Return to flip book view

HEXIS NEW ANTIMICROBIAL FILM Performance and protection anywhere anytime ANTIMICROBIAL PROTECTION AT YOUR PREMISES

24 7 THE NEW ANTIMICROBIAL FILM BY HEXIS PROTECTS YOUR PREMISES 24 7 YOU COMPLY WITH THE GOOD HYGIENE PRACTICE GHP AND YOU WISH YOUR ENVIRONMENT TO BE 01 Perfectly maintained 02 Regularly cleaned 03 Covered with waterproof smooth and easy to wash materials HOWEVER HAZARD SHALL DEVELOP BETWEEN 2 CLEANING PHASES 24h 24h 24h 01 A biofilm may form 02 Germs may spread 400000 350000 300000 See page 17 Regulation EC No 852 2004 of the European Parliament on the hygiene of foodstuffs EVOLUTION OF BIOFILM without PURE ZONE with PURE ZONE 250000 200000 2 150000 HEXIS Antimicrobial Film PURE ZONE

BIOFILM DANGER BIOFILM IS COMPOSED OF MICRO ORGANISMS AND A MUCOUS LAYER THAT REQUIRES A MECHANICAL CLEANING ACTION THIS IS WHERE BACTERIA PROLIFERATE BIOFILMS FORM VERY QUICKLY Studies suggest that silver ions are capable of destabilising the biofilm matrix 1 preventing the spread of germs within the matrix and enabling the cleaning products to be effective 1 Chaw KC Manimaran M tay FEH Role of silver ions in destabilization of intermolecular adhesion forces measured by atomic force microscopy in Staphyloccus epidermidis biofilms Antimicrob Agent chemother 2205 49 12 4853 59 A biofilm is a complex microbial community consisting of bacteria and on occasion fungal species embedded within a protective polysaccharide matrix Managing biofilm requires Reducing the microbial load through intensive cleaning in order to eliminate dormant bacteria Preventing the biofilm from reforming with silver ions that destroy the so called solitary free floating planktonic bacteria for instance 400000 400000 350000 350000 300000 300000 250000 250000 Bacterial population 200000 200000 150000 150000 100000 100000 HOW A BACTERIAL POPULATION GROWS without PURE ZONE 50000 50000 00 00 55 1010 1515 2020 2525 3030 Time hours with PURE ZONE Performance and protection anywhere anytime 3

THE NEW HEXIS ANTI MICROBIAL FILM Germs need humidity to proliferate The HEXIS film is waterproof and forms a barrier against humidity THIS IS A DECISIVE INNOVATION During cleaning operations as well as in the presence of humidity silver ions are released from the top layer of the film These ions come into contact with the bacteria blocking their metabolism and or interrupting their proliferation mechanism leading to their destruction When the PVC film is manufactured by HEXIS silver ions encapsulated in a glass matrix are distributed over the film in a uniform manner Bacteria Silver ions Ag 4 HEXIS Antimicrobial Film PURE ZONE

THE ANTI MICROBIAL EFFICIENCY OF SILVER IONS rotects 24h a day 7 days a week and thus between P 2 cleaning phases Protects inaccessible areas Inhibits the development of 99 99 of the germs tested tests in conformity with the ISO 22196 standard Reduces a bacterial population by 4 logs Prevents the formation of biofilm Active for 5 years Perfectly ecological No nanoparticles WITHOUT HUMAN INTERVENTION 0 20 REDUCTION OF 99 99 OF THE BACTERIA A fast process Reduction in 40 percentage of the number of bacteria in relation to a 60 non protected surface 80 100 0 5 10 15 20 25 Time hours Performance and protection anywhere anytime 5

HE ANTI MICROBIAL T ACTION OF SILVER IONS In its elemental metallic form silver is inert and does not kill bacteria Silver atoms written as Ag or Ag0 must lose an electron and become positively charged silver ions Ag Silver is ionised in air but above all in a humid environment Silver ions are highly reactive and affect multiple sites in bacterial cells guaranteeing their destruction Bacteria SILVER IONS Produce alterations to the cell wall When transported into the cell bind with proteins and interfere with the production of energy enzyme function and cell replication Silver ions are active on a broad spectrum of bacteria 6 Silver ions Ag HEXIS Antimicrobial Film PURE ZONE

UNCONTROLLED MICROBIAL GROWTH IS THE MAJOR RISK SUCH AS SALMONELLA LISTERIA ETC PROOF OF THE EFFICIENCY OF SILVER IONS ON LISTERIA Cell wall Plasme membrane STRUCTURE OF A BACTERIUM Capsule Cytoplasm Pili Nucleoid Plasmids Bacterial flagellum Ribosomes AFTER A LATENT PHASE DEVELOPMENT BECOMES EXPONENTIAL Number of bacterial cells Stationary phase Development Decline Latency Time Performance and protection anywhere anytime 7

PROOF OF THE EFFICIENCY OF SILVER IONS ON LISTERIA OPERATIVE PROCEDURE Seed the inside wall of a fridge with a Listeria colony 4 C 39 2 F Without silver ions With silver ions Sampling Dilution Counting D0 D7 D 28 IF UNPROTECTED PROLIFERATION OF THE GERMS 180 000 160 000 140 000 120 000 Counting the colonies of bacteria in terms of CFU cm3 Colony Forming Units CFU cm3 100 000 80 000 60 000 40 000 20 000 0 0 days With silver ions 8 7 days 28 days Without silver ions HEXIS Antimicrobial Film PURE ZONE

HOW TO MEASURE THE ACTIVITY OF ANTI MICROBIAL FILMS CONTACT TEST ISO 22196 A colony of 106 colonies is deposited Neutral surface Anti microbial film Incubation 24 h at 35 C 95 F Counting 106 colonies 102 colonies RESULTS Decrease of 4 log or 99 99 in the number of bacteria There is a correlation between the logarithmic reduction and the percentage of reduction in the bacteria Decrease of 1 Log Reduction of 90 in the number of bacteria Decrease of 2 Logs Reduction of 99 in the number of bacteria Decrease of 3 Logs Reduction of 99 9 in the number of bacteria Decrease of 4 Logs Reduction of 99 99 in the number of bacteria Performance and protection anywhere anytime 9

PROOF FROM TESTS ANTI BACTERIAL ACTION 01 Fast Rapid penetration into the bacterial cell 02 Powerfull Active even at very low concentrations 03 Prolonged 24h a day 7 days a week for several years THE ACTIVITY OF THE HEXIS ANTI MICROBIAL FILM Strain Reduction in bacteria as a Logarithmic decrease Salmonella enterica subsp enterica 99 99 4 6 Listeria monocytogenes 99 99 4 2 Staphylococcus aureus 99 99 4 1 Escherichia coli 99 99 4 5 MRSA 99 99 3 5 P aeruginosa 99 99 5 7 N B The logarithmic reductions obtained with silver ions may diff er depending on the techniques used and in relation to the incubation periods and milieus used 10 HEXIS Antimicrobial Film PURE ZONE

LECERTIFICATE PREUVE OF ANALYSIS PAR LES TESTS Performance and protection anywhere anytime 11

PROOF FROM TESTS AN ANTIVIRAL ACTIVITY EFFECTIVE ON EVERYDAY CONTACT SURFACES 01 Proven and tested effica cy on coronovirus HCoV229E type viruses 02 Powerful reduction of the viral load by 99 87 03 Quick in just one hour 04 Permanent 24 7 According to the standard ISO 21702 2019 Feline coronavirus Strain Munich HCoV 229E TESTS VIRHEALTH CONCLUSION ON HCOV 229E STRAIN 12 PRODUCT contact duration min Logarithmic reduction log 10 Antiviral efficiency PUREZON060 PRZ150 PURECOVER 15 1 3 94 99 60 2 9 99 87 HEXIS Antimicrobial Film PURE ZONE

CERTIFICATE OF ANALYSIS 68 F Performance and protection anywhere anytime 13

PROOF FROM TESTS THE HEXIS FILM CAN BE APPLIED EVERYWHERE The tested product is NON IRRITANT Safe for use on human skin Assessment and analysis of the irritant effect do not reveal any irritant effect which demonstrates good skin compatibility of the product PURE ZONE ANTIMICROBIAL FILM ANTI MICROBIAL FILM ANTI MICROBIAL FILM ANTI MICROBIAL FILM 14 HEXIS Antimicrobial Film PURE ZONE

CERTIFICATE OF ANALYSIS Performance and protection anywhere anytime SKIN TOLERANCE 15

IN YOUR PREMISES THE SAME TECHNIQUE THE SAME ADVANTAGES HEXIS ADHESIVE FILMS ARE USED ON TRAINS UNDERGROUNDS PLANES AND ARE THUS EXPOSED TO SIGNIFICANT CONSTRAINTS 01 Strong adhesion 02 Easy to clean 03 Waterproof 03 Conformable 16 HEXIS Antimicrobial Film PURE ZONE

HEXIS PVC ADHESIVE FILMS S mooth and sleek so easy to clean Perfectly waterproof I n all areas subject to health constraints clean rooms white rooms cold stores asy to apply without E Compatible with your cleaning disrupting your organisation all substrates constructions insulated panels sandwich panels etc protocols Resistant to most chemical agents alcohol diluted acids oils Performance and protection anywhere anytime YOUR CLEANING PROTOCOL IS RESPECTED The films have an acrylic adhesive which is pressuresensitive Adhesion is immediate and permanent after 24h of contact M anufactured in France at the Hexis factory Hexis international patent 17

THE PURE ZONE LABEL To allow your clients staff and partners to identify the areas protected with the anti microbial film Hexis have created the PURE ZONE label which can be applied to doors counters windows tables etc thus indicating MANAGEMENT OF ANTI MICROBIAL PROTECTION ON YOUR PREMISES 18 HEXIS Antimicrobial Film PURE ZONE

EUROPEAN REGULATIONS ON FOOD HYGIENE 852 2004 OBLIGATIONS IN TERMS OF REGISTRATION Establishments that produce foodstuffs of animal origin may be authorised under certain conditions see regulation 853 2004 The concept of cooperation with the control administrations is clearly defined in the regulations EQUIREMENTS APPLICABLE IN TERMS R OF HYGIENE AS OF 01 JANUARY 2006 1 Equipment and materials In general terms these requirements come from the principle of an obligation for results rather than of means with the exception of toilets hand washing stations and changing rooms The principle of making progress in time and space has been retained A few key points Clean premises in a good state of upkeep Sufficient ventilated work areas to prevent any condensation phenomena Avoid all risk of contamination and cross contamination Control the cold chain Have surfaces floor wall ceiling doors windows and equipment surfaces that are smooth and easy to maintain Have waterproof noncorrosive materials and equipment Have adequate systems for cleaning and disinfecting tools materials etc Performance and protection anywhere anytime ight against pests F Good lighting cleanliness and a good state of upkeep of the premises cleaned and disinfected Specific provisions for cars shops and transport are also set out in the regulation 19

ANTIMICROBIAL SOLUTIONS FOR DECORATION PURE ZONE FILM 4 FINISHES 01 PURZONE060B Gloss finish 02 PURZONE060M Matt finish 03 PCAPMGB Leather grain 04 PCWOOD Wood grain PURE ZONE FILM CAN BE USED 01 to protect a simple surface 02 to protect a printed graphic design 20 HEXIS FilmAntimicrobial antimicrobienFilm HEXIS PURE PUREZONE ZONE

PURE ZONE FILMS CAN BE APPLIED ON MANY SUBSTRATES 01 02 Smooth Metal Sheet Wood 04 05 Glass 03 MDF Marble YOU ONLY HAVE TO CHOOSE 01 your printable film 2D 3D Short to long term Type of adhesive depending on substrate 02 The PURE ZONE finish and your design HEXIS offer lots of texture on hexperience hexis graphics com 03 Your laminate Leather grain wood grain gloss or matt Performance and protection anywhere anytime 21

GLOSSARY MICROBE It is a living organism that is not visible to the naked eye In this family there are bacteria fungi yeasts molds but also viruses BACTERIA Micro organisms characterized by the absence of a cell nucleus They spread by cell division at a speed that may vary depending on the environment They are characterized by their cellular membrane Gram positive or Gram negative as well as their shape coccus or bacillus FUNGI YEASTS MOLDS Still single or multiple cell living organisms that absorb organic molecules directly into the environment they are VIRUS Microorganism that requires the presence of a host cell to reproduce Smaller in size than other microbes BACTERICID Molecule or substance is called bactericide when it has the ability to kill bacteria This is characterized by a 99 999 reduction or log 5 of bacterial load according to ISO 22196 BACTERIOSTATIC Molecule or substance is called bactericidal when it has the ability to kill bacteria This is characterized by a reduction of 99 or log 2 to 99 999 log5 of bacterial load according to ISO 22196 BIOCIDE Any substance or mixture in the form in which it is delivered to the user consisting of one or more active substances containing or producing which is intended to destroy repel or turn harmful organisms to be harmless to prevent their action or to fight them in any other way than a simple physical or mechanical action These products are managed by EU Directive 98 8 EC of 16 February 1998 replaced in 2012 by a regulation PATHOGEN A pathogenic agent is a factor chemical molecule or organism than can lead to an injury or cause a disease NOSOCOMIAL A nosocomial infection is an infection contracted in a health facility It is defined as any infection that occurs during or following patient care process diagnostic therapeutic or preventive act provided that the infection is neither present nor incubating at the time of patient care process a 48 hours delay after hospitalization is usually admitted SILVER SALT Neutral chemical molecule consisting of a positive silver ion and a negative counter ion eg silver nitrate Ag No3 SILVER ION Oxidized form of metallic silver always associated with a counter ion and which under this state has biocide properties on microbes HOW THE BIOCIDE IS ACTING IN THE FILM Active agent disrupts the wall of the bacteria It then penetrates the cell binds to a protein and disrupts energy production enzyme functions and cell duplication phenomena This is acting by contact The bacterium does not die but its spread is greatly reduced There is no biocide emission in the surrounding atmosphere SURFACE EFFICIENCY KINETICS After one hour of contact following Iso 22196 99 of Salmonella bacteria were destroyed FILM CLEANING No decrease of the activity after 365 cleaning operations with water ethanol bleach or ANIOSURF ESCHERICHIA COLI Gram bacteria found in mammals They represent 80 of human s intestinal flora It can cause diarrhea urinary and gastric infections meningitis septicaemia 22 HEXIS Antimicrobial Film PURE ZONE

STAPHYLOCOCCUS AUREUS Gram bacteria found in humans in the nasal cavity or throat It can cause food poisoning skin infections pus production An untreated infection or if on an immunosuppressed patient can lead to septicaemia that might be fatal METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS MRSA Gram bacteria it is a specific strain of S Aureus that has developed resistance to an antibiotic methicillin and is therefore more difficult to control It is part of the multi resistant bacteria MRB It can cause infections and septicaemia which are more serious and therefore there is a higher mortality than with ordinary staphylococcus aureus LISTERIA Gram The human contamination comes mainly from food poorly washed fruits undercooked meats It can cause listerioris more or less severe symptoms fevers headaches meningitis septicaemia especially among fragile people eg pregnant women SALMONELLA Gram This bacterium is able to colonize food manufacturing premises and its vector is therefore food It can cause gastroenteritis food infections septicaemia meningitis infants and typhoid fevers PSEUDOMONAS AERUGINOSA Gram They are one of the most resistant and difficult bacteria to handle They have a strong ability to form biofilms They can cause eye infections sores urinary intestinal and lung infections septicaemia for immunosuppressed patients as well BIOFILM multi bacterial layer organized and aggregated on a surface resistant to certain cleaning and disinfection protocols This is the next step after bacterial colonization METHICILLIN Discovered in 1959 it is a lactamine type antibiotic belonging to penicillase resistant penicillins group ANTIBIOTIC An antibiotic from ancient Greek anti against and bios life is a natural or synthetic substance that destroys or blocks the growth of bacteria In the first case it is called a bactericidal antibiotic and in the second case a bacteriostatic antibiotic GRAM AND GRAMGRAM test consists of coloring the membrane If the bacterium has a thick membrane a coloration appears and the bacteria is called gram If no coloration is visible on the bacterium it is called Gram COCCUS BACTERIA The bacterium is in a spherical form it is called coccus BACILLUS BACTERIA The bacterium is in a more or less elongated stick form it is called bacillus ISO 22196 International standard that measures the decline of bacteria in contact with a substance 106 colonies of bacteria are put in a box or in a liquid and after a certain period 24 hours to 35 C in general remaining colonies are counted ANIOSURF disinfection liquid from the company Anios widely used in the medical community VIRUCIDE FUNGICIDE YEASTICIDE a product or process that has the ability to inactivate viruses fungi or yeasts under defined conditions Performance and protection anywhere anytime 23

Z I Horizons Sud CS970003 34118 FRONTIGNAN CEDEX HEXIS HEADQUARTERS w 33 4 67 18 66 86 FRANCE 33 4 67 18 36 98 export hexis fr www hexis graphics com PURE ZONE 08 2020 HEXIS S A 2020 Photos Andriy Petrenko Tyler Olson william87 Minerva Studio Dmitry Vereshchagin vipavlenkoff Deklofenak adisa CandyBox Images 2012 Dmitry Vereshchagin Temistocle Lucarelli Fotolia Christophe Recoura Hexis