes the remarkable neurologic recovery of anewborn with asphyxia, hypotonia, and absent gag reflex followinga single dose of classical homeopathy. It highlights howfundamental homeopathic training can support critical care whenconventional options are limited.Amazonian Medicine for Modern Addiction: Exploring Ayahuasca’sClinical PotentialConor Watters, NDAyahuasca, a traditional Amazonian plant medicine, is gainingattention as a potential treatment for substance use disorders.This article reviews the latest research, cultural context, legalconsiderations, and personal healing experiences.Article Submissions: Articles should be original,previously unpublished, and should cover aspecific topic, protocol, modality, diagnostic,philosophy, commentary, or case study pertainingto naturopathic medicine rather than a generaloverview. Illustrations, photographs, charts, andprotocols are encouraged. Naturopathic DoctorNews & Review does not reprint articles fromother publications except under unusualcircumstances. Typical word requirements are 700 to 2000 words per article. Topics of interestinclude:TOLLE TOTUM314192439JUNE 2025 - VOLUME 20 | ISSUE NO. 063442503045

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20YEAREST. 2005ANNIVERSARYLetter from the PublisherDear Readers,Mind-body medicine is not a recent innovation—it is arediscovery of naturopathic medicine’s original wisdom.Long before integrative and functional medicine entered themainstream conversation, naturopathic physicians wereaddressing illness as a multidimensional experience. Theroots of our profession trace back over a century to theNature Cure movement of 19th-century Europe, whichemphasized the body’s self-healing capacity and theinterconnectedness of all aspects of the human being. Asthese ideas migrated to the United States, early leaders likeBenedict Lust, Henry Lindlahr, and Otis G. Carroll helpedshape what we now recognize as the core tenets ofnaturopathic medicine: treat the whole person, address theroot cause, and support the vital force.This month’s issue of NDNR honors that lineage byfocusing on mind-body medicine not as a peripheralinterest, but as a central and enduring pillar ofnaturopathic practice. The articles within reflect how thisphilosophy continues to guide innovative, compassionate,and personalized care. You’ll find case studies and clinicalexplorations that exemplify the ND’s unique capacity tohold space for both the physical and psycho-emotionaldimensions of healing.We open with Dr. Jennifer Ruthensteiner’s exploration ofbreathwork as a clinical tool. Drawing on both ancienttraditions and contemporary science, she demonstrates howconscious breathing not only modulates the nervous systembut empowers patients to participate actively in their ownhealing. It is a reminder that some of the most powerfulinterventions require no prescription—only presence andpractice.Applied Naturopathic Medicine 20 Annual Mind/Body Medicine Issueth4NATUROPATHIC DOCTOR NEWS & REVIEWOther contributors take us into the heart of neuroimmune medicine,trauma resolution, and psychospiritual care. Dr. Anna Kolomitsevapresents a compelling case in which chronic, medication-resistantmigraines were resolved through a whole-person approach targetinggut-brain dynamics, hormone balance, and neurologic support.Meanwhile, Dr. Erin Hayford shares how a trauma-informed,mind-body protocol for a woman with early-onset rheumatoidarthritis helped uncover and rewire the underlying patternssustaining her illness. Her transformation was not only physical butexistential—proof of the healing that becomes possible when weaddress the body and the story it carries.These case reports are more than symptom resolutions—theydemonstrate the ND’s ability to bridge medical science withemotional insight. NDs understand that trauma is not justpsychological, but biologically imprinted, influencing immunefunction, pain response, hormone cycles, and digestion. Truehealing requires more than a quick diagnosis; it requires atherapeutic relationship built on time, trust, and compassion.As you read this issue, you’ll also encounter powerful stories ofrecovery through neuroprotective supplementation, sensoryintegration, homeopathy, and root-cause prevention. Each articleserves as a reminder that naturopathic medicine is not just relevant—it is essential.Thank you for your commitment to this path and for honoring theroots of a profession designed to uplift the whole person.In Health, Razi Berry | Publisher NDNRMIND/BODY MEDICINE ISSUERazi Berry

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EDITORIALPUBLISHERSTAFFCIRCULATION MANAGERRAZI BERRYpublisher@ndnr.comCONTENT MANAGERMEDICAL EDITORDR. NATASHA MACLEAYART DIRECTIONMATTHEW KNAPPadmin@ndnr.comMCKENZIE O’CONNOReditor@ndnr.comDr. Kareem Kandil drkandil@ndnr.comSHANE POWELLads@ndnr.comADVERTISINGOn a monthly basis, NDNR covers the practice ofnaturopathic medicine and includes the products andservices that natural medicine physicians use andprescribe. The content consists of articles written bypracticing NDs for practicing NDs. Contributors alsoinclude the presidents of the accredited naturopathicuniversities, university department chairs, and leadingdoctors. Every issue theme covers pertinent case studies,clinical pearls, and discussions on the usage ofnutraceuticals, botanicals, IV and injection therapies,homeopathy, and other naturopathic modalities.6Activation ProductsProudly Sponsors NDNR’s20th AnniversaryJUNE 2025 - VOLUME 20 | ISSUE NO. 06Cobourg, ON – May 21, 2025 — Activation Products is honoredto announce its sponsorship of the 20th anniversary ofNaturopathic Doctor News & Review (NDNR), celebrating twodecades of commitment to naturopathic and integrative medicine.Since its founding in 2005, NDNR has become a touchstone forthe naturopathic medicine movement and a vital clinical resourceutilized by NDs, MDs, DOs, DCs, NPs, PhDs, and PAs. NDNRrecently relaunched its monthly journal as Applied NaturopathicMedicine, emphasizing its role as a vital tool for evidence-basednatural care.Activation Products shares NDNR’s mission to empowerpractitioners with tools, continuing education, and clinicallyproven natural health products that deliver measurable patientoutcomes.“This is so much more than a sponsorship,” said Ian Clark,Founder and CEO of Activation Products. “This is a mission andacknowledgment of everything the natural medicine movementachieves every single day.”"Ian Clark’s integrity and dedication to excellence have alwaysstood out to me in our shared industry," said Razi Ann Berry,Founder of NDNR. "Activation Products is a natural choice forpartnering with NDNR because of our aligned commitment toclinically effective and pure natural products."Founded in 2005, NDNR’s clinical leadership team includesKareem Kandil, MD, ND, Medical Director; Natasha McCleay,ND, Medical Editor; and Node Smith, ND, Associate Director ofContinuing Education.In honor of this anniversary, NDNR has launched several newinitiatives to support clinical excellence and collaboration,including:Accredited Continuing Medical Education (CME) platformMonthly roundtable case discussions for practitionersA Find-a-Doctor directory powered by NDNR.com andNaturalPath.net“We welcome you to join us celebrating NDNR’s 20thanniversary and to also celebrate your heart-centered work andthe wonderful opportunity to continually make this world abetter and better place,” Clark added.

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These patterns become habitual over time, disconnectingindividuals from healthy breathing. These patterns becomehabitual over time, disconnecting individuals from healthybreathing.Sedentary Lifestyles and Poor Posture: Long hours spent sittingcompress the diaphragm, restricting its movement andencouraging inefficient chest breathing. Slouched postureexacerbates this, reducing oxygen intake and poor lung capacity.Environmental Challenges: Exposure to pollutants and allergenscontributes to airway inflammation, making deep, full breathsmore difficult. Over time, these factors can condition individualsto adopt maladaptive breathing strategies.Unconscious Habits: Many people unknowingly breathe throughtheir mouths, over-breathe, or take quick, shallow breaths. Thesehabits disturb the natural oxygen-carbon dioxide balance,impacting physical and cognitive performance.Consequences of Dysfunctional BreathingNervous System Imbalance: Dysfunctional breathing perpetuatessympathetic dominance, keeping the body in a state ofheightened alertness. This dysregulation hinders recovery,increases cortisol levels, and contributes to chronic stress-relatedillnesses.2Impaired Oxygen Delivery: Shallow breathing reduces theefficiency of oxygen exchange, depriving tissues and the brain ofthe oxygen necessary for optimal function. Studies indicatehyperventilation and reduced CO2 levels impair oxygentransport, leading to fatigue, brain fog, and decreased energy.3Exacerbation of Chronic Conditions: Conditions like asthma areparticularly affected. Dysfunctional breathing increases airwayresistance and compromises respiratory efficiency, worseningsymptoms and reducing quality of life. Breathing disordershave also been linked to anxiety, panic attacks, andcardiovascular strain.4, 5, 6Restoring Breath: The Case for RetrainingThe good news is that breathing patterns can be retrained.Techniques like diaphragmatic breathing, Buteyko breathing,and yoga-based practices have been shown to:Improve oxygen and CO2 balance.7Reduce reliance on medications in conditions like asthma.8, 9Enhance quality of life through better nervous systemregulation.10, 11, 12, 13Ancient Wisdom: Breath as Sacred PracticeMany ancient traditions view breath as a bridge between thebody, mind, and spirit, with mindful breathing fosteringconnection within oneself, the environment, and the divine.Yoga and Pranayama: In yoga, breath (prana) is the life force.Pranayama, the conscious regulation of breath, balances energy,detoxifies the body, and clears the mind. Techniques like NadiShodhana and Kapalabhati promote vitality and mental clarity.Buddhist Mindful Breathing: In Buddhism, mindful breathing, astaught in the Ānāpānasati Sutta, cultivates inner peace andenhances concentration and mindfulness.Indigenous Perspectives on Breath: Indigenous cultures usebreath in healing rituals to align with nature, cleanse the body,and connect with ancestral wisdom.Qi Gong and Taoist Practices: In Chinese medicine, breathwork(Qi Gong) harmonizes the body, boosts vitality, and promoteslongevity by aligning with natural rhythms.Shamanic Traditions: Shamanic cultures use breath in rituals toalter consciousness, with techniques like circular breathing toconnect with higher realms.Sufism and Mystical Traditions: In Sufism, synchronized breathwith chants enhances spiritual awareness, linking humanity andthe divine.In these traditions, intentional breath harnesses and transformsmental, physical, and spiritual well-being.Modern Disconnection from Breath: A Silent EpidemicIn today’s fast-paced world, dysfunctional breathing patterns,characterized by shallow, rapid chest breathing, are alarminglycommon. This disconnect from natural, diaphragmaticbreathing undermines physical and mental health, perpetuatingcycles of stress, fatigue, and illness. While breathing is an innatefunction, modern lifestyles have distorted this essential rhythm,leading to widespread physiological disruptions.The Modern Breathing CrisisStress and Shallow Breathing: Chronic stress activates thesympathetic nervous system, locking the body in fight-or-flightmode. This triggers rapid, shallow breathing patterns thatexacerbate anxiety and hinder the parasympathetic system’sability to promote relaxation.¹ 9NEUROLOGY & MIND/BODY MEDICINE ISSUE

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JUNE 2025 - VOLUME 20 | ISSUE NO. 0610Buteyko Breathing was a breathing technique developed byUkrainian doctor Konstantin Buteyko in the mid-1900s. It wasdesigned to normalize overbreathing (or hyperventilation) andhas been found particularly beneficial for conditions likeasthma, anxiety, and other respiratory issues. Buteykobreathing helps to reduce symptoms of asthma, chronicobstructive pulmonary disease (COPD), and bronchitis byencouraging shallow breathing, which improves CO2 retentionin the body. It has also been shown to calm the nervous systemby controlling the breath and promoting relaxation.The Buteyko breathing technique focuses on nose breathingand slow, controlled breaths to reduce air volume duringinhalation. Key elements include:Gentle inhalations and exhalations through the nose,avoiding deep or rapid breaths.Holding the breath briefly (5–10 seconds) after exhalationto increase CO2 levels and train the body to tolerate highercarbon dioxide.Breathing in a way that minimizes excessive air intaketriggers the relaxation response.By addressing the root causes of dysfunctional breathing andincorporating intentional breathwork practices, individualscan reclaim this vital tool for health and resilience.How Breath Influences the Body: The HolisticPerspectiveBreathing is far more than an automatic process. It is acornerstone of human physiology, impacting everything fromcellular function to emotional resilience. Naturopathicmedicine emphasizes the interconnectedness of systems, andbreath plays a pivotal role in bridging the physical, mental,and emotional realms.Breath and Cellular Health: Optimal breathing supportscellular energy by delivering oxygen efficiently for ATPproduction. Disrupted patterns, like chronic hyperventilation,lower carbon dioxide levels, impair oxygen release via the Bohreffect. Research links proper breathing to improved oxygenuptake, reduced oxidative stress, and enhanced cellularlongevity.14, 15Breath and the Nervous System: Slow, controlled breathingactivates the vagus nerve, promoting parasympathetic activityto lower heart rate, reduce blood pressure, and enhance stressresilience. In contrast, rapid, shallow breathing triggers thesympathetic nervous system, increasing stress. Research showsthat slow breathing techniques effectively reduce anxiety,panic, and PTSD symptoms.16NATUROPATHIC DOCTOR NEWS & REVIEWBreath and Detoxification: The lungs play a crucial role indetoxification, expelling carbon dioxide, a byproduct of cellularmetabolism. Inefficient breathing impairs this detox process,potentially accumulating metabolic waste and contributing tosystemic inflammation. Breath-focused practices likediaphragmatic breathing enhance lung function, supporting thebody’s natural detox pathways.17 Breath and Cardiovascular Health: Controlled breathing cansignificantly influence cardiovascular health by improvingheart rate variability (HRV), a marker of the heart'sadaptability to stress. High HRV is associated with betteroverall health and reduced risk of cardiovascular disease.Research shows deep, slow breathing improves bloodcirculation, lowers hypertension, and reduces cardiacworkload.18 - Breath and Mental Clarity: Oxygen is vital forbrain function, and dysfunctional breathing can cause cerebralhypoxia, leading to brain fog and fatigue. Alternating nostrilbreathing (Nadi Shodhana) improves oxygenation, enhancesfocus, and supports mental clarity by balancing brainhemispheres. 19Breath and the Gut-Brain Connection: Deep, diaphragmaticbreathing stimulates abdominal organs, improving gut motilityand digestion. Poor breathing patterns can worsen stress-related gastrointestinal issues like IBS. Breathwork practices,such as slow, deep breathing, help alleviate these symptoms bymodulating the nervous system and reducing inflammation.20, 21Incorporating Breathwork into Daily LifeIntegrating intentional breathwork into a daily routine canprofoundly affect physical, emotional, and mental well-being.A consistent practice helps regulate stress, enhance energy, andrestore balance to the body’s systems. Below are strategies forbuilding a sustainable breathwork practice, supported byfunctional medicine and mindfulness-based interventions.

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JUNE 2025 - VOLUME 20 | ISSUE NO. 0612How to Practice:Sit or lie down in a comfortable position.Place one hand on your chest and the other on yourabdomen.Inhale deeply through your nose, allowing your abdomen torise while keeping your chest still.Exhale slowly through your nose or pursed lips, feeling yourabdomen fall.Practice for 5-10 minutes daily, gradually increasingduration.Structured Breathwork TechniquesSeveral evidence-based techniques can be adapted to suityour needs and schedule. These include:Box Breathing: A practice used by athletes and militarypersonnel to improve focus and reduce stress.Inhale for 4 seconds Hold for 4 seconds Exhale for 4seconds Hold for 4 seconds.Repeat for 2-5 minutes.Buteyko Breathing: Aimed at reducing over-breathing andrestoring CO2 levels for optimal oxygenation. Useful forindividuals with asthma or anxiety.24Coherent Breathing: Focuses on maintaining a consistentrhythm of 5-6 breaths per minute. Studies suggest this can lowerblood pressure and improve heart rate variability.25Mindfulness-Based PracticesMindfulness practices often integrate breath awareness as a corecomponent, fostering both emotional and physiological balance.Techniques like alternate nostril breathing (Nadi Shodhana)have been shown to enhance focus and reduce anxiety bybalancing the autonomic nervous system.26How to Practice:Sit comfortably and close your right nostril with yourthumb.Inhale deeply through your left nostril.Close your left nostril with your ring finger, release yourthumb, and exhale through your right nostril.Repeat, alternating nostrils, for 3-5 minutes.Breathwork for SleepBreathing techniques designed to calm the nervous system canenhance sleep quality. Practices like the 4-7-8 method have beenshown to reduce pre-sleep anxiety and promote relaxation byelongating the exhalation phase.NATUROPATHIC DOCTOR NEWS & REVIEWHow to Practice:Inhale deeply through your nose for a count of 4.Hold your breath for a count of 7.Exhale slowly through your mouth for a count of 8.Repeat for 4 cycles, increasing as needed.Integrating Breathwork into Daily RoutinesBuilding a habit of intentional breathing doesn’t require hoursof dedication. Small, consistent practices can yield significantbenefits:Morning Activation: Begin your day with 2–5 minutes ofdiaphragmatic breathing or energizing breathwork, likeKapalabhati ("skull-shining breath").Midday Reset: Use box breathing during work breaks to reducestress and refocus.Evening Wind-Down: Incorporate 4-7-8 breathing or gentlediaphragmatic breathing before bed to calm the mind.Tracking ProgressMonitoring metrics like heart rate variability, stress levels, andreadiness through wearables is a great way to track progress.Journaling your experiences and perceived benefits alsoprovides valuable insights.Modern Science Validates Ancient WisdomScience is increasingly recognizing intentional breath controlfor its ability to influence physiological states, supportemotional regulation, and enhance cognitive function. Studiesshow controlled breathing improves heart rate variability,oxygenation, and the nervous system, reducing anxiety andenhancing focus . Ancient practices linking breath to energyflow and mindfulness align with these physiological benefits.27, 28

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Key FindingsNervous System Regulation: Pranayama and deep breathingactivate the parasympathetic nervous system, reduce cortisol,and improve heart rate variability .29Oxygen and CO2 Balance: Techniques like Buteyko breathingsupport optimal oxygen delivery and cellular function. 30Focus and Emotional Regulation: Breath-focused practicesimprove attention, reduce anxiety, and promote emotionalbalance .31Cardiovascular and Pulmonary Benefits: Controlled breathinglowers blood pressure, enhances lung capacity, and easesrespiratory conditions like asthma .32Bridging Ancient Wisdom with Modern ScienceIntegrating ancient breathwork with modern insights creates aholistic approach to well-being. Practices rooted in nature'srhythms become even more powerful when performedoutdoors. Wearable devices and biofeedback tools personalizethis practice, measuring changes like heart rate variability andstress. Combining timeless wisdom with modern science,breathwork empowers stress reduction, health, and spiritualgrowth for a balanced future.13NEUROLOGY & MIND/BODY MEDICINE ISSUEDr. Jennifer Ruthensteiner, a restorativenaturopathic physician with over 20 years ofexperience, founded Reboot Center for InnovativeMedicine to offer membership-based, root-causecare. She combines biohacking, restorativemedicine, and nutrigenomics to optimize wellnessand reverse disease. Her approach includesdetoxification, hormone balancing, cellularrejuvenation, peptide therapy, and metabolictherapies. Passionate about empowering others, Dr.Ruthensteiner shares her expertise throughspeaking engagements, articles and other writingengagements, group visits, and personalizedconsultations. She also collaborates with clinics tohelp them shift to a membership-based care model.Dr. Ruthensteiner declares no conflict of interest,no financial support was received, and there are noaffiliations that could influence this work.1.Russo MA, O’Rourke SM, Kase R. The physiological andpsychological effects of controlled breathing: A systematic review.Front Psychol. 2017;8:457.2.Russo MA, Santarelli DM, O'Rourke D. The physiological effects ofslow breathing in the healthy human. Breathe. 2017;13(4):298-309.3.Russo MA, O’Rourke SM, Kase R. The physiological andpsychological effects of controlled breathing: A systematic review.Front Psychol. 2017;8:457.4.Barker N, Thevasagayam R, Ugonna K, Kirkby J. Pediatricdysfunctional breathing: Proposed components, mechanisms,diagnosis, and management. Front Pediatr. 2020;8:379.5.Agache I, Ciobanu C, Paul G, et al. Dysfunctional breathingphenotype in adults with asthma - incidence and risk factors. ClinTransl Allergy. 2012;2:18.6.Maratou E, Koumpagioti D. Dysfunctional breathing in children andadults with asthma. Front Respir Med. 2021;8:642991.7.Vagedes K, Kuderer S, Ehmann R, et al. Effect of Buteyko breathingtechnique on clinical and functional parameters in adult patients withasthma: a randomized, controlled study. Eur J Med Res.2024;29(1):42. 8.Singh R, Gupta A, Mehta V, et al. Role of breathing exercises inasthma—yoga and pranayama. Indian J Pediatr. 2022;89(11):1032-1039.9.O’Connor E, Patnode CD, Burda BU, Buckley DI, Whitlock EP.Breathing exercises and/or retraining techniques in the treatment ofasthma: comparative effectiveness. Rockville, MD: Agency forHealthcare Research and Quality (US); 2012. Report No.: 12-EHC092-EF. AHRQ Comparative Effectiveness Reviews. PMID:23101047. Bookshelf ID: NBK109355.10.Russo A, et al. Effect of Buteyko breathing technique on clinical andfunctional parameters in adult patients with asthma: A randomized,controlled study. Eur J Med Res. 2023;28(1):1-10. 11.O'Driscoll BR, Howard LS, Earis J, Mak V. British Thoracic Societyguideline for oxygen use in adults in healthcare and emergencysettings. Thorax. 2017;72(6).12.Patrick M. The Oxygen Advantage: The Simple, Scientifically ProvenBreathing Techniques. 1st ed. New York, NY: St. Martin's Press;2020.13.Ma X, Yue Z, Gong Z, et al. The effect of diaphragmatic breathing onattention, negative affect, and stress in healthy adults. Front Psychol.2017.14.Canning P, Parameshwaran V, Cook J, Dorris L, Bellelli G. Pediatricdysfunctional breathing: A review of the evidence and clinical practicerecommendations. Front Pediatr. 2018;6:406. 15.Courtney R, Greenwood KM, Cohen M. Relationships betweenmeasures of dysfunctional breathing in a population with concernsabout their breathing. J Bodyw Mov Ther. 2019;23(2):266-272. 16.Canning P, Parameshwaran V, Cook J, Dorris L, Bellelli G. Pediatricdysfunctional breathing: A review of the evidence and clinical practicerecommendations. Front Pediatr. 2018;6:406. 17.Canning P, Parameshwaran V, Cook J, Dorris L, Bellelli G. Pediatricdysfunctional breathing: A review of the evidence and clinical practicerecommendations. Front Pediatr. 2018;6:406.18.Canning P, Parameshwaran V, Cook J, Dorris L, Bellelli G. Pediatricdysfunctional breathing: A review of the evidence and clinical practicerecommendations. Front Pediatr. 2018;6:406. 19.Canning P, Parameshwaran V, Cook J, Dorris L, Bellelli G. Pediatricdysfunctional breathing: A review of the evidence and clinical practicerecommendations. Front Pediatr. 2018;6:406. Remaining References on NDNR.comREFERENCES

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Tauroursodeoxycholic acid (TUDCA) is one of the mosthydrophilic bile acids.³⁰ It is synthesized in hepatocytes byconjugating ursodeoxycholic acid (UDCA) with the aminoacid taurine. UDCA, which is made by gut bacteria, is FDA-approved in the United States for the treatment of certaincholestatic liver diseases.9 Humans make TUDCA to some extent, but it is found incopious amounts in the bile of bears. It’s fascinating, therefore,to note that bear bile has been used therapeutically in ChineseMedicine for centuries.9TUDCA is classified as a chemical chaperone. Chemicalchaperones are naturally occurring substances that can correctinappropriately localized or aggregated proteins in theendoplasmic reticulum (ER) by stabilizing a protein’s structureand facilitating its folding process. If this process becomesderanged, as can happen during oxidative stress, it signals anER stress response, which is associated with reduced proteinsynthesis, malfunction of the unfolded protein response, andcell death.¹¹ TUDCA attenuates the ER stress response,inhibits cell death, and preserves cellular function.91012One clinical trial measured brachial artery flow-mediateddilation (FMD) at baseline and 60 and 120 min after an oralglucose challenge in 12 young healthy subjects (seven men, fivewomen). Subjects were tested twice after oral ingestion ofTUDCA or placebo capsules. NEUROLOGY & MIND/BODY MEDICINE ISSUE15FMD was reduced from baseline during hyperglycemia underplacebo (-32% at 60 min and -28% at 120 min post oral glucoseload; P<0.05 from baseline) but not with TUDCA ingestion(-4% at 60 min and +0.3% at 120 min post oral glucose load;P>0.05 from baseline). Thus, postprandial hyperglycemia maycause endothelial dysfunction through ER stress, andhyperglycemia-induced endothelial dysfunction may bemitigated by TUDCA ingestion.5Bile acids are an important aid to lipid absorption in theintestines, and regulate cholesterol homeostasis. Cholesteroland related lipid molecules are critical components of myelin,and neuronal and glial cell membranes. 9 2526,27TRANSFORMYOUR SKIN. RESTORECONFIDENCE.Every scar tells a story, but it doesn’thave to stay. Dr. Speron’s Natural ScarTreatment fades scars with medical-grade silicone, oxygenated water, andhyaluronic acid—restoring your skin’snatural beauty. GLOW WITH CONFIDENCEFRESH START BEGINS HERE.drsperonsnaturalskincare.com (847) 232-8280

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16NATUROPATHIC DOCTOR NEWS & REVIEWStudies are pointing to the possibility that neurodegenerativediseases may also originate from early life movements andtrauma, as well as worsen with age. Neurological dysfunctionin middle-aged and elderly individuals can significantlydecrease quality of life. With Alzheimer’s disease (AD)expected to continue with a rise in life expectancy, there is apressing need to find effective treatments.1 Furthermore,evidence continues to support a strong correlation betweenmetabolic disorders and AD. Disturbances in insulin resistanceand lipid metabolism are potential AD risk factors.Aging has been associated with insulin resistance andhyperinsulinemia, contributing to the prevalence of Type 2Diabetes. In 18-month-old mouse models (considered oldmice), TUDCA was shown to reduce body weight, adiposity,and liver lipid accumulations, as well as improve glucosetolerance, insulin sensitivity, and insulin clearance. TUDCAalso reversed age-related memory loss in these mouse models.4The greatest risk factor by far for neurodegenerative disordersis aging. The aging process has widespread effects, includingpotentially disrupting the gut microbiome-brain axis.Diminished bioavailability of microbial metabolites, likesecondary bile acids and short-chain fatty acids, which haveimmunoregulatory properties, can lead to persistentinflammation, gut mucosal thinning, and reduced microbiomediversity and stability. Bile acid-mediated signaling islikely bidirectional within the gut microbiome-brain axis tomodulate metabolic status and cholesterol balance centrally.Dysregulation of homeostasis in this pathway has beenassociated with neurodegenerative conditions. For example,high levels of secondary bile acids are found in theneurodegenerating brain, possibly due to increased bile acidproduction by a disordered microbiome. Increased levels ofbile acids in systemic circulation can also adversely affectblood-brain barrier permeability.31,32,3328Serum levels of 15 primary and secondary bile acids weremeasured in 1464 subjects: 24% of subjects were healthy adultswith normal cognitive function; approximately 19% had earlymild cognitive impairment; 34% had late mild cognitiveimpairment; and 21% were diagnosed with AD. Significantlylower serum concentrations of cholic acid (CA), a primary bileacid, and higher levels of the bacterially produced, secondarybile acid, deoxycholic acid, were found in AD subjectscompared to cognitively normal adults. An increaseddeoxycholic acid:CA ratio, mediated by gut bacteria, isassociated with cognitive decline. JUNE 2025 - VOLUME 20 | ISSUE NO. 06This study encourages more research into the role of gutdysbiosis in the pathogenesis of AD.8Hydrophilic bile acids, particularly TUDCA, can cross theblood–brain barrier. They can act as bile acid receptor agonistsand appear to confer neuroprotective effects.34,35TUDCA has been shown to have neuroprotective effects byinhibiting cell death in several neurodegenerative conditionsthat are characterized by dysregulations in apoptosis, forexample, Alzheimer's disease, Parkinson's disease,Huntington's disease, and amyotrophic lateral sclerosis.The mechanisms of action that underlie the anti-apoptoticproperties of TUDCA include its ability to: 14,15,16,36 1718,19 20Inhibit mitochondrial pathways of cell deathPrevent the production of reactive oxygen speciesMitigate endoplasmic reticulum stressStabilize the unfolded protein response.21,22A 2020 study found that adult and pediatric patients withmultiple sclerosis (MS) had lower levels of circulating bile acidmetabolites when compared with controls. Alterations in bileacid metabolite levels were most pronounced in adults withprogressive forms of MS. Receptors for bile acids were alsonoted on immune and glial cells in the white matter brainlesions of post-mortem human tissue samples. In an in vitroexperiment, TUDCA was found to prevent the expression ofthe neurotoxic phenotype of astrocytes and theproinflammatory phenotype of microglia in a dose-dependentmanner. Activated astrocytes and microglia play importantroles in MS pathophysiology, especially in the progressivephase. It is possible that reduced signaling through bile acidreceptors is associated with increased neuroinflammation.Supplementation with TUDCA in an animal model of MSimproved signs of neuropathology and reduced diseaseseverity.23Markers for dopaminergic function, neuroinflammation,oxidative stress, and autophagy were assessed in a progressivemouse model of Parkinson’s disease. Pretreatment withTUDCA alleviated dopaminergic neuronal damage,attenuated microglial and astroglial activation, and preventeddopamine and DOPAC7 (3-4-dihydroxyphenylacetic acid – ametabolite of dopamine ) reductions, and reduced proteinoxidation and autophagy.67

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1.Song, H., Liu, J., Wang, L., et al. (2024). Tauroursodeoxycholic acid: Abile acid that may be used for the prevention and treatment of Alzheimer'sdisease. Frontiers in Neuroscience, 18, 1348844.https://doi.org/10.3389/fnins.2024.1348844https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10909943/2.Mahmoudian Dehkordi, S., Arnold, M., Nho, K., et al. (2019). Alteredbile acid profile associates with cognitive impairment in Alzheimer'sdisease—An emerging role for gut microbiome. Alzheimer’s & Dementia,15(1), 76–92. https://doi.org/10.1016/j.jalz.2018.07.217https://pubmed.ncbi.nlm.nih.gov/30337151/3.Kusaczuk, M. (2019). Tauroursodeoxycholate—Bile acid with chaperoningactivity: Molecular and cellular effects and therapeutic perspectives. Cells,8(12), 1471. https://doi.org/10.3390/cells8121471https://pubmed.ncbi.nlm.nih.gov/31757001/4.Yoon, Y. M., Kim, S., Han, Y. S., et al. (2019). TUDCA-treated chronickidney disease-derived hMSCs improve therapeutic efficacy in ischemicdisease via PrPC. Redox Biology, 22, 101144.https://doi.org/10.1016/j.redox.2019.101144https://pubmed.ncbi.nlm.nih.gov/30785084/5.Walsh, L. K., Restaino, R. M., Neuringer, M., et al. (2016).Administration of tauroursodeoxycholic acid prevents endothelialdysfunction caused by an oral glucose load. Clinical Science, 130(21),1881–1888. https://doi.org/10.1042/CS20160501https://pubmed.ncbi.nlm.nih.gov/27503949/6.Özcan, U., Yilmaz, E., Özcan, L., et al. (2006). Chemical chaperonesreduce ER stress and restore glucose homeostasis in a mouse model of type2 diabetes. Science, 313(5790), 1137–1140.https://doi.org/10.1126/science.1128294https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741373/7.Zangerolamo, L., Carvalho, M., Barssotti, L., et al. (2022). The bile acidTUDCA reduces age-related hyperinsulinemia in mice. Scientific Reports,12(1), 22273. https://doi.org/10.1038/s41598-022-26915-3https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789133/8.Zhou, W., Gallagher, A., Hong, D. P., et al. (2009). At low concentrations,3,4-dihydroxyphenylacetic acid (DOPAC) binds non-covalently to alpha-synuclein and prevents its fibrillation. Journal of Molecular Biology,388(3), 597–610. https://doi.org/10.1016/j.jmb.2009.03.053https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719782/9.Cuevas, E., Burks, S., Raymick, J., et al. (2022). Tauroursodeoxycholicacid (TUDCA) is neuroprotective in a chronic mouse model of Parkinson'sdisease. Nutritional Neuroscience, 25(7), 1374–1391.https://doi.org/10.1080/1028415X.2020.1859729https://pubmed.ncbi.nlm.nih.gov/33345721/Remaining References can be found on NDNR.comREFERENCESDevin Miles, ND is a clinician who providesintegrative and natural approaches to kidneyfunction, cardiovascular health, digestion,autoimmunity, and prevention. She graduatedfrom Sonoran University of Health Sciences(previously Southwest College of NaturopathicMedicine) in Arizona. She enjoys educatingpatients via social media, webinars, and in-personpresentations and has been interviewed in variouspodcasts and radio shows. Dr. Miles has alsolaunched an online course sharing naturalsupport for kidney and blood pressure health.She is a medical writer and has written fortraditional, integrative, naturopathic, andfunctional medicine sources. Dr. Miles is aMedical Advisor for Restorative Formulations. 17NEUROLOGY & MIND/BODY MEDICINE ISSUEBile acids can be absorbed into circulation and have systemiceffects.⁹ TUDCA has extensive therapeutic benefits beyond thehepatobiliary system, such as inflammatory metabolicdisorders like atherosclerosis, diabetes, and renal disease.13 Although considered a vascular disease, reports of diabeticretinopathy have shown that retinal neurons are also affected.TUDCA notably reduced cell death in cultured retinal neuralcells affected by increased glucose concentration, preventedmitochondrial and nuclear release of apoptosis-inducing factor(AIF), and reduced oxidative stress biomarkers.2Tail vein injection of TUDCA-treated CKD-hMSCs (humanmesenchymal stem cells derived from patients with chronickidney disease) in a CKD murine hindlimb ischemia model ledto improvements in blood perfusion ratio, blood vesselformation, kidney recovery, and limb salvage, suggesting apromising new intervention that addresses cardiovascularproblems and CKD in patients.3Orally ingested TUDCA can cross the blood-brain barrier toreach neuronal tissue and prevent cell death.²⁴ Though furtherhuman studies need to be conducted, evidence continues tomount in support of its potential clinical application as part ofa therapeutic approach to treating neuroinflammatory andneurodegenerative conditions.Dr. Elizabeth (Liz) Sutherland began herundergraduate degree at the Universityof Cambridge in Classics and finished itat Tufts University with a BS inBiopsychology. She earned her doctoratein naturopathic medicine (ND) fromNational University of NaturalMedicine (NUNM), in Portland, OR,after which she completed post-doctoralresearch fellowships at the KaiserPermanente Northwest (KPNW) Centerfor Health Research (where shesubsequently became the first KPNWResearch Associate to hold an NDdegree) and the University of ArizonaCollege of Medicine. She also earned aCertificate in Human Investigations forclinical trials at Oregon Health andScience University. Currently, Dr.Sutherland serves as Vice President ofContinuing Education Compliance forAARM, and editor in chief of theJournal of Restorative Medicine. Inaddition, she helps physicians andscientists from several wellness andmedical disciplines write grantproposals, books, and manuscripts forsubmission to academic journals.

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This article is not intended to comprehensively explain Bio-Electric concepts but to build upon previous articles andstrengthen the foundation for why this approach should bestandard training in naturopathic and functional medicalpractice. In the May 20, 2023, edition of the Townsend e-letter,I explained the concepts of a 5-Phase restorative healthlifestyle designed to increase awareness of one’s environmentand self, minimize negative energy loads on the body, enhanceenergy efficiency, and naturally support detoxification andrestoration of health. Additionally, I discussed using urine pHto identify foods with optimal forms of calcium to improvemineral bioavailability and energy efficiency. This articleintroduces the clinical insights that the Reams’ analysis offers. Reams’ Analysis is a simple in-office or home urine and salivatest using a refractometer, pH meter, conductivity meter, and asoil nitrate and ammonia nitrate test. The measured resultsprovide the analytical variables that are compared to ideal,and what Dr. Reams called the healing range, which outlineschemical energy efficiency, the line of energy resistance, anddirects the practitioner for needed support or signs of toxicity.In his book, Biological Ionization as Applied to HumanNutrition, Dr. A.F. Beddoe is considered the textbook forbetter understanding Dr. Reams’ principles and testing.In my years of studying Dr. Reams’ lectures, reviewing histeachings, and attending retreats to replicate Reams’ resultswith clients, I found that none offered a perspectiveencompassing the naturopathic understanding of the body’srestorative process. The general rule of thumb is “go by thenumbers” and support accordingly. 20NEUROLOGY & MIND/BODY MEDICINE ISSUEI hope to demonstrate a basic medical association for whatthose numbers reveal, facilitating critical thinking to bestsupport clients through a restorative process.One of my favorite philosophical lectures at NCNM was byDr. Jared Zeff, who described a hierarchy of therapeutics andthe application of the least toxic therapies to adhere to theprinciple of “no harm” in supportive care.¹ Dr. Zeff alsofrequently discussed healing patterns, highlighting that thedischarge or detox phase before restoration indicates thathealing is underway. Building on this wisdom, I aim todemonstrate how Reams’ analysis can determine whether thetherapies enhance or deplete the vital force. I also intend toexplain how the equation measures Energy-in vs Energy-outand its relevance to detoxification capacity when necessary.In reviewing Reams’ analysis, the principle is that byidentifying what is mathematically “perfect,” the numbersfurthest from perfection reveal where the greatest energy lossoccurs. Understanding the physiological significance of thesenumbers provides a roadmap for identifying the most burdenedsystems to direct support. Again, you “go by the numbers”.The chart below is a basic outline to stimulate critical thinkingand analysis of the information that Reams’ analysis provides.Suggested within the chart is a hierarchy of natural processesfrom Energy efficiency-> Chemistry efficiency-> Metabolicefficiency-> Clinical Significance-> “Dis-ease” associations.This chart is not intended as a diagnostic tool but to highlighthow Reams’ analysis demonstrates cause-and-effectassociations in health restoration or deterioration.“Illness starts when you continue to burn up more energy than you take in.” ~ Dr. Carey Reams

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On a fundamental restorative level, you must generate moreenergy than you consume. In the May 2018 NDNRpublication², I explained how Reams’ analysis values of Brix,pHs, and Conductivity represent Energy-In. Conductivity, CellDebris, and Nitrate elimination represent Energy-Out within abiological system. I recommend reviewing that article tounderstand how Reams’ analysis values correlate withsymptom presentations, and how symptoms can be predictedwhen you learn how the numbers interrelate.“The brix has the greatest effect on overallconscious and subconscious feeling of the body thanany other number in the equation.” ~Dr. A.F. BeddoeOn a chemical level, Energy-In variables (Brix, pHs,Conductivity) represent oxygen availability, rate or speed ofreactions, the thickness or density of fluids that impactelectrical and heat transfer, and influence temperatureregulation. The Brix percentage represents sugar regulationand reveals potential energy available, directly associated withoxygen availability to the liver and brain; this explains why theBrix can have the most influence on both conscious andsubconscious well-being.³ Given that pH levels affect theelectrical availability of minerals and vitamins in chemicalprocesses and influence oxidative stress potential, it becomesclear how metabolic disorders may develop. Additionally, theassociations of fluid density and energy movement with theconductivity variable allow an understanding of how nerveconductivity capacity can become excessive, potentially leadingto neurological breakdown or impaired energy distribution. Itell my clients that excess Conductivity is comparable toconsistently running 20 amps through a 15 amp wire, whicheventually causes a breakdown.On an Energy-Out level, Conductivity, Cell Debris, andNitrate elimination represent the body’s ability to eliminateexcesses and reflect the efficiency of detox metabolism.Conductivity indicates the thickness of body fluids; Cell Debriscorrelates with fluid density and the kidney’s ability to handlecellular waste, while the nitrates reflect digestive efficiency byindicating the balance of toxic (ammonia nitrate) vs usablenitrogen (nitrate nitrate) from proteins. Understanding howthe equation works together tells you if the person can handlethe body’s load and their ability to detoxify. A Reams’ analysisprovides chemical insights into the physiological capacity toconvert food into energy and the body’s ability to eliminatemetabolic and physical waste. Comprehending energy andmetabolic efficiency underscores the effectiveness ofrecommended lifestyle, diet, and supportive therapies. Oncethe clinical correlations are understood, how to best supportclients and minimize adverse detoxification symptoms duringthe restorative health process becomes clear.Constantine Hering, the first American homeopathic doctor,developed what is known as Hering’s Laws of Cure throughobservation. Hering described the patterns exhibited by thebody during a healing reaction, with the opposite patternsindicating “dis-ease” progressing deeper into the body.Hering’s Laws are: the body heals from top to bottom, frominside out, from the most important to the least importantorgan, and in reverse order of symptoms experienced in the“dis-ease” process. Naturopathic philosophy teaches toobserve these patterns to assess if the therapeutic approach isstimulating the vital force to restore health. ”Why guess when you can know?” - Dr. CareyReamsMost practitioners with a “dis-ease” based mindset arelooking for a pattern in signs and symptoms presented byclients to make an educated guess about what is occurring inthe body. My naturopathic education at the NationalUniversity of Natural Medicine (NCNM) emphasizedunderstanding pathology to prevent disease processes andideally achieve a cure. Detailed instruction was given on thenatural progression of “dis-ease” and on using food,supplements, therapies, detoxification, and other naturalmechanisms to stimulate the “nature cure”. Reams’ analysishelps gain the ability to understand how chronic chemistryimbalances drive the “dis-ease” process, which can then besystematically identified and corrected. Hering’s Lawsmanifest through patterns in the Reams’ analysis numbers,which merits an article of its own. In looking at the abovechart, I find that focusing on clinical significance helps memeet my clients where they are, especially in addressing theirprimary complaints. There is a basic approach to understanding the chemistry of aReams’ Analysis; when you learn to control the Brix andsaliva pH through lifestyle modifications, the other numberswill adjust, demonstrating how the body can respond.Controlling the Brix involves hydration and resultant oxygenavailability by removing negative-energy foods (foodsensitivities) that act as a chronic immune burden, and byconsidering the macronutrient ratios based on chemistryspeed (pH urine), improved energy efficiency can beobserved. As digestion improves, the pH of saliva will reflectenhanced liver bile strength, leading to better mineral andvitamin absorption and availability, alongside improvedmetabolic speed and proteins/fat-to-energy conversion. Manyother patterns in Reams’ Analysis indicate restoration at theenergy, cellular, biochemical, and microbiological levels. Ihope this approach illustrates the complexity of Reams’Analysis in understanding the body’s homeostaticoptimization.21NEUROLOGY & MIND/BODY MEDICINE ISSUE

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1.Misak, D. (2018, May 31). Bio-Electric chemistry connections.NDNR.com, Mind-Body Health. https://ndnr.com/mind-body/bio-electric-chemistry-connections/2.Beddoe, A. F. (2008). Biological ionization as applied tohuman nutrition (pp. 41–42, 47, 125–132). Advanced IdealsInstitute. (Original work published 1984)3.Chen, W., Zhang, J., Song, Y., Dong, X., Tan, M., Wang, D.,& Yu, X. (2020). Urinary metabolic biomarkers of diet qualityin European children are associated with metabolic health.Scientific Reports, 10(1), 14381.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217399/REFERENCESDr. Darrell S.C.S. Misak, ND, RPh is aWVU Pharmacy graduate that later becamea Naturopathic Doctor after earning hisdegree at National College of NaturopathicMedicine in 2000. Realizing the pitfalls oftraditional medicine and pharmacy, Dr.Misak searched for truth in health, whichdirected him to naturopathic medicine, andto explain that truth through his 5 PhaseOptimal Health Mentality and Bio-ElectricChemistry quantum health understanding.Dr. Misak has a goal to teach and equipothers to create health awareness and changethe world. He has been published multipletimes in Naturopathic Doctor News andReview (NDNR), performs lectures,podcasts, and has done YouTube videosteaching an analytical and quantum Bio-Electric approach of health to optimizepersonal energy efficiency, correctdeficiencies, and observe natural healthrestoration.22NEUROLOGY & MIND/BODY MEDICINE ISSUEThe general rule of thumb is that the body will use what isavailable in its internal environment, operating at the highestrate and efficiency possible in pursuit of restoration. Thisbeautiful process slows down when overburdened withexcessive stimulation and support. Consequently, more is notalways better regarding energy efficiency. If the body lacksonly 10 specific nutrients and a multivitamin has 40 or 50ingredients, the things the body does not need may become anenergetic burden, increasing conductivity, causing nerveirritation, and creating a phlegmatic effect on body fluids.For this reason, I use single nutrients based on identifieddeficiencies through Reams’ analysis and live bloodmicroscopy, adjusting therapies according to subsequentanalysis data. Another article on supplemental needs based onReams’ analysis would be a logical next step for thoseinterested in a straightforward approach to deficiency vs excessin treatment.In summary, Reams’ Analysis offers the practitioner aquantum understanding of introductory chemistry and theefficiency of biological systems. It gives clients a tool to assesswhether they eat the right foods, drink adequate water, or needadditional support and guidance. Dr. John Bastyr was onceasked if he only had one tool as a naturopathic physician; hechose his hands. If I were asked? It’s Reams’ analysis. In myview, the self hierarchy starts with bio-electric energycomposed of anions and cations, leading to atoms, molecules,elements, minerals, and ultimately cells and their structures.Enhancing elemental chemistry and energy positively impactscellular, hormonal, neurological, biochemical, and microbialprocesses, allowing the identification and correction ofdeficiencies through functional medical techniques available tophysicians.

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Hormonal, Neurological & Gut-BrainRestoration in Chronic MigraineA Case StudyANNA KOLOMITSEVA, NDMigraines are a prevalent and debilitating neurologicalcondition significantly impacting quality of life and healthcareexpenditures. In the United States alone, migraines resulted inan estimated annual inpatient healthcare burden of $6.16billion, underscoring the economic impact and necessity foreffective treatment strategies.¹ Conventional treatmentsfrequently offer limited relief and carry potential side effects,highlighting the need for more holistic, sustainable solutions.²This case study explores the efficacy of an integrativenaturopathic protocol for chronic migraines, addressingneurological, hormonal, and psychosocial factors.A 46-year-old female with a 27-year history of chronicmigraines experienced migraines 4–5 times weekly, despitepharmacological interventions including CGRP monoclonalantibody injections and serotonin receptor agonists.Contributing factors included poor sleep, hormonal disruptionpost-hysterectomy, elevated stress, and gastrointestinaldysbiosis.²,³A personalized, multimodal naturopathic protocol wasimplemented, including nutritional strategies, botanicalmedicine, phytohormonal support, adaptogens, magnesium,probiotics, and lifestyle interventions.⁴⁻⁶ Within 6 weeks,migraine frequency reduced to 1–2 per week and eventuallyresolved. Sleep quality improved and pharmacologicaltreatments were discontinued. Sustained remission wasachieved through consistent application of naturopathicprinciples.This case highlights the potential of a systems-basednaturopathic approach to deliver meaningful outcomes inchronic migraine care and supports broader clinical integrationof naturopathic neurology.⁷TOLLE TOTUM24NATUROPATHIC DOCTOR NEWS & REVIEWNEUROLOGY & MIND/BODY MEDICINE ISSUEIntroductionChronic migraines represent a complex neurological conditioncharacterized by significant healthcare utilization and impairedquality of life. Migraine pathophysiology is increasinglyunderstood as an interplay of neurological, hormonal,gastrointestinal, and environmental factors, complicatingtreatment and necessitating multifaceted interventions.¹⁻³Despite substantial healthcare spending, estimated atapproximately $6.16 billion annually in the United States forinpatient care alone, conventional pharmacological treatmentsfrequently offer limited relief and present notable side effects orfinancial burdens.¹,²Emerging evidence supports the efficacy of integrative,naturopathic approaches, which emphasize personalized caretargeting root causes of migraine pathology, such as hormonaldysregulation and gut-brain axis disturbances.³′⁴ Naturopathicmedicine, grounded in systems biology and patient-centeredstrategies, provides a unique, holistic approach that is oftenunderutilized in conventional migraine management but showssignificant potential in achieving sustainable symptomresolution.³⁻⁵This case illustrates the effective resolution of chronic,medication-resistant migraines through a systems-basednaturopathic protocol, highlighting the clinical value andreproducibility of integrative naturopathic care in neurologicalpractice.

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25NATUROPATHIC DOCTOR NEWS & REVIEWNEUROLOGY & MIND/BODY MEDICINE ISSUECase PresentationPatient ProfileA 46-year-old female presented in March 2024 with a 27-yearhistory of migraines, previously managed with a monthlyCGRP monoclonal antibody injection (120 mg) and abortiveserotonin receptor agonist (100 mg). She reported poorefficacy of these interventions and expressed frustration withside effects and cost. The patient also had a long-standinghistory of insomnia, endometriosis, and a recent onset ofpostmenopausal symptoms following a hysterectomy in 2021.Symptoms and ExaminationShe experienced migraines 4–5 times weekly, often uponwaking, with symptoms including aura, photophobia,dizziness, nausea, neck stiffness, and sleep disruption.Triggering factors included cumulative sleep debt, weatherchanges, and perceived stress. While no physical exam wasperformed, symptom progression was closely monitored acrossvisits.Diagnostic TestingLaboratory testing included a DUTCH Complete hormonepanel (April 2024), which revealed postmenopausal levels ofestrogen, progesterone, and testosterone, with elevated freecortisol and low DHEA. Organic acid analysis showed lowglutathione marker (pyroglutamate) and elevated indican,suggesting intestinal dysbiosis. Imaging ruled out structuralcauses of abdominal pain, such as hernia or kidney stones.TimelineInitial visit (March 2024) focused on lifestyle, sleep, anddietary triggers. By Visit 2 (April), DUTCH results guidedhormonal support. Visit 3 addressed persistent migraines andhot flashes. Visit 4 targeted new IBS symptoms. By Visit 5(August), the patient achieved migraine resolution, improvedenergy, and consistent sleep.Relevant History and Contributing Factors The patient was monitored across five visits spanning Marchto August 2024, with progressive improvement in symptomsand adherence to the plan. Relevant contributing factors included:History of endometriosis and multiple abdominal surgeriesRecurrent UTIsSleep dysfunction since early adulthoodPerceived stress and caregiving responsibilities (mother offour children)Regular consumption of artificial sweeteners (e.g., dietsoda)Postmenopausal hormonal disruption followinghysterectomyDifferential Diagnosis1. Hormonal MigraineSupported by symptom onset post-hysterectomy, poor sleep,and hot flashes. Confirmed by low estrogen, progesterone, andtestosterone levels on DUTCH panel.2. Chronic Migraine Without AuraPatient reported classic migraine features with and withoutaura. Chronicity confirmed by duration (>15 days/month for>3 months). Aura was intermittent.3. Vestibular MigraineConsidered due to dizziness and visual disturbances, but ruledout as symptoms were not strongly linked to positionalchanges or vertigo-like episodes.4. Cervicogenic HeadacheConsidered due to occipital pain and neck stiffness. Ruled outas the primary cause based on patient history and symptompatterns, without physical exam findings to support it.5. Tension-Type HeadacheRuled out due to presence of photophobia, aura, andmoderate to severe pain impacting daily function.6. Secondary Headache (Structural or Infectious)Ruled out via lack of red flag symptoms (e.g., fever, suddenonset, neurological deficit).History of endometriosis and multiple abdominal surgeriesRecurrent UTIsSleep dysfunction since early adulthoodPerceived stress and caregiving responsibilities (mother offour children)Regular consumption of artificial sweeteners (e.g., dietsoda)Postmenopausal hormonal disruption followinghysterectomy

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26NATUROPATHIC DOCTOR NEWS & REVIEWInterventionsTreatment OverviewThe patient was prescribed a multimodal naturopathicregimen (Figure 2) that included magnesium glycinate (360mg at bedtime), activated B-complex with L-5-MTHF,Coenzyme Q10 (100 mg daily), and a multistrain probioticcontaining approximately 22 billion CFUs daily at peakdose.⁴⁻⁶ Botanicals included adaptogenic agents such asRhodiola, Magnolia, and L-theanine to regulate HPA-axisdysregulation.⁵ Topical wild yam cream was used twicedaily for hormone support. The dietary plan emphasizedprotein- and fiber-rich meals, matcha for L-theanine, andprobiotic foods such as sauerkraut and kombucha. Sleepand hydration protocols were integrated into the dailyplan.RationaleMagnesium and B-vitamins were used to supportmitochondrial function and neurological stability.²,⁴Adaptogens were included to moderate cortisol levels andsupport emotional resilience.⁵ Probiotics and probioticfoods were prescribed to address intestinal dysbiosis.³Phytohormone support was introduced due to lowpostmenopausal sex hormones,⁸ while matcha and eveningsnacks helped regulate energy and sleep-wake cycles.⁹AdjustmentsSupplement protocols were titrated over time based ontolerance and response. Cortisol-regulating botanicals wereincreased gradually. As symptoms of constipation and IBSemerged, digestive enzymes and probiotic timing wereadjusted. NEUROLOGY & MIND/BODY MEDICINE ISSUECastor oil was added topically for both abdominal pain andmuscle tension. The patient independently chose to discontinuepharmaceutical treatments and maintained adherence to thenaturopathic protocol throughout the intervention window.Outcomes and Follow-UpWithin six weeks of initiating the naturopathic protocol, thepatient experienced approximately a 75% reduction in migrainefrequency, decreasing from 4–5 episodes weekly to 1–2 (Figure1). By the fifth visit, the patient reported complete resolution ofmigraines (100% reduction in frequency), with no recurrencethrough follow-up (Figure 3). This resolution coincided withimproved sleep quality, reduced stress perception, and betterenergy regulation. Subjectively, the patient reported feeling"more herself," noted less puffiness, and required no abortiveor prophylactic medications.Hormonal symptoms such as hot flashes and night sweatsbecame infrequent and manageable, and sleep maintenanceimproved significantly with magnesium, dietary adjustments,and evening routine support. The patient also reportedimproved digestion and resolution of sugar cravings.While IBS symptoms emerged mid-treatment and required planadjustments, they were well-managed by the final visit and didnot interfere with migraine outcomes. The patient continued tofollow her meal plan, probiotic protocol, and adaptogensupport consistently through to the final visit.At the time of the last follow-up in August 2024, the patienthad not experienced a migraine in over six weeks and wasmaintaining her progress without pharmacological support.

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28NATUROPATHIC DOCTOR NEWS & REVIEWDiscussionThis case contributes to the growing literature on naturopathicneurology and the role of integrative care in chronic migrainemanagement. Migraines, particularly in postmenopausalwomen, often result from complex interactions involvingneuroendocrine disruption, stress physiology, and digestivesystem imbalances.²,³,⁸Traditional migraine treatments primarily focus onsymptomatic relief, which may overlook underlying systemiccontributors to migraine pathology. In contrast, thenaturopathic model emphasizes the resolution of systemicdysfunctions by addressing root causes rather than merelymanaging symptoms.⁶ The success observed in this case,particularly the medication-free resolution of chronicmigraines, reinforces the effectiveness and potential ofnaturopathic approaches to deliver lasting results whereconventional approaches have limited efficacy or toleranceissues.The utilization of botanical adaptogens to regulate cortisol andstress responses,⁵ mitochondrial nutrients to improveneurological stability,⁴ and probiotics to balance the gutmicrobiome³ represents an integrative, multifaceted approachwell supported by current evidence but remains underutilizedin conventional neurological practice. Additionally, dietarychanges, particularly the removal of artificial sweeteners,significantly contributed to the patient's improvement, aligningwith research linking dietary triggers to migraineexacerbation.¹⁰This case study thus provides valuable insight and a replicablemodel for clinical naturopathic intervention in chronicmigraines, highlighting the importance of personalized,systems-based treatment protocols in achieving sustainedremission and improving overall patient health.ConclusionThis case study illustrates how individualized naturopathiccare can lead to the resolution of chronic, medication-resistantmigraines. By identifying and addressing the underlyingneuroendocrine, digestive, and lifestyle contributors, thepatient achieved complete and sustained migraine remission.Her outcomes—improved sleep, stabilized hormonal patterns,and reduced stress response—reflect the effectiveness of asystems-based, patient-centered approach. These findingssupport the increasing clinical relevance of naturopathicphysicians in managing chronic neurological conditions andunderscore the importance of expanding integrative caremodels within the broader healthcare landscape.JUNE 2025 - VOLUME 20 | ISSUE NO. 06Dr. Anna Kolomitseva, ND (CT-Licensed) is anaturopathic doctor with over a decade of clinicalexperience in chronic and complex conditions. Sheis a 2015 graduate of the Canadian College ofNaturopathic Medicine (CCNM) and the founderof Independently Healthy Wellness & Coaching(IHWC), with locations in Connecticut andGeorgia. She received the State of Georgia PowerWomen Award in 2022 and was named a “Best ofGeorgia” 2024 winner in both the SpecialtyHealthcare Providers and Holistic & NaturopathicPractices categories. Dr. Kolomitseva iscommitted to advancing naturopathic neurologythrough clinical innovation and scholarlycontribution.REFERENCES1.Law HZ, Chung MH, Nissan G, Janis JE, Amirlak B. Hospital burden ofmigraine in United States adults: a 15-year national inpatient sampleanalysis. Plast Reconstr Surg Glob Open. 2020;8(4):e2790.doi:10.1097/GOX.00000000000027902.Ashina M. Migraine. N Engl J Med. 2020;383(19):1866-1876.doi:10.1056/NEJMra1915327.3.Arzani M, Jahromi SR, Ghorbani Z, et al. Gut-brain axis and migraineheadache: a comprehensive review. J Headache Pain. 2020;21(1):15.doi:10.1186/s10194-020-1087-2.4.Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin inmigraine prophylaxis: a randomized controlled trial. Neurology.1998;50(2):466-470. doi:10.1212/WNL.50.2.466.5.Talandashti MK, Shahinfar H, Delgarm P, Jazayeri S. Effects of selecteddietary supplements on migraine prophylaxis: a systematic review anddose-response meta-analysis of randomized controlled trials. Neurol Sci.2025;46(2):651-670. doi:10.1007/s10072-024-07794-0.6.Sarris J, Panossian A, Schweitzer I, Stough C, Scholey A. Herbal medicinefor depression, anxiety, and insomnia: a review of psychopharmacologyand clinical evidence. Eur Neuropsychopharmacol. 2011;21(12):841-860.doi:10.1016/j.euroneuro.2011.04.002.7.Millstine D, Chen CY, Bauer B. Complementary and integrative medicinein the management of headache. BMJ. 2017;357:j1805.doi:10.1136/bmj.j1805.8.MacGregor EA. Perimenopausal migraine in women with vasomotorsymptoms. Maturitas. 2012;71(1):79-82.doi:10.1016/j.maturitas.2011.10.008.9.Buse DC, Andrasik F. Behavioral medicine for migraine. Neurol Clin.2009;27(2):445-465. doi:10.1016/j.ncl.2008.11.010.10.Chiu HY, Yeh TH, Huang YC, Chen PY. Effects of intravenous and oralmagnesium on reducing migraine: a meta-analysis of randomizedcontrolled trials. Pain Physician. 2016;19(1):E97-E112.11.Martin VT, Vij B. Diet and headache: part 1. Headache. 2016;56(9):1543-1552. doi:10.1111/head.12952.Moreover, this case contributes to the growing body of clinicalknowledge supporting naturopathic neurology and offers areplicable treatment framework for similarly complexpresentations. It reinforces the value of multidisciplinary,systems-informed strategies and highlights a need for broaderinclusion of naturopathic perspectives in academic research andclinical guideline development.

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Through these experiences, I’ve come into direct contact withthe deeper essence of the vital force and how it aligns withwhat quantum physicists call the quantum field, the zero point,and pure potentiality: all of this together may be perceived asthe divine. This divine vital force constantly moves into us,flows within our body, and animates our being, not as an idea,but as a reality. My StoryEarlier in my life, I had been overwhelmed by almost constantanxiety, stress, and numerous other negative emotionsconnected to past trauma. I also had physical symptomsconnected to this trauma, including severe eczema, allergies,insomnia, and heart palpitations. When I made full contactwith the divine energy within me through long periods ofmeditation, my life drastically changed. Not only did Iexperience a profound awakening, but I also had significantemotional, mental, and physical healing experiences. Mysymptoms decreased, and now I rarely experience them. Because I am a naturopathic doctor with the heart of a healer,I examined these encounters to replicate them with patients. Idiscovered that with focus and intention on both parts, I couldguide my patients to align with their divine vital force as ahealing power by helping them connect with their higher self,their spirit. When I helped my patients make contact with thispotent, living divine vital spark, the resulting healingsbordered on the miraculous. I saw numerous patients finally come back home to peace afteryears of spiraling in ongoing anxiety, depression, PTSD,and/or chronic stress. As the process profoundly changed howthey felt within themselves and how they saw life, theiremotional symptoms abated. I have also worked with patientswho were struggling with physical issues, such as autoimmuneconditions, multiple chemical sensitivities, chronic fatigue, andpathogenic issues such as Lyme disease and its co-infections.When these patients fully opened to the living, vital spark ofthe divine meeting their core issues, their symptoms improved,and they could get back to their lives with their inner life forcerenewed and activated. The ProcessThe process I used includes guiding patients in a facilitatedmeditative process to make contact with the energies of theirhigher selves and the divine and to bring this presence into theplaces that need attention. 31NEUROLOGY & MIND/BODY MEDICINE ISSUEThese places were usually somatic contractions of old pain andtrauma. As the energy within my patients’ contractionssoftened, they learned to trust and opened to divine energythrough this process, and the dense energy of traumadissolved. The internalized negative ego voices and physicalsymptoms that this dense energy had been directly fueling alsodissolved. I observed this result so often, within myself andothers, that I saw it as nothing short of a divine alchemicalprocess of transmutation. This process and healing modalityhave transformed countless lives, and I now teach it and amwriting a book about it. Susan’s Transformative Journey to HealingSusan stepped into my practice 5 years ago. She was sufferingfrom excruciating gastrointestinal (GI) spasms that frequentlysent her to the emergency room. She struggled with even thesimplest daily activities, and as a result, was on disability.Despite seeing numerous gastroenterologists, she remainedundiagnosed and ill. Susan sensed that her gastrointestinal pain was somehowlinked to her traumatic childhood and was sometimes so severethat she could barely tolerate it. She was extremely limited inwhat she could eat and was underweight and debilitated.Without effective treatment, she could continue to deteriorate,losing even more weight and strength.I learned that Susan had experienced multiple levels of abuseas an infant, continuing into childhood. Her GI symptoms alsostarted when she was very young. I intuitively perceived thatthis past abuse was manifesting as chronic post-traumaticstress disorder (C-PTSD) symptoms in her GI tract. AlthoughSusan had gone through years of traditional talk therapy, shehad not been treated from the deeper mind-body and somaticperspective that I sensed she needed.Most of her flare-ups were connected to stress: a fight with herboyfriend, a harrowing incident with a family member, or aproblematic business call could cause excruciating pain. Shefelt bombarded by relatively minor external stressors, whichwould easily trigger overwhelming negative inner voices, awhirlwind of anxiety, and agonizing pain.Treatment We began by exploring both naturopathic protocols and mind-body medicine. The supplements and herbs had hardly anypositive effects, which is a common experience when theprimary underlying issue is rooted in mind-body dynamics.

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JUNE 2025 - VOLUME 20 | ISSUE NO. 0632Over the next few months, we dove into the healing journeyutilizing this new mind-body-spirit technique. Throughthese sessions, Susan began to experience relief from hersymptoms, as well as from her internalized mind-body strifeand anxiety.Given the strong connection between Susan’s physicaldiscomfort and her emotional and energetic pain, I guidedher through a meditative process to connect with her higherself witness consciousness (HSWC). This inner aspect bringsprofound presence, love, and compassion to any areaneeding healing. Once Susan accessed her HSWC, Iencouraged her to direct this energy to the parts of her bodythat required the most attention. The presence of theHSWC allowed her to engage with her pain without beingoverwhelmed by it, while also staying present andcompassionate toward whatever arose during the process. As Susan dove into the pain within her body, she discoveredthat it was connected to imprinted layers of traumaticchildhood memories and the multiple somatic contractionscaused by these imprints. As she got to know these somaticcontractions, she discovered they held traumatic energy thatwas frozen in time, hurt, scared, and at times evenaggressive. It became clear that the individual somaticcontractions had merged into a tremendous collectivecontraction of pain so intense that it took over her life. This technique is about uncovering the pain held within andbringing in the stabilizing and healing energy of the higherself, the divine, and its potent vital force. I often guidedSusan to experience the powerful connection between thetraumatic energy stored in her somatic contractions and thedynamic presence and divine vitality flowing from herHSWC. In this process, I supported Susan, helping her toperceive and feel the ability of her HSWC to maintain aconstant state of loving awareness and compassionateinteraction with the energy and emotions trapped within hertraumatic contractions. As a result, the past trauma storedwithin these contractions began to feel seen and safe,allowing the previously trapped energy and emotion withinSusan to open and express the more profound feeling thathad been trapped inside. As the traumatized energies within the contractions startedto feel safe and trust Susan’s process, they began to acceptthe healing energy of presence, love, and compassion. Overthe next few months, this process expanded. As the energyand emotions within Susan’s contractions shared theirdeepest pain with trust, vulnerability, and authenticity, thenext stage occurred spontaneously: the conduit of divinitywas activated. NATUROPATHIC DOCTOR NEWS & REVIEW

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REFERENCES1.Coulter I, Snider P, Neil A. Vitalism–a worldview revisited: a critique ofvitalism and its implications for integrative medicine. NIH: NationalLibrary of Medicine.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217401/. Published June18, 2019. Accessed September 30, 2024.2.Kachadourian LK, Harpaz-Rotem I, Tsai J, et al. Mindfulness as amediator between trauma exposure and mental health outcomes: resultsfrom the National Health and Resilience in Veterans Study. NationalLibrary of Medicine.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500672/. PublishedJanuary 21, 2021. Accessed October 15, 2024Melissa Sophia Joy, ND, is a naturopathic doctor,a specialist in mind-body-spirit medicine, and amedical intuitive. She has been in practice for over24 years. She is also an internationally knownspiritual teacher and author. She is writing a bookon Somatic Awakening®, which she founded(along with the Sophia Healing Academy) andteaches to those who want to heal and awaken intheir own life and those wanting to becomeSomatic Awakening practitioners in their healingpractice. For more information, go tosophiahealingacademy.com.33NEUROLOGY & MIND/BODY MEDICINE ISSUEThis divinity conduit, likened to a river containing asignificant amount of energy and the vital force of the divine,now started to flow into Susan’s traumatic contractions. Asthese contractions began to be exquisitely met profoundly,they finally received what they most wanted: divine vitalforce. This divine energy of unconditional love, ultimatepresence, oceans of nurturing, and powerful care healedSusan in a way no external source could. When this energywas fully engaged, the contractive energy of trauma thatSusan had carried for decades began to transmute anddissolve. Susan has now healed on a very deep level, physically,emotionally, and energetically. She is a new woman, living awhole life on her terms. She rarely has GI flare-ups, and whenshe does, she knows how to address them utilizing thismethod to calm and transmute her anxiety and stress. Thenegative inner talk of her ego has diminished considerably.Her life is now aligned with peace, sovereignty, and freedomin a way she hadn’t experienced before this healing journey. ConclusionPatients who end up at my practice usually have trauma tothe point of physical symptoms. In the large majority of cases,their trauma has not been treated on a somatic level,especially a level that engages their powerful divine vital forcein the healing process. This process provides a transformative experience thatalchemizes painful and dense aspects of our existence: difficultsomatic contractions of trauma, the negative inner dialogueof the ego, and the density we hold within our body. In thisprocess, the density of trauma within the physical body istransformed, enabling us to release symptoms rooted in pasttraumas and difficulties.² As a result of our establishing aprofound connection with the essence of our divine vitalforce, the burdens of trauma no longer weigh us down,allowing our beings to become lighter and experience lesssuffering. Therefore, we are freed—body, mind, and spirit—to return to a place of proper health.

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Cognitive & Genetic MarkersMoCA Score (28/30): Her thinking and memory are stillhealthy. But because she notices small changes and has afamily history of Alzheimer’s, we didn’t want to wait forbigger problems.ApoE Genotype (ε3/ε4): She carries one gene (ε4) linked tohigher Alzheimer’s risk. This means her brain may be moresensitive to inflammation and stress, so prevention is key.Advances in biomarker testing now allow us to identify thesechanges years before symptoms appear. Key tools include:Neurofilament Light Chain (NfL): Indicates damage to nervefibers in the brainApolipoprotein E (ApoE ε3/ε4): The strongest known geneticrisk factorLow plasma Aβ42/40 ratio: Reflects early amyloid-betaaccumulationpTau-217: Helps distinguish preclinical AD from otherneurodegenerative diseasesThis case highlights how a 49-year-old woman with a strongfamily history of Alzheimer’s took early action using a holisticand root-cause approach. With the help of advanced testing,targeted nutrition, supplements, and nervous system support,she built a personalized plan to delay or prevent cognitivedecline.Case PresentationPatient ProfileName: Serena (pseudonym)Age: 53Gender: FemaleOccupation: AttorneyPrimary Concern: Family history of Alzheimer’s disease1. Subjective FindingsSerena, a 53-year-old attorney, was concerned about subtlechanges in her memory and mental clarity. She describedoccasional word-finding issues, misplacing everyday items, andneeding to re-read materials to absorb them, especially in theevenings. She also noticed more frequent mental fatigue anddifficulty staying focused during complex tasks at work.In addition, she reported delayed sleep onset and nighttimeanxiety, especially after mentally demanding days. She has along-standing history of anxiety dating back to her 20s, althoughshe’s never taken medication. She denied any history of mooddisorders, trauma, tremor, or diagnosed neurological conditions.Her maternal grandmother and uncle were both diagnosed withAlzheimer’s disease in their early 60s. Given her family historyand high cognitive demands at work, Serena was highlymotivated to explore early prevention strategies.2. Objective FindingsHere’s a breakdown of Serena’s lab results to help youunderstand what’s going on inside her brain and body, and whywe focused on the areas we did.35NEUROLOGY & MIND/BODY MEDICINE ISSUEMarkerResultInterpretationMoCA Score28/30NormalcognitionApoE Genotypeε3/ε4Increasedgenetic riskAlzheimer’s BiomarkerspTau-217 (0.61 pg/mL): This is a marker of brain celldamage (tau tangles). Her level is still in the normal range,which is good, but we know things can shift quickly if otherrisks aren’t addressed.Aβ42/40 Ratio (0.064): This ratio is slightly low, which maymean her brain is starting to hold on to sticky amyloidproteins. These are some of the earliest signs ofAlzheimer's-related changes.Neurofilament Light Chain (NfL, 8.3 pg/mL): A axonalinjury marker reflecting early neurodegeneration.Thankfully, her level is within the normal range, indicatingno active nerve damage and supporting a focus onprevention.MarkerResultInterpretationpTau-217(plasma)0.61 pg/mLNormal,borderlinepreclinical phaseAβ42/40 Ratio(plasma)0.064Slightly low –suggests earlyamyloid burdenNeurofilamentLight Chain8.3 pg/mLNormal – noactive axonaldegeneration

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JUNE 2025 - VOLUME 20 | ISSUE NO. 0636NATUROPATHIC DOCTOR NEWS & REVIEWNutritional & Methylation MarkersVitamin D (23 ng/mL): Her levels are too low. Vitamin Dis more than a bone vitamin—it helps the brain clear outtoxins and regulates the immune system.MTHFR Gene + MMA (B12): Her MTHFR gene isnegative, and her B12 markers (including MMA) arewithin normal range, indicating efficient methylation andno functional deficiency.Metabolic & Inflammatory MarkersOmega-3/6 Ratio (0.19): A low omega-3 to omega-6 ratiocan worsen neuroinflammation and contribute to amyloidbuildup. Optimizing omega-3 levels helps protect braintissue and modulate inflammation.Glucose, Insulin, A1c: Her blood sugar isn’t dangerouslyhigh, but it’s high enough to show early signs of insulinresistance—what we call “Type 3 diabetes” when it affectsthe brain. This can starve brain cells of fuel and raiseinflammation.ESR (26 mm/hr) and CRP (3.9 mg/L): These inflammationmarkers are both elevated. Chronic inflammation is like aslow fire in the brain—it’s one of the key triggers formemory problems later in life.MarkerResultInterpretationOmega-3/6Ratio0.19Low–elevatedneuroinflammationFasting Glucose101 mg/dLMildhyperglycemiaFasting Insulin13 μIU/mLInsulinresistanceHemoglobin A1c5.7%Prediabetes/metabolic riskESR26 mm/hrElevatedinflammationhs-CRP3.9 mg/LSystemicinflammationMarkerResultInterpretationVitamin D (25-OH)23 ng/mLDeficientMTHFR (C677T)NegativeNormalmethylationMMA145 nmol/LNormalSerum B12540 pg/mLNormal3. AssessmentGenetic Risk for Alzheimer’s Disease (Z82.3)Early Amyloid Deposition (R41.3 + Z13.850)Type 3 Diabetes Physiology / Insulin Resistance (E88.81)Neuroinflammation (R53.83 + R79.82)Vitamin D Deficiency (E55.9)4. PlanWeeks 0–4: FoundationsIn addition to naturopathic and lifestyle interventions, Serena wasreferred to neurology for supportive co-management. This allowedus to pursue prevention using evidence-based, natural strategieswhile keeping her connected to conventional care if future needsarise.Each intervention was selected based on Serena's unique biomarkerprofile and personalized root-cause assessment. Below is a summaryof the foundational strategies:MIND Diet: This diet combines the Mediterranean and DietaryApproaches to Stop Hypertension (DASH) to deliverneuroprotective nutrients like polyphenols, omega-3s, andfolate. It is designed to lower inflammation, oxidative stress, andinsulin resistance. Moderate adherence is associated with a 35%lower risk of Alzheimer’s.2Exercise: Combination of aerobic activity (30 minutes, 3x/week)and strength training (2x/week). Research shows that aerobicactivity helps reduce amyloid plaque buildup, while resistancetraining supports insulin sensitivity and protects against brainatrophy.11,12Lifestyle: 60 minutes of daily stress management throughmeditation, breathwork, or yoga reduces cortisol, protects thehippocampus (an area in the brain associated with memory), andsupports restorative sleep.

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JUNE 2025 - VOLUME 20 | ISSUE NO. 0637NATUROPATHIC DOCTOR NEWS & REVIEWSupplements & Botanicals:Vitamin D3 (5,000 IU/day): Supports neuroimmune health,reduces inflammation, and improves glymphatic wasteclearance.Omega-3s (2,000 mg EPA + DHA/day): Supports brain cellmembrane health, reduces neuroinflammation, and may loweramyloid burden.Mitochondrial Support Formula (containing Acetyl-L-carnitine1.5 g, CoQ10 100 mg, and Alpha-Lipoic Acid 900 mg):Enhances mitochondrial energy production and reducesoxidative stress.Berberine (1,500 mg/day): Improves insulin sensitivity andmetabolic function.Nootropics: Lion’s Mane (1,000 mg/day): Stimulates nerve growth factor,improves neuroplasticity, and supports memory in earlycognitive decline.¹³Bacopa monnieri (350 mg/day): Enhances memory, focus, andstress resilience; protects neurons from beta-amyloid toxicity.¹⁴Curcumin (1,000 mg/day with black pepper): Crosses the blood-brain barrier to reduce inflammation and amyloidaccumulation; improves working memory and mood.10Outcomes: By 12 weeks, Serena reported:Improved focus and mental energyReduced brain fog after mealsMore restorative sleepLab follow-up: Vitamin D improved to 48 ng/mL, A1c stabilizedat 5.5%, CRP decreased to 1.8 mg/LSerena felt empowered by her progress and committed to long-termmonitoring and support.Discussion and ConclusionThis case illustrates how proactive, personalized care can shift thetrajectory of cognitive health in individuals with elevatedAlzheimer’s risk, before symptoms begin. By integrating advancedbiomarker testing with functional assessments, we identified subtlesigns of neuroinflammation, early amyloid deposition, andmetabolic dysfunction consistent with the early Alzheimer’scontinuum.Her low Aβ42/40 ratio, elevated inflammatory markers, and insulinresistance suggested a silent but active process of neurodegeneration,even in the absence of tau elevation or memory loss. This reflects the“amyloid-first” progression outlined in the biomarker cascademodel⁴, reinforcing the importance of early intervention.

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Key strategies included optimizing vitamin D levels, reducingsystemic inflammation, improving insulin sensitivity, andsupporting mitochondrial and neuronal resilience throughlifestyle, targeted supplementation, and stress management. Over12 weeks, Serena Outcomes: By 12 weeks, Serena reportedimprovements in focus, mental clarity, sleep quality, andinflammatory markers—showing that risk reduction ismeasurable and meaningful.While Serena had no overt symptoms, her labs revealed:ApoE ε3/ε4 genotype: Increased AD riskLow Aβ42/40 ratio: Early amyloid burden despite normal tauElevated CRP and ESR: Systemic inflammationInsulin resistance: A key metabolic driver ofneurodegenerationThis case demonstrates that brain health is modifiable even witha genetic predisposition. With the right tools, education, andguidance, individuals like Serena can build resilience, delayneurodegeneration, and take ownership of their cognitive future.REFERENCES1.Alzheimer’s Association. (2023). 2023 Alzheimer’s disease facts and figures.Alzheimer's & Dementia, 19(4), 1598–1695. https://doi.org/10.1002/alz.130552.Morris, M. C., et al. (2015). MIND diet slows cognitive decline. Alzheimer's& Dementia, 11(9), 1007–1014. https://doi.org/10.1016/j.jalz.2015.04.0113.Rockwood, K., et al. (2002). Prevalence and outcomes of vascular riskfactors in dementia. CMAJ, 166(5), 507–512.4.Jack, C. R., Jr., et al. (2010). Hypothetical model of dynamic biomarkers ofthe Alzheimer’s pathological cascade. The Lancet Neurology, 9(1), 119–128.https://doi.org/10.1016/S1474-4422(09)70299-65.Liu, C. C., et al. (2013). Apolipoprotein E and Alzheimer disease: Risk,mechanisms and therapy. Nature Reviews Neurology, 9(2), 106–118.https://doi.org/10.1038/nrneurol.2012.2636.Janelidze, S., et al. (2016). Plasma β-amyloid in Alzheimer’s disease.Scientific Reports, 6, Article 26801. https://doi.org/10.1038/srep268017.Palmqvist, S., et al. (2020). Accuracy of plasma phospho-tau217 forAlzheimer diagnosis. JAMA, 324(8), 772–781.https://doi.org/10.1001/jama.2020.121348.de la Monte, S. M., & Wands, J. R. (2008). Alzheimer’s disease is type 3diabetes. Journal of Diabetes Science and Technology, 2(6), 1101–1113.https://doi.org/10.1177/1932296808002006199.Arnold, S. E., et al. (2018). Brain insulin resistance in Alzheimer’s disease.Nature Reviews Neurology, 14(3), 168–181.https://doi.org/10.1038/nrneurol.2017.18510.Small, G. W., et al. (2018). Bioavailable curcumin improves memory. TheAmerican Journal of Geriatric Psychiatry, 26(3), 266–277.https://doi.org/10.1016/j.jagp.2017.10.01011.Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A.,Chaddock, L., ... & Kramer, A. F. (2011). Exercise training increases size ofhippocampus and improves memory. Proceedings of the National Academyof Sciences of the United States of America, 108(7), 3017–3022.https://doi.org/10.1073/pnas.101595010812.Cassilhas, R. C., Viana, V. A. R., Grassmann, V., Santos, R. T., Santos, R.F., Tufik, S., & Mello, M. T. (2007). The impact of resistance exercise onthe cognitive function of the elderly. Medicine & Science in Sports &Exercise, 39(8), 1401–1407. https://doi.org/10.1249/mss.0b013e318060111f13.Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2009).Improving effects of the mushroom Yamabushitake (Hericium erinaceus)on mild cognitive impairment: A double-blind placebo-controlled clinicaltrial. Phytotherapy Research, 23(3), 367–372.https://doi.org/10.1002/ptr.263414.Calabrese, C., Gregory, W. L., Leo, M., Kraemer, D., Bone, K., & Oken,B. (2008). Effects of a standardized Bacopa monnieri extract on cognitiveperformance, anxiety, and depression in the elderly: A randomized, double-blind, placebo-controlled trial. Journal of Alternative and ComplementaryMedicine, 14(6), 707–713. https://doi.org/10.1089/acm.2008.0018JUNE 2025 - VOLUME 20 | ISSUE NO. 0638NATUROPATHIC DOCTOR NEWS & REVIEWStephanie Yang, ND is a licensed primary carenaturopathic physician specializing in cognitive healthfor busy professionals. Having experienced brain fogfirsthand, Dr. Yang understands the profound impactit has on both work and personal life. She helpsindividuals overcome cognitive symptoms byaddressing root causes such as chronic stress,perimenopausal shifts, digestive inflammation,metabolic imbalances, and nutritional deficiencies.Using a holistic approach, Dr. Yang combinesEastern, Western, and Naturopathic medicine tocreate evidence-based and personalized solutions thatrestore focus, resilience, and well-being. Dr. Yangoffers online consultations through her telemedicinepractice and in-person consultations at Puget SoundFamily Health in Tacoma, Washington.

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JUNE 2025 - VOLUME 20 | ISSUE NO. 0640NATUROPATHIC DOCTOR NEWS & REVIEWColor Psychology: Mood Enhancement ThroughVisual HarmonyColor therapy, or chromotherapy, involves using specificcolors to elicit psychological and physiological effects. Simplechanges—like repainting a room or using colored light bulbs—can positively impact mood and stress levels.Color has long been known to evoke emotional responses.Each color influences the brain and body in specific ways:1,2- Blue is calming and associated with peace and trust.- Green soothes and restores balance.- Yellow stimulates optimism and energy.- Red increases alertness and energy.- Purple is often linked to spirituality and mindfulness.Color psychology suggests that specific hues can evokeemotional and physiological responses. Cool tones like blueand green have been shown to reduce heart rate and anxiety,creating a calming atmosphere conducive to relaxation andmental clarity. In therapeutic settings, carefully curated colorpalettes are increasingly used to support stress reduction andenhance mood regulation.3The Science of Light: Illuminating Mental HealthLight therapy, also known as phototherapy, has become amainstream approach to treating Seasonal Affective Disorder(SAD), a form of depression linked to the lack of naturalsunlight during winter months. Exposure to bright light—especially early in the morning—can reset the body’s circadianrhythm, regulate melatonin production, and boost serotoninlevels, all of which are critical to mood and sleep.4,5 Full-spectrum light exposure has also been found to improvefocus, reduce fatigue, and increase feelings of vitality. Red andnear-infrared light (low-level laser therapy), known asphotobiomodulation, is being explored for its neuroprotectiveeffects, potentially reducing symptoms of anxiety and cognitivedecline. Furthermore, red and near-infrared light therapy hasbeen linked to improved sleep quality, reduced inflammation,and enhanced mood through its effects on cellular energy andneural signaling.6Aromatherapy: Scents That Soothe the SoulAromatherapy uses essential oils from plants for therapeuticpurposes and works through the olfactory system to affect thelimbic system—the brain’s emotional center.⁷ Researchsupports the effectiveness of certain essential oils:8,9- Lavender: Calming and reduces cortisol.- Bergamot: Lowers heart rate and improves mood.- Frankincense: Promotes relaxation.- Peppermint and eucalyptus: Relieve mental fatigue.- Ylang ylang: Supports emotional release.These can be used in diffusers, topical applications, orinhalation during meditation or relaxation routines. Healing Through Sound: Frequencies for EmotionalAlignmentIt has been said that music can heal the soul. Culture andcommunity have used sound and song for many purposesthroughout time. Sound therapy is based on using resonantfrequencies to rebalance the body’s natural rhythm:10,11- Binaural beats influence brain states.- Solfeggio frequencies restore balance.- Singing bowls and gongs promote deep relaxation.- Nature sounds recalibrate the nervous system.These modalities have been shown to reduce anxiety, improvesleep, and enhance mindfulness. Binaural beats and naturalsounds can slow brainwave activity, enhance parasympathetictone, and promote a meditative, restorative state.Integrating Technology for a Holistic SymphonyWhile powerful, combining color, light, aromatherapy, andsound amplifies their impact. A digitally programmed,multisensory experience, possibly stimulating, can quiet themind and restore peace. Multisensory environments thatintegrate these elements have synergistic effects in reducingstress and promoting overall wellness.12Full-spectrum light exposure has also been found to improve focus,reduce fatigue, and increase feelings of vitality. Red and near-infraredlight (low-level laser therapy), known as photobiomodulation, is beingexplored for its neuroprotective effects, potentially reducing symptomsof anxiety and cognitive decline.

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These practices are simple, affordable, and effective ways tosupport mental health daily. As modern technology integrateswith healthcare, wearable devices, virtual reality glasses,telemedicine, and AI will play an increasing role in treatmentoptions and opportunities. Online platforms and in-office “experiential” systems are beingintroduced to offer accessible and effective approaches tocreating a balanced mind and body. Initial studies show apowerful positive impact on anxiety, depression, addiction,and more. Could modalities as basic as color, light, sound, andsmell offer the best solutions for mental health support andoverall well-being? The potential for this “energeticpsychedelic” treatment option is surely one to keep an eye outfor.REFERENCESDr. Rob Streisfeld is a passionate consumer advocateand educator with over 20 years of Natural Health &Natural Products Industry experience. A Doctor ofNaturopathic Medicine and Certified Natural FoodChef, “Doc Rob” as widely known, provides aninformed and innovative perspective to supporteducation, product development, branding,marketing, PR, and other business developmentneeds. Over the past decade, Doc Rob has helped toidentify and expand key health categories such asprobiotics, enzymes, whey protein, fermented foods,whole food supplements, and more. His focus ontraditional and cultural aspects of food and therapiesoffer unique insight on a wide variety of topics.1.Kaya, N., & Epps, H.H. (2004). Relationship between color and emotion:A study of college students. College Student Journal, 38(3), 396–405.2.Hemphill, M. (1996). A note on adults’ color–emotion associations. TheJournal of Genetic Psychology, 157(3), 275–280.3.Küller, R., Ballal, S., Laike, T., Mikellides, B., & Tonello, G. (2009). Theimpact of light and colour on psychological mood: A cross-cultural studyof indoor work environments. *Ergonomics, 49*(14), 1496–1507.https://doi.org/10.1080/001401306008581424.Terman, M., et al. (1989). Light therapy for seasonal affective disorder: Areview of efficacy. Psychopharmacology Bulletin, 25(3), 311-315.5.Golden, R.N., et al. (2005). The efficacy of light therapy in the treatmentof mood disorders: A review and meta-analysis. American Journal ofPsychiatry, 162(4), 656–662.6.Zhao, H., Tian, Z., Cheng, L., & Liu, C. (2018). The therapeutic effect oflow-level laser therapy on depression: A systematic review and meta-analysis. *Lasers in Medical Science, 33*, 1111–1119.https://doi.org/10.1007/s10103-018-2478-57.Herz, R.S. (2009). Aromatherapy facts and fictions: A scientific analysisof olfactory effects on mood, physiology and behavior. InternationalJournal of Neuroscience, 119(2), 263–290.8.Sayorwan, W., et al. (2012). The effects of lavender oil inhalation onemotional states, autonomic nervous system, and brain electrical activity.Journal of the Medical Association of Thailand, 95(4), 598–606.9.Buckle, J. (2003). The role of aromatherapy in nursing care. NursingClinics of North America, 38(1), 35–52.10.Chuang, C.Y., et al. (2010). Effects of music therapy on subjectivesensations and emotion in patients with depression. Journal of ClinicalNursing, 19(7-8), 1004–1013.11.García-Argibay, M., Santed, M.A., & Reales, J.M. (2019). Efficacy ofbinaural auditory beats in cognition, anxiety, and pain perception: Ameta-analysis. Psychological Research, 83(2), 357–372.12.Jiang, S., Li, D., Larsen, L., & Sullivan, W. C. (2020). A dose–responsecurve describing the relationship between urban tree cover density andself-reported stress recovery. *Environment and Behavior, 52*(7), 726–753. https://doi.org/10.1177/0013916518824060JUNE 2025 - VOLUME 20 | ISSUE NO. 0641NATUROPATHIC DOCTOR NEWS & REVIEW

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Differential DiagnosisGiven the patient’s history and symptoms, differential diagnosisincluded fibromyalgia, chronic fatigue syndrome, generalizedanxiety disorder, and dysautonomia. While the patient did indeedexperience overlapping symptoms of dysautonomia and anxiety, theprimary lens of this case was not to rule out one diagnosis in favorof another, but rather to reframe the diagnosis itself as acommunication tool from the body. RA was not questioned as adiagnosis; instead, its role as a life-preserving mechanism wasinvestigated.InterventionsThe treatment centered around a structured mind-body frameworkdesigned to help the patient decode the specific nervous systemprogramming connected to her symptoms. Interventions included:Somatic Experiencing® to support nervous system regulationStructured journaling on identity, boundaries, and familialpatterningGuided meditative visioning based on subconsciousreprogramming methodsExploration of core beliefs around worthiness, visibility, andsafetySomatic tracking of symptom location and shifts duringemotional processingPractical behavior changes around nourishment, rest, andconnectionEach session included space for the patient to process memories andtriggers as they arose, along with support in integrating dailypractices to cultivate inner safety. Weekly assignments often focusedon self-attunement: What do I want? What does my body needtoday? What does it mean to take a break without needing illness asan excuse?Outcomes and Follow-UpOver several months, Jane self-reported more change than she hadin decades. Her nervous system shifted from chronic vigilance toincreased windows of regulation. She began to trust her owninternal cues and slowly unhooked from the perfectionism andproductivity patterns that had defined her adult life. Her schedule,which had previously been dictated by overwork and people-pleasing, was restructured to reflect her values. Her chronicsymptoms became guideposts rather than enemies.JUNE 2025 - VOLUME 20 | ISSUE NO. 0643NATUROPATHIC DOCTOR NEWS & REVIEWIntroductionRheumatoid arthritis (RA) is a progressive autoimmune condition thatcommonly affects the synovial joints and is frequently associated withchronic inflammation, pain, and disability. While pharmacologicinterventions are often effective at symptom management, they rarelyaddress the underlying psychosocial and emotional terrain that maycontribute to the onset and perpetuation of disease. Emerging researchhas linked cumulative childhood trauma to an increased risk ofautoimmune diseases in adulthood. Additional studies havehighlighted the significant impact of early life stress on lifelong healthoutcomes, including autoimmunity.12This case study offers a window into what is possible when chronicillness is viewed through a trauma-informed, mind-body lens. Ratherthan centering the treatment around reducing joint inflammation ormodifying the immune response, this approach focused on the body’sinnate intelligence, treating illness as an attempt to interruptunsustainable nervous system activation and the resulting adaptivebehaviors and beliefs. Here, RA served as a protective mechanism—aphysiological expression of the patient’s internalized “no” when herexternal boundaries were not safe or allowed. This case offers valuableinsight into how deep inner work, when guided with care and clinicalskill, can catalyze transformation far beyond physical relief.Case PresentationThe patient, "Jane," is a 30-year-old female who was diagnosed withRA at a young age. At the time she pursued care with me, she had beenliving with the diagnosis for over two decades. Her symptoms includedfatigue, joint and muscle pain, cognitive fog, poor immune resilience,low libido, abnormal menstrual cycles, and chronic back and neck pain.She also reported feelings of disconnection, dissociation, difficultyconcentrating, and a longstanding fear of being seen.Though Jane had tried nearly every conventional approach—includingmethotrexate, prednisone, hydroxychloroquine, sulfasalazine, and low-dose naltrexone—she had been on biologics for the past decade, whichcontrolled her joint inflammation but did not bring the full-bodyhealing she sought. Her motivation to begin care was rooted in a desireto finally bridge the gap between an intellectual understanding of therole her nervous system was playing in her illness and embodiedhealing. She was familiar with nervous system-based tools but struggledto implement them consistently. She described herself as caught in aloop: highly capable of analyzing her symptoms and beliefs, but unableto change or embody new ways of being.Jane's symptom history and emotional narrative pointed clearly towardcomplex PTSD (cPTSD). Her childhood had been marked byemotional neglect, verbal abuse, unpredictable explosions of anger, andinconsistent support from her primary caregivers. Her nervous systemhad adapted by cycling between fawn and freeze responses. From ayoung age, her strategy for safety was to stay small, agreeable, andperform excellence—from elite gymnastics to Advanced Placementcourses—in order to maintain any semblance of approval andconnection.

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Perhaps the most profound outcome was her insight that RAhad always been her body’s way of saying "no" when shecould not. The illness had functioned as a socially acceptableexcuse to step back from toxic environments when herconscious self could not yet set boundaries. As she learned tolisten to herself more deeply, the need for symptoms asprotection began to dissolve. She also began to grieve theidentity she had built around being sick and released the storythat her worth was dependent on her suffering. DiscussionThis case highlights a critical reframe for naturopathicclinicians: illness is not always something to eliminate;sometimes it is the body’s wisest communication strategy. Forpatients with trauma histories, especially those with early-onset autoimmunity, symptoms may serve as embodiedboundaries, protectors, or signals of misattunement andmisalignment with the core self for survival purposes.Naturopathic doctors are uniquely positioned to work at theintersection of body, mind, and soul. By expanding ourapproach beyond treatment protocols to include trauma-informed inquiry, we honor the full complexity of ourpatients. This case is not an argument against pharmaceuticalsor conventional care, but rather a call to integrate emotionaland somatic context into our treatment frameworks. In doingso, we can then consider the question: to what end are wehelping our patients get well? If the goal is simply to restorefunctionality so they can return to the same life thatcontributed to their illness, we may be missing the deeperinvitation entirely. True healing requires reassessing the very architecture of apatient’s life—their relationships, obligations, environment,and internalized beliefs—all of which are often adaptations totrauma. These foundations must be questioned andreimagined. As this patient put it, “I finally feel like I’m nothealing to get back to life. I’m healing so I can live a differentkind of life.”ConclusionThis case serves as a reminder that the aim of healing is notsimply to return patients to the life they had before, but to helpthem create one that is more attuned to who they truly are—physiologically, emotionally, and spiritually. In this case,rheumatoid arthritis became the patient’s gateway into radicalself-honesty, nervous system awareness, and a more alignedlife. By treating the trauma that shaped her biology, ratherthan the biology alone, we were able to catalyze meaningfulchange. Naturopathic medicine, when applied through a mind-body lens, offers a powerful pathway for this kind oftransformation.REFERENCES1.Dube, S. R., Fairweather, D., Pearson, W. S., Felitti, V. J., Anda, R. F.,& Croft, J. B. (2009). Cumulative childhood stress and autoimmunediseases in adults. Psychosomatic Medicine, 71(2), 243–250.https://doi.org/10.1097/PSY.0b013e31819078882.Lanius, R. A., Vermetten, E., & Pain, C. (Eds.). (2010). The impact ofearly life trauma on health and disease: The hidden epidemic. CambridgeUniversity Press.3.Walker, E. A., Gelfand, A., Katon, W. J., Koss, M. P., Von Korff, M.,Bernstein, D., & Russo, J. (1999). Adult health status of women withhistories of childhood abuse and neglect. The American Journal ofMedicine, 107(4), 332–339. https://doi.org/10.1016/S0002-9343(99)00235-1Dr. Erin Hayford is a Naturopathic Doctor andSomatic Experiencing Practitioner® specializing inthe mind-body connection, chronic illness, andtrauma healing. Located in Missoula, Montana butserving clients virtually, she guides people touncover the deeper messages behind their symptomsand realign with their authentic selves. Dr. Hayfordblends neuroscience, nervous system regulation, anda profound belief in the body’s innate wisdom tohelp patients transform not just their health, buttheir lives. Find her at www.aurorasomatic.com oron Instagram @drerinhayfordJUNE 2025 - VOLUME 20 | ISSUE NO. 0644NATUROPATHIC DOCTOR NEWS & REVIEW

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JUNE 2025 - VOLUME 20 | ISSUE NO. 0646NATUROPATHIC DOCTOR NEWS & REVIEWIntroductionAsphyxia is a state of hypoxia caused by any means thatdisrupts proper oxygenation, although a common cause ischoking. Perinatal asphyxia, AKA birth asphyxia, is whenoxygenation and blood gas concentrations are altered directlybefore, during, or after delivery. This has multiple potentialcauses and is considered separately from asphyxia in aneonate away from the delivery process, such as with choking.1Neurologic impacts of neonatal asphyxia includeencephalopathy, which can result in hypotonia, apnea, issueswith sucking ability, seizures, and abnormal oculomotor andpupillary movements. MRI can be abnormal, and in someinstances, neonatal asphyxia can result in Periventricularleukomalacia (PVL).1PVL is a condition in infants caused by a lack of oxygensupply to the periventricular area of the brain that results indeath of white matter tissue. It is most common in prematureinfants. This periventricular area of the brain is found aroundthe ventricles - the fluid-filled spaces in the brain - whichhouse the neurons that innervate the corresponding muscles ofthe body.23Through their development, children suffering from PVL mayexperience : 2,3Troubles with coordinationDelays in cognitive developmentVision and/or hearing impairmentVarious motor disordersPVL is also the leading cause of cerebral palsy.2There is no treatment for PVL, but severity may be minimizedearly by carefully monitoring arterial blood gases.2Given the limited medical interventions available in a case ofprolonged brain hypoxia, employing a safe modality such asclassical homeopathy should be a consideration among allother options available.Case PresentationPhone visit (without video) of a 10-day-old female with ahistory of asphyxia of unknown duration in the first hourafter her cesarean (C-section) delivery.Subjective: Mother reports a healthy pregnancy with deliveryat 37 weeks. She labored for 13 hours at home, and the child’sheart rate dropped. They were then transferred to the hospital.The infant was delivered via C-section. Within the first hour postpartum, the mother beganbreastfeeding the infant (Sky). After 15 minutes, Sky made agurgling sound and fell asleep on her mother’s breast. Dadnoticed that Sky “looked a little blue”. Mom pulled her away,and there was blood coming out of her nose and mouth, andshe wasn’t breathing. It is unclear how long she might not havebeen breathing. The medical staff performed CPR, and the child was intubatedand flown to the nearest major hospital center, where she hasbeen in the NICU ever since (10 days ago). She was on a CPAP initially for the first 3 days. Had been onher side all day at first. A nurse rolled her on her back, and shestopped breathing again and was intubated again for 4 hours.Not on CPAP currently but on high-flow oxygen, at 4L/min..They went to 2L/min. The oxygen saturation went to 70-80% acouple of days ago. Lying on her back, her O2 saturation getsworse. Sometimes her breathing is too fast, and she usesaccessory muscles. Description of the child as given by the mother:She has a secretion in her throat, and they don't know whereit's coming from.It causes a snoring sound pretty regularly. The secretion gets inthe way of breathing and eating, and is suctioned out by themedical staff every hour. She is getting IV nutrition and afeeding tube with some breast milk. The doctor says she has nogag reflex. The secretions are a clearish, whitish phlegm. Theylook pretty thick. She lost a lot of weight. She was 5 lbs 6 oz.At birth, it went down to 4 lbs 8 oz, and is now back up to 5 lbs—3 oz. Neurologists were worried about her brain and thought sheprobably had PVL on the first MRI. They said she could havecerebral palsy or a delay in learning. They returned later andsaid the head neurologist didn’t think it showed this, so it’sunclear. She is non-responsive. “Like a ragdoll. Floppy.” She is moving her arms and legs a bit more than initially.Responds to mom's voice sometimes.Didn't cry for many days. She did cry the other day when shegot a heel prick.Overall, though, she is unresponsive to stimuli.“She barely opens her eyes. Maybe half of one eye here andthere.” Sleeps most of the time (more than a typical infant).

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JUNE 2025 - VOLUME 20 | ISSUE NO. 0647NATUROPATHIC DOCTOR NEWS & REVIEWShe “does little quivers.” When she was born,her jaw would move weirdly side to side, anddoctors were worried about seizures. Now,this is not happening with her jaw. She getsshort spurts of full-body shaking orquivering, and her back muscles have alsodone that.ENT scope demonstrated dysmotility in heresophagus.No vomiting of milk.Skin color is pink.All other body systems were reported asnormal.Objective: No observations due to it being aphone call.Differential DiagnosisIn homeopathy, the differential diagnosisinvolves identifying a list of remedies thatmay represent the simillimum- those mostclosely matching the totality of the case. Ichose to share this case primarily to illustratethat even if you don’t regularly practicehomeopathy—even if you only half-paidattention to homeopathy in school, or aren’tfamiliar with the repertory—there’s still astrong chance you could arrive at the correctremedy by stepping back and focusing on thecore themes of the case. At Bastyr University,I was taught that Dr. Bastyr used to say youneed “three legs to sit on a stool” - meaningthree clear, confirmatory symptoms of theremedy to justify prescribing it. That conceptapplies well here. In a case like this, it is important not tobecome overwhelmed by the situation'sseriousness, whether it involves an infant orany other fear or discomfort that may arise.Instead, reflect on what remedies come tomind based on what is known.This infant experienced oxygen deprivation.Her key presenting features are:1. “Floppy”, “Like a ragdoll”2. Relatively unresponsive to stimuli (evenher gag reflex doesn’t respond)3. Excessive sleepiness. Do any remedies come to mind? These three legs of your stool are strong inthis case - symptoms you know without a doubt. You can lean hard on themto get to a few possible remedies.If no remedies come to mind, you could always present these themes to ahomeopath friend, and they could quickly guide you to a remedy to help thischild. Getting the main ideas/themes is your primary job.Here is the way I repertorized this case using the Cycles and Segmentsmethod. The repertoire used is Synthesis Treasure Edition 2009.Segments (themes) in this case:1. Hypotonic/“Floppy”2. Sleepy 3. Asphyxia4. Unresponsive to stimuli 5. Snoring6. Tremors/QuiveringAll of these represent different clear themes in the case.SleepyHypotonic/'Floppy'Unresponsiveto stimuliAsphyxiaTremors/QuiveringSnoring

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REFERENCES1.Gillam-Krakauer M, Shah M, Gowen Jr CW. Birth Asphyxia. [Updated2024 Oct 5]. In: StatPearls [Internet]. Treasure Island (FL): StatPearlsPublishing; 2025 Jan-. Available from:https://www.ncbi.nlm.nih.gov/books/NBK430782/2.Deng W, Pleasure J, Pleasure D. Progress in periventricular leukomalacia.Arch Neurol. 2008;65(10):1291-1295. doi:10.1001/archneur.65.10.1291 3.National Institute of Neurological Disorders and Stroke. PeriventricularLeukomalacia. [Web Page.] National Institute of Health website.https://www.ninds.nih.gov/health-information/disorders/periventricular-leukomalacia Accessed 5/2/2025Dr. Blake Myers is a Naturopathic Physician andAssistant Professor in graduate studies in Integrativeand Functional Nutrition at Saybrook UniversityThey graduated from Bastyr University in 2014 andfrom Iowa State University of Science andTechnology with a B.S. in Biology in 20210. Dr.Blake’s clinical experience ranges from primary careto complex chronic illness. From 2016 until 2020, theyworked with an addiction medicine specialist doingintegrative addiction medicine, accelerated opiatedetoxification, and served as an attending physician atThe Clearing residential treatment center on San JuanIsland, WA. They currently live in Spearfish, SD. DiscussionThis case demonstrates that while the effective clinical use ofclassical homeopathy can sometimes feel like a daunting andtime-consuming undertaking, there are also instances where itcan be just as straightforward. When we have patients who arefaced with potentially life-altering or life-threateningscenarios, in particular when there is little that conventionalmedicine has to offer to address the issues at handmeaningfully, homeopathy should be a welcome treatmentmodality alongside all other potential interventions. Those ofus exposed to the fundamentals of this centuries-old system ofmedicine have the opportunity, and the obligation, toimplement it to the best of our ability. It may shift thetrajectory of health positively, even in our youngest patientsand most concerning cases. The purpose here is not to demonstrate or attempt to convinceof the efficacy of homeopathy. Instead, I hope to inspire mycolleagues who perhaps don’t utilize homeopathy regularly totrust their potential to have a meaningful impact in caseswhere they may not have the tools to help otherwise.ConclusionA 10-day-old with asphyxia shortly after birth experienced arapid and clear improvement of symptoms followingadministration of the homeopathic remedy Opium 200C. Thiscase demonstrates that in certain instances, anyone withfundamental homeopathic training can take the primarysymptoms and themes from a case to find the simillimum andhave a meaningful impact.JUNE 2025 - VOLUME 20 | ISSUE NO. 0649NATUROPATHIC DOCTOR NEWS & REVIEW

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JUNE 2025 - VOLUME 20 | ISSUE NO. 0651NATUROPATHIC DOCTOR NEWS & REVIEWCurrent Treatment Approaches for SUDStandard of care treatments for substance use disorder (SUD)encompass a range of evidence-based pharmacological andbehavioral interventions, tailored by substance subtype.Behavioral therapies—including cognitive-behavioral therapy(CBT), motivational interviewing (MI), and contingencymanagement—form a cornerstone across all SUDs. For opioiduse disorder (OUD), first-line pharmacotherapies includeopioid agonists such as methadone and buprenorphine, as wellas the opioid antagonist naltrexone.⁷,⁸ Alcohol use disorder(AUD) treatment integrates behavioral strategies withpharmacotherapies such as naltrexone, acamprosate, anddisulfiram.⁹,¹⁰ Stimulant use disorders, including cocaine andmethamphetamine addiction, currently lack FDA-approvedpharmacotherapies; however, contingency management andCBT have demonstrated the strongest evidence of efficacy.¹¹Cannabis use disorder is similarly managed through behavioraltherapies, particularly CBT and motivational enhancementtherapy (MET), with family-based approaches provingeffective in adolescents.¹² Integrated psychosocial supports—such as peer recovery programs, 12-step facilitation, andcommunity reinforcement approaches—are recommendedadjuncts across substance categories to improve engagementand long-term outcomes.Substance Use Disorder StatisticsThe most common substances involved in SUD includealcohol, marijuana, cocaine, heroin, and methamphetamine.According to the 2022 National Survey on Drug Use andHealth (NSDUH), the prevalence rates among individualsaged 12 or older were as follows: alcohol use disorder at 10.5%(29.5 million people), marijuana use disorder at 6.7% (19.0million), cocaine use disorder at 0.5% (1.4 million), heroin usedisorder at 0.3% (900,000), and methamphetamine use disorderat 0.6% (1.8 million).¹³Treatment efficacy varies by modality and substance. Forinstance, long-term residential treatment programs havedemonstrated abstinence rates ranging from 68% to 71%among women who remained in treatment for six months ormore.¹⁴ Behavioral therapies, such as contingency managementand cognitive-behavioral therapy (CBT), have showneffectiveness in reducing substance use and improvingtreatment retention.¹⁵ Pharmacotherapies, includingmethadone, buprenorphine, and naltrexone, are effective foropioid use disorder, with studies indicating improvedtreatment outcomes and reduced relapse rates.¹⁶What is Ayahuasca?Pharmacologically, Ayahuasca is a combination of adimethyltryptamine (DMT)- containing leaf and a monoamineoxidase inhibitor (MAOi)- containing vine. The leaf is mosttypically Psychotria viridis, and the vine is most typicallyBanisteriopsis caapi.Ethnographically, Ayahuasca is a cultural product of SouthAmerican peoples, including the Shipibo-Conibo.Legal Status of AyahuascaLegally, Ayahuasca is a nuanced topic. In the United States,DMT is classified as a Schedule I controlled substance underthe Controlled Substances Act of 1970.¹⁷ Several churches thatuse Ayahuasca as a sacrament in worship have obtained aDEA exemption through the Religious Freedom RestorationAct of 1993.¹⁸ Namely, the Church of the Eagle and the Condor(2024), the Santo Daime¹⁹, and the União do Vegetal.²⁰ TheUnited States played a significant role in advancinginternational drug control treaties during the 1970s, includingthe 1971 United Nations Convention on PsychotropicSubstances.²¹ The international rules that apply to the DMT inAyahuasca are enforced under that Convention in the majorityof signatory nations. The Peruvian government officiallyrecognizes Ayahuasca as a cultural phenomenon that isprotected as part of the nation’s heritage.²² In other words,Ayahuasca is protected and legal in Peru.Scientific Research on Ayahuasca and SUDScientific research has been pre-clinical, with animal andchemical, observational, and narrative studies. Althoughrandomized controlled trials on Ayahuasca do exist, they arefew and far between.Pre-clinical studies on animals have found that conditionedplace preference is erased. Rodents were fed a drug of abuse,such as ethanol, cocaine, or methylphenidate. It was observedthat they would return to the same place where they werehabitually administered the drug of abuse to obtain more of thedrug. This would happen for sequential days. Ayahuascawould be administered to the rodents. It was observed that therodents no longer sought the drug of abuse. They did notreturn to the place of administration seeking the druganymore.23

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JUNE 2025 - VOLUME 20 | ISSUE NO. 0652NATUROPATHIC DOCTOR NEWS & REVIEWChemical studies have found, like all plants, that the activeconstituents in the leaf and root of Ayahuasca vary inconcentrations. This leads to variation in effect betweenharvests and batches of brew. Practitioners developpreferences for batches for which they attribute nuancedenergetic properties. One example in the literature is thatmembers of the Uniao do Vegetal (UDV) church were foundto prefer the brew when rich in tetrahydroharmine comparedto harmine and harmaline levels. Tetrahydroharmine is theonly harmala alkaloid shown to have a selective serotoninreuptake inhibition effect. It is also asserted that thepreparation method of the brew can alter thetetrohydroharmine levels.24242424Pharmacokinetically, the MAOI allows for enteric absorptionof the DMT and dramatically slows down the breakdown ofDMT in the neural synapses. This allows a saturation of thenervous system that causes the desired pharmacologicalactivation. Furthermore, harmine (a MAOI compound)stimulates the proliferation of human neural progenitors,which is speculated to help with repair of damage from druguse.24, 2524, 26Neuropsychiatric and physical changes occur duringAyahuasca “intoxication,” including hallucinations,diaphoresis, tachycardia, excitement, nervousness, flatulence,eructations, nausea, and emesis. Harmine was once coined as“telepathine” because of subjective reports of telepathybetween individuals co-experiencing the same ceremony.Harmala alkaloids and DMT are both thought to interactwith 5-HT2 receptors and cause hallucinations.Antidepressant effects are thought to come from harmine,causing restoration of the brain-derived neurotrophic factor(BDNF) signal.2424Narrative studies have found greater self-connectedness,increased self-esteem, a better ability to engage in groupdynamics, trust, love, and hopefulness.A study involving Coast Salish people in British Columbiafound that substance use disorder behaviors decreased. Amajority of the participants were able to abstain from asubstance with which they had a troubled relationship. Thestudy was conducted during a retreat weekend, and guestshamanic healers from South America performed severalAyahuasca ceremonies.A study involving members of the UDV church in Brazilfound that members had reduced alcohol abuse ratescompared to earlier in their lives.A study by Gabrielle Agin-Leibs et al found that Ayahuascawas helpful for treatment-resistant depression. This was anotable randomized controlled trial.An observational study in 2021 found that the ShipiboAyahuasca ceremony improved wellness.23Personal Reflection: Healing in the AmazonThis story is not just academic—it’s personal. I witnessed theremarkable when I traveled to the Amazon region of Peru to aShipibo lineage Ayahuasca healing center. I was a medicalstudent then, accompanied by a naturopathic doctor whoguided me and my peers through an immersive journey ofobservation and experience. We witnessed Maestro RicardoAmaringo of Nihue Rao Centro Espiritual conducting hishealing work in the traditional maloca (“ceremonial house”)setting. I saw individuals undergo profound healing from a range ofconditions— severe childhood trauma, heroin addiction,recovery from automobile accidents, chronic illness resultingfrom brain trauma, and even emotional resilience in the face oflifelong limitations from congenital disabilities. I found theapproach of the Shipibo healers to be remarkably aligned withthe nature cure philosophy at the heart of naturopathicmedicine. The experience of Ayahuasca healing in the jungle was anincredible fusion of ecotherapy and psychopharmacology.Each night, the visual and sonic motifs of the Amazon blendedinto an all-encompassing sensory journey. The shamans’ songspierced the evening air as ceremonial participants rode theirmedicine experiences through. Frog, insect, monkey, and birdsymphonies abounded. Dreams of my forefathers' lives flashedthrough my mind, revealing possible epigenetic moments oftrauma and resilience. These visions resonated with me asexplanations for my own experience of my nature as anindividual rooted in lineage. It brought new personal meaningto healing seven forward and backward generations in time, ascommonly attributed to North American indigenous culture. As I saw the darkness my ancestors had accumulated and felt itwithin my being, I felt it viscerally. This was not easy. Acascade of powerful and overwhelming emotions movedthrough me. Fear, terror, regret, sadness, woe, misery in whatfelt like only a few heartbeats. Visions of what might have beenmy own past life crossed through my mind. I had not been asgood to others as I could have. I cried and in a profound stateof spiritual communion, I asked God to forgive me forwhatever wrongs I had done and also to take away the painand darkness that I carried from my forefathers.

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Dr. Conor Watters ND MSAS PATP practices atHealing Watters PLLC. He is located in thePinehurst neighborhood of Seattle, Washington,USA. His website is www.healingwatters.com andhis business line is 425-380-3098. He graduated fromBastyr University in 2022 with a Doctorate inNaturopathic Medicine. He earned his Masters ofScience in Ayurvedic Medicine in 2018 from BastyrUniversity. Between the graduate degrees, he servedin the WA Army National Guard and he ran 911calls as an EMT with American Medical Responseduring the COVID-19 pandemic. He is mostpassionate about working with servicemembers,veterans, first responders, and outdoors enthusiasts.In his book Fellowship of the River (2017), Dr. Joe Tafur, MD,explains how Ayahuasca's ceremonial healing helps people.25 Ihighly suggest this book, as he speaks eloquently in languagethat bridges Western medical science and Latin Americantraditional healing. His book is full of cases and truly an assetfor the naturopathic doctor’s bookshelf.JUNE 2025 - VOLUME 20 | ISSUE NO. 0653NATUROPATHIC DOCTOR NEWS & REVIEWI felt heard in a very big way when the lead shaman’s songseemed to hit me right in the gut - I had a completelyuncontrollable bout of emesis into my bucket (yes, it ispart of the kit each participant has at their place). Thiswas very thorough throughout a song that lasted for whatI can only guess was ten minutes. It was veryuncomfortable. “Just breathe through it”, I told myselfwhile being grateful for years of yogic breathwork andmore recently biofeedback training. In that moment, I witnessed a hallucinatorypersonification of the dark energy riding the wave ofemesis out of my body, dissolving as it left me. I feltlighter, cleaner, and deeply relieved. Unlike alcoholpoisoning, this experience, though messy, felt distinctlysalutary… I returned to a place of calm introspection,observing my thoughts and sensations with clarity andgrace. The altered state continued, filled with insight andreverence. Later, the master shaman called me forward to receive apersonal medicine song. He allowed me a moment to settleinto a seated posture, then began singing over me. Fromhis mat several feet away, his acoustic vibrations carriedand seemed to bathe over my corporeal and psychic being.My nervous system downshifted multiple gears. Aprofound peace bloomed behind my mind’s eye. Visions of hope and joy filled my inner world. I feltimmense gratitude for living in a world where good thingsstill happen. The medicine showed me glimpses of futureclinical paths –visions of hydrotherapy, water birthing,frog peptides from Kambo (another Amazonianmedicine), and even death doula work in a remote,temperate rainforest. I watched as the medicine taught melessons about the forest and how to move wisely throughit. I gained knowledge about soldiering and hunting. Idreamed awake about letting metaphorical sleeping dogslie and embracing paths of peace and mercy. It was aprofound, alive, and intelligent tutelage, and I consider ita direct transpersonal encounter with Vis MedicatrixNaturae.This experience underscored for me that Ayahuascashould only be administered by well-trained facilitatorswho are capable of holding space for the deep emotionaland spiritual processes that can emerge in ceremony. Istrongly urge anyone considering this path to vet theguides they choose to work with carefully. Chris Kilhamdescribes approaches to do this in his book “TheAyahuasca Test Pilots Handbook” (2014). 24REFERENCES1.United Nations Office on Drugs and Crime. (2023). World drug report2023. United Nations. https://www.unodc.org/unodc/en/data-and-analysis/world-drug-report-2023.html2.Degenhardt, L., Charlson, F., Ferrari, A., Santomauro, D., Erskine, H.,Mantilla-Herrera, A., Whiteford, H. A., & Vos, T. (2018). The globalburden of disease attributable to alcohol and drug use in 195 countriesand territories, 1990–2016: A systematic analysis for the Global Burdenof Disease Study 2016. The Lancet Psychiatry, 5(12), 987–1012.https://doi.org/10.1016/S2215-0366(18)30337-73.American Psychiatric Association. (2013). Diagnostic and statisticalmanual of mental disorders (5th ed.). American Psychiatric Publishing.4.World Health Organization. (2024). Global status report on alcohol andhealth and treatment of substance use disorders.https://www.who.int/publications/i/item/97892400967455.National Institute on Drug Abuse. (2020). Trends & statistics. NationalInstitutes of Health. https://www.drugabuse.gov/drug-topics/trends-statistics6.National Drug-Free Workplace Alliance. (n.d.). Cost of substance abuse.https://www.ndwa.org/drug-free-workplace/cost-of-substance-abuse/7.Substance Abuse and Mental Health Services Administration. (2021).TIP 63: Medications for opioid use disorder.https://store.samhsa.gov/product/TIP-63-Medications-for-Opioid-Use-Disorder-Full-Document/PEP21-02-01-0028.American Society of Addiction Medicine. (2020). National practiceguideline for the treatment of opioid use disorder: 2020 focused update.Journal of Addiction Medicine, 14(2S Suppl 1), 1–91.9.National Institute on Alcohol Abuse and Alcoholism. (2023). NIAAAAlcohol Treatment Navigator. https://alcoholtreatment.niaaa.nih.gov/Remaining references can be found at NDNR.com

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June 2025 | Volume 20 | Issue 6

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