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2018 Annual Report

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THE SCIENCE OF LEADERSHIP Annual Report 2018

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Leadership is at the core of our mission We do not simply fund cancer research We identify and enable new generations of future scientific leaders capable of discovering radical new approaches to how we prevent diagnose and cure the many forms of cancer We do this because it will take exceptional people to ultimately defeat a disease as pernicious and wily as cancer We select these young scientists with great care and provide them with funding mentorship and support They then go on to lead the most innovative and paradigm shifting research research that has saved and will continue to save lives At the end of this year our current President and Chief Executive Officer Lorraine W Egan is stepping down after 18 years at the helm of the Damon Runyon Cancer Research Foundation She will be succeeded by Yung S Lie PhD our Deputy Director and Chief Scientific Officer At this momentous time for Damon Runyon it is fitting that the theme of this year s annual report is leadership In the pages that follow we share our thoughts on leadership and how we are paving the way for new breakthroughs against cancer by finding and fostering the scientific leaders who will make the end of all suffering from cancer a reality 2018 ANNUAL REPORT 1

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INTRODUCING Our Next Leader When our Fellowship Award Committee selected Yung S Lie PhD as a Damon Runyon Fellow in 2000 little did they know that they were picking Damon Runyon s future President and CEO She will be the first scientist and alumna to lead the organization since it was founded in 1946 Dr Lie received her BA degree from UC Berkeley and her PhD from Stanford University As a Damon Runyon Fellow from 2001 2004 Dr Lie studied how cells migrate and navigate their environment at the University of California San Francisco and The Rockefeller University She joined Damon Runyon in 2008 and currently serves as its Deputy Director and Chief Scientific Officer Under her leadership Damon Runyon scientists have pioneered the fields of immunotherapy genomic and precision medicine its award programs have expanded to target the greatest areas of need in cancer research and Damon Runyon s research funding has grown by 225 to more than 18 million annually Dr Lie s postdoctoral mentor Mary Beth Hatten PhD Professor at The Rockefeller University and member of the National Academy of Sciences calls her a superb scientist and astute judge of scientific talent Congratulations to Damon Runyon on an outstanding choice to lead their organization 2 DAMON RUNYON CANCER RESEARCH FOUNDATION

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LO R RA I N E W EGA N EIGHTEEN YEARS O F E XT RAO R D I N A RY LEADERSHIP In the scientific community Damon Runyon is held in the highest esteem for its commitment to young scientists and rigor in selecting the best of the best I am thrilled and honored to continue this important work and am confident that it will lead to new breakthroughs against cancer YUNG S LIE PhD The Damon Runyon Cancer Research Foundation is grateful to Lorraine W Egan for her leadership for the past eighteen years Thousands of scientists have been funded during her tenure and they have contributed significantly to accelerating progress against cancer during this century She has built a deeply committed community of supporters who have enabled Damon Runyon to expand its research funding and develop new programs to ensure that the best young minds have the resources they need to pursue bold ideas Lorraine has set the gold standard for leadership says Damon Runyon Board Chair Alan M Leventhal Her commitment to our scientists keen ability to inspire others and above all relentless drive to end cancer will have a lasting impact 2018 ANNUAL REPORT 3

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EXECUTIVE Q A Reflections on Leadership The following are edited excerpts from an interview with Lorraine W Egan current President of the Damon Runyon Cancer Research Foundation and her successor Yung S Lie PhD For video of the full interview visit www damonrunyon org 4 Lorraine what makes Damon Runyon a leader in cancer research Lorraine The most important thing that comes to mind when I think about Damon Runyon is its commitment to excellence We stand for excellence in the science that we fund but also in terms of how we run our organization and steward our donors gifts Our donors are incredibly generous to support us and we take that very seriously Our Board of Directors looks for excellence in the people to lead the organization I m honored that they selected me years ago and now it s incredible for me to pass the baton to somebody who is first of all a Damon Runyon alumna and secondly clearly the right person to lead Damon Runyon going forward It s the ultimate success that we can have a seamless transition and maintain the quality and excellence of our organization DAMON RUNYON CANCER RESEARCH FOUNDATION

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As a scientist and former award recipient Yung is the ideal person to lead our organization She completely understands our mission She understands the science I can t think of a better person to take the helm of Damon Runyon L O R R A I N E W E G A N What makes Yung the best choice to lead Damon Runyon Lorraine It s exciting for me to be able to hand off the leadership to such a perfect person Damon Runyon is all about the science It is more important to us than anything that we fund the best scientists doing paradigm shifting work As a scientist and former award recipient Yung is the ideal person to lead our organization She completely understands our mission She understands the science I can t think of a better person to take the helm of Damon Runyon As the outgoing CEO of Damon Runyon what advice do you have for her Lorraine I m not sure Yung needs any advice because she s so incredibly talented but what has made us a good team and what she ll carry on is staying focused on our mission It s all about the science and the scientists If we stay true to that no matter where the science goes and what new discoveries are made funding brilliant people is always going to be the secret to success Yung what are you particularly excited about moving forward in this new role Yung We are funding more research and more scientists than ever before and there s the capacity to do more I m excited about the opportunity to work with our scientific leadership to identify the right places for Damon Runyon to fund more cancer research to make a greater impact Lorraine The science is moving so fast and the discoveries are incredible It s possible that during Yung s tenure as CEO tremendous breakthroughs will be made in cancer and more and more people s lives will be saved I ll be a little jealous not to be at the helm for that As a female scientist yourself can you talk about some of the challenges that female scientists have Yung Science is a particularly challenging career path for everyone but we know that for women it is especially difficult to balance a very demanding career with having a young family and trying to be successful in all aspects of their lives At Damon Runyon we try to support our women scientists in ways that help them get through these times that can be very difficult We help by providing all of our scientists who have young children with a childcare allowance and also provide women with additional resources to bring their children to our retreats for example We can also be mentors and provide additional support and advice as they need it Are you ready to take the helm Yung I feel very excited honored and confident about stepping into this new role as the CEO at Damon Runyon In part it s because of the deep history and experience that I ve had with Damon Runyon having been a Fellow myself and then leading the scientific programs for so many years Lorraine has been an incredible person to work with and to learn from and so I do feel that I m in the absolute best position to now move into this role 2018 ANNUAL REPORT 5

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OUR SCIENTISTS The Science of Identifying Future Leaders Twelve scientists funded by Damon Runyon have received the Nobel Prize Seventy four are members of the prestigious National Academy of Sciences Countless others are behind recent progress in precision medicine and immunotherapy and spearheading promising and diverse new fields of research What is behind this stellar track record in choosing future leaders Award selection committees that are as creative risk taking and scientifically diverse as the candidates they evaluate Clearly our peer review process has to be spectacular You need exceptional people evaluating these individuals and their proposals because we are seeking the best and brightest people The world renowned scientists on Damon Runyon s award committees hail from the nation s most prestigious research organizations and academic institutions They are laserfocused on selecting the most brilliant young scientists and providing the support needed to turn their high risk ideas into breakthroughs against cancer For our junior faculty awards finalists must pitch their proposals in person a dynamic process that allows committee members to interact with applicants in real time Are they fearless willing to push outside of their comfort zone or are they going to take the obvious path We like people who ask big important interesting questions and they have to be courageous in the way they pursue them For William G Kaelin Jr MD Damon Runyon Board Member and Vice Chair of Scientific Programs a rigorous selection process is key to identifying these rising stars 6 The award selection committees also think broadly about the best science to fund As Dr Kaelin observes You can t always predict what DAMON RUNYON CANCER RESEARCH FOUNDATION

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the outcomes of the work are going to be The person who s working on breast cancer might break the back of some other cancer problem unrelated to breast cancer Rachel Green PhD Chair of the Fellowship Award Committee and also a former Damon Runyon Fellow says Our role is to do our very best to help come up with a balanced set of views on the committee That really does enable us to pick the best set of people Dr Green a biochemist acknowledges The committee members diverse backgrounds allow them to identify the exciting ideas and approaches across many disciplines as they emerge to understand and target cancer And new doesn t always mean better Something isn t good just because it uses new methods and doesn t ask hard questions says Dr Green This explains why Damon Runyon alumni dominate the biomedical ecosystem running top tier research laboratories publishing landmark studies and founding biotech companies to move their discoveries to patients Dr Kaelin emphasizes that Damon Runyon plays a critical role in keeping the most promising scientists engaged in cancer research I can t help but wonder how many of these people along with their potential contributions toward improving cancer care would be lost without the support of Damon Runyon and its generous donors William G Kaelin Jr MD D amon Runyon Board Member and Vice Chair Scientific Programs 2016 Present Chair Physician Scientist Training Award Committee 2015 Present Member Clinical Investigator Award Committee 2006 2016 Chair 2013 2016 Dana Farber Cancer Institute Harvard Cancer Center Rachel Green PhD C hair Fellowship Award Committee 2018 present Member 2015 2018 Member Innovation Award Committee 2008 2014 Damon Runyon Fellow 1993 1996 Johns Hopkins University School of Medicine 2018 ANNUAL REPORT 7

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OUR SCIENTISTS Grooming Future Leaders Mentorship is a critical part of enabling young scientists to reach their highest potential 8 Every day researchers pour their energy and passion into work they hope will contribute to lifesaving discoveries but along the way they will face experimental failures and disappointment Strong mentors not only support them through these rough times but also foster the skills needed to have long and successful careers in research DAMON RUNYON CANCER RESEARCH FOUNDATION

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Elaine has this exquisite ability like an oracle to see where the field is going and navigate in that direction That isn t always intuitive Working with her you hone that skill JULIE SEGRE PhD Damon Runyon Board Member and former Damon Runyon Fellow Elaine V Fuchs PhD is exactly the kind of mentor we seek First and foremost her own career makes her the perfect role model She is one of the most renowned cell biologists today highly recognized for her breakthrough discoveries regarding the biology of the skin and the role of stem cells in communicating with immune dermal and other cells in their environment She is a Professor at The Rockefeller University a Howard Hughes Medical Institute Investigator and has received numerous prestigious awards for her groundbreaking science Beyond her personal success she has trained many of the current leaders in science including seven Damon Runyon scientists Developing young researchers to be tomorrow s leaders is critical to the future of discovery says Dr Fuchs Julie Segre PhD currently at the National Human Genome Institute completed her Damon Runyon Fellowship with Dr Fuchs Elaine fostered a vibrant scientific environment where you were challenged to be fearless She pushed her mentees out of their comfort zones Elaine V Fuchs PhD D amon Runyon Board Member Damon Runyon Fellow 1977 1979 Laboratory Head Laboratory of Mammalian Cell Biology and Development Rebecca C Lancefield Professor The Rockefeller University OPPOSITE PAGE L to R Shruti Naik PhD Elaine V Fuchs PhD Julie Segre PhD to find unconventional solutions to the problems they were investigating says Dr Segre The scientists coming out of the Fuchs lab are not only trained in laboratory science but also the business and infrastructure of running a lab They learn how to advocate for themselves have direction and purpose network and communicate their research Elaine has this exquisite ability like an oracle to see where the field is going and navigate in that direction That isn t always intuitive Working with her you hone that skill explains Dr Segre Dr Segre now mentors many others including Damon Runyon Dale F Frey Breakthrough Scientist and former Fellow Shruti Naik PhD They met at the National Institutes of Health during Dr Naik s graduate studies Dr Naik went on to work under Dr Fuchs for her Damon Runyon Fellowship before launching her own lab at New York University School of Medicine this year My mentors have been my anchors in science Julie along with my graduate advisor and Elaine have been fantastic in leading by example They are really daring scientists who ask big questions says Dr Naik Ultimately the level at which science can advance depends on investing time and effort in emerging leaders says Dr Fuchs As a mentor that requires answering questions probing those failed experiments and being open minded to new ideas It also means taking the time to understand the individual in the lab coat By doing this you empower them to go out into the world and do great things adds Dr Naik 2018 ANNUAL REPORT 9

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OUR SCIENTISTS Successful Leadership Our Ultimate Goal Je R K a lo in m p Damon Runyon has countless examples of scientists we identified and supported as young scientists who have gone on to become leaders in research K b re o re th 2 W fo yo fo Jedd D Wolchok MD PhD D amon Runyon Clinical Investigator 2003 2008 Chief Melanoma Immunotherapeutics Service at MSK Director Parker Institute for Cancer Immunotherapy at MSK D w o to b im an F ex ev P th D 10 DAMON RUNYON CANCER RESEARCH FOUNDATION 348814_DRC_Book_TXT_R4 indd 10 10 29 18 3 06 PM

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I remember the day that Dr Wolchok walked in with the scans saying The tumors are gone I cried and he said Why are you crying You should be happy And he was right K A R E N TA P H O R N Jedd D Wolchok MD PhD a former Damon Runyon Clinical Investigator at Memorial Sloan Kettering Cancer Center is a case in point He is a scientist we take great pride in having funded long before he became an international leader in immunotherapy which has transformed melanoma from deadly to a treatable disease for people like Karen Taphorn Karen s melanoma first appeared in 2011 as a bleeding mole on her back They surgically removed it and we hoped that was the end of the journey Within a year melanoma had returned in the scar tissue Six months after that a scan revealed the cancer had spread to 24 tumors in her lungs She was devastated When someone gives you a diagnosis of stage four melanoma a thousand things go through your mind You just want to live Then she found Dr Wolchok Damon Runyon funded Dr Wolchok at a time when many doubted that immunotherapy or harnessing patients immune systems to attack cancers would ever work We believed in Dr Wolchok and his conviction that immunotherapy would ultimately be successful and enabled him to pursue this lifesaving work For the first 20 years of my career we could expect a person to survive six or seven months even after treatment with chemotherapy Patient survival has now changed to more than three years and sometimes indefinitely says Dr Wolchok Dr Wolchok led the clinical trials of the first immunotherapy approved by the FDA He enrolled Karen in a more recent clinical trial he was leading that combined two immunotherapy KAREN TAPHORN drugs called checkpoint inhibitors The drugs release the natural brakes on immune cells allowing them to recognize and attack tumors The results were astounding Karen went through the entire trial She had no significant side effects and has had a durable complete remission which lasts until today Karen maintained her quality of life during cancer treatment The side effects were so slight that nobody knew I was sick period I did not lose my hair I did not lose weight I did not sleep all the time I carried on my life just as I did before they told me that I was sick I remember the day that Dr Wolchok walked in with the scans saying The tumors are gone I cried and he said Why are you crying You should be happy And he was right This is what funding future leaders is all about This year s Nobel Prize in Physiology or Medicine recognized immunotherapy as a breakthrough that has led to an entirely new class of lifesaving drugs Dr Wolchok helped bring this treatment to patients by conducting the first clinical trial of the first checkpoint inhibitor approved for cancer Watch Anatomy of a Breakthrough the story of Dr Jedd Wolchok s cutting edge work in immunotherapy at www damonrunyon org 2018 ANNUAL REPORT 11

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DAMON RUNYON CANCER RESEARCH FOUNDATION Board of Directors VICE CHAIR Scientific Programs VICE CHAIR Audit and Secretary William G Kaelin Jr MD Professor of Medicine Dana Farber Cancer Institute and Harvard Medical School Howard Hughes Medical Institute Investigator Boston Massachusetts Sanford W Morhouse Esq Of Counsel Schulte Roth Zabel LLP New York New York VICE CHAIR Investments and Treasurer CHAIR Alan M Leventhal Chairman and Chief Executive Officer Beacon Capital Partners LLC Boston Massachusetts Steven J Burakoff MD Dean for Cancer Innovation Tisch Cancer Institute Lillian and Henry M Stratton Professor of Cancer Medicine Icahn School of Medicine at Mount Sinai New York New York Deborah J Coleman Legal Counsel Convexity Capital Management LP Boston Massachusetts Robyn Coles President TRATE Properties LLC Boston Massachusetts Gary E Erlbaum President Greentree Properties Ardmore Pennsylvania Thomas J Fahey Jr MD Senior Vice President Emeritus Memorial Sloan Kettering Cancer Center New York New York 12 Leon G Cooperman Chairman and Chief Executive Officer Omega Advisors Inc New York New York Buck French General Partner X10 Capital San Francisco California Elaine V Fuchs PhD Laboratory Head Laboratory of Mammalian Cell Biology and Development Rebecca C Lancefield Professor The Rockefeller University Howard Hughes Medical Institute Investigator New York New York VICE CHAIR Board Development Michael L Gordon Chief Executive Officer and Chief Investment Officer Angelo Gordon Company LP New York New York VICE CHAIR Development and Marketing David M Beirne General Partner X10 Capital San Francisco California Howard Hughes Medical Institute Investigator Cambridge Massachusetts Scott Greenstein President and Chief Content Officer SiriusXM New York New York Steve Hayden Vice Chairman and Chief Creative Officer Retired Ogilvy Mather Worldwide New York New York Richard B Gaynor MD President of Research and Development Neon Therapeutics Cambridge Massachusetts Jay W Ireland President and Chief Executive Officer Retired GE Africa New York New York Todd R Golub MD Chief Scientific Officer and Director Cancer Program Broad Institute of MIT and Harvard Charles A Dana Investigator in Human Cancer Genetics Dana Farber Cancer Institute Professor of Pediatrics Harvard Medical School Morana Jovan Embiricos PhD Managing Partner F2 Capital Ventures LLP London United Kingdom DAMON RUNYON CANCER RESEARCH FOUNDATION Steven A Kandarian Chairman President and Chief Executive Officer MetLife Inc New York New York

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Noah Knauf General Partner Kleiner Perkins Caufield Byers Menlo Park California Gabrielle Layton PhD Palo Alto California David M Livingston MD Deputy Director Dana Farber Harvard Cancer Center Chief Charles A Dana Division of Human Cancer Genetics Emil Frei Professor of Genetics and Medicine Harvard Medical School Boston Massachusetts David G Marshall Chairman and Chief Executive Officer Amerimar Realty Company Philadelphia Pennsylvania John H Myers Director Academy Securities Fairfield Connecticut EMERITUS MEMBERS Sidney Altman PhD Professor Emeritus of Molecular Cellular and Developmental Biology and Chemistry Senior Research Scientist of Molecular Cellular and Developmental Biology Yale University New Haven Connecticut David Baltimore PhD President Emeritus Robert Andrews Millikan Professor of Biology California Institute of Technology Pasadena California Kenneth G Langone Chairman and Chief Executive Officer Invemed Associates LLC New York New York Ronald Levy MD Robert K and Helen K Summy Professor Stanford University School of Medicine Stanford California Richard J O Reilly MD Chief Pediatric Bone Marrow Transplant Service Memorial Sloan Kettering Cancer Center New York New York Andrew S Rachleff President and Chief Executive Officer Wealthfront Inc Redwood City California William M Raveis Jr Chairman and Chief Executive Officer William Raveis Real Estate Southport Connecticut Michael V Seiden MD PhD President and Chief Medical Officer The US Oncology Network McKesson Specialty Health The Woodlands Texas Nancy Simonian MD Chief Executive Officer Syros Pharmaceuticals Inc Cambridge Massachusetts Cynthia Sulzberger Wellington Florida Peter Van Camp Executive Chairman Equinix Inc Redwood City California James A Wells PhD Professor Department of Pharmaceutical Sciences Harry Wm and Diana V Hind Distinguished Professor University of California at San Francisco San Francisco California Karen D Seitz Founder and Managing Director Fusion Partners New York New York Lorraine W Egan President and Chief Executive Officer Damon Runyon Cancer Research Foundation Connie Lurie Atherton California Craig B Thompson MD President and CEO Memorial Sloan Kettering Cancer Center New York New York I George Miller Jr MD John F Enders Professor of Pediatrics Prof of Epidemiology and of Molecular Biophysics and Biochemistry Section Chief Pediatric Infectious Diseases Yale School of Public Health New Haven Connecticut Henry C Pitot MD PhD Professor Emeritus of Oncology Pathology and Laboratory Medicine 522 McArdle Laboratory for Cancer Research University of Wisconsin Madison School of Medicine and Public Health Madison Wisconsin Virginia Ueberroth Chairman The Ueberroth Family Foundation Corona del Mar California Robert C Wright Senior Advisor Lee Equity Partners LLC New York New York Robert C Young MD Former Chancellor Fox Chase Cancer Center President RCY Medicine Philadelphia Pennsylvania Katharine F Plum Hobe Sound Florida Samuel C Silverstein MD John C Dalton Professor of Physiology and Cellular Biophysics Professor of Medicine Columbia University College of Physicians and Surgeons New York New York 2018 ANNUAL REPORT 13

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Bay Area Committee Carson Eltoukhy Atherton California Connie Lurie Atherton California Judy Swanson Hillsborough California Buck French General Partner X10 Capital San Francisco California Carole Middleton Hillsborough California Peter Van Camp Executive Chairman Equinix Inc Redwood City California Noah Knauf General Partner Kleiner Perkins Caufield Byers Menlo Park California Andrew S Rachleff President and Chief Executive Officer Wealthfront Inc Redwood City California Gabrielle Layton PhD Palo Alto California Gordon M Ringold PhD Chief Executive Officer Quadriga Biosciences Palo Alto California Brigette Lau Partner Social Capital LP Palo Alto California Karen D Seitz Founder and Managing Director Fusion Partners New York New York James Wells PhD Professor Department of Pharmaceutical Sciences Harry Wm and Diana V Hind Distinguished Professor University of California at San Francisco San Francisco California New York Metro Area Committee Kathy Braddock Managing Director William Raveis New York City New York New York Erica Evans Gioffre Head of Client Engagement Hirtle Callaghan Co West Conshohocken Pennsylvania Melissa L Cohn Executive Vice President of the Private Client Group at Family First Funding New York New York Gerald M Marshall Co Chairman and Chief Executive Officer Amerimar Enterprises Inc New York New York Robyn Coles President TRATE Properties Boston Massachusetts Joseph R Osborne MD PhD Chief of Nuclear Medicine and Molecular Imaging Division Clinical Chief of Molecular Imaging Innovation Institute MI3 New York Presbyterian Hospital Weill Cornell Medicine New York New York 14 DAMON RUNYON CANCER RESEARCH FOUNDATION Karen D Seitz Founder and Managing Director Fusion Partners New York New York

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Award Programs In FY2018 Damon Runyon awarded nearly 18 3 million to 69 newly selected exceptional scientists D A M O N R U N YO N R A C H L E F F I N N O VAT I O N AWA R D D A M O N R U N YO N C L I N I C A L I N V E S T I G AT O R AWA R D Supports the next generation of exceptionally creative thinkers with high risk high reward ideas that have the potential to significantly impact our understanding of and approaches to the prevention diagnosis or treatment of cancer Supports early career physician scientists conducting patient oriented research The goal of this innovative program is to increase the number of physicians capable of moving seamlessly between the laboratory and the patient s bedside in search of breakthrough treatments TWO YEAR AWARD 300 000 THREE YEAR AWARD 450 000 with possibility of extension up to an additional 300 000 plus up to 100 000 for medical school loan repayment with possibility of extension up to an additional 300 000 D A M O N R U N YO N F E L L O W S H I P AWA R D D A M O N R U N YO N S O H N P E D I AT R I C C A N C E R F E L L O W S H I P AWA R D Supports the training of the brightest postdoctoral scientists as they embark upon their research careers This funding enables them to be mentored by established investigators in leading research laboratories across the country FOUR YEAR AWARD 231 000 Supports dedicated basic scientists and clinicians who conduct research with the potential to significantly impact the prevention diagnosis or treatment of one or more pediatric cancers FOUR YEAR AWARD 231 000 D A M O N R U N YO N D A L E F F R E Y AWA R D F O R B R E A K T H R O U G H SCIENTISTS Supports a select few Damon Runyon Fellows who have greatly exceeded the Foundation s highest expectations This additional investment in these exceptional individuals catapults their research careers and their impact on cancer TWO YEAR AWARD 100 000 D A M O N R U N YO N P H YS I C I A N S C I E N T I S T T R A I N I N G AWA R D Supports and encourages outstanding recent medical school graduates to pursue cancer research careers by providing them with the opportunity for a protected research training experience under the mentorship of a highly qualified and gifted mentor FOUR YEAR AWARD 460 000 plus up to 100 000 for medical school loan repayment 2018 ANNUAL REPORT 15

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DAMON RUNYON RACHLEFF Innovation Award Committee CHAIR Kenneth W Kinzler PhD Professor of Oncology Director Ludwig Center at Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center Baltimore Maryland Benjamin F Cravatt PhD Professor and Gilula Chair of Chemical Biology Department of Chemistry The Scripps Research Institute La Jolla California Dafna Bar Sagi PhD Senior Vice President Vice Dean for Science Chief Scientific Officer Professor Department of Biochemistry and Molecular Pharmacology Professor Department of Medicine NYU Langone Medical Center New York New York Abby F Dernburg PhD Howard Hughes Medical Institute Investigator Professor of Cell and Developmental Biology University of California Berkeley Lawrence Berkeley National Laboratory Berkeley California Tarun M Kapoor PhD Pels Family Professor Head Laboratory of Chemistry and Cell Biology The Rockefeller University New York New York David G Kirsch MD PhD Professor and Vice Chair for Basic and Translational Research Department of Radiation Oncology Professor of Pharmacology and Cancer Biology Duke University Medical Center Durham North Carolina Richard L Klemke PhD Professor Department of Pathology Moores Cancer Center University of California San Diego La Jolla California Lewis L Lanier PhD American Cancer Society Professor and Chair Department of Microbiology and Immunology J Michael Bishop MD Distinguished Professor University of California San Francisco Leader Cancer Immunology Program UCSF Helen Diller Family Comprehensive Cancer Center San Francisco California Joshua T Mendell MD PhD Howard Hughes Medical Institute Investigator Professor and Vice Chair Department of Molecular Biology University of Texas Southwestern Medical Center Dallas Texas Joseph R Osborne MD PhD Chief of Nuclear Medicine and Molecular Imaging Division Clinical Chief of Molecular Imaging Innovation Institute MI3 New York Presbyterian Hospital Weill Cornell Medicine New York New York Julie Segre PhD Senior Investigator Chief Translational and Functional Genomics Branch Head Microbial Genomics Section National Human Genome Research Institute NIH Bethesda Maryland FO U N D I N G M E M B E R Ronald Levy MD Robert K and Helen K Summy Professor Stanford University School of Medicine Stanford California The funding has enabled me to pursue a highly innovative project which would have been difficult to do without the help from the Foundation It has allowed me to expand the research of my lab in a new direction G U I L L E M P R AT X P h D Damon Runyon Rachleff Innovator 2015 2018 Stanford University 16 DAMON RUNYON CANCER RESEARCH FOUNDATION

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DAMON RUNYON RACHLEFF Innovation Awards CA L I FO R N I A N EW YO R K N O RT H CA R O L I N A Rushika M Perera PhD Mechanisms of cellular transformation at the signal organelle level at the University of California San Francisco Arnold S Han MD PhD Precision T cell receptor based cancer therapies at Columbia University New York Lawrence A David PhD and Anthony D Sung MD Personalized prebiotics to optimize microbiota metabolism and improve transplant outcomes at Duke University Durham M ASSAC H U S E T TS Eric S Fischer PhD Novel mechanisms for small molecule induced targeted degradation of RRM family proteins at Dana Farber Cancer Institute Boston Marcela V Maus MD PhD Next generation CAR T cells for EGFRvIII positive glioblastoma at Massachusetts General Hospital Boston Amaia Lujambio PhD Overcoming the resistance to anti PD1 immunotherapy in hepatocellular carcinoma at the Icahn School of Medicine at Mount Sinai New York Benjamin L Martin PhD and David Q Matus PhD Cell cycle regulation of cellular behaviors associated with cancer metastasis at Stony Brook University Stony Brook OHIO Wayne O Miles PhD Maximizing pro apoptotic protein levels at The Ohio State University Columbus Initial Year DAMON RUNYON RACHLEFF Innovation Award Stage 2 Funding CA L I FO R N I A Scott J Dixon PhD Exploring the role of reductive stress in promoting cancer cell death at Stanford University Stanford Nicholas T Ingolia PhD Cis regulatory code for the translational control of gene expression at the University of California Berkeley Peter J Turnbaugh PhD Nadia s Gift Foundation Innovator The gut microbiome an unexpected contributor to cancer drug resistance at the University of California San Francisco Roberto Zoncu PhD Identifying and disabling organelle circuits that fuel cancer cell metabolism at the University of California Berkeley M A RY L A N D Christopher M Jewell PhD Harnessing intra lymph node controlled release to study and enhance tumor immunity at the University of Maryland College Park OHIO Christin E Burd PhD Exploiting mutational specificity to target RAS driven melanoma at The Ohio State University Columbus WAS H I N GTO N Brian H Shirts MD PhD Participatory genetics for defining genotype phenotype associations of rare cancer variants at the University of Washington Seattle W I S CO N S I N Philip A Romero PhD Digital circulating tumor cell detection using scalable molecular logic at the University of Wisconsin Madison Initial Year 2018 ANNUAL REPORT 17

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DAMON RUNYON Clinical Investigator Award Committee CHAIR Charles L Sawyers MD Chair Human Oncology and Pathogenesis Program The Marie Jos e and Henry R Kravis Chair Howard Hughes Medical Institute Investigator Memorial Sloan Kettering Cancer Center New York New York Karla V Ballman PhD Chief of the Division of Biostatistics and Epidemiology Professor Department of Healthcare Policy and Research Weill Cornell Medicine New York New York David P Carbone MD PhD Barbara J Bonner Chair in Lung Cancer Research Professor Division of Internal Medicine Director James Thoracic Oncology Center The Ohio State University Comprehensive Cancer Center Columbus Ohio Nancy E Davidson MD Senior Vice President Director and Full Member Clinical Research Division Fred Hutchinson Cancer Research Center Head Department of Medicine Division of Medical Oncology University of Washington Seattle Washington S Gail Eckhardt MD Associate Dean of Cancer Programs Director of the LIVESTRONG Cancer Institute Chair Department of Oncology Dell Medical School The University of Texas at Austin Austin Texas 18 Howard A Fine MD Director of the Brain Tumor Center New York Presbyterian Weill Cornell Medical Center Associate Director for Translational Research Sandra and Edward Meyer Cancer Center Feil Professor of Medicine Chief Division of Neuro Oncology Department of Neurology Weill Cornell Medicine New York New York Amato J Giaccia PhD Jack Lulu and Sam Willson Professor in Cancer Biology Director Division of Radiation and Cancer Biology Department of Radiation Oncology Stanford University School of Medicine Stanford California Carl H June MD Richard W Vague Professor in Immunotherapy Department of Pathology and Laboratory Medicine Perelman School of Medicine Director Center for Cellular Immunotherapies Director Parker Institute for Cancer Immunotherapy Abramson Cancer Center University of Pennsylvania Philadelphia Pennsylvania Andrew L Kung MD PhD Chair Department of Pediatrics Memorial Sloan Kettering Cancer Center New York New York Drew M Pardoll MD PhD Director Bloomberg Kimmel Institute for Cancer Immunotherapy Co Director Cancer Immunology Program Sidney Kimmel Comprehensive Cancer Center Abeloff Professor in Oncology Johns Hopkins University School of Medicine Baltimore Maryland DAMON RUNYON CANCER RESEARCH FOUNDATION Ramon Parsons MD PhD Director Tisch Cancer Institute Icahn Scholar Ward Coleman Chair Cancer Research Professor and Chairman Department of Oncological Sciences Icahn School of Medicine at Mount Sinai New York New York David R Piwnica Worms MD PhD Chair and Professor Department of Cancer Systems Imaging Deputy Division Head Research Affairs Division of Diagnostic Imaging The University of Texas MD Anderson Cancer Center Houston Texas Stanley R Riddell MD Full Member Fred Hutchinson Cancer Research Center Clinical Research Division Program in Immunology Professor of Medicine and Oncology University of Washington School of Medicine Seattle Washington Kwok Kin Wong MD PhD Anne Murnick Cogan and David H Cogan Professor of Oncology Department of Medicine Director Division of Hematology Medical Oncology Laura and Isaac Perlmutter Cancer Center NYU Langone Health New York New York Sandra L Wong MD MS Chair Department of Surgery Senior Vice President of the Surgical Service Line Dartmouth Hitchcock Medical Center The Geisel School of Medicine at Dartmouth Lebanon New Hampshire FO U N D I N G M E M B E R Richard J O Reilly MD Chief Pediatric Bone Marrow Transplant Service Claire L Tow Chair in Pediatric Oncology Research Memorial Sloan Kettering Cancer Center New York New York

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DAMON RUNYON Clinical Investigator Awards CA L I FO R N I A M I SS O U R I Ami S Bhatt MD PhD Applying microbiome based therapeutics in cancer patients with Linda Boxer MD PhD and Michael P Snyder PhD Stanford University School of Medicine Stanford Vivek K Arora MD PhD Defining a targetable oncogenic dyad in bladder cancer with Lee Ratner MD PhD Washington University in St Louis Collin M Blakely MD PhD Doris Duke Damon Runyon Clinical Investigator Mechanisms of incomplete response and primary resistance to osimertinib in EGFR mutant lung cancer with Trever G Bivona MD PhD University of California San Francisco Catherine C Smith MD Defining structure function and therapeutic impact of oncogenic FLT3 mutations with Neil P Shah MD PhD University of California San Francisco ILLINOIS Jaehyuk Choi MD PhD Doris Duke Damon Runyon Clinical Investigator Identification of genetic basis of altered T cell receptor signaling in cutaneous T cell lymphoma with Stephen D Miller PhD and John D Crispino PhD Northwestern University Chicago M ASSAC H U S E T TS Geoffrey R Oxnard MD Gordon Family Clinical Investigator Noninvasive genotyping of cell free plasma DNA cfDNA as a tool for guiding personalized lung cancer care with Pasi Janne MD PhD DanaFarber Cancer Institute Boston Mark G Shrime MD PhD Cash transfers for cancer surgery in West Africa their health and economic consequences with John G Meara MD DMD MBA Massachusetts Eye and Ear Infirmary Boston Gavin P Dunn MD PhD Characterizing the immunogenic landscape of glioblastoma with John DePersio MD PhD and Robert Schreiber PhD Washington University School of Medicine in St Louis N EW YO R K Vinod P Balachandran MD William Raveis Charitable Fund Investigator Defining the evolutionary dynamics and antigen potential of neoantigens for human pancreatic cancer immunotherapy with Steven D Leach MD and Jedd D Wolchok MD PhD Memorial Sloan Kettering Cancer Center New York Christopher E Barbieri MD PhD MetLife Foundation Clinical Investigator Presurgical trials to target distinct subclasses of localized prostate cancer with Lewis C Cantley PhD Weill Cornell Medicine New York Adrienne A Boire MD PhD William Raveis Charitable Fund Investigator Molecular determinants of leptomeningeal metastasis a translational approach with Joan Massagu PhD Memorial Sloan Kettering Cancer Center New York Matthew D Hellmann MD Defining intratumoral and peripheral mechanisms mediating initiation of response durability and resistance to PD 1 blockade to inform rational immunotherapeutic development in NSCLC with Charles M Rudin MD PhD and Jedd D Wolchok MD PhD Memorial Sloan Kettering Cancer Center New York Andrew M Intlekofer MD PhD Metabolic coupling of the hypoxic niche to stemness with Ross L Levine MD Memorial Sloan Kettering Cancer Center New York Alex Kentsis MD PhD Richard A Lumsden Foundation Investigator Mechanism and function of regulatory signaling in acute myeloid leukemia with Scott A Armstrong MD PhD and Ross L Levine MD Memorial Sloan Kettering Cancer Center New York Christopher A Klebanoff MD Clinical development of nextgeneration T cell receptor TCR based adoptive immunotherapies for the treatment of patients with common epithelial malignancies with Michel Sadelain MD PhD and Larry Norton MD Memorial Sloan Kettering Cancer Center New York Piro Lito MD PhD Modeling the evolution of resistance to ERK signaling inhibitors at the single cell level with Neal X Rosen MD PhD and Charles M Rudin MD PhD Memorial Sloan Kettering Cancer Center New York Heather L Yeo MD Use of mobile applications to evaluate post surgical recovery in aging patients with GI cancer with Manish A Shah MD and Deborah Estrin PhD MS Weill Cornell Medicine New York P E N N SY LVA N I A Brian C Capell MD PhD Defining the role of epigenetic enhancer dysfunction in epithelial carcinogenesis with Shelley L Berger PhD University of Pennsylvania Philadelphia Initial Year 2018 ANNUAL REPORT 19

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DAMON RUNYON Clinical Investigator Award Continuation Grants CA L I FO R N I A L Elizabeth Budde MD PhD Targeting CD123 using chimeric antigen receptor T cells for treatment of acute myeloid leukemia with Stephen J Forman MD FACP City of Hope Duarte M ASSAC H U S E T TS Priscilla K Brastianos MD Investigation of novel targeted therapeutic approaches for brain metastases with Keith T Flaherty MD and Tracy T Batchelor MD Massachusetts General Hospital Boston Eliezer M Van Allen MD Dissecting response to conventional and emerging DNA damage and repair therapies with Geoffrey I Shapiro MD PhD Dana Farber Cancer Institute Boston M I SS O U R I Stephen T Oh MD PhD Targeting aberrant signaling pathways in myeloproliferative neoplasms with Daniel Link MD Washington University School of Medicine in St Louis N EW YO R K Joshua Brody MD William Raveis Charitable Fund Investigator Flt3L primed in situ vaccination for low grade lymphoma with Nina Bhardwaj MD PhD and Miriam Merad MD PhD Icahn School of Medicine at Mount Sinai New York WAS H I N GTO N Aude G Chapuis MD Multifaceted transgenic TCR approach to high risk AML with Philip D Greenberg MD Fred Hutchinson Cancer Research Center Seattle Initial Award DAMON RUNYON Fellowship Award Committee CHAIR Rachel Green PhD Howard Hughes Medical Institute Investigator Bloomberg Distinguished Professor Professor of Molecular Biology and Genetics Johns Hopkins University School of Medicine Baltimore Maryland VICE CHAIR Greg Barton PhD Class of 36 Endowed Chair Department of Molecular and Cell Biology Professor of Immunology and Pathogenesis University of California Berkeley Berkeley California 20 Martin D Burke PhD MD Professor of Chemistry University of Illinois at Urbana Champaign Urbana Illinois Jayanta Chaudhuri PhD Professor Immunology Program Memorial Sloan Kettering Cancer Center New York New York Jennifer Gerton PhD Investigator Associate Professor Department of Biochemistry and Molecular Biology The University of Kansas School of Medicine Stowers Institute for Medical Research Kansas City Missouri DAMON RUNYON CANCER RESEARCH FOUNDATION Antonio J Giraldez PhD Howard Hughes Medical Institute Scholar Fergus F Wallace Professor and Chair Department of Genetics Yale University School of Medicine New Haven Connecticut Lucy A Godley MD PhD Co Director Center for Clinical Cancer Genetics Professor Department of Medicine Section of Hematology and Oncology Cancer Research Center The University of Chicago Medicine Chicago Illinois

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DAMON RUNYON Fellowship Award Committee continued Richard Gregory PhD Professor Department of Biological Chemistry and Molecular Pharmacology Department of Pediatrics Harvard Medical School Harvard Stem Cell Institute The Stem Cell Program at Boston Children s Hospital Boston Massachusetts Howard C Hang PhD Richard E Salomon Family Associate Professor Laboratory of Chemical Biology and Microbial Pathogenesis The Rockefeller University New York New York E Jane Albert Hubbard PhD Professor Department of Cell Biology Skirball Institute of Biomolecular Medicine New York University School of Medicine New York New York Susan Kaech PhD Professor and Director NOMIS Laboratories for Immunobiology and Microbial Studies NOMIS Chair Salk Institute for Biological Studies La Jolla California Jonathan C Kagan PhD Professor of Pediatrics Harvard Medical School Shwachman Chair in Gastroenterology Boston Children s Hospital Boston Massachusetts Lynne E Maquat PhD J Lowell Orbison Endowed Chair and Professor Department of Biochemistry and Biophysics School of Medicine and Dentistry Director University of Rochester Center for RNA Biology Chair University of Rochester Graduate Women in Science University of Rochester Rochester New York Philip A Newmark PhD Howard Hughes Medical Institute Investigator Burnell R Roberts Chair in Regenerative Biology Morgridge Institute for Research Department of Zoology University of Wisconsin Madison Wisconsin Joel Rothman PhD Professor and Wilcox Family Chair in Biotechnology University of California Santa Barbara Santa Barbara California David Ruggero PhD Professor Helen Diller Family Endowed Chair in Basic Research University of California San Francisco School of Medicine Member UCSF Comprehensive Cancer Center San Francisco California M Celeste Simon PhD Scientific Director and Investigator Abramson Family Cancer Research Institute Associate Director Shared Resources Abramson Cancer Center Arthur H Rubenstein MBBCh Professor Department of Cell and Developmental Biology University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania Jessica Tyler PhD Professor Department of Pathology and Laboratory Medicine Weill Cornell Medicine New York New York Matthew G Vander Heiden MD PhD Eisen and Chang Career Development Professor Associate Professor of Biology Associate Director Koch Institute for Integrative Cancer Research at MIT Cambridge Massachusetts Amy Wagers PhD Forst Family Professor Stem Cell and Regenerative Biology Harvard University Cambridge Senior Investigator Joslin Diabetes Center Harvard Medical School Boston Massachusetts Susan R Schwab PhD Associate Professor Department of Pathology Skirball Institute of Biomolecular Medicine New York University School of Medicine New York New York 2018 ANNUAL REPORT 21

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DAMON RUNYON Fellowship Awards CA L I FO R N I A Salk Institute Corina E Antal PhD Robert Black Fellow Stromal reprogramming as a therapeutic approach in pancreatic cancer with Ronald M Evans PhD Jeanine L Van Nostrand PhD Elucidating the AMPK dependent regulation of mTOR signaling in the metabolic checkpoint of tumorigenesis with Reuben J Shaw PhD Scripps Research Institute Marsha M Hirschi PhD Dennis and Marsha Dammerman Fellow Molecular engineering of an optically controlled glutamate receptor with Gabriel C Lander PhD Joseph D Schonhoft PhD Merck Fellow Probing the relation between sequence aggregation and proteotoxicity in cardiac amyloidoses caused by free antibody light chains with Jeffery W Kelly PhD Xiaoyu Zhang PhD Discovery of chemical probes that support targeted protein degradation in human cancer with Benjamin F Cravatt PhD Stanford University Christopher J Cambier PhD HHMI Fellow In vivo characterization of mycobacterial cording with Carolyn R Bertozzi PhD Kelsie A Eichel PhD Robert A Swanson Family Fellow Mechanisms of polarized membrane protein trafficking with Kang Shen PhD Ryan A Flynn MD PhD The interplay between cellular metabolism and RNA homeostasis in disease with Carolyn R Bertozzi PhD 22 Victoria Hung PhD Kathrin Leppek PhD Fraternal Order of Eagles Fellow Layton Family Fellow Defining the post translational landscape of ribosomes in control of gene regulation and cell fate with Maria Barna PhD Mechanistic characterization of 5 UTR RNA elements that confer translational specificity to shape vertebrate embryonic development with Maria Barna PhD John C Janetzko PhD A biophysical approach to studying GRK GPCR complexes with Brian K Kobilka MD Chuan Li PhD Connie and Bob Lurie Fellow Quantifying epistasis between tumor suppressor genes and revealing the underlying expression profiles at the single cell level in murine lung adenocarcinoma with Dmitri Petrov PhD Jianjin Shi PhD Layton Family Fellow Biochemical and genetic dissection of axon degeneration with Marc TessierLavigne PhD Shaogeng Steven Tang PhD Merck Fellow Toward small molecule inhibitors against human immune checkpoint PD 1 with Peter S Kim PhD Leeat Yankielowicz Keren PhD Studying the tumor immune microenvironment in breast cancer using a novel multiplexed imaging platform with Michael R Angelo MD PhD and Edgar G Engleman PhD Stanford University School of Medicine Anupam K Chakravarty PhD Investigating the phenomenon of epigenetic inheritance mediated by non amyloid protein aggregates with Daniel F Jarosz PhD Christopher P Lapointe PhD Regulatory roles of the 3 untranslated region in human translation with Joseph Puglisi PhD DAMON RUNYON CANCER RESEARCH FOUNDATION Fangfei Qu PhD Decoding the molecular and cellular mechanisms of the growth of brain metastases with Julien Sage PhD Albert G Tsai MD PhD Diagnosis of hematologic malignancies from paucicellular aspirate material using highly multiplexed single cell analysis with Sean C Bendall PhD Jing Lin Xie PhD The Mark Foundation for Cancer Research Fellow Remembering the past epigenetic mechanisms of cancer drug resistance with Daniel F Jarosz PhD University of California Berkeley Gina V Caldas PhD Analysis of CSR function in C elegans embryonic cell division with Abby F Dernburg PhD Allison Didychuk PhD Viral mimics of host transcription factors in oncogenic herpes viruses with Britt Glaunsinger PhD Stephanie Gates PhD HHMI Fellow Decoding the ubiquitin receptor recognition mechanism of the 26S proteasome with Andreas Martin PhD Jamie Lahvic PhD The Mark Foundation for Cancer Research Fellow Uncovering cell non autonomous mechanisms of tumor suppression with Iswar Hariharan MMBS PhD Andrew C Murley PhD HHMI Fellow Cell non autonomous communication of ER stress resistance with Andrew G Dillin PhD

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University of California Los Angeles Magdalena E Potok PhD The relationship between epigenetic gene silencing nuclear architecture and genome stability with Steven E Jacobsen PhD Christina M Termini PhD Proteoglycan remodeling of the bone marrow niche regulates hematopoietic stem cell regeneration with John P Chute MD University of California San Diego Richard W Baker PhD Understanding the mechanisms of SWI SNF mediated chromatin remodeling and its misregulation in cancer with Andres E Leschziner PhD University of California San Francisco Vladislav Belyy PhD Mapping the unfolded protein response signaling network with optogenetic actuators with Peter Walter PhD Kyle G Daniels PhD Controlling T cell signaling and fate choice using synthetic receptors with Wendell A Lim PhD Qi Hu PhD Design of inhibitors of cancerassociated mutant GNAS with Kevan M Shokat PhD Jeffrey A Hussmann PhD Rebecca Ridley Kry Fellow Genome wide measurement of ribosome spacing on individual transcripts with Carol A Gross PhD Trang Nguyen PhD Bypassing the unresponsiveness of T cell anergy and exhaustion with Arthur Weiss MD PhD Thomas M Norman PhD Identifying the stochastic determinants of drug resistance with Jonathan S Weissman PhD Linda T Vo PhD Off the shelf T cells from human pluripotent stem cells with precise tumor recognition using combinatorial antigen sensing circuits with Jeffrey A Bluestone PhD Lan Wang PhD Conferring organelle specificity to tail anchored proteins with Peter Walter PhD Andrew L Wolfe PhD The therapeutic potential and biological effects of targeting oncogenic KRAS with Frank McCormick PhD Yale School of Medicine Zhuobin Liang PhD Mechanistic dissection of the Fanconi anemia pathway in coordinating R loop processing and DNA repair with Patrick Sung DPhil and Gary Kupfer MD Esen Sefik PhD HHMI Fellow The effect of microbes diet on the intestinal immune system in the context of obesity with Richard A Flavell PhD Seyed Fakhreddin Torabi PhD Robert Black Fellow Evolution of triplex forming RNAs from random sequences a search for additional MALAT1 like triplex motifs with Joan A Steitz PhD ILLINOIS The University of Chicago Jiaxi Wu PhD Mechanism of dendritic cell missingself recognition and migration to activate CD4 T cell responses with Jason G Cyster PhD John D Leonard PhD Yichen Xu PhD Elucidating the role of ER as a novel RNA binding protein and its function in regulating translation with Davide Ruggero PhD Sigrid Nachtergaele PhD The dynamic N1 methyladenosine methylome in eukaryotic mRNA with Chuan He PhD Dian Yang PhD Dissecting intratumoral heterogeneity and hierarchy at single cell resolution with Jonathan Weissman PhD and Trever G Bivona MD PhD Brian J Laidlaw PhD Ziyang Zhang PhD HHMI Fellow HHMI Fellow Role of EBI2 in the regulation of lymphocyte migration during viral infection and cancer with Jason G Cyster PhD Controlling the activity of bispecific T cell engagers with a chemically cleavable molecular switch with Kevan M Shokat PhD Kara L McKinley PhD Mechanisms and functions of cellular rearrangements in epithelia with Ronald D Vale PhD Xin Zhou PhD Lyndsay M Murrow PhD Fate specification of mammary stem cells by cell self sorting with Zev J Gartner PhD CO N N ECT I CU T Robert Black Fellow Self antigen recognition by regulatory T cells with Erin J Adams PhD and Peter A Savage PhD University of Illinois Daniel J Blair PhD Illini 4000 Fellow An automated small molecule synthesizer for the discovery of new anti cancer agents with Martin D Burke MD PhD Sarah Z Tasker PhD HHMI Fellow Synthesis and evaluation of a collection of complex molecules biased for penetration of the blood brain barrier with Paul J Hergenrother PhD Merck Fellow Engineering Glue domains to enable cryo EM study of small cancer protein structures with James A Wells PhD 2018 ANNUAL REPORT 23

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M A RY L A N D Johns Hopkins University School of Medicine Xintong Dong PhD HHMI Fellow Investigating ligand receptor interactions between defensins and mrgprs in cutaneous inflammation and wound healing with Xinzhong Dong PhD Daniel H Goldman PhD Merck Fellow Elucidating the role of the exon junction complex in regulating translation of spliced mRNA with Rachel Green PhD Vu Quang Nguyen PhD Role of chromatin organization in dynamics of transcription initiation with Carl Wu PhD Evan J Worden PhD The mechanistic basis of crosstalk between histone H2B ubiquitylation and H3K79 methylation with Cynthia Wolberger PhD Boris Zinshteyn PhD HHMI Fellow Mechanisms of splicing independent nonsense mediated mRNA decay with Rachel Green PhD National Institutes of Health Danfeng Cai PhD Protein crowding and protein folding landscapes as predictors of healthy and diseased cell states with Jennifer Lippincott Schwartz PhD Warakorn Kulalert PhD Characterization of the microbiotamediated cutaneous neuroimmune interface and its impacts on tumorigenesis and cancer therapy with Yasmine Belkaid PhD M ASSAC H U S E T TS Boston Children s Hospital Megan L Insco MD PhD William Raveis Charitable Fund Fellow Investigating transcriptional cyclin dependent kinases as novel melanoma drug targets with Leonard I Zon MD 24 Yuxiang Zhang MD PhD Harvard Medical School HHMI Fellow Mechanisms that promote DNA double strand break clusters in brain and liver with Frederick W Alt PhD Brigham and Women s Hospital Emma V Watson PhD Suzanne and Bob Wright Fellow Metabolic stress response Exploring transcript level regulation of metabolic feedback with Stephen J Elledge PhD Anne E Dodson PhD Transgenerational inheritance of structure based infections with Scott G Kennedy PhD Ivana Gasic PhD Merck Fellow Broad Institute Matthew Bakalar PhD Predicting the interactions of T cell receptors with peptide MHC complexes with Nir Hacohen PhD Dana Farber Cancer Institute Molecular elucidation of the interphase microtubule integrity response MIR with Timothy Mitchison PhD Zhejian Ji PhD HHMI Fellow Phillip A Dumesic MD PhD Identification of muscle secreted factors responsible for local and systemic effects of exercise with Bruce M Spiegelman PhD Tikvah K Hayes PhD David M Livingston MD Fellow Systematic genomic and functional analysis of small cell lung cancer with Matthew L Meyerson MD PhD Whitney L Johnson PhD Using organoid cancer models to identify genome catastrophe mechanisms with David S Pellman MD Neil T Umbreit PhD Elucidating the mechanism of chromosome bridge resolution with David S Pellman MD Eric S Wang PhD Robert Black Fellow Enhancing anti tumor immunity via pharmacological inhibition of kinases with Nathanael Gray PhD Harvard T H Chan School of Public Health Jeeyun Chung PhD Unraveling the cellular mechanism of lipid droplet biogenesis with Tobias C Walther PhD and Robert V Farese Jr PhD DAMON RUNYON CANCER RESEARCH FOUNDATION Justin A Bosch PhD Characterizing novel molecules and mechanisms that mediate cellcell communication with Norbert Perrimon PhD Function of the CDc48 ATPase in protein degradation with Tom A Rapoport PhD Lucy Liu PhD In vivo characterization of muscle autophagy in health and disease with Norbert Perrimon PhD Nagarajan Nandagopal PhD Philip O Bryan Montgomery Jr MD Fellow Signal integration by bHLH circuits to enable cell fate decisions with Galit Lahav PhD and Sean Megason PhD Natasha M O Brown PhD Molecular and cellular mechanisms of transcytosis regulation in blood brain barrier function with Chenghua Gu PhD Sarah J Pfau PhD Investigating the molecular determinants of blood brain barrier heterogeneity with Chenghua Gu PhD Deepshika Ramanan PhD National Mah Jongg League Fellow Identifying functions of regulatory T cell subsets in intestinal inflammation and colorectal cancer with Christophe Benoist MD PhD Justin L Sparks PhD Replicative helicase bypass of bulky DNA adducts with Johannes C Walter PhD Benjamin M Stinson PhD Mechanism of DNA processing during non homologous end joining with Johannes C Walter PhD and Joseph L Loparo PhD

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Damon Runyon Fellows are incredibly enthusiastic They are the brightest minds out there the leaders of the scientific community They are essentially the key to going forward in science A A R O N F S T R A I G H T P h D Damon Runyon Fellowship Award Committee Member 2018 Present Damon Runyon Gordon Family Scholar 2005 2007 Damon Runyon Fellow 1998 2001 Stanford University School of Medicine Chuchu Zhang PhD Molecular dissection of area postrema and its role in nausea with Stephen Liberles PhD Harvard University Philip B Abitua PhD Developmental mechanisms of killifish cell dispersion and aggregation with Alexander F Schier PhD Brian J Beliveau PhD HHMI Fellow Decoding Polycomb mediated gene regulation in single cells with single molecule super resolution imaging and synthetic biology with Peng Yin PhD Monica E McCallum PhD Understanding alanosine biosynthesis to discover new cancer chemotherapeutics with Emily P Balskus PhD Christopher Wilson PhD Iva Tchasovnikarova PhD Deciphering the role of chromatin remodeling in epigenetic repression by the HUSH complex with Robert E Kingston PhD Kurt J Warnhoff PhD Molybdenum cofactor biosynthetic enzymes modulate miRNA biology and development with Gary B Ruvkun PhD Massachusetts Institute of Technology Single cell genomic approaches for tracing the contribution of inflammation to human colon cancer with Alex K Shalek PhD Peter M Westcott PhD Exploiting endogenous mutational processes in cancer to enhance response to immunotherapy with Tyler E Jacks PhD Whitehead Institute for Biomedical Research HHMI Fellow Laura V Blanton PhD Targeting protein folding mechanisms to stimulate anti tumor immune responses with Tyler E Jacks PhD Lallage Feazel Wall Fellow Lindsay M LaFave PhD Investigating epigenetic mechanisms of transformation in SWI SNFmutant non small cell lung cancer with Tyler E Jacks PhD Allison N Lau PhD Development of a programmable writer and eraser of m6A RNA methylation with David R Liu PhD Robert Black Fellow Kai Mao PhD Mechanisms of xenobiotic surveillance and regulation with Gary B Ruvkun PhD HHMI Fellow Alexander M Jaeger PhD Marion Abbe Fellow Massachusetts General Hospital Jose M Ordovas Montanes PhD Understanding metabolic heterogeneity in pancreatic cancer with Matthew G Vander Heiden MD PhD Evan C Lien PhD Impact of diet on tumor metabolism and progression with Matthew G Vander Heiden MD PhD The impact of sex chromosome constitution on immune cell gene expression and function with David C Page MD Nora Kory PhD HHMI Fellow Identifying new components of mitochondrial one carbon metabolism with David M Sabatini MD PhD Daniel H Lin PhD HHMI Fellow Global influence of mRNA conformation on eukaryotic translational regulation with David P Bartel PhD Benjamin R Sabari PhD Investigating the role of aberrant genome structuring in T ALL with Richard A Young PhD 2018 ANNUAL REPORT 25

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Lacy J Barton PhD M I C H I GA N Cornell University University of Michigan Sudeep Banjade PhD Swathi Yadlapalli PhD Neural and genetic basis of metabolic regulation with Orie T Shafer PhD and Edgar Meyhofer PhD M I SS O U R I Washington University School of Medicine in St Louis Darryl A Wesener PhD Synthetic food particles for studying human gut microbiota function with Jeffrey I Gordon MD HHMI Fellow Division of labor in ESCRT III proteins during polymer assembly and membrane remodeling with Scott D Emr PhD Memorial Sloan Kettering Cancer Center Harihar Basnet PhD Identifying determinants of latency in brain metastatic breast cancer cells with Joan Massagu PhD Bryan C King PhD Berger Foundation Fellow N E W J E R S EY Princeton University Andrew A Bridges PhD HHMI Fellow Bacterial cell fates The role of quorum sensing in biofilm patterning with Bonnie L Bassler PhD Antony J Burton PhD Sculpting chromatin architecture in live cells using protein chemistry with Tom W Muir PhD N E W YO R K AMPK induced catabolism of extracellular proteins a novel survival mechanism for nutrientdeprived cancer cells with Craig B Thompson MD William Razzell PhD The role of tension in Hippo pathway signaling with Jennifer A Zallen PhD Aaron D Viny MD William Raveis Charitable Fund Fellow Role of the Cohesin complex in oncogenic transformation of AML with Ross L Levine MD New York University School of Medicine Columbia University J Brooks Crickard PhD The Mark Foundation for Cancer Research Fellow Visualizing the strand invasion during homologous recombination on the single molecule level with Eric C Greene PhD Robert S Banh PhD William Raveis Charitable Fund Fellow Mechanisms of directed cell migration in a complex in vivo environment with Ruth Lehmann PhD June Yong Lee PhD Investigation of potential roles of serum amyloid A in peripheral Th17 cell pathogenicity with Dan R Littman MD PhD The Rockefeller University Aleksey Chudnovskiy PhD Defining dendritic cell T cell interaction history within the tumor microenvironment using enzymatic labeling with Gabriel D Victora PhD Yusong R Guo PhD HHMI Fellow Structural and mechanistic characterization of mechanosensitive Piezo channels with Roderick MacKinnon MD Jonathan R Whicher PhD GE Asset Management Fellow Structure and mechanism of the voltage gated potassium channel hEag1 with Roderick MacKinnon MD Linghe Xi PhD Dale F and Betty Ann Frey Fellow WNT signaling and fate specification of normal versus tumorigenic stem cells with Elaine V Fuchs PhD Merck Fellow Metabolic contribution of sensory neurons via peripheral axons to pancreatic tumorigenesis and serine metabolism with Alec Kimmelman MD PhD and Michael Pacold MD PhD The Damon Runyon Fellowship was liberating and enabling for my science as it provided me with resources to freely test different ideas S U N GWO O K WO O P h D Damon Runyon Fellow 2014 2018 Harvard University 26 DAMON RUNYON CANCER RESEARCH FOUNDATION

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Weill Cornell Medicine Eric E Gardner PharmD PhD Kenneth G and Elaine A Langone Fellow Interrogating lung adenocarcinoma transformation to small cell lung cancer at single cell resolution with Harold E Varmus MD O R EG O N Oregon Health and Science University Yunsik Kang PhD Molecular mechanisms regulating phagocytosis of neurons with Marc R Freeman PhD P E N N SY LVA N I A University of Pennsylvania Geoffrey P Dann PhD Merck Fellow Proteomics to bridge protein arginylation chromatin and cancer with Benjamin A Garcia PhD Romain Riscal PhD Fructose 1 6 bisphosphatase nuclear localization new functions and implication in hepatocellular carcinoma progression with M Celeste Simon PhD T E X AS University of Texas Southwestern Medical Center Lindsay B Case PhD Robert Black Fellow Elise C Jeffery PhD Characterizing a new hematopoietic stem cell niche factor with Sean J Morrison PhD Ying Qi Shirleen Soh PhD Mapping paths and mechanisms of virus host adaptation with Jesse D Bloom PhD U TA H Yi Yin PhD Global analysis of DNA break repair by single cell sequencing with Jay A Shendure MD PhD University of Utah School of Medicine Alesia N McKeown PhD HHMI Fellow Novel roles for retrogenes in host immunity with Nels C Elde PhD and Cedric Feschotte PhD WAS H I N GTO N Fred Hutchinson Cancer Research Center Tera C Levin PhD HHMI Fellow Master microbial manipulators how hosts are shaped by bacterial infections with Harmit S Malik PhD GERMANY European Molecular Biology Laboratory Albert Tsai PhD Single molecule imaging of transcription factors binding dynamics in Drosophila embryos with Justin Crocker PhD Initial Year Physician Scientist Jeremy I Roop PhD Fayez Sarofim Fellow Defining virus host co evolutionary dynamics that underlie the unusually broad HIV neutralizing antibody response in infants with Julie M Overbaugh PhD Alistair B Russell PhD Merck Fellow Impact of heterogeneity on the cellular recognition of influenza infection with Jesse D Bloom PhD Regulation of integrin clustering on supported lipid bilayers with Michael Rosen PhD Damon Runyon selects and supports some of the most driven research in the scientific community but inspiration alone cannot drive progress As with all human endeavors practical support is essential B R I T TA N Y A D A M S O N P h D Damon Runyon Fellow 2014 2017 University of California San Francisco 2018 ANNUAL REPORT 27

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DAMON RUNYON SOHN Pediatric Cancer Fellowship Award Committee CHAIR Andrew L Kung MD PhD Chair Department of Pediatrics Memorial Sloan Kettering Cancer Center New York New York Scott A Armstrong MD PhD Chair Department of Pediatric Oncology Dana Farber Cancer Institute David G Nathan Professor of Pediatrics Harvard Medical School Associate Chief of the Division of Hematology Oncology at Boston Children s Hospital Boston Massachusetts Patrick A Brown MD Director Pediatric Leukemia Program Associate Professor Department of Oncology Johns Hopkins University School of Medicine Baltimore Maryland Peter D Cole MD Professor of Pediatrics Chief Division of Pediatric Hematology Oncology Embrace Kids Foundation Chair in Pediatric Hematology Oncology Rutgers Cancer Institute of New Jersey Robert Wood Johnson Medical School Rutgers The State University of New Jersey New Brunswick New Jersey Adolfo A Ferrando MD PhD Professor of Pediatrics and Pathology Director WOLF Foundation Leukemia Lymphoma Laboratory Institute for Cancer Genetics Columbia University Medical Center New York New York Martine F Roussel PhD Member and Endowed Chair in Molecular Oncogenesis Co Leader Cancer Biology Program St Jude Children s Research Hospital Professor Department of Molecule Sciences The University of Tennessee Health Science Center Memphis Tennessee Agata Smogorzewska MD PhD Associate Professor Head Laboratory of Genome Maintenance The Rockefeller University New York New York James M Olson MD PhD Member Division of Clinical Research Fred Hutchinson Cancer Research Center Professor of Pediatric Hematology Oncology University of Washington School of Medicine Seattle Washington The Damon Runyon Sohn award was a vital resource for me as an early career scientist with the goal of making an impact in the treatment of pediatric cancer I was afforded time to explore the biology of these malignancies and make discoveries that will benefit the lives of patients M A R K W Z I M M E R M A N P h D Damon Runyon Sohn Pediatric Fellow 2014 2018 Damon Runyon Jake Wetchler Awardee 2016 Dana Farber Cancer Institute 28 DAMON RUNYON CANCER RESEARCH FOUNDATION

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DAMON RUNYON SOHN Pediatric Cancer Fellowship Awards CA L I FO R N I A zlem Aksoy PhD Understanding the role of translational control in humanized mouse models for medulloblastoma with Davide Ruggero PhD University of California San Francisco Zhipeng Lu PhD Layton Family Fellow of the Damon RunyonSohn Pediatric Cancer Fellowship Award Elucidating the role of dynamic RNA structures in cancer with Howard Y Chang MD PhD Stanford University School of Medicine Stanford Kathryn R Taylor PhD The effect of neuronal activity on pediatric glioma invasion with Michelle L Monje MD PhD Stanford University School of Medicine Stanford M A RY L A N D Stacy L Cooper MD The Cebpa 37kb enhancer is a critical target of transformation in acute myeloid leukemia with Alan D Friedman MD Johns Hopkins University Baltimore Michael A Koldobskiy MD PhD DNA methylation stochasticity in pediatric pre B cell acute lymphoblastic leukemia with Andrew P Feinberg MD Johns Hopkins University Baltimore Cara A Rabik MD PhD Determination of the role of WT1 in hematopoiesis and leukemogenesis with Patrick A Brown MD Johns Hopkins University Baltimore M ASSAC H U S E T TS Adam D Durbin MD Interrogation of neuroblastoma dependencies and non coding RNAs on the core regulatory circuitry for therapeutic inhibition with A Thomas Look MD Dana Farber Cancer Institute Boston Amanda Balboni Iniguez PhD Targeting the EWS FLI oncoprotein in Ewing sarcoma with CDK12 13 inhibitors with Kimberly Stegmaier MD Dana Farber Cancer Institute Boston Sarah N Olsen PhD Targeted degradation of the MLL AF9 fusion oncoprotein in acute myeloid leukemia with Scott A Armstrong MD PhD Dana Farber Cancer Institute Boston Maxim Pimkin MD PhD Divergent core transcriptional circuitries highlight context specific vulnerabilities in AML with Stuart Orkin MD Harvard Medical School Boston N EW YO R K Robert L Bowman PhD Interrogating the subclonal architecture and functional contributions of mutation order in FLT3 ITD mutant AML with Ross L Levine MD Memorial Sloan Kettering Cancer Center New York Srinjoy Chakraborti PhD Mining pHLA and T cell receptor TCR specificities by phage display for de novo TCR engineering and personalized cancer therapy with Jonathan R Lai PhD Albert Einstein College of Medicine Bronx Marissa Rashkovan PhD Targeting metabolic vulnerabilities in ETP ALL with Adolfo A Ferrando MD PhD Columbia University Medical Center New York Yadira M Soto Feliciano PhD Dissecting the role of Menin in acute leukemia with C David Allis PhD The Rockefeller University New York WAS H I N GTO N Jay F Sarthy MD PhD Characterization of the epigenomic landscape of diffuse midline gliomas with Steven Henikoff PhD Fred Hutchinson Cancer Research Center Seattle M I C H I GA N Challice L Bonifant MD PhD Dual antigen targeting by ENG T cells as improved anti AML therapy with Pavan Reddy MD University of Michigan Ann Arbor 2018 ANNUAL REPORT 29

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DAMON RUNYON DALE F FREY AWARD for Breakthrough Scientists Ryan D Baldridge PhD Investigating the mechanism of retro translocation by ERAD at the University of Michigan Ann Arbor Michigan Liron Bar Peled PhD Identification of cysteine liabilities in NRF2 driven cancers at Massachusetts General Hospital Boston Massachusetts Chao Lu PhD Shruti Naik PhD Giannandrea Family Breakthrough Scientist Marilyn and Scott Urdang Breakthrough Scientist Chromatin dysregulation as driver of oncogenesis at Columbia University New York New York Matthew P Miller PhD Deciphering tension dependent stabilization of kinetochoremicrotubule interactions at the University of Utah Salt Lake City Utah Immune epidermal stem cell crosstalk in skin inflammation at New York University School of Medicine New York New York Neel H Shah PhD Identifying divergent mechanisms of oncogenicity in tyrosine kinases at Columbia University New York New York Initial Year DAMON RUNYON Physician Scientist Training Award Committee CHAIR William G Kaelin Jr MD Professor of Medicine Dana Farber Cancer Institute and Harvard Medical School Howard Hughes Medical Institute Investigator Boston Massachusetts David P Carbone MD PhD Barbara J Bonner Chair in Lung Cancer Research Director Thoracic Oncology Center Professor Division of Medical Oncology Comprehensive Cancer Center The Ohio State University Columbus Ohio 30 Lucy A Godley MD PhD Co Director Center for Clinical Cancer Genetics Professor Department of Medicine Section of Hematology and Oncology Cancer Research Center The University of Chicago Medicine Chicago Illinois Peter S Nelson MD Member Division of Human Biology Endowed Chair for Prostate Cancer Research Fred Hutchinson Cancer Research Center Professor Division of Medical Oncology Adjunct Professor Genomic Sciences and Pathology University of Washington School of Medicine Seattle Washington DAMON RUNYON CANCER RESEARCH FOUNDATION Kornelia Polyak MD PhD Professor of Medicine Department of Medical Oncology Dana Farber Cancer Institute Harvard Medical School Boston Massachusetts Jeremy N Rich MD Professor of Medicine Director Neuro Oncology Director Brain Tumor Institute University of California San Diego La Jolla California Cassian Yee MD Professor Department of Melanoma Medical Oncology Professor Department of Immunology Division of Cancer Medicine Director Solid Tumor Cell Therapy Center for Cancer Immunology Research The University of Texas MD Anderson Cancer Center Houston Texas

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DAMON RUNYON Physician Scientist Training Awards Pavan Bachireddy MD Coevolution of tumor and T cell heterogeneity following immunotherapy with Catherine J Wu MD DanaFarber Cancer Institute Boston Massachusetts Michael W Drazer MD Defining leukomogenic mechanisms in hereditary hematologic malignancies with Lucy A Godley MD PhD The University of Chicago Medicine Chicago Illinois Giada Bianchi MD PhD Lee Cooperman Physician Scientist Damon Runyon Celgene Physician Scientist Molecular mechanisms of ROBO1 in multiple myeloma pathogenesis with Kenneth C Anderson MD DanaFarber Cancer Institute Boston Massachusetts Kristopher R Bosse MD GPC2 as an oncogene and immunotherapeutic target in highrisk neuroblastoma with John M Maris MD Children s Hospital of Philadelphia Philadelphia Pennsylvania Julia C Carnevale MD Developing new therapeutic approaches for pancreatic cancer with homologous recombination repair defects with Alan Ashworth PhD University of California San Francisco California Jennifer L Caswell Jin MD Breast cancer evolution and resistance in response to HER2targeted therapy with Christina N Curtis PhD and Allison W Kurian MD MSc Stanford University Stanford California Nicholas C DeVito MD Investigating the role of EMTmediated dendritic cell tolerization in checkpoint inhibitor resistance with Brent A Hanks MD PhD Duke University Durham North Carolina John R Ferrarone MD Seeking and evaluating novel therapeutic targets in human lung adenocarcinomas with loss offunction mutations in LKB1 with Harold E Varmus MD Weill Cornell Medicine New York New York Christopher J Gibson MD Elucidating the connection between clonal hematopoiesis and lymphoma in humans with Benjamin L Ebert MD PhD Dana Farber Cancer Institute Boston Massachusetts Lillian M Guenther MD Investigation of CITED2 as a novel dependency in Ewing sarcoma with Kimberly Stegmaier MD DanaFarber Cancer Institute Boston Massachusetts Carolyn C Jackson MD MPH Genetic dissection of pediatric classic Kaposi sarcoma with Jean Laurent Casanova MD PhD Memorial Sloan Kettering Cancer Center New York New York David M Kurtz MD PhD Response prediction and personalized therapy from mathematical modeling of circulating tumor DNA in non Hodgkin lymphoma with Arash Ash Alizadeh MD PhD Stanford University School of Medicine Stanford California Loretta S Li MD Mechanisms of disease and resistance in CRLF2 rearranged B cell acute lymphoblastic leukemia with David M Weinstock MD DanaFarber Cancer Institute Boston Massachusetts David Liu MD Dissecting differential therapy response in melanoma through clinical computational oncology with Eliezer M Van Allen MD and Keith T Flaherty MD Dana Farber Cancer Institute Boston Massachusetts Harshabad Singh MBBS Cellular origins of Barrett s esophagus and its role in development of adenocarcinoma with Ramesh A Shivdasani MD PhD Dana Farber Cancer Institute Boston Massachusetts Melody Smith MD CD19 targeted donor T cells improve graft versus tumor activity and reduce graft versus host disease with Marcel R M van den Brink MD PhD Memorial Sloan Kettering Cancer Center New York New York Sakiko Suzuki MD AON directed alternative splicing as a novel therapy for leukemia with Michelle A Kelliher PhD and Peter E Newburger MD University of Massachusetts Medical School Worcester Massachusetts Initial Year 2018 ANNUAL REPORT 31

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Thank You to Our Donors Your support this year enabled us to invest nearly 18 3 million in the next generation of leading cancer researchers exploring bold new ideas Since our founding in 1946 in partnership with donors across the nation Damon Runyon has invested close to 355 million and funded nearly 3 700 young scientists DONOR SPOTLIGHT The 1 million Connie and Robert Lurie Breakthrough Challenge Fund was established to mark Damon Runyon s upcoming 75th Anniversary in 2021 and to generate new support for Damon Runyon scientists working at Stanford University the Gladstone Institute and the Universities of California at San Francisco Berkeley and Santa Cruz Our heartfelt thanks go to the Lurie Family for generations of support beginning with Louis Lou Lurie then his son Robert Bob Lurie and his wife Connie who have been extremely generous to Damon Runyon supporting 14 Damon Runyon scientists and introducing countless people to our important work BOB AND CONNIE LURIE We hope the Challenge Fund will encourage new support by people who don t know about the work of the Foundation and inspire them to get involved Our goal is to put Damon Runyon on the map as a critically important supporter of the best young scientists in the Bay Area Connie Lurie AWA R D S P O N S O R S We are grateful to our individual foundation and corporate sponsors who have partnered with us to launch new programs or are funding one or more of our scientists Donors can choose to fund scientists based on location institution research focus or cancer type and the award can be named in recognition of their gift For more information go to www damonrunyon org get involved sponsor AWARD SPONSORS ARE LISTED ON PAGES 34 36 32 DAMON RUNYON CANCER RESEARCH FOUNDATION BRYAN C KING PhD Berger Foundation Fellow with RENEE BERGER at the Breakthroughs by the Beach event in Sag Harbor

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Events Broadway Tickets 2 0 1 8 A N N U A L B R E A K FA S T R U N YO N 5 K AT YA N K E E S TA D I U M Our 2018 Annual Breakfast raised a recordbreaking 2 6 million Board Member Leon G Cooperman Founder Chairman and CEO of Omega Advisors Inc was honored and introduced by Damon Runyon Emeritus Board member Kenneth G Langone Chairman and CEO of Invemed Associates LLC In April 2018 the tenth annual Damon Runyon 5K at Yankee Stadium drew nearly 2 300 participants and raised more than 420 000 The event was presented by MetLife Foundation with additional support from Poland Spring RXBAR Utz Cabot 24 Hour Fitness New York Post SiriusXM and the New York Yankees R AV E I S R I D E WA L K B R O A D WAY T I C K E T S The William Raveis Charitable Fund hosted the third annual Raveis Ride Walk in October 2017 raising more than 500 000 for Damon Runyon scientists We are grateful to everyone at William Raveis for their partnership and support in raising more than 1 5 million for Damon Runyon over three years Damon Runyon Broadway Tickets offers premium seats to all of Broadway s hit shows We are grateful to the Shubert Organization Nederlander Productions Jujamcyn Theaters and Disney Theatrical Productions for making this program possible Special thanks to our Premier Circle members for their ongoing support of our efforts to end cancer To purchase tickets or gift certificates please visit www damonrunyon org broadway 2018 ANNUAL REPORT 33

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Sponsored Awards We are fortunate to have individual foundation and corporate sponsors who have partnered with us to launch or provide continuing support for specific award programs We sincerely thank them for their vision DA M O N R U N YO N RAC H L E F F I N N OVAT I O N AWA R D S C L I N I CA L I N V EST I GATO R CO N T I N UAT I O N G RA N T This award was established thanks to the vision and generosity of Debbie and Andy Rachleff Follow up funding for select Clinical Investigators has been provided thanks to the William K Bowes Jr Foundation Nadia s Gift Foundation Innovator Peter J Turnbaugh PhD University of California San Francisco C L I N I CA L I N V EST I GATO R AWA R DS This award was initially established in partnership with Eli Lilly and Company In addition to the named awards it is supported by Accelerating Cancer Cures a collaboration between Damon Runyon and leading biopharmaceutical companies Gordon Family Clinical Investigator Geoffrey R Oxnard MD Dana Farber Cancer Institute MetLife Foundation Clinical Investigator Christopher E Barbieri MD PhD Weill Cornell Medicine Richard A Lumsden Foundation Clinical Investigator Alex Kentsis MD PhD Memorial Sloan Kettering Cancer Center William Raveis Charitable Foundation Clinical Investigators William Raveis Charitable Foundation Clinical Investigator Joshua Brody MD Icahn School of Medicine at Mount Sinai F E L LOWS H I P AWA R DS The following awards are funded by donors who have generously endowed an award in perpetuity or sponsored an individual Fellow Berger Foundation Fellow Bryan C King PhD Memorial Sloan Kettering Cancer Center Connie and Bob Lurie Fellow Chuan Li PhD Stanford University Dale F and Betty Ann Frey Fellow Linghe Xi PhD The Rockefeller University David M Livingston MD Fellow Tikvah K Hayes PhD Dana Farber Cancer Institute Dennis and Marsha Dammerman Fellow Vinod P Balachandran MD Memorial Sloan Kettering Cancer Center Marsha M Hirschi PhD Scripps Research Institute Adrienne A Boire MD PhD Memorial Sloan Kettering Cancer Center Jeremy I Roop PhD Fred Hutchinson Cancer Research Center 34 Fayez Sarofim Fellow DAMON RUNYON CANCER RESEARCH FOUNDATION Fraternal Order of Eagles Fellow Victoria Hung PhD Stanford University GE Asset Management Fellow Jonathan R Whicher PhD The Rockefeller University Howard Hughes Medical Institute HHMI Fellows Sudeep Banjade PhD Cornell University Brian J Beliveau PhD Harvard University Andrew A Bridges PhD Princeton University Christopher J Cambier PhD Stanford University Xintong Dong PhD Johns Hopkins University School of Medicine Stephanie Gates PhD University of California Berkeley Yusong R Guo PhD The Rockefeller University Alexander M Jaeger PhD Massachusetts Institute of Technology Zhejian Ji PhD Harvard Medical School Nora Kory PhD Whitehead Institute for Biomedical Research Brian J Laidlaw PhD University of California San Francisco

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Daniel H Lin PhD Whitehead Institute for Biomedical Research Alesia N McKeown PhD University of Utah School of Medicine Andrew C Murley PhD University of California Berkeley Jose M Ordovas Montanes PhD Massachusetts Institute of Technology Esen Sefik PhD Yale School of Medicine Sarah Z Tasker PhD University of Illinois Yuxiang Zhang MD PhD Boston Children s Hospital Ziyang Zhang PhD University of California San Francisco Boris Zinshteyn PhD Johns Hopkins University School of Medicine Illini 4000 Fellow Daniel J Blair PhD University of Illinois Kenneth G and Elaine A Langone Fellow Eric E Gardner PharmD PhD Weill Cornell Medicine Lallage Feazel Wall Fellow Merck Fellows William Raveis Charitable Fund Fellows Robert S Banh PhD New York University School of Medicine Lacy J Barton PhD New York University School of Medicine Geoffrey P Dann PhD University of Pennsylvania Megan L Insco MD PhD Boston Children s Hospital Ivana Gasic PhD Harvard Medical School Aaron D Viny MD Memorial Sloan Kettering Cancer Center Daniel H Goldman PhD Johns Hopkins University School of Medicine Alistair B Russell PhD Fred Hutchinson Cancer Research Center Joseph D Schonhoft PhD Scripps Research Institute Shaogeng Steven Tang PhD Stanford University Xin Zhou PhD University of California San Francisco National Mah Jongg League Fellow Deepshika Ramanan PhD Harvard Medical School Philip O Bryan Montgomery Jr MD Fellow Nagarajan Nandagopal PhD Harvard Medical School Rebecca Ridley Kry Fellow Jeffrey A Hussmann PhD University of California San Francisco DA M O N RU N YO N DA L E F F R EY AWA R D FO R B R E A KT H R O U G H S C I E N T I STS Giannandrea Family Breakthrough Scientist Chao Lu PhD Columbia University Marilyn and Scott Urdang Breakthrough Scientist Shruti Naik PhD New York University School of Medicine DA M O N RU N YO N S O H N P E D I AT R I C CA N C E R F E L LOWS H I P AWA R D This award program was launched in partnership with the generous support of the Sohn Conference Foundation Damon Runyon Sohn Pediatric Cancer Fellows supported by the Sohn Conference Foundation zlem Aksoy PhD University of California San Francisco Laura V Blanton PhD Whitehead Institute for Biomedical Research Robert A Swanson Family Fellow Layton Family Fellows Robert Black Fellows Kathrin Leppek PhD Stanford University School of Medicine Corina E Antal PhD Salk Institute Challice L Bonifant MD PhD University of Michigan Jianjin Shi PhD Stanford University Lindsay B Case PhD University of Texas Southwestern Medical Center Stacy L Cooper MD Johns Hopkins University Marion Abbe Fellow Kelsie A Eichel PhD Stanford University Christopher Wilson PhD Harvard University Allison N Lau PhD Massachusetts Institute of Technology The Mark Foundation for Cancer Research Fellows John D Leonard PhD The University of Chicago J Brooks Crickard PhD Columbia University Jamie Lahvic PhD University of California Berkeley Jing Lin Xie PhD Stanford University School of Medicine Seyed F Torabi PhD Yale School of Medicine Eric S Wang PhD Dana Farber Cancer Institute Suzanne and Bob Wright Fellow Emma V Watson PhD Brigham and Women s Hospital Amanda Balboni Iniguez PhD Dana Farber Cancer Institute Adam D Durbin MD PhD Dana Farber Cancer Institute Michael A Koldobskiy MD PhD Johns Hopkins University Cara A Rabik MD PhD Johns Hopkins University Marissa Rashkovan PhD Columbia Presbyterian Medical Center Jay F Sarthy MD PhD Fred Hutchinson Cancer Research Center 2018 ANNUAL REPORT 35

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Kathryn R Taylor PhD Stanford University School of Medicine DA M O N R U N YO N P H YS I C I A N SCIENTIST TRAINING AWARDS Layton Family Fellow of the Damon Runyon Sohn Pediatric Cancer Fellowship This award was established thanks to the generosity of Damon Runyon Board Members Leon G Cooperman and Michael L Gordon Zhipeng Lu PhD Stanford University School of Medicine Damon Runyon Celgene Physician Scientist DA M O N RU N YO N JA K E W E TC H L E R AWA R D FO R P E D I AT R I C I N N OVAT I O N This 5 000 award is named in honor of Jake Wetchler who died at age 20 after a heroic fight against two different cancers Giada Bianchi MD Dana Farber Cancer Institute Amanda Balboni Iniguez PhD Dana Farber Cancer Institute Lee Cooperman Physician Scientist In perpetuity John R Ferrarone MD Weill Cornell Medicine Accelerating Cancer Cures Thank you to Eli Lilly and Company Celgene Genentech Gilead Merck and Novartis for partnering with us to support the Damon Runyon Clinical Investigator Award and for helping foster communication and collaboration between our scientists and the biopharmaceutical industry 36 DAMON RUNYON CANCER RESEARCH FOUNDATION

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Our Contributors The Damon Runyon Cancer Research Foundation acknowledges the generosity of the many donors who supported our brilliant researchers through gifts to the Foundation from July 1 2017 to June 30 2018 Those whose individual lifetime giving is 100 000 or more are in bold and those whose lifetime giving exceeds 1 million are in blue We are especially grateful to these extraordinarily generous and committed donors 1 0 0 0 0 0 0 Anonymous William K Bowes Jr Foundation Estate of Myra Cohen The Leon and Toby Cooperman Family Foundation 5 0 0 0 0 0 9 9 9 9 9 9 Michael L Gordon The Mark Foundation for Cancer Research Merck Company Inc William Raveis Charitable Fund Sohn Conference Foundation 1 0 0 0 0 0 49 9 9 9 9 American Endowment Foundation The Bakewell Foundation Sol and Margaret Berger Foundation Robert Black Charitable Foundation The Carefree Foundation Estate of Adrienne and Harry Chamberlain Estate of Alice E Conover Emanuel J Friedman Philanthropies Fidelity Investments Charitable Gift Fund Samuel Freeman Charitable Trust Genentech Inc The Giannandrea Family Fund Estate of Mary A Higgs Howard Hughes Medical Institute The Layton Family Fund Sherry and Alan Leventhal Family Foundation Eli Lilly and Company Richard A Lumsden Foundation MetLife Foundation Nadia s Gift Foundation National Mah Jongg League Foundation Debbie and Andy Rachleff Schwab Charitable Judy C Swanson U S Trust Company of New York Estate of Winifred Wiederkerr 5 0 0 0 0 9 9 9 9 9 Angelo Gordon Co Terry and David Beirne Deborah J Coleman and Timothy W Diggins Community Foundation for Monterey County Hettinger Foundation MetLife Louis and Rachel Rudin Foundation Inc Select Equity Group Foundation Silicon Valley Community Foundation Anita Tarr Turk Fund for Breast Cancer Research The Varelas Family Fund 25 0 0 0 49 9 9 9 American Media Anonymous Appaloosa L P BasePoint Beacon Capital Partners LLC Robyn and Tony Coles MD Fiona and Stanley Druckenmiller Shelley and Steven Einhorn Estate of Rita Eisenberg Erlbaum Family Foundation F2 Ventures Goldman Sachs Grand Aerie Fraternal Order of Eagles Illini 4000 Independent Charities of America Elaine and Kenneth Langone Sandy and David Marshall John McKeown Gordon H and Karen M Millner Family Foundation Paul Montrone and Perspecta Trust Mary and Eugene F Murphy The New York Community Trust Estate of Selina L Purcell The Frances and Abraham Reichman Charitable Trust The Bruce Robert Reid Family Foundation Karen D Seitz Cynthia F Sulzberger and Steven B Green Textor Family Foundation 1 0 0 0 0 24 9 9 9 Anonymous Arbor Realty Trust Barthold Family Foundation Baupost Group LLC Nancy and Larry Bossidy BTIG LLC Charles Schwab Co Estate of Irene H Cohn James J Combs Echlin Foundation Lorraine and Bill Egan Edward P Evans Foundation Fiduciary Trust International The Fine and Greenwald Foundation Inc Betty Ann Frey Glover Acquisitions LLC Paula and James Gould Joan Lobis Brown and Jeremy Grayzel Sharon and Scott Greenstein Steve Hayden Estate of Irma T Hirschl Andre Hunter Caroline and Ed Hyman Valerie and Jay Ireland Iridian Asset Management LLC Jewish Communal Fund Jewish Community Federation Steven A Kandarian Mel Karmazin Our donor lists are checked carefully However if you have any corrections or questions please call us at 877 722 6237 The full pledge amount is listed in the year the pledge is made In subsequent years pledge payments are listed 2018 ANNUAL REPORT 37

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OUR CONTRIBUTORS CONTINUED Angela and Noah Knauf Brigette Lau and Chamath Palihapitiya The Lichtenberger Foundation Anthony F LoFrisco Lonsdale Family Philanthropic Fund Katherine and Henry Mannix III McKesson Corporation Paul Weiss Rifkind Wharton Garrison LLP Pyramid Hotel Group The Raiff Foundation Rebecca and Arthur Samberg Gary M Saretsky Schulte Roth Zabel LLP Paula Ryan MD PhD and Michael Seiden MD PhD Henry J and Kathleen Singer Family Foundation The Richard C and Theresa P Smith Memorial Fund State Street Global Advisors The Symonds Foundation Carol and Lee Tesconi Tzedakah Foundation Laura and Peter Van Camp Vanguard Charitable Volpi Cupal Family Fund The Jake Wetchler Foundation Peter J Worth Julia J Young 5 0 0 0 9 9 9 9 The Altman Kazickas Foundation Judy Hart Angelo Bank of America Charitable Gift Fund Arnold and Mary Jo Barnett Family Philanthropic Fund Barbara Lieb Baumstein The Howard Bayne Fund Benevity Community Impact Fund Isabel and Steven Berg Edgar Berner Family Fund of the Jewish Community Foundation BNY Mellon Ann and Frank Bumstead The Calf Island Foundation Russell L Carson Elizabeth M Christiansen Estate of Laurelia M Clifford Daniel G Cohen Paula and Martin Cohen The Jodi and Wayne Cooperman Charitable Fund Dorothy D Amato 38 Alyce and Philip DeToledo Helga and Frank Doyle Jane and Larry Droppa Cheryl and Blair Effron Ensemble Capital LLC Estate of Edward and Bozena Etnyre Fairfield County s Community Foundation The Frances and Jeffrey Fisher Charitable Foundation Linda Frankel Kelly and Buck French Friedman Family Foundation Gabelli Funds Erica Evans Gioffre and Michael Gioffre The Walter F and Alice Girham Foundation Inc Mignon Groch Heitman LLC Donald Herdrich Joan and Robert Hess Lisa Gross and Richard Hoffman Sandra Horbach and Steven Skoler Lori and Wayne Hummel Interco Charitable Trust JANA Partners LLC Jewish Community Foundation San Diego Anla and Mark Kingdon Richard A Konigsberg Emsie and Kyle Kozloff Estate of Laurie D Lima Clare and Kenneth Livak PhD Emily and David Livingston MD Loews Corporation The Luppe And Paula Luppen Family Foundation Susan and Morris Mark Sam Martini Jami W McKeon The Leo Model Foundation Inc Jody and John Myers Network For Good Perrigo Company Foundation Karen C Phillips Julie and James Pulk Richard Reiss Emily and Michael Repperger Lisa and Michael Rome Linda and Jerry Saslow John M Shapiro and Shonni J Silverberg Philanthropic Fund Suzy Sang Shechtman DAMON RUNYON CANCER RESEARCH FOUNDATION Nancy Simonian MD Robie and John Spector Patricia and James Staley Stewart Senter Inc Barbara and Peter Strauss Philanthropic Fund Suhler Family Fund Jennifer Toll Jennifer and Don Torey The Turk Family Foundation UBS Donor Advised Fund Lief Sannen and Lawrence Wieman Estate of Carl J Wilson Roy J Zuckerberg Family Foundation 1 0 0 0 4 9 9 9 Kara and Jon Aborn Steven I Abrams William J Alexander Carolyn Aller Sharman and David Altshuler Advised Fund Dean V Ambrose America s Best Charities America s Charities Mary and Roy Anderson Charitable Foundation Anonymous Ashner Family Evergreen Foundation Wendy Askew Jerry Avorn and Karen Tucker Charitable Fund Susannah Bailin Bank of America Merrill Lynch Patricia A Baran Bridget Barber Richard Barnett Tim Barton F Harlan Batrus Julie and Roger Baumann Thomas Bean Edna Beaudette Jill C Bee Kathleen Bellamy Debra and Marc Bennet Ann and Thomas Berger Sandye Berger The Len and Laura Berlik Foundation Inc Melissa Berman Bernard Family Charitable Fund Robert Bernard Julia and Edgar Berner Bessemer Trust Karen E Binkhurst Eugenie and Robert Birch

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OUR CONTRIBUTORS CONTINUED Bismarck Capital LLC Richard Blair Mindee Blanco Bob Blau BLL Foundation Steven Bloch Harold Block Jonathan Block David Bloom William Boeh Nadine E Bognar The Boisi Family Foundation Marilyn Booker Gail and Richard Bowen Bonnie and Thomas Bown II June and Thomas Bracken Daniel Brennan Gloria P Briggs Karen and Louis Briskman Frank Brosens and Deenie Brosens Foundation Janet and Richard Bruce Audrey Buchner Judy Buechner Advised Fund Lisa Bullock Suzanne and Steven J Burakoff MD Edmund S Burke Burlingame Foundation James A Burns Yvette Calderon Valerie Caproni Kim Carmack Muckleroy Lucille and Charles Carothers Bonnie Carpenter Michael Carter Susan K Carter Edward Cassel Danae Cavadias Bryan D Cavalier Ellen and Jon Channing Judy Chase Chatham Asset Management LLC David Chazen Jerome A Chazen Philip J Clark The Clark Family Private Foundation Clayman Raiman Foundation Cynthia and Jay L Cohan Charitable Gift Fund Gala Cohen The Cohen Family Foundation Harvey Coleman The Colton Family Foundation Combined Jewish Philanthropies Communities Foundation of Texas CFT The Coneway Family Foundation Cara Cook H J Cooperman Family Charitable Trust Teresa and Jim Copenhaver Daniel W Cotten Elinor and Michael Crames Brenda L Crane Yvonne B Craver Kristine and Jonathan Crawford Kimberly Creem Betsy and Philip Darivoff Lawrence H David Spencer Davidson Barbara and Robert Davis Ellen and Pierre de Vegh Defined Health Dennis Delafield Colleen DeSimone Herb Deuschel Barbara Deutsch MD Nanci and Harold Deutsch Alice Diamond Nicholas Didycz Monica Duvall DiLella MD and Daniel DiLella Dagmar Dolby Elizabeth Donahue Marjorie Doniger Barry L Dorfman DoubleBlue Capital Management Robin N Dracos James Drought Josephine J Dumm Patricia and Michael Dweck Carol and Dexter Earle Jennifer and Don Eddington Eric Edelstein Margaret Engel Julia Espel and Kenneth Chang The Ettl Family Philanthropic Fund Marilyn and Erwin Ezzes Facebook Eleanor and Thomas J Fahey Jr MD Lynne Farbman Farella Braun Martel LLP Phyllis and Samuel Feder Lori and Michael Feldstein Ilene Fine and Jay Pomerance Roberta Fine Nancy A Federspiel PhD and Robert F Fisher PhD Terry Fisher Jill and Mark Fishman Not only has this award had a tremendous impact on my career on a personal level but it has also allowed us to do some great science and help many patients along the way A lot of what I have been able to achieve over the past few years simply would not have been possible without your support R YA N B C O R C O R A N M D P h D Damon Runyon Clinical Investigator 2012 2017 Massachusetts General Hospital 2018 ANNUAL REPORT 39

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OUR CONTRIBUTORS CONTINUED David Fleishhacker Philip Floyd Alan Franco Roxanne Frank Kimberly G Frankenthal Amy and Wendy Franklin Willis Arlene Sharpe MD PhD and Gordon Freeman PhD Mary Ann Frenzel Mary Ann Fribourg Lois Fried Harold And Elaine Friedland Foundation Joseph Frye FTI Consulting Elaine Fuchs PhD and David Hansen Sarah Gannon Mary and Doyle Garriott Elizabeth F Gaudreau Nancy and Richard Gaynor MD Janet Gelbart General Electric Foundation Cindy and Stan Gersch Wayne Gibbens Jean and Robert Gibson Jr Warren Ginsberg Alfred S Glazier Ken Globus Judith M Gnys Garry E Gold Paul D Goldenheim Goldie Anna Charitable Trust Neil Goldmacher Estate of Stephanie Goldman Lawrence Goldrich Barbara Goldstein N S Goldstein Foundation Inc Arthur H Goldstone Goldstone Fund Inc Ellen M Golub Charitable Foundation Martha and Todd Golub MD Jose Antonio Gonzalez Paul Goodman James S Gordon William Grabe Sam Grant Elizabeth A Gray Aileen J Grebow Paul Greenbaum Judy and Billy Greenblatt Terri Grodzicker PhD Eleanor Gross Eric Gross Warren Grover 40 Judith Gushner and Robert Beber Julie S Haggey Edmund A Hajim Nanci and Robert Halper Lynne and Howard Halpern Meredith and Michael Hammerman Michael Hanley Lisa C Hargrove Penelope P Harris Kristy and Robert Harteveldt Kimberly and Alan Hartman The Hartman Family Foundation Richard L Haydon Elizabeth Hazard Healey Family Foundation Marilyn and Gary Hellinger Olga and Enrique Hernandez Stephen Hess William E Hess and Louise A Hess Charitable Fund Thomas Hesselbrock Marion Hindin Deborah Hirtle Jane and R Lee Hite Ashley and Harriet Hoffman The Harold and Ethel Horowitz Family Charitable Foundation Clair Howey Celia Pohani and Daniel Huber Mary I Hull Mary Gwen and Ben Hulsey David Humphrey Kirsten and Kevin Hungate Sheila and Miles Hurwitz Phyllis Hyde Tom Ike Scott R Isdaner J Ira and Nicki Harris Family Foundation J I Foundation Inc Judith Jaehning PhD Jewish Community Foundation of MetroWest New Jersey Jewish Foundation of Greensboro Lauren Johnson Johnson Miller Foundation Joyce and Stephen Joseph JPMorgan Chase Foundation Marnee Kaltman Ed and Ann Kania Foundation Howard Karpoff Shelly and Michael Kassen Vicki and Samuel Katz Marcia Kaufman Shari Kaufman DAMON RUNYON CANCER RESEARCH FOUNDATION Wayne D Kent Sharon K Kilmer Jennifer and James Kimenker Kathryn King Sue F King Douglas Kinney Gerold F L Klauer Lee P Klingenstein Jacqueline and Mitchell Knapp Abby Kohnstamm Dorothy Davies and Jeremy Kramer Krasdale Foods Sandra Krause Wendy Kreeger The Krimendahl Saint Amand Foundation J Kenneth Kruvant Amy R Kurland Luis Lainer Barbara Landau Elizabeth Landes William D and E M Lane Foundation Ellen S Lane Janice R Lane Jasbeena and Ralph Layman Elizabeth and Mark Lazarus Clarence Lear IV Fabienne Lecole Carolann and Steven Leffler Tova Leidesdorf David S Leinwand Amy Lejuez Lisa Lesavoy Levin Capital Strategies LP The Nate and Ann Levine Family Foundation Jeffrey S Levitt Betty Levy Daniel Levy William Guy and Marcia Levy Shoshana and Ronald Levy MD Estate of Franklin S Lewis Keith Liberman Lisa and Steven Lieberman Stephen Lightman Linden Motor Freight Company Inc Susan and Martin Lipton Mary and Fred Litwin Michael Lorusso Frank E and Miriam Loveman Foundation Inc Barbara Macklowe Heather and Michael Madden Jean and Michael Maher

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OUR CONTRIBUTORS CONTINUED Gail and Richard Maidman Alix Mann Marble Fund Inc Michael Marquardt Julie and Gerald Marshall Carlos Martir Ellen Mathias The August Mattheyses Fund of the Community Foundation of New Jersey Helen and Tom May MB Real Estate Christine S McKiernan Marni McKinney Michael W McMahon John McStay Katherine L Meier Mark Melchiorre Joshua Mellen Kathleen and Woodson Merrell MD Martin Messinger Carole Middleton Fund Fred Middleton Louise Middleton Payne W Middleton I George Miller MD Laura Miller Suzy Nancy and Carol Minkoff Charitable Fund Morgan Stanley Patty Hogan and Sanford Morhouse Esq Laurie Morris John Murphy PhD Muffie Bancroft and W Stephen Murray Miles S Nadal Susan and Kenneth Narva Herbert Natof MD Sarah and Thomas Neff Susan Neisloss New Jersey Performing Arts Center Jane E Newman Sonia and Phillip Newmark PhD Nolan Securities Corporation Harriett and Harvey Nusbaum William O Boyle Paula Oppenheim Susan Orman Jeffrey Ostrove Donor Advised Fund David Page Barbara and Robert Paget Paisley Family Fund Palisade Capital Management Catherine Park Debra and Ronald Parr John Passios PayPal Charitable Giving Fund Steven S Payson Cindy and Robert Pearlstein Joan O Pearlstein Agnes Peelle Victoria and Robert Pennoyer Elizabeth Perry Petruzzelli Herrera Fund Pfizer Foundation Pfizer Inc Linda McFarlin and Edwin Phelps Joseph Piorkowski Lori and Larry Pitkowsky Vickie and Rahn Pitzer Catherine and Leon Pollack Peter M Polow Sr Greg Poole Elizabeth Portland and Thomas Toce Elizabeth and Tim Portland Ronnie Potter Sheldon Pressler Mary and Ron Pressman Carol and David Pulver Paul Purcell and James Souther Steve Pustil Richard and Robin Pzena Charitable Fund Tina Rafowitz Meghan and Ryan Raveis Kimberly and Chris Raveis RBC Wealth Management Katherine M Reeves Joan and John Regan Kathleen Reid Diane L Reidy Garrett Reisman Susan Richardson Susan and Jeffrey Rieder David Rimmer Jane and D Paul Rittmaster Ed Robbins Paula Robichaud Lori J Robinson Mary Beth Roche Marian and David Rocker Nancy J Rocker Karen and Gary Rockhold Elizabeth Roddin Miriam K Rothenberg Nina Rothstein The Roxe Foundation Kimberly Rubin Steven Rudman Larry Rush Hodgson Russ LLP Carol Saginaw Liz Salguero Sylvia and Norman Samet The Sylvia L and Norman G Samet Family Philanthropic Fund Sanderson Family Charitable Fund Kim Sands Ilene and Steven B Sands Shamba Sandy Jane and Angelo Santinelli Family Fund Padma and Anand Savur Kathleen and James Sayre Randy Schekman PhD Marvin Schildkraut Norman R Schlanger Harriet P Schleifer Henry Scholder Mendon F Schutt Family Fund Eugene P Schwartz Family Foundation Harry A and Joseph Schwartz Family Foundation David Schwartz Marvin C Schwartz Madeline and Steven Schwartz William Scroggins Robert Sechan Peggy Segal Marianne Lee and William Sellers MD Ethel G Sensenig Brian Shapiro Felice Shea Barbara Sherman Abraham I and Jean Sherr Foundation Inc Lois Sherwin Robert Sherwin Phyllis Brown Shmalo Susan and Bill Shmerler Shmerler Foundation Inc Joan Shore The Sidewater Family Foundation Inc Steven N Siegel Gary N Siegler Karen and Harvey Silverman Patricia Silverstein Julia Reidhead and Jamil Simon Susan Simon Michael Simonds Eric Small 2018 ANNUAL REPORT 41

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OUR CONTRIBUTORS CONTINUED Amy Smith Jeff Smith Estate of Lidie Anne Smith Estate of Mildred A Smith Marie Noelle and Jeffrey Smith Sarah Snell Nancy and Stephen Snell Garry Snook The Sokol Family Gift Fund Sharon Sokolow Gerri and Andrew Sommers Vinton H Sommerville Philippe Soriano DSc PhD Teresa and Kenneth Stabler Dale and Harold Stahler Esq Keren and Alex Stankevich State Street Foundation Matching Gift Program Ian Steele Elizabeth Steidel Sarah Stenn C Scotland Stevens Gloria and Rodney Stone Leila and Melville Straus Judith Studer Mark Stueve Diane Sullivan Roy Sutherland T Rowe Price Trust Co Dorothy Tananbaum Karen and Sanford Teplitzky Patricia and J Ronald Terwilliger Tullia Lindsten MD PhD and Craig Thompson MD Daniel Tracy Dina Treanor and Jeffrey Taschler Karen Tucker and Jerry Avorn Jane Turley J Page Turney UBS Financial Services Inc Steven Urbach Kathy Van Camp Mariah Varner Craig Varrelman CFA Elizabeth J Vega Kathryn Vizas Anastasia Vournas Linda and Edward Wacks Robert Waldbauer Joni Walser and Andrew Church The Walt Disney Company Judith and Peter Wasserman The Wasserman Foundation Waterfall Family Foundation Georgianna and Robert Waters Anita and Alan Weber Michele and Donald Weeden Samuel G Weinberg Vicki and Victor Weinstein Wendy Weinstein David Weinstock MD David and Candace Weir Foundation Carol Windsor and James A Wells PhD Wells Fargo Philanthropic East Wells Fargo Wealth Management Donald and Barbara Werner Foundation Caroline Werther Janet and Alan Widra Barbara and David Wiederecht Byron R Wien Allison C Williams George Wilson Gregory Wilson Eleanor and Benjamin Winter Jami McLaughlin and Owen Witte MD Elaine and Harold Wolchok Peggy Wong Rod Wood Wright Investors Service Holdings Inc Barbara and Robert Young Julie Yu Gayle and Emmett Zimmerman III Seymour W Zises Benjamin Zuckerman Receiving this Fellowship meant that I could focus my time as a postdoctoral fellow on research instead of applying for grants to fund my work I am thankful for the opportunity to have connected with so many high achieving scientists A L L I SO N L AU P h D Damon Runyon Fellow 2015 2019 Massachusetts Institute of Technology 42 DAMON RUNYON CANCER RESEARCH FOUNDATION

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Broadway Premier Circle The Broadway Premier Circle is a group of loyal Damon Runyon Broadway Tickets customers who have made a special donation in support of cancer research The Premier Circle offers members priority access to tickets and other benefits David Altshuler Susannah Bailin Julie and Roger Baumann Barbara Lieb Baumstein Jill C Bee Bonnie Bernard Julia and Edgar F Berner Gail and Richard L Bowen Janet and Richard E Bruce Ann and Frank M Bumstead Elizabeth M Christiansen Philip J Clark Samuel T Cohen Dorothy D Amato Alyce and Philip DeToledo Dagmar Dolby Marjorie Doniger Jane and Larry D Droppa Carol and Dexter D Earle Marian and Robert Ettl Jill and Mark Fishman Linda Frankel Harold And Elaine Friedland Foundation Paul D Goldenheim N S Goldstein Foundation Inc Sam Grant Mignon Groch Eleanor Gross Nanci and Robert M Halper MD Penelope P Harris Donald Herdrich The Harold Ethel Horowitz Family Charitable Foundation Andre Hunter Phyllis Hyde MD Scott R Isdaner Robert Kaplan Vicki and Samuel L Katz Jennifer and James H Kimenker Kathryn King Gerold F L Klauer Richard A Konigsberg Emsie and Kyle S Kozloff Dorothy R Davies and Jeremy R Kramer Sandra Krause Ellen S Lane Elizabeth and Mark Lazarus The Nate and Ann Levine Family Foundation Marcia D Levy and William Guy Martin and Susan Lipton Clare and Kenneth J Livak PhD Frank E Miriam Loveman Foundation Inc Michael W McMahon Carole Middleton Nancy and Russell C Minkoff Joan O Pearlstein Agnes Peelle Clayman Raiman Foundation Paula Robichaud Kimberly Rubin Jane and Angelo Santinelli Linda and Jerry Saslow David G Schwartz Eugene P Schwartz Family Foundation Harry A Joseph Schwartz Family Foundation Madeline and Steven Schwartz Barbara Sherman Abraham I Jean Sherr Foundation Inc Lois Sherwin Shmerler Foundation Inc The Sidewater Family Foundation Inc Diane Sullivan Jennifer Toll Susan Waterfall Waterfall Family Foundation Vicki and Victor J Weinstein MD Caroline Werther Janet M and Alan Widra Jami McLaughlin and Owen N Witte MD Barbara and Robert C Young MD Discovery Society Discovery Society members are valued supporters who have informed us that they have provided for the Damon Runyon Cancer Research Foundation through future planned gifts These donations provide a vital source of support and fuel future breakthroughs against cancer If you have made a planned gift to the Foundation please contact Hilary Rogers at 212 455 0535 Elaine M Addis Judy Chase Paula and Martin J Cohen Ann K Cote Anne C Burkholder PhD and Stephen P Eisenberg PhD Phyllis Farleigh Nancy A Federspiel PhD and Robert F Fisher PhD Mary Ann Frenzel Nancy and Richard B Gaynor MD Rick J Govern Georgia M and William C Hines Rebecca R Kry Linda B Lloyd and Lewis L Lanier PhD Catherine and Leo LoFrisco D G Mitchell Debra L and Ronald E Parr Lynne and Rick Robinson Seymour Rosenheck Esther E and Herbert Schwartz William Scroggins Phoebe H Showers Wallace Specter Carol H Stix Rose Vaccariello Jacqueline and Arthur Walker 2018 ANNUAL REPORT 43

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Ways to Give Online Phone www damonrunyon org donate 1 877 7CANCER or 1 877 722 6237 9 am 5 pm ET Monday to Friday Mail Estate Planning One Exchange Plaza 55 Broadway Suite 302 New York NY 10006 Visit our website for more information www damonrunyon org get involved Damon Runyon Broadway Tickets Damon Runyon Broadway Tickets offers Broadway s best seats and the opportunity to support cuttingedge cancer research at the same time Orchestra seats are available for even the most popular shows Join our Premier Circle to enjoy benefits like priority access to tickets before they go on sale each month and more 44 Our Gift Certificates are perfect for holiday gifts as well as birthdays anniversaries or any occasion a fun night and a meaningful gift DAMON RUNYON CANCER RESEARCH FOUNDATION Call us for tickets and more at 212 455 0550 between 9 am 5 pm ET Monday to Friday Purchase tickets online at www damonrunyon org broadway

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Financial Summary Fiscal Year 2018 As in previous years the financial activities of the Damon Runyon Cancer Research Foundation were audited by RMS US LLP Below is a snapshot of FY2018 For our complete audited financial statements please visit our website at WWW DAMONRUNYON ORG TOTAL OPERATING EXPENSES TOTAL REVENUE 22 22 MILLION MILLION Award Programs 83 5 Fundraising 14 0 General Administration 2 5 Contributions 56 2 Damon Runyon Broadway Tickets 3 3 Donated Services 3 7 Bequests and Trusts 8 3 Misc Income 1 0 Allocation from Investments 27 5 SUMMARY OF BALANCE SHEETS Total Assets Total Liabilities Total Net Assets 2017 2018 142 411 870 30 256 220 112 155 650 148 707 992 32 236 227 116 471 765 Our overhead is paid from our endowment and Damon Runyon Broadway Tickets allowing 100 of your donation to support cancer research

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100 OF YOUR DONATION FUNDS BRILLIANT SCIENTISTS We pay our low overhead from Damon Runyon Broadway Tickets and our endowment For more information visit WWW DAMONRUNYON ORG GET INVOLVED ONE EXCHANGE PLAZA 55 Broadway Suite 302 New York New York 10006 1 877 7CANCER T 212 455 0500 F 212 455 0509 www damonrunyon org