Congress 2022 Handbook : simplebooklet.com

GENERAL INFORMATION Contacts 2Welcome from the Congress Committee 5Congress App 6Education ‘Drop In’ Sessions 10CPD Entitlement 10The Stephen Barnett First Time Presenters’ Session - for the Jack Mundy Prize 2022 12Best Poster Prizes 2022 15Andrew Blake Tribute Award 2022 16Animal Technology and Welfare Journal Prize 2021 18Life and Honorary Members 20AAALAC International Fellowship Award 25Annual General Meeting Agenda 29North East Branch Charity 2022 Appeal 30Sponsorship 88Index to Advertisers 101Congress 2023 IBCSCIENTIFIC PROGRAMME At A Glance Tuesday / Wednesday / Thursday 34Paper Presentations 40Kevin Dolan Memorial Lecture 60Workshop Sessions 62Poster Presentations and Displays 74SOCIAL PROGRAMME Events and Entertainment 82TRADE EXHIBITION Flash Trade Presentations 84Passport Competition 85Trade Exhibition Plan and Listings 86Exhibiting Companies 89Animal Technologists – the key workers for medical researchThe IAT roundel logo is a registered trademarkof the Institute of Animal TechnologyCONGRESS 2022 CONTENTS

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Animal Technologists – the key workers for medical researchCONGRESS 2022 CONTACTSDuring Congress, the Committee can be contacted via the Congress ReceptionAfter Congress, contact should be made via email to: congress@iat.org.ukRegistered Ofﬁce:Institute of Animal Technology, 5 South Parade, Summertown, Oxford OX2 7JL, UK© Copyright Institute of Animal Technology 2022 All rights reserved; no part of this handbook may be reproduced, by any means without prior written permission of the Institute of Animal Technology and the Publisher. Reproduction in whole or part without the express written permission of the copyright holders is prohibited.This HANDBOOK is highly conﬁdential. Please DO NOT leave it unattended during Congress.All information contained is correct at the time of going to pressPublished on behalf of IAT Congress 2022 by PRC Associates LtdDesigned and Printed in Great Britain

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General Information5WELCOME Welcome to Congress 2022Welcome back – it’s lovely to see you all in person again!Who would have thought that we would miss out on two years of face-to-face Congresses? Although we did manage to meet up virtually in 2021, there is no substitute for meeting everyone ‘in the ﬂesh’ once more.So welcome to Harrogate, home of the spa. Whilst we are not offering spa facilities(!), we are hoping that you will leave Congress with refreshed knowledge, renewed enthusiasm and a positive outlook on where the future of Animal Technology is going.Please take a few moments to look through the handbook, or browse the App, to see what is on offer during Congress 2022. There are plenty of papers, workshops and poster sessions to go to, as well as the large trade exhibition to look around. Alan Graham, Chair of the IAT Congress Committee, will open the platform sessions on Wednesday morning, with a welcome and housekeeping notes for the event. Workshops will take place over Tuesday afternoon, Wednesday and Thursday morning. The platform sessions will conclude on Thursday afternoon with the Kevin Dolan Memorial Lecture. Come along to ﬁnd out more about The Living Biobank presented by Tullis Matson.Posters will be on display throughout Congress 2022, with authors in attendance at various times. We are very grateful to LBS Serving Biotechnology who have very generously agreed to increase the sponsorship of the Best Poster Award to include two prizes – one for the best environmental enrichment poster and one for the best scientiﬁc based poster. Each winner will receive £250 as their prize.We are also delighted to be welcoming back our wonderful trade partners, who support our industry all year round and especially at Congress. Come along and meet up with friends, old and new and see what innovations have been taking place whilst we have been away!As you are all no doubt aware, AST2020 did not go ahead in March 2021. We got very close to the date for AST2020 and so we had already obtained sponsorship for many delegate items. We were very keen that these items should not go to waste but should be utilised at the next f-2-f IAT Congress and LASA Winter Meeting. So on a ﬁrst come, ﬁrst served basis, we will be handing out ‘Limited Edition’ AST2020 items.Due to changing needs, we decided that this year we would not offer accommodation for delegates. We couldn’t however, not offer evening entertainment – especially when Ken had agreed to run a Quiz Night! So on Tuesday evening, join us for a wine reception and fork buffet at the Opening of Trade. On Wednesday evening, we will have a sit down buffet followed by the legendary ‘Ken’s Quiz’ and Congress will culminate in the Gala Dinner on Thursday evening. The Gala Dinner will take place in the stunning Royal Hall. All entertainment is via tickets, which must be obtained in advance.We are thoroughly looking forward to Congress 2022, and hope you are too. If you have any comments or thoughts to pass onto the Congress Committee, please send them to congress@iat.org.uk or speak to a committee member at the Congress Reception.Enjoy Congress 2022! IAT Congress Committee

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GENERAL INFORMATION7General InformationTHE VENUEWe are making a very welcome return to the Harrogate Convention Centre. We are utilising a slightly different set of rooms and locations within the venue, so please check you are familiar with the layout of the venue. There is a useful map in the Note Pad to help you ﬁnd your way around. You are invited to attend the Ice Breaker session to meet other delegates.This year we have not offered accommodation as part of the Congress package, so all delegates will be responsible for their own accommodation arrangements.All evening events will take place in the Harrogate Convention Centre (HCC).CONGRESS RECEPTIONThroughout Congress, the Congress Reception will be located in the Queen’s Suite Foyer.Opening hours:Tuesday 29th March 10.00 – 17.45 Wednesday 30th March 08.00 – 17.00 Thursday 31st March 08.00 – 13.00 FIRST TIME AT CONGRESS?Or would you just like to know where you are going? Then come along to the Congress Reception and just ask!ICE BREAKERThe Ice Breaker session starts at 16.30, where you can get to know fellow attendees and meet up with other technicians. Meet at the Congress Reception. We are very grateful to DBM Scotland who loyallysponsor this session.AGMThe 36th Annual General Meeting of the Institute of Animal Technology will be held in the Queen’s Suite in the conference centre on Tuesday at 18.00. A full agenda appears on page 29 and attendance is open to ALL delegates.MEALSBuffet Lunch:Wednesday 13.00 – 14.00 Thursday 13.00 – 14.00 Lunch on both days will be served in the Trade Exhibition situated in Hall C. On Tuesday evening, dinner will be served in the Trade Exhibition Hall at 19.00 hours. This will be a fork buffet dinner with a wine reception marking the ofﬁcial opening of the Trade Exhibition.

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General Information8GENERAL INFORMATIONGala Dinner TicketYou will receive your ticket for the Gala Dinner when you arrive at Congress and collect your badge, bag, etc.Exhibiting companies will sometimes invite you to join their table for the Gala Dinner and in this instance you should hand them your ticket stub so they can reserve a place for you. If you do not wish to join an exhibitor’s table, or if you have come to Congress on your own and are unsure of where to sit, please see a member of the Congress Committee prior to Thursday lunchtime, who will be happy to help you ﬁnd a seat.Table plans for the Gala Dinner will be available at the Congress Reception from 10.30 on Wednesday (coinciding with the morning coffee break). Dinner on Wednesday evening will be served at 19.30 in Hall D. This will be followed by our legendary ‘Ken’s Quiz’. If you haven’t been to one of these before, brush up on your general knowledge and pit your wits against fellow delegates to see who will be victorious! You will need to have pre-booked to attend the dinner and quiz and should have a ticket with your delegate badge in order to gain entry.Thursday’s Gala Dinner Dance starting at 20.00 and will be held in The Royal Hall. Please note that the dress code is smart (i.e. no jeans, trainers or fancy dress please). Gala Dinner tickets also need to have been pre-booked.TEA AND COFFEERefreshments will be served at the following times:Wednesday 10.30 – 11.00 Trade Exhibition Hall 16.00 – 16.30 Trade Exhibition HallThursday 10.30 – 11.00 Trade Exhibition Hall 15.30 – 16.00 Foyer Queen’s SuiteTRADE EXHIBITIONThe Trade Exhibition is situated in Hall C within the main conference centre. Opening times:Tuesday 19.00 – 22.30 (Ofﬁcial opening)Wednesday 09.30 – 17.00 Thursday 09.30 – 14.30 A plan of the Trade Hall and the Exhibitors appear on pages 86/87.FLASH TRADE PRESENTATIONSAlways fun! Main programme details appear on page 44 and the list of companies participating can be found on page 84.

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GENERAL INFORMATIONGeneral Information 9Trade Passport Competition2022 sees the return of in-person meetings and also the return of the Trade Passport Competition! To add a bit more of a challenge this year, there is a question at each stand taking part for you to get the answer to. It might be on the stand, about the company, or about the product…you’ll need to ask someone on the stand. Don’t be worried though, they love to talk! You’ll ﬁnd your entry form in your Congress Delegate bag. Once you have completed it, hand it to Nicky Windows at the Datesand stand by 12 noon on Thursday and you could be walking away with 1 of 2 Amazon vouchers. It’s as easy as that… so what are you waiting for! Also see page 85.Hartelust B.V.Phone: +31 13 4555189Email: info@hartelust.netWe proudly present our company as an important provider of non human primates for research only.Our animals are selected, monitored and shipped out right from the source, prior to our quarantine facilities in the Netherlands.From there they can be shipped to any destination worldwide. We have all permits to meet the regulations in the EU regarding quarantine and transport.Please feel free to contact us for your requirements and we will make a suitable offer to meet your protocol and individual wishes.

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GENERAL INFORMATIONGeneral Information10Education ‘Drop-In’ Sessions Wednesday and Thursday 10.30 – 11.00IAT FE and HE QualiﬁcationsAre you interested in developing your career?Or are you looking for some CPD opportunities?Maybe you just have some questions about the IAT qualiﬁcation system, or what the next step is for you?Whatever your query, come along to the Education ‘Drop-In’ Sessions and have a chat.The sessions will take place on the IAT stand (situated in the Trade Exhibition Hall) during the coffee break on Wednesday and Thursday mornings.Further details on all the IAT qualiﬁcations can be found on the IAT Education website www.iateducation.co.ukAdvice on recording your CPD at CongressContinuing Professional Development (CPD) demonstrates your commitment to your role in upholding the IAT ethical statement. By undertaking CPD you show that you are striving to improve your knowledge and keep up to date with new technologies and developments within the care and welfare of laboratory animals.The IAT CPD system is maintained online, via the members’ area of mySociety and we would encourage you to upload each activity as it is completed, rather than wait for the end of the year.Activities can fall under one of the ﬁve areas below:1. Work based learning2. Professional activity3. Formal/Educational4. Self-directed learning5. OtherWhen you select the area your activity falls under, you will also be shown various sub-categories for your activity. Once selected, this will allocate the appropriate number of points that can be claimed for each hour you have spent on your activity.Further details on the allocation of points can be found on the IAT website - https://www.iat.org.uk/cpd

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GENERAL INFORMATIONGeneral Information11LECTURES AND PAPERSThe Platform Programme will be held in the Queen’s Suite.Please refer to pages 34 and 59 within the Scientiﬁc programme section for information on the Paper presentations.The Kevin Dolan Memorial Lecture this year will be given by Tullis Matson FRAgs on Thursday at 16.15. The abstract for his paper, entitled The Living Biobank can be found on page 60. We are grateful to IPS for their generous sponsorship of the Kevin Dolan Memorial Lecture.WORKSHOPS Workshops will be taking place on Tuesday, Wednesday and Thursday and will have been pre-booked online prior to Congress.Everyone who has registered must conﬁrm their attendance at the Congress Reception.Reviews on each workshop and the presenters start on page 62.All workshops are IAT CPD credited.Improving the welfare of mice used in the study of ageingLinda Horan, Gillian Borland and Michael WilkinsonWhy, how and what happened next – an introduction to scientiﬁc writingJas BarleyBest practice in breeding laboratory miceHelen Bailey, Clive Da Costa and Antony HorwoodEnvironmental enrichment for laboratory ZebraﬁshChloe StevensTime to get schooled: an introduction to ZebraﬁshMollie MillingtonManaging aggression in laboratory animal speciesJoanna Stanley and Khia DobbinsonMaking the frame ﬁt the picture: how should we talk about animal research?John Meredith and Bella WilliamsCare-full stories? Introducing a training resource to explore the ‘Culture of Care’ from the perspective of different stakeholdersBeth Greenough and Reuben MessageHow to help your AWERB promote a Culture of Care – including caring for youPenny Hawkins

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GENERAL INFORMATIONGeneral Information12PRIZES AND AWARDS THE STEPHEN BARNETT FIRST TIME PRESENTERS’ SESSIONStephen has been involved with the IAT for many years as a training provider, examiner and advisor for the IAT qualiﬁcations. Many IAT members owe a great deal of gratitude to Stephen for his patience and commitment to their education.The IAT were very keen to recognise Stephen’s hard work and dedication. It was therefore decided that the First Time Presenter Session at Congress be named after him and hope this recognition will remind everyone of his tireless commitment to our Institute.Fellow colleagues wished to offer their support with these quotes. “Steve has always been an innovator in the ﬁeld of technical training and while at Paddington College in the early 1990s he established the BSc and MSc in Animal Technology, which was the ﬁrst degree-level qualiﬁcation for Animal Technologists. Though these courses subsequently ceased to exist due to changes in Government support for FE Colleges, they provided the springboard for many senior professionals involved in LAS&T.”“Steve continued to champion the need for radical reform of the Institute of Animal Technology (IAT) educational offering and because of Steve’s initiative in June 2007 the IAT became a recognised awarding body by QCA (now Ofqual) offering FE Level 2 and 3 qualiﬁcations. However, this was not enough as Steve recognised the need for Animal Technologists to study for HE qualiﬁcations, he worked in 2012 with Middlesex University to establish the HE Diploma and then in 2014 the BSc in Animal Technology. These has subsequently become the IAT Levels 4, 5 and 6 Diplomas, delivered by CLAST.”“Delighted to endorse this recognition of Steve’s tremendous educational achievements, the vast majority of which was purely in a voluntary unpaid capacity” “In addition to Steve’s outstanding professional successes, he remains a generous and caring individual, who puts others before himself.”Stephen W Barnett BA MSc DipLaw FRSB FIAT(Hon)Stephen Barnett spent the ﬁrst 18 years of his working life on the technical staff of the Royal Veterinary College, London. For the next 30 + years, he was involved in the education of Animal Technicians and Animal Technologists, ﬁrst as a senior lecturer at City of Westminster College and later as an independent Education Consultant. During this time he contributed to the development of Higher Education courses in Laboratory Animal Science and Technology for the IAT. He is editor of the book Introduction to Laboratory Animal Science, Technology and Welfare and The Manual of Animal Technology (second edition in preparation) and is also co-author of A Colour Atlas of Veterinary Anatomy: the Ruminants.Stephen Barnett is a Vice President and Honorary Fellow of the Institute of Animal Technology and previously was a Trustee of both the Animals in Science Education Trust (AS-ET) and the College of Laboratory Animal Science and Technology (CLAST).

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GENERAL INFORMATIONGeneral Information15BEST POSTER PRIZES An excellent variety of posters for you to browse through during the whole of Congress are being displayed in the Foyer of the Queen’s Suite.The award for best poster has been extended this year – one for the best poster on environmental enrichment and the other for the best scientiﬁc based poster.The two best posters are selected by a panel, nominated by the Congress Committee, who judges each poster according to criteria for best content, clarity and quality of science.The criteria covers: improvement in animal welfare, innovation, ease of replication of work, presentation and layout.Regular sponsors, LBS Serving Biotechnology have very kindly agreed to provide the two cash prizes of £250.00 each and the winners for both categories will be announced prior to Close of Congress on Thursday afternoon.All poster authors will be in attendance at their posters on Wednesday from 10.30 – 11.00 and on Thursday from 15.30 – 16.00 to answer questions from delegates.The Poster Presentations take place on Thursday starting at 12.30 in the Queen’s Suite. Two authors have agreed to present this year.Abstracts for all the posters appear on page 74 onwards.The winning Best Poster at last year’s Virtual Congress wasDevelopment of a feeding device to reduce reliance on ﬁeld trials to test novel poultry red mite controls by authors, Francesca Nunn, Kathryn Bartley and Alasdair Nisbet from the Moredun Institute, Edinburgh.Congress 2022Congress 2022BEST POSTER WINNER ON ENVIRONMENTAL ENRICHMENTBEST POSTER WINNERFOR SCIENTIFIC BASISBEST POSTER WINNERCongress 2021

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16 General InformationANDREW BLAKE TRIBUTE AWARD 2022We all have a responsibility for the welfare of the animals in our care and it is often the little things that make a signicant difference. The Andrew Blake Tribute Award is awarded by the Institute of Animal Technology and sponsored by The Association of the British Pharmaceutical Industry (the ABPI) to an Animal Technologist at any level, judged to have made a signicant contribution to improving laboratory animal welfare.The 2022 deserving winner is:Rosie Payne BSc (Hons)Faculty of Health & Medical Science University of SurreyFor her paper:‘Exploring environmental enrichment as a tool for assessing cognitive degeneration in ageing mice’ Rosie will present her paper on Thursday afternoon at 14.30.She will receive an engraved plaque and a total cash award of £250.00.ANDREW BLAKETRIBUTE AWARDANDREW BLAKETRIBUTE AWARD

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About the author:After completing her BSc (Hons) in Zoology, Rosie started working at the University of Surrey’s Biomedical Research Facility in 2016 as an Animal Technician where she worked with mice, rats, rabbits and voles. In 2018 she completed her IAT level 2 and soon after became a Licensed Animal Technician.Rosie is now one of the NACWOs at Surrey and enrichment is something she is passionate about improving. In fact, she is continually thinking of new enrichment ideas and how to better rene them!17General InformationANDREW BLAKE TRIBUTE AWARD 2022The Andrew Blake Tribute Award commemorates the work and life of Andrew Blake, who suffered from Friedrich’s ataxia, a hereditary condition described as one of the “worst of neurological diseases”. Andrew died in May 2002 aged 39. Andrew was passionate about the need to support scientists in their work and his commitment to speaking out against animal rights activists took up much of the last ten years of his life. He died shortly before he was to collect his MBE.For 2023, the application process is being reviewed. Further details will be published on the website, in IAT Bulletin and e-Newsletters.

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General Information18Animal Technology and WelfareMarjorie (Sandiford) Whittingham was a late arrival on Council in 1966 serving 11 years until she retired from work in the late 1970s. For the 7 years prior to her retirement, she was Secretary to the Institute and was also a Member of the Exam Board for all of those 11 years. Marjorie’s husband, Dick Whittingham and Council set up the prize fund after her untimely death in Kenya where they had retired to. The enormity of the amount of work that Marjorie completed during that period made her shorter service even more exceptional.Journal Article – Marjorie (Sandiford) Whittingham Prize 2021Paper AbstractMouse shelters can provide mice with security, help them thermoregulate, offer darkness to prevent damage to their eyes and enable climbing and gnawing opportunities. For laboratory mice, there is a vast array of commercially available cage furniture, so choosing which shelter to provide can be difﬁcult. We investigated whether an in-cage handling tunnel alone is sufﬁcient as a shelter or whether an additional cardboard tube or igloo shelter is beneﬁcial. Using 12 cages of adult C57BL/6 mice (5 x female, 7 x male), we conducted a repeated measures experiment, providing the handling tunnel alone or with a cardboard tube or with an amber dome in a randomised order for one week per cage. Cages also contained bedding, nesting material and a gnawing block. We observed that, compared with a handling tube alone, mice with the additional dome sheltered three times more (P<0.001), probably because the dome enabled more mice to simultaneously shelter. The dome signiﬁcantly reduced time spent using nesting material (P<0.001), so it may have partially substituted for nesting. Some mice used the cardboard tube less than expected by chance, implying that it reduced the useable space available to mice. When the cage was opened for handling, mice with a dome were less likely to spontaneously enter the handling tunnel (P<0.001), so the dome needed brieﬂy removing before tunnel-handling mice. The handling tunnel was not sufﬁcient as a shelter, and a shelter large enough for several mice to occupy it simultaneously should be additionally provided.The IAT Editorial Board, chaired by Jas Barley, has selected Charlotte Burns and Ria Popatas the 2021 winners of the Animal Technology and Welfare Journal Prizefor their paperA tunnel is not enough: mice beneﬁt from in-cage provision of a communal shelter as well as a handling tunnelpublished in the December 2021 issue Vol. 20.3 pp203-810 www.atwjournal.com

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19General InformationAuthors Charlotte BurnsCharlotte is the Associate Professor (Reader) in Animal Welfare and Behaviour Science at the Royal Veterinary College and she leads a BSc in the subject. She is a biologist and her research interests include the mechanisms and motivations behind animal behaviour, and how to make concrete improvements to animal welfare. She completed her DPhil on laboratory rat husbandry at Oxford University in 2006, before going onto a post-doc at Bristol and then joining the RVC as a Research Fellow in 2008. Her research covers diverse animal species but reﬁnement of animal research remains a key theme for her. She is a trustee of the BVA’s Animal Welfare Foundation charity and is the RVC’s Local Network Lead for the UK Reproducibility Network aiming to increase the robustness and validity of scientiﬁc practice.Ria PopatRia is currently undertaking an MSc at the University of Bristol in Global Wildlife Health and Conservation. She has a keen interest in behaviour and welfare and her latest project will look into the use of drones to optimise monitoring of green turtles in Western Australia. During her undergraduate degree at the Royal Veterinary College, she was awarded a project studentship by the University Federation of Animal Welfare (UFAW) to study the impact of different shelters on the welfare of laboratory mice with Dr Burn. Since then, the ﬁndings were published in Animal Technology and Welfare (ATW) Journal and Ria had previously presented them at the UFAW 2019 conference. Her shelter recommendations have been implemented as standard practice for RVC laboratory mice.A commemorative plaque and monetary gift of £250.00 will be awarded to the deserved winners at the Awards Ceremony taking place prior to Close of Congress on Thursday afternoon in the Queen’s Suite.Animal Technology and Welfare

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General Information20IAT LIFE MEMBER Life Membership is the highest accolade awarded by the Institute and is given in recognition of especially long and valuable service to the Institute. Council may elect any person but only one Life Member is created in any calendar year.The presentation for this award has been postponed since nomination in July 2020 due to the COVID-19 pandemic and will take place at the AGM on Tuesday evening.Ken Applebee OBE FIAT FRSBKen is currently the CEO of Applebee Advisory, which specialises in vivo management solutions.After starting as a Junior Animal Technician in 1972 aged 15, Ken had a long and successful career in managing research animal facilities, including a ten-year tenure as Director of Biological Services at King’s College London.Ken’s current professional activities include Chair of the Board of Trustees College of Laboratory Animal Science and Technology (CLAST) and is a founding Trustee of Animals in Science - Education Trust (AS-ET).Ken was ﬁrst elected to IAT Council in 1980 and served on the Examination Board, stepping down four years later due to work commitments.Elected again to Council in 1991, he acted in various roles including Membership Secretary, Honorary Secretary, Chair of the CPD Board, Board of Educational Policy and the Registration and Accreditation Board. Ken also served two terms as Chair and CEO of Council totalling nine years, before stepping down as a Council member in 2019.For six years until May 2019, Ken was a specialist member of the UK Government’s Animals in Science Committee, including Deputy Chair of the Project Licence Application Subgroup.Ken’s ongoing major interest is the provision and development of education and training for laboratory animal care staff, for which in 2014, he was made an Ofﬁcer of the British Empire, for services to Animal Technician Education and Animal Technology.

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General Information21IAT HONORARY MEMBER IAT Council may nominate an Honorary Member at the Annual General Meeting, subject to prior approval. Any person, who in the opinion of Council, has subsequently furthered the interests of the Institute can be proposed and once nominated, the recipient will be invited to Congress to receive their award. The period of election is ﬁve years.The presentation for this award has been postponed since nomination in July 2020 due to the COVID-19 pandemic and will take place at the AGM on Tuesday evening.Stuart Mackrell FIAT RAnTechStuart has acquired over ﬁfty-years’ experience as a technician, manager and advisor within the Animal Technology industry. He has been an active member of the Institute throughout his career, having been a committee ofﬁcial of four Branches in various positions, including Chair of Surrey, Hampshire and Sussex.Stuart also served on IAT Council for six years, four of them as Promotions Ofﬁcer. He has been involved with the training of technicians and promotion of the IAT in all his managerial posts.He started his career in the late 1960s as a junior Animal Technician at HLS (now Invito) where he progressed to the position of Chief Technician. He was involved in the introduction of GLP and a Technician Training Programme. Also during this time he gained his Fellowship (FIAT).Further career moves over twenty years saw Stuart working at GD Searle as Animals Facilities Supervisor, Senior Manager at GlaxoSmithKline (GSK) and as Head of Animal Care Services at the Animal Plant and Health Agency (APHA) - then known as VLA – during this time he co-assisted setting up an in-house IAT intermediate course. From 2014, until he retired in 2020, he worked as Animal Services Advisor at The Pirbright Institute (TPI) with the building project team on a new animal facility, including an SPF poultry facility and SAPO4 buildings.In 2021 he joined CCTech as Associate Director Biocontainment.

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General Information25Call for nominations now open for the popular2022 AAALAC International Fellowship UK AwardIf you are an IAT Registered Technologist (RAnTech) apply by 1 June 2022The AAALAC International Fellowship recognises two outstanding individuals – one IAT Registered (RAnTech) and one AALAS or CALAS (Canada) Registered (RALAT, RLAT, RLATG, CMAR, ARLAT, RMLAT) – who have made (or have the potential to make) signiﬁcant contributions to the ﬁeld of laboratory animal care and use. This Fellowship is valued at more than £3,000. The UK winner will receive a week-long guest visit to prestigious biomedical research facilities in the USA this Autumn, plus complimentary attendance at the National AALAS Meeting, the USA’s largest laboratory animal science and technology meeting being held in Louisville, Kentucky. All registration, travel, accommodation, meals and out-of-pocket expenses are covered (receipts are required).TO APPLY:1. Write a brief letter nominating yourself (or have someone write this letter on your behalf). 2. Include a 500-word written statement describing why you should be selected. 3. Include a copy of your CV. 4. Include no more than three letters of support. TIPS:Be sure to address these points in your application… – What have you done to promote animal welfare and reﬁnement in your workplace? (i.e. involvement in AWERB, training others, advising on reﬁnement, etc) – What have you done to promote animal welfare and reﬁnement outside of your workplace? (i.e. IAT activities, school visits, public presentations, etc) – How have you shared your knowledge of laboratory animal care with others? (i.e. lectures, posters, workplace projects, etc) – If you are selected, how will this award beneﬁt your career and your associates? – How will you translate this experience back to your workplace and your local association? – Does your package include evidence of leadership or leadership potential and participation with posters, presentations or publications? – Based on your experience, what role does AAALAC International play in ensuring the humane treatment of animals in science? Describe your interactions with AAALAC International (e.g. participated in a visit, helped prepare your organisation/workplace for a site visit, reviewed the information on the AAALAC International website such as the FAQs, position statements, newsletters, attended an AAALAC presentation, etc)? – Have you participated in overseas meetings in the past?Awardees are expected to share their experiences brieﬂy by preparing a written report for AAALAC International and a full report for publication in the IAT Bulletin.Awardees are also expected to communicate their experiences to peers by presenting at a local or national conference (i.e. branch meeting or Congress). Apply online www.aaalac.org/awards/fellowship.award/ 1 June 2022 If you have any questions email: fellow@aaalac.orgFor complete details and a list of selection criteria, visit www.aaalac.org. Receipt of application will be conﬁrmed by email to candidates by 7th June 2020. If you have not received conﬁrmation or have any questions about this award, please call +301.696.9626 or email fellow@aaalac.org.The AAALAC International Fellowship Award is presented by AAALAC International through grants from Priority One Services, Inc., and Datesand Group Ltd, in cooperation with AALAS, IAT, MRC and NIH.Don’t delay get your application in now!Individuals interested in applying for the Fellowship Award are expected to consider both real (i.e., ﬁnancial or other personal or professional considerations, such as employment at AAALAC International, Priority One Services, Inc. or Datesand Group Ltd) and perceived (i.e., an appearance of being at an advantage) conﬂicts of interest before submitting their applications. Questions regarding a potential conﬂict of interest may be directed to the AAALAC international Chief Executive Ofﬁcer, Dr. Kathryn Bayne (kbayne@aaalac.org).

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GENERAL INFORMATIONGeneral Information26AAALAC International Fellowship AwardJohn Waters BSc (Hons) MIAT RAnTech – 2019 UK recipient At the time of winning the Fellowship, John served as Chief Animal Technician and Named Animal Care and Welfare Ofﬁcer (NACWO) for the Mammalian Evolution and Behaviour Group at the University of Liverpool. There he has been instrumental in implementing and promoting an exceptional “Culture of Care” at a facility that houses both laboratory species and wild animals, and is known for its research within the areas of chemical communication, reproductive strategies and animal welfare. John assisted in the daily management of the facility, including ensuring high standards of animal care and welfare through continuous communication and interaction with all registered departmental users including staff, Home Ofﬁce Licensees, Facilities Management personnel, the Laboratory Animal Health Ofﬁce and the Home Ofﬁce Inspectorate. Prior to joining the Mammalian Evolution and Behaviour Group, he worked with animal facilities at the Liverpool School of Tropical Medicine and the Medical School at the University of Liverpool.John is a long-time member of the IAT and author of numerous presentations on tail-free mouse handling. He has been a pivotal ﬁgure in promoting and training other facilities in the correct implementation of welfare practices, for which he received the Andrew Blake Tribute Award in 2017.A full account of his two week experience as the 2019 UK AAALAC Fellowship recipient in America during October 2019 was published in the February 2020 issue of IAT Bulletin (56.2). Also in 2020 John received the prestigious Times Higher Education Outstanding Technician award.He now works at Impex Services International in the role of Business Development Manager and currently sits on IAT Council and is a member of the Congress Committee and EDI Group.

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GENERAL INFORMATIONGeneral Information27Kelly S. Patterson, MLAS, CMAR, RLATG – 2020 USA recipient Due to lockdown being implemented across the UK in March 2020, Kelly’s intended two week visit was unable to take place. We are therefore delighted to welcome her to Yorkshire. She joins us having spent a week touring our UK biomedical host facilities Kelly hails from New Jersey and at the time of winning this award served as Director, Vivarium Operations at PsychoGenics Inc., in Paramus, where she oversaw the day-to-day vivarium operations including the management of the supervisors, animal care and cagewash technicians. Additionally, she was active in onsite AALAS training for staff, manages ﬁscal resources, and assists with the animal care and use programme in the AAALAC accredited facility.Kelly now works for LabCorp, making the change in February 2021 and working in the Early Development Division, her ofﬁcial title is Manager II – Rodent Toxicology and Sample Processing.Prior to her current position, Kelly was a founding director for the vivarium at Montclair State University in New Jersey, and was also an Adjunct Professor. She also worked for Purdue Pharma, L. P. and Columbia University.She received her Master’s in Laboratory Animal Science from Drexel University of Medicine in Philadelphia and has co-authored numerous publications on gastric cancer research. Kelly is an active member in the New Jersey Branch of AALAS, where she has served as President, Chair of Education and on the Board of Trustees. She is also an active member of LAWTE, National AALAS PRIM&R AND NJAALAS and has served on the Educational Resource Committee, as well as being an active member of Laboratory Animal Management Association (LAMA) where she held the ofﬁces of Membership Committee Chair and was on the Board of Directors. Kelly is the recipient of the John Savarino Memorial Scholarship Award, Outstanding Contribution and Enhancement or Improvement of Animal Welfare, awarded by New Jersey AALAS. At 15.00 on Thursday, she will present her paper ‘Reﬂections of 30 years in laboratory animal science’. We hope you will all come along and support her.AAALAC International Fellowship Award

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General Information29NOTICE OF AGMTHIRTY-SIXTH ANNUAL GENERAL MEETING OF THE INSTITUTE OF ANIMAL TECHNOLOGYTo be held Tuesday 29th March at 18.00 in the Queen’s SuiteAGENDA1. Apologies for absence2. To consider the minutes of the thirty-ﬁfth Annual General Meeting held virtually on Tuesday 9th March 20213. Matters arising from the Minutes (as published in full on the Members’ section of the IAT website and in abridged form in the Bulletin Vol. 57 No. 6).4. Correspondence5. Annual Report / Council Objectives6. Financial Report7. Appointment of the Auditor 8. Election of Ofﬁcers: (i) President (ii) Vice Presidents (iii) Council 9. Proposals for Honorary and Life Memberships10. Any other businessTHE AGM IS OPEN TO ALL DELEGATESVoting rights are restricted to voting members only1 Ken Applebee2 Steven Cubitt3 Simon Cumming4 Haley Daniels5 Glyn Fisher6 Linda Horan7 Elaine Kirkum8 Tina O’Mahony9 Toby SandersCOUNCIL ELECTIONS 2022As there were nine nominations for the nine vacancies on Council, no ballot took place and therefore the following were elected to serve on Council for a three year term as from May 2022.Linda HoranCEO & Chair of CouncilSimon Cumming Honorary Secretary

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AS-ET is extremely grateful and appreciative to be chosen, once again, to beneﬁt from the IAT Congress Rafﬂe.We would like to thank the North East Branch for organising it, all the Branches for donating prizes and ALL OF YOU for buying tickets.By awarding bursaries to enable individuals to attend courses to improve their own knowledge and skills, directly leading to ever improving standards of animal welfare, AS-ET has also awarded grants to support research projects and the development and provision of short courses and educational meetings.To date, our bursary applicants have beneﬁtted from around £100,000 in grants to support their education and welfare activities, but we are entirely dependent on funds donated from those employed in or having an interest in Animal Technology.2022 CHARITY NOMINATED BY THE NORTH EAST BRANCHwww.animalsinscienceeducationtrust.org.ukAS-ET is a charity that has the objective of advancing education and promoting excellence in the care and welfare of animals used in science Emma Tozer, Smith & NephewThe John Walton Prize for Level 6, 2020Gemma Dykes, King’s College London AS-ET/West Middlesex Prize for Level 4, 2020

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Patron: Professor Lord Naren Patel KT Chair of Trustees: Professor Sir Richard Gardner FIAT (Hon) FRS Secretary to the Trust: Ken Applebee OBE FIAT FRSBTrustees: Jasmine Barley MSc FIAT RAnTech, Charlie Chambers MIAT, Karen J Gardner, Wendy Steel BSc (Hons) FIAT Registered Charity Number 1133119Registered Ofce: 5 South Parade, Summertown, Oxford OX2 7JLSTOP PRESS ……Due to the on-going humanitarian crisis in the Ukraine and following representations by the AS-ET Board of Trustees, it has been agreed by the Branches that the proceeds from the Branch Rafﬂe will be donated to the Disasters Emergency Committee (DEC) for their Ukraine appeal. More than a million people have ﬂed their homes to escape the conﬂict in Ukraine. Heavy ﬁghting, shelling and air strikes across the country have had devastating consequences for ordinary people. At Ukraine borders with Poland, Romania, Hungary, Slovakia and Moldova, huge numbers of people are arriving with only what they can carry. DEC charities and their local partners are in Ukraine and neighbouring countries providing food, water, shelter and medical assistance.Please support this very worthy cause by purchasing rafﬂe tickets for the Branch rafﬂe.Tickets will be on sale throughout Congress, with the draw taking place on Thursday lunchtime.Thank YOU for your supportBusi Mogodi, University of CapetownBRET Scholarship, 2021

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GENERAL INFORMATIONGeneral Information32CONGRESS BADGESIt is important that you wear your badge at all times within the conference venue. You will not gain access to the Exhibition Hall, Papers, Posters and Workshops if you are not wearing it. Please also make sure you are wearing it at meal times and for all of the social events. If you are not wearing it admittance will be refused.We do however recommend you remove your badge when you leave the conference venue but please remember it for evening functions.If you lose your badge, please report your loss immediately to a member of the Congress Committee.MOBILE PHONES AND PAGERSOut of courtesy to speakers and other delegates, pagers and mobile phones must be switched off or put on non-audible alerts BEFORE entering the main lecture theatre and the areas hosting the posters and workshops.Mobile phones and mobile phone cameras MUST NOT be used in any of the scientiﬁc sessions at Congress.ENQUIRIESIf you have any questions or comments regarding Congress, please direct them to the Congress Reception.

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General Information33IAT BRANCHESYOUR BRANCH NEEDS YOU - COME ALONG AND GET INVOLVED If you don’t know about the IAT Branches, or if you do but would like to ﬁnd out more, come along and meet some Branch members. Our Branches are only able to function with your involvement.They will be in attendance at the IAT Branch poster displayed in the Queen’s Suite Foyer at the following times:Wednesday:10.30 – 11.00 / 13.00 – 13.30 / 16.00 – 16.30 Thursday:10.30 – 11.00 / 13.00 – 13.30The IAT Branch Map will also be on display to help you decide which Branch is right for you.Branches are always keen for people to join the Branch Committees, but just as happy for enthusiastic members to join the Branch.Please support your local Branch – we need you!CambridgeHuntingdon,Suffolk and NorfolkSurrey, Hampshireand Sussex LondonWest Middlesex North East of EnglandNorth Westof EnglandMidlandsEdinburghWest of ScotlandIreland AberdeenOxford Wales andWest CountryInstitute of Animal TechnologyIAT BRANCHES

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Scientiﬁc Programme34TIME TUESDAY 29th MARCH10:00Registration Opens – Congress Reception – Foyer Queen’s Suite14:00Improving the welfare of mice used in the study of ageingWhy, how and what happened next – scientiﬁc writingBest practice in breeding laboratory miceEnvironmental enrichment for laboratory ZebraﬁshTime to get schooled: an Introduction to Zebraﬁsh14:3015:0015:3016:0016:30Enrich it! A collaborative game design session – Room 2 Queen’s SuiteIce Breaker – Meet at Congress Reception17:0017:3018:00 AGM – Queen’s SuiteTIME WEDNESDAY 30th MARCH09.00 – 09.05 Opening AddressPoster Displays Foyer Queen’s Suite09.05 – 09.25 TSBFTPS Claire Dobinson – The use of ultrasound imaging as a reﬁnement to early detection …09.25 – 09.45 TSBFTPS Claire Pearce – Adverse affects of adverse effectsTrade Exhibition09.45 – 10.05 TSBFTPS Theo Issitt – Breath sampling in mice: reducing stress for optimal results10.05 – 10.30 Flash Trade Presentations10.30 – 11.00Refreshments – served in Exhibition Hall Poster Authors in attendance – Queen’s Suite Foyer11.00 – 11.30Helen Emery – Deﬁning a good Culture of CareImproving the welfare of mice used in the study of ageingEnvironmental enrichment for laboratory ZebraﬁshManaging aggression in laboratory animal speciesMaking the frame ﬁt the pictureTime to get schooled: an Introduction to Zebraﬁsh11.30 – 12.00Pete Willan – Procurement planning12.00 – 12.30Steven Cubitt – The low carbon animal facility12.30 – 13.00Karen Petersen – Controlling relative humidity13.00 – 14.00Lunch – Dining Area Hall C14.00 – 14.30Targeted Supplier – Animal rights extremistsBest practice in breeding laboratory miceMaking the frame ﬁt the pictureCare-full stories: Culture of Care training resourcesHow to help your AWERB14.30 – 15.00Wendy Jarrett – Animal rights activism15.00 – 15.30Mark O’Neill – Personal security15.30 – 16.00Simon Breeden – Technician Commitment16.00 – 16.30Refreshments – served in Exhibition Hall16.30 – 17.00Graham Goodfellow - How little we knew17.00 – 17.30Isaac Johnson – Pre-clinical cancer researchAT A GLANCE FULL PROGRAMME

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Scientiﬁc Programme35TIME TUESDAY 29th MARCH10:00Registration Opens – Congress Reception – Foyer Queen’s Suite14:00Improving the welfare of mice used in the study of ageingWhy, how and what happened next – scientiﬁc writingBest practice in breeding laboratory miceEnvironmental enrichment for laboratory ZebraﬁshTime to get schooled: an Introduction to Zebraﬁsh14:3015:0015:3016:0016:30Enrich it! A collaborative game design session – Room 2 Queen’s SuiteIce Breaker – Meet at Congress Reception17:0017:3018:00 AGM – Queen’s SuiteTIME WEDNESDAY 30th MARCH09.00 – 09.05 Opening AddressPoster Displays Foyer Queen’s Suite09.05 – 09.25 TSBFTPS Claire Dobinson – The use of ultrasound imaging as a reﬁnement to early detection …09.25 – 09.45 TSBFTPS Claire Pearce – Adverse affects of adverse effectsTrade Exhibition09.45 – 10.05 TSBFTPS Theo Issitt – Breath sampling in mice: reducing stress for optimal results10.05 – 10.30 Flash Trade Presentations10.30 – 11.00Refreshments – served in Exhibition Hall Poster Authors in attendance – Queen’s Suite Foyer11.00 – 11.30Helen Emery – Deﬁning a good Culture of CareImproving the welfare of mice used in the study of ageingEnvironmental enrichment for laboratory ZebraﬁshManaging aggression in laboratory animal speciesMaking the frame ﬁt the pictureTime to get schooled: an Introduction to Zebraﬁsh11.30 – 12.00Pete Willan – Procurement planning12.00 – 12.30Steven Cubitt – The low carbon animal facility12.30 – 13.00Karen Petersen – Controlling relative humidity13.00 – 14.00Lunch – Dining Area Hall C14.00 – 14.30Targeted Supplier – Animal rights extremistsBest practice in breeding laboratory miceMaking the frame ﬁt the pictureCare-full stories: Culture of Care training resourcesHow to help your AWERB14.30 – 15.00Wendy Jarrett – Animal rights activism15.00 – 15.30Mark O’Neill – Personal security15.30 – 16.00Simon Breeden – Technician Commitment16.00 – 16.30Refreshments – served in Exhibition Hall16.30 – 17.00Graham Goodfellow - How little we knew17.00 – 17.30Isaac Johnson – Pre-clinical cancer researchAT A GLANCE FULL PROGRAMMEEvents Trade Sessions WorkshopsPresentationsKEY

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Scientiﬁc Programme36AT A GLANCE FULL PROGRAMMETIME THURSDAY 31st MARCH09.00 – 09.30Will Reynolds, ASRU - Home Ofﬁce Update and Q&A SessionPoster Displays Foyer Queen’s Suite09.30 – 10.00Trade Exhibition10.00 – 10.30Steven Trim – Veterinary care of invetebrates10.30 – 11.00Refreshments – served in Exhibition Hall11.00 – 11.30Joanne Mains – The evolution of the rat playroomWhy, how and what happened next – scientiﬁc writingManaging aggression in laboratory animal speciesCare-full stories: Culture of Care training resourcesHow to help your AWERB11.30 – 12.00Gary Stephens – Creating antibodies from llamas12.00 – 12.30Linda Horan – Setting up a CEF12.30 – 13.00Poster Presentations13.00 – 14.00Lunch – Dining Area Hall C14.00 – 14.30Vanessa Ashall – Managing moral stress14.30 – 15.00ABTA 2022 - Rosie Payne – Exploring EE15.00 – 15.30AAALAC Fellowship – Kelly Patterson - Reﬂections15.30 – 16.00Refreshments – served in Exhibition Hall Poster Authors in attendance – Queen’s Suite Foyer16.00 – 16.30KDMLTULLIS MATSON – THE LIVING BIOBANK16.30 – 17.0017.00 – 17.30Awards Ceremony and Close of Congress

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Scientiﬁc Programme37AT A GLANCE FULL PROGRAMMETIME THURSDAY 31st MARCH09.00 – 09.30Will Reynolds, ASRU - Home Ofﬁce Update and Q&A SessionPoster Displays Foyer Queen’s Suite09.30 – 10.00Trade Exhibition10.00 – 10.30Steven Trim – Veterinary care of invetebrates10.30 – 11.00Refreshments – served in Exhibition Hall11.00 – 11.30Joanne Mains – The evolution of the rat playroomWhy, how and what happened next – scientiﬁc writingManaging aggression in laboratory animal speciesCare-full stories: Culture of Care training resourcesHow to help your AWERB11.30 – 12.00Gary Stephens – Creating antibodies from llamas12.00 – 12.30Linda Horan – Setting up a CEF12.30 – 13.00Poster Presentations13.00 – 14.00Lunch – Dining Area Hall C14.00 – 14.30Vanessa Ashall – Managing moral stress14.30 – 15.00ABTA 2022 - Rosie Payne – Exploring EE15.00 – 15.30AAALAC Fellowship – Kelly Patterson - Reﬂections15.30 – 16.00Refreshments – served in Exhibition Hall Poster Authors in attendance – Queen’s Suite Foyer16.00 – 16.30KDMLTULLIS MATSON – THE LIVING BIOBANK16.30 – 17.0017.00 – 17.30Awards Ceremony and Close of CongressAT A GLANCE FULL PROGRAMMEEvents Trade Sessions WorkshopsPresentationsKEY

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BioFlex® Isolators > High Quality> Expert Knowledge> Experience> Innovation> Latest Technology> Reliability> Design Flexibility> Specialise in Bespoke Designs> Flexible Film, Semi-Rigid or Fully-Rigid Designs> Large Animal Isolator DesignsBell Isolation Systems lead the way in the design and manufacture of high quality flexible film and rigid isolators using the latest materials and technology, coupled with over forty years of innovation developing standard, customised and bespoke products.Contact for further information:Bell Isolation Systems LtdUnit 12a, Oakbank Park WayLivingston EH53 0THScotland, UKTelephone: +44 (0) 1506 442916Fax: +44 (0) 1506 440780Email: info@bell-isolation-systems.comWebsite: www.bell-isolation-systems.comInnovative solutions for laboratory animal containment

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39Scientiﬁc ProgrammeCPD WORKSHOP SESSIONS AND MAIN PROGRAMMETuesday 29th March14.00 – 15.30WORKSHOPSImproving the welfare of mice used in the study of ageing – details on page 62.Why, how and what happened next: an introduction to scientiﬁc writing – details on page 64.Best practice in breeding laboratory mice – details on page 66.Environmental enrichment for laboratory Zebraﬁsh – details on page 68.Time to get schooled: an introduction to Zebraﬁsh – details on page 69.16.30 – 17.30Room 2 Queen’s SuiteEnrich it! A collaborative game design sessionThis prototype Tetris-style, tabletop game, asks players to add enrichment items to a cage. The ﬁnite space on the board means players must think about each enrichment item and prioritise. Players then look at the cage with certain prompts, e.g. is there food and water? Is there enough space to move around? Can you see into the cage? What are the labour implications? What are the welfare implications? This 60-minute session will act as a play test and provide an opportunity for you to provide feedback and add to the content and design. This will form part of the Animal Research Nexus public engagement portfolio. The ﬁnal version will be freely available for anyone to use for outreach, engagement, and educational purposes. Other initiatives produced by the Animal Research Nexus include Psychic Fish and The Mouse Exchange.Bentley CrudgingtonCreative FacilitatorAnimal Research Nexus, University of Manchester Bentley is a creative practitioner working at the interface of human, animal and environmental health. Originally trained and working within veterinary and biomedical science, they have since transitioned out of laboratory research into creative facilitation. Their main motivation has been to address the culture of communication around animal research and reimagine who could inform these discussions and how it might feel to participate. By diversifying and investing in the culture of communication, the sector can get a deeper and more nuanced understanding of societal concerns and begin working to collectively address them. Their work varies from large scale immersive theatre to intimate one-on-one discussions between two people. These activities differ in form and methods, but they foreground the conversation as the unit of exchange, and by centring care and ethics, help people have difﬁcult and normally private conversations publicly.

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Scientiﬁc Programme40PAPER PRESENTATIONS AND MAIN PROGRAMME16.30Ice Breaker SessionMeet at Congress Reception 18.00 – 19.0036th Annual General MeetingHeld in the Queen’s SuiteAn agenda appears on page 29.SCIENTIFIC PROGRAMME QUEEN’S SUITEWednesday 30th March09.00 – 09.05OPENING OF CONGRESSAlan GrahamChair IAT Congress Committee Alan has been a career Animal Technologist since he started work as a junior Animal Technician at the Royal College of Surgeons in 1978. He has worked with an extremely wide variety of species including some exotics, mainly within academia. Alan also has some zoo experience with big cats and venomous snakes, which came about when he managed the Isle of Wight Zoo for a few years back in the 1980s.He now holds a Senior Management position within Cambridge University as one of the Deputy Directors for Facilities and Operations and over his 30 years at Cambridge he has held several different positions under Animals (Scientiﬁc Procedures) Act 1986. He was actively involved in the local animal welfare and ethical review process (AWERB) and the recruitment and retention of Animal Technologists within the University, promoting good practice and continued professional development within the workplace.He is currently involved with a couple of local animal management colleges offering work experience placements for young people looking to work with animals in science as a career.Since early on in Alan›s career he was actively involved with the IAT and when working in London was the Branch Secretary for several years, and was subsequently the Chairman of the Cambridge Branch for seven years following his move to Cambridge in 1992. He has held several positions on the IAT Council including Branch Liaison Ofﬁcer, and was the registrar for our annual conference for many years, and is now as Chair of the Congress Committee, responsible for the sourcing of new venues and the general organisation of what is the largest laboratory animal conference in the UK. This gives him great personal satisfaction when it all comes together, providing the membership and trade with an informative, interactive and safe meeting.“Very pleased to get back to a “Face 2 Face” Congress and see friends and colleagues in the ﬂesh.”

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Scientiﬁc Programme42PAPER PRESENTATIONS AND MAIN PROGRAMMEChair: Stephen W Barnett, Vice President, Institutue of Animal Technology09.05 – 10.05THE STEPHEN BARNETT FIRST TIME PRESENTERS’ SESSION09.05 – 09.25The use of ultrasound imaging as a reﬁnement to early detection of neuroblastoma in mice and orthoptic injection techniquesImaging modalities in cancer studies offer signiﬁcant 3Rs beneﬁts. We use portable ultrasound imaging for a number of procedures that would otherwise be more invasive and less accurate. In this presentation I compare the use of Ultrasound with MRI and palpation in the early detection of neuroblastoma in transgenic mice together with the reﬁnements offered when conducting orthotopic intracardiac injections. We have demonstrated that Ultrasound imaging can be a fast, efﬁcient and non-invasive tool to help in the reﬁnement of procedures. Claire DobinsonBSU and Study ManagerInstitute of Cancer Research Claire started her career in 2001 at St George’s Hospital Medical School, South London as a trainee Animal Technician.Over 21 years’ she has gained her MIAT, is a PIL holder and now a NACWO. She is currently directly responsible for the PDX programmes for Paediatric and Prostate Cancer work in the facility. She also oversees ‘isolator’ work for Sir Mel Greaves research for childhood leukaemia, whilst managing a well skilled and experienced BSU team. Claire’s main passion is surgery and procedural work and she has extensive experience in numerous aseptic techniques required for surgery as well as regulated procedures which she carries out on a daily basis. As the BSU unit is based in the centre of cancer imaging, she has a great deal of involvement in imaging techniques, MRI, IVIS, ultrasound, SARRP, as well as input into the work carried out.09.25 – 09.45Adverse affects of adverse effects Within the majority of animal research facilities there will be occasions when a project Standard Condition 18 report needs to be submitted if the severity limits speciﬁed in the licence, or other controls stated, have been, or are likely to be breached. For example, breaches may occur if a new transgenic line exhibits an unknown phenotype that was not accounted for in the PPL, or if death has unexpectedly occurred as a direct result of a scientiﬁc procedure. Adverse effects are often experienced in research studies but at the time of publishing the results, they are rarely mentioned. The ARRIVE Guidelines 2.0 recommend detailing scientiﬁc implications of a study, including adverse effects, but this is not part of the essential 10 areas that should be covered in a publication. By sharing the unexpected adverse events more widely in the research community there is the opportunity to reﬁne techniques, thereby reducing the number of animals used and the potential pain, distress and lasting harm they may experience. This talk will address how research facilities could encourage the research community to share the unexpected adverse events they have encountered and how they overcame them to successfully meet the scientiﬁc aims and objectives of their research.

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Scientiﬁc Programme43PAPER PRESENTATIONS AND MAIN PROGRAMMEClaire PearceBSU ManagerKing’s College London Claire’s career within Animal Technology has spanned over 17 years. She has worked with a whole variety of animals from rodents and Zebraﬁsh to marmosets. Research ﬁelds she has supported include pain, cancer, neurodegeneration and spinal cord injury, amongst others.Starting as a trainee technician and progressing to her current role as facility manager, Claire has used the IAT Career Pathway of qualiﬁcations and is currently completing Level 6. In recent times Claire has managed facility refurbishments and coordinating the relocation of research groups from other institutions.Claire has always had a passion for advancement in our ﬁeld, particularly in terms of the 3Rs and welfare. Using her vast experience of research models and welfare impacts, her goal is the reﬁnement of scientiﬁc procedures through increased awareness of welfare impacts.09.45 – 10.05Breath sampling in mice: reducing stress for optimal results Stress is intrinsically linked to respiratory function and alterations to breathing and lung architecture present immediately in the gases released. Because of this, animal handling, environment and any other factor affecting stress needs to be considered when researching the compounds found in breath. Therefore the use of animals for breath biomarker research must reduce stress for direct implications upon immediate results. This in turn affects scientiﬁc reproducibility, translatability in addition to ethical and welfare concerns. This talk will discuss how these challenges have been overcome through specialist chambers and methodological approaches to discover new biomarkers in the breath of mice bearing tumours. These biomarkers can then be discovered in the breath of humans to provide fast, non-invasive diagnostic tests.Theo IssittPhD StudentUniversity of York Theo Issitt has spent the majority of his career split between business development and scientiﬁc research and is currently researching breath biomarkers at the University of York. His previous research has focussed on mitochondrial dynamics in cardiovascular and respiratory biomedical research at Imperial College and live cell imaging at the Institute of Cancer Research. After taking a few years out of science as a musician, his passion for science brought him back to research and a PhD. A wide and varied research path has led to an interest in how breath can tell the story of our bodies.

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Scientiﬁc Programme44PAPER PRESENTATIONS AND MAIN PROGRAMME10.05 – 10.30FLASH TRADE PRESENTATIONSSee page 84 for a running order of companies participating.Our ever popular Flash Trade Session will see 21 of our trade partners present in just ONE minute. This is an ideal opportunity to tell you about their latest products and innovations and invite you to their Exhibition stand.10.30 – 11.00Refreshments served in Hall C Dining Area11.00 – 12.30Chair: Wendy Steel, Trustee, Animals in Science - Education TrustWORKSHOPSImproving the welfare of mice used in the study of ageing – details on page 62.Managing aggression in laboratory animal species – details on page 70. Environmental enrichment for laboratory Zebraﬁsh – details on page 68.Time to get schooled: an introduction to Zebraﬁsh – details on page 69.Making the frame ﬁt the picture: how should we talk about animal research – details on page 71.PAPER PRESENTATIONS11.00 – 11.30Deﬁning a good Culture of Care in an animal research facility and how this is translated into organisation practices Culture of Care forms part of the regulatory requirements under Animals (Scientiﬁc Procedures) Act 1986 (ASPA) and has been under discussion for some time in animal research facilities in the UK. This talk identiﬁes gaps by explaining a Culture of Care in the context of an academic animal research facility, understanding what could be learnt from health care organisations Culture of Care and the translation into organisational practices. A deﬁnitive description of ten organisational practices that inﬂuence organisations to be compliant has been identiﬁed. The support that Named Persons working under ASPA require from their organisation identiﬁes how they can demonstrate effective working and the promotion of Culture of Care. A theoretical training framework for all stakeholders supports them to understand their own responsibilities, contributing towards compliance and supporting the organisational vision and mission statement. Introducing two additional ‘Rs, Responsibility and Respect, provides a signiﬁcant link between the animal and stakeholders, thus identifying the organisational behaviour expected. Deﬁning a Culture of Care should involve the contribution of all stakeholders and provides animal research facilities with a deﬁnitive outline of how to deﬁne their own Culture of Care.

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Scientiﬁc Programme45PAPER PRESENTATIONS AND MAIN PROGRAMMEHelen EmeryOperations ManagerUniversity of Leicester Helen Emery has worked within the Division of Biomedical Services at the University of Leicester for 8 years. She is the Operations Manager and holds the roles of Home Ofﬁce Liaison Contact (HOLC), Named Training and Competency Ofﬁcer (NTCO) and Named Information Ofﬁcer (NIO). Helen has just completed her Master’s degree in Business Administration which she studied at the University of Leicester. Her dissertation was to deﬁne a Culture of Care within an animal research facility. Helen decided to draw on the health care sector’s Culture of Care practices and translate her research ﬁndings into organisational practices. The recommendations from Helen’s research have been presented to the Animal Welfare and Ethical Review Body (AWERB) at Leicester who agreed to formulate actions and plans for implementation. Helen continues to promote her research across the University and has had the opportunity to present to other organisations. Culture of Care is her passion and she hopes to promote her research more widely across the research sector supporting managers and organisations. A good Culture of Care equates to quality animal welfare and scientiﬁc output.11.30 – 12.00Procurement planning in laboratory animal facilitiesAnimal Care Technicians, may be thinking... this doesn’t really affect me. However for many Animal Technologists and veterinarians whose careers eventually develop into a facility senior and/or management position, procurement can, and usually does, become a fundamental part of their roles, often with little, or no formal training or an understanding of the implications and responsibilities involved in the procurement process. Whether it’s buying some stationary for the ofﬁce, diet and bedding for the animals, or small and major equipment purchases, they may be responsible for spending many thousands of £GBP or in the case of Facility Design and Build, many millions of £GBP.This presentation will outline some of the processes involved, with a case study and potential training options.Pete C Willan Senior LAS Business ConsultantCastium Ltd Pete has been employed in a laboratory animal care and welfare and management role for 52 years, in both academia and pharmaceutical facilities, and more recently at Castium Ltd. Establishing a career as an Animal Technician through to Facility Manager, he was extensively involved in developing animal care and welfare, training and the design, relocation, planning and refurbishment of facilities and the design and construction of new buildings. He has been an Honorary Member of the IAT, with experience in Branch and Council committees. He has also represented the IAT as a member of the AALAS International Advisory Committee as well as being an ad-hoc specialist for AAALAC International (Association for Assessment and Accreditation of Laboratory Animal Care.) Having maintained an avid interest in training and development of technical and scientiﬁc staff,

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Scientiﬁc Programme46PAPER PRESENTATIONS AND MAIN PROGRAMMEanimal care, and environmental enrichment, he has always been dedicated to the spirit of the 3Rs. Pete is strongly committed to continued public openness and awareness programmes in the use of animals in the pursuance of good biomedical research. 12.00 – 12.30The low carbon animal facilityAmongst all the challenges of the last 18 months, the move to zero/low carbon is one of many but over the next 10 years this is likely to be the most important topic. Animal research facilities are normally the most energy intensive buildings on the campus and the move to all electric energy can increase energy costs by up to a factor of 3. If these costs are to be fully recovered, this will have consequences which are yet to unfold. This presentation looks that the changes that will be required in construction, operation and compliance that are needed to start this journey to zero/low carbon.Steven CubittManaging DirectorCCTech Ltd Steven’s early career involved roles managing facilities at Babraham Institute, where he completed his ﬁrst facility project, delivering a new research building in 1985. He then progressed to a senior technical management role at Merck, Sharpe and Dohme (MSD), joining a team delivering a $1Bn global research facilities. This led to Steven founding the ﬁrst of two companies, The Cube, followed by CCTech, which provides specialist services on a wide range of projects in the UK, Europe and globally. Steven is Chair of the Board of Educational Policy for the Institute of Animal Technology and plays an active role in the education and development of Animal Technologists in the UK. His involvement includes the promotion of IAT Education outside of UK https://iateducation.co.uk/.Over the last year he has been engaged on 15 biomedical, biocontainment and GMP projects for universities, pharmaceutical companies, CROs, government and the NHS in the UK, Scandinavia, Europe and Asia.12.30 – 13.00Controlling relative humidity – a way of improving breeding performance of an immunodeﬁcient mouse strain?Home Ofﬁce Code of Practice for Housing and Care of Animals Bred, Supplied or Used for Scientiﬁc Procedures provides the guideline that relative humidity (RH) above 70% or below 40% should be avoided for prolonged periods. This is because RH levels below 30-40% in the laboratory rodent facility may increase the risk of certain physiological conditions in mice and rats, including skin and eye conditions and a delayed puberty in female mice. Likewise, a RH level above 60-70% seems to induce the ﬁrst oestrus earlier in mice. To investigate how control of RH varying within regulatory guidelines can have a beneﬁcial but non-harmful effect on breeding performance of nude mice, we controlled RH accurately at cage level, comparing to room-controlled RH, where the variation was greater. In collaboration with a commercial breeding facility, we collected productivity and RH data from a commercial breeding colony of immunodeﬁcient nude mice over a multigenerational breeding period. The ScanClime (SCANBUR A/S) was used to control RH at cage level in individually ventilated cages (IVCs) at a set point of 55% with an accuracy

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Scientiﬁc Programme47PAPER PRESENTATIONS AND MAIN PROGRAMMEof maximum 3% under this set level. Thus, the humidity is always above 52%. The breeding performance in the ScanClime ventilated cages was compared to breeding performance in cages ventilated by a standard air handling unit not capable of humidifying, and the humidity in these cages was controlled at room level. RH in a humidity-controlled barrier room environment is controlled centrally, and the RH can ﬂuctuate within speciﬁed set points with variable weather conditions. Simultaneously and for comparison, productivity data was gathered over the same period from colonies of the same immunodeﬁcient nude strain housed in IVCs in the same barrier environment where humidity was controlled at the room level only. As a further level of control, multigenerational productivity data was also gathered over a period where humidity was controlled at the room level only, and the cage level humidity control afforded to a subset of the immunodeﬁcient nude colony within the barrier environment was not active. Productivity was measured as a monthly average in Production Index, deﬁned as the number of animals weaned per breeding female per week (homozygous animals only). We hypothesise that the higher RH control offered by the ScanClime (SCANBUR A/S) can have a beneﬁcial effect on colony productivity in particular in the winter months, when RH in the barrier environment can be lower. At the time of submitting this abstract, this difference between the RH in the room and in the cages is becoming distinct and measurable and it is our hypothesis that productivity data will follow.Karen Ekkelund PetersonScientiﬁc Affairs Manager SCANBUR Karen graduated as a veterinarian from the University of Copenhagen in 2012 and since then she has been working with experimental animals during her PhD studies whilst at SCANBUR. Her PhD involved diabetes, cardiovascular disease and obesity and in her almost six years at SCANBUR the research focus has been laboratory animal science and improving housing conditions and welfare for laboratory rodents. Karen has experience with teaching and knowledge about different housing systems, the legislation in this area and animal welfare.13.00 – 14.00LUNCH – meals and refreshments served in Hall C Dining Area14.00 – 15.30WORKSHOPSBest practice in breeding laboratory mice – details on page 66.Making the frame ﬁt the picture: how should we talk about animal research – details on page 71.Care-full stories: Culture of Care training resources – details on page 72.How to help your AWERB promote a Culture of Care – details on page 73.

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Scientiﬁc Programme48PAPER PRESENTATIONS AND MAIN PROGRAMMEChair: Alan Graham, Chair Congress CommitteePAPER PRESENTATIONS14.00 – 14.30Animal rights extremists, why we should all share the burden of this crisisAre we Ostriches or are we Meerkats …? In times of crisis, some take their information up a notch, and some bury their heads in the sand. The case for “the middle ground” has never been more important in the midst of our current crisis. One of the greatest collective achievements of humanity over the last ﬁfty years is our increased connectedness. You are invited to explore and openly discuss how our connectedness as an industry, including suppliers, with the power of well-managed information can strengthen our opportunities to reach this optimal middle ground and manage this crisis better, together. Speaker A formerly targeted supplier14.30 – 15.00Animal rights activism – how openness helps us deal with the challenge ?The UK bioscience sector is succeeding in creating better public understanding and acceptance of the use of animals in research: Recent polling found that 92% of the public understands that animals are used to try to develop new treatments for speciﬁc diseases and 79% believe that they should be used for this purpose. Yet a tiny but vocal minority remains implacably opposed to animal research and is stepping up its campaigning against our sector. While peaceful protest and opposition are to be expected and welcomed in a democratic society, tactics that are harmful to individuals and institutions are not acceptable. This presentation will analyse the current situation and demonstrate how our community’s open communications have increased our resilience to protest. It will also highlight what we need to persevere with in order to maintain public understanding and acceptance.Wendy JarrettChief ExecutiveUnderstanding Animal Research Wendy studied Classics at University but has focussed on science and health communication for most of the past 30 years. Her work has included awareness programmes on the risk factors for heart disease, male cancers and a campaign to persuade the UK food industry to reduce the amount of salt added to products. She is a trustee of the Blood Pressure Research Trust.In 2004 Wendy joined the Coalition for Medical Progress (CMP), launching the People’s Petition in support of animal research; creating an image and video library of research animals and encouraging institutions to allow access to news cameras. She led on the merger of CMP with the Research Defence Society to create Understanding Animal ResearchIn late 2009 Wendy moved to the UK’s National Institute for Heath and Clinical Excellence to introduce a more open approach to media relations, returning to UAR as Chief

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Scientiﬁc Programme49PAPER PRESENTATIONS AND MAIN PROGRAMMEExecutive in November 2012. She led the development of the Concordat on Openness on Animal Research in the UK, as well as helping to set up the European Animal Research Association (EARA). Wendy is a Vice President of the Institute of Animal Technology. She also sits on the UK’s Animals in Science Committee and the Board of EARA.15.00 – 15.30Animal rights activism: how to protect you and your staffIt is a long-standing tradition in this country that people have the right to protest and are free to gather together in order to demonstrate their views (even if some people may be uncomfortable with these views), as long as they do so within the law. Over the last 2 years we have seen an increase in Animal rights activity and although we are only talking a small number of protesters, the tactics they use can be harmful to individuals and organisations. This presentation will provide individuals and organisations advice on how to deal with protesters and protect themselves from overt and covert protest.Mark O’NeillSecurity Advisor to the IAT Mark has over 27 years’ experience within the security industry, with extensive senior security management within Contract Research Organisations and conducting security audits/reviews of establishments and companies within the animal research industry. The inherent threats that organisations face have provided Mark with valuable experience in providing security solutions to the research industry. He is a subject matter expert on the threat of Single-Issue Extremism, from both commercial experience and involvement with professional bodies and organisations and has advised numerous organisations within academia and the private sector throughout the UK in how to deal tactically and strategically with demonstrations, supply chain targeting, staff support and Security Policies & Procedures.Mark is a member of the Security Institute and continues to support the research industry. He is the Security Advisor to the IAT and he also continues to provide Security Services to the IAT and LASA annual conferences.15.30 – 16.00Animal Technicians and the Technician CommitmentThe Technician Commitment is a university and research institution initiative, led by a steering board of sector bodies, with support from the Science Council and the Technicians Make It Happen campaign. The Commitment aims to ensure visibility, recognition, career development and sustainability for technicians working in higher education and research, across all disciplines. Universities and research institutes are invited to become signatories of the Technician Commitment and pledge action against the key challenges affecting their technical staff.The presentation will give the background to the Technician Commitment identifying the signiﬁcant impact it has had since its launch in 2017 and update on recent activities including how it has been working with the IAT to support technicians in the sector.

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Scientiﬁc Programme50PAPER PRESENTATIONS AND MAIN PROGRAMMESimon BreedenHead of Technical ServicesUniversity of York After a career in research in both the UK and Republic of Ireland, Simon was appointed as Operations Manager for the Chemistry Department at the University of York in September 2012. During that time he was responsible for all technical services within the department through leading a team of around sixty technicians. In May 2021 Simon was appointed as Head of Technical Services at the University of York where, with the superb support of a truly excellent team of Technical Operations/Facility Managers, he has responsibility for technical services in all academic departments delivered by an exceptional team of well over 200 technicians. Simon has been a passionate supporter of technicians both within and outside of the University of York empowering the teams he works with to deliver excellent technical support and develop skills through continuing professional development.Simon was seconded to the Technician Commitment/Science Council in May 2020 and it is in his role as Associate Lead of Technician Commitment that he will be speaking today. Simon is a passionate advocate for networking and engaging with colleagues at all levels of an organisation, believing that the most effective way to learn is from understanding other’s successes and, often his own, failures.16.00 – 16.30Refreshments served in Hall C Dining AreaChair: Glyn Fisher, Honorary Treasurer, Institute of Animal Technology16.30 – 17.00How little we knew … starting a lifetime in Animal TechnologyThis presentation will put forth a lifetime of experience, to share with the audience and set out that even the modest of accomplishments in a career can be very worthwhile. At the start of a career in Animal Technology, learning and understanding various practices, technical lessons mastered, aspects of the role that surprised or astonished plus early attempts at presenting a paper to peers (including the need for good audio-visual aids!) will all be addressed. Also and importantly, how new innovations have taken the industry forward and lastly as a summary, abiding memories.Graham GoodfellowRetired Animal TechnologistAgenda Resource Management Graham entered the world of Animal Technology aged twenty-one, when many of the things we take for granted today were in their infancy it could be said, though working with animals began long before this. His ﬁrst job was with a large pharmaceutical company and he started attending IAT training courses. One Home Ofﬁcer Inspector imparted to a group of eager young Animal Technicians that Graham was part of, “we were the eyes and ears of the Home Ofﬁce”, indicating a degree of reliance upon us to do the right thing, and call upon them for assistance (though only if this was necessary obviously).

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Scientiﬁc Programme51PAPER PRESENTATIONS AND MAIN PROGRAMMEAchieving a Fellowship (FIAT), most of Graham’s career has been working for companies supporting research, such as an animal breeder and those supplying specialist equipment or services, working on numerous sites around the country. He feels very fortunate to have chosen a career in Animal Technology, playing a small part in this very important industry.17.00 – 17.30Pre-clinical cancer research: the processes, pardigms and prominence of in vivomodels The world is on a mission to increase cancer survival, with huge strides having been made over the last few decades in prevention, detection, diagnosis, and treatment of this deadly disease. However, with the prognosis of some cancer types having changed little during this time (CRUK, 2014), there is still much more work to be done. With an estimated 10 million people dying of cancer every year worldwide, it’s no surprise that over $50 billion was invested in oncology research and development in 2018 (McKinsey). During this talk we will discuss what role in vivo models of cancer play in the development of new cancer therapies, with a focus on models used for efﬁcacy studies, as well as Verinnogen’s mission to aid cancer researchers and technicians worldwide with our technology.Isaac JohnsonCEOVerinnogen Biotechnology Research After completing his PhD in Oncology at the University of Cambridge in 2017, Isaac moved to the Cancer Research UK Cambridge Institute to work as a postdoctoral scientist in the laboratory of Professor Duncan Jodrell. Working on developing new treatments for pancreatic cancer, he was involved with in vitro and in vivo assessment of cancer therapies with the aim of providing key data that could inform clinical trials. This experience exposed him to a key unmet need in cancer research: a better method for quick and reliable measurements of subcutaneous tumours. After developing and testing a prototype device with a focus on welfare and reproducibility, Isaac co-founded Verinnogen and, since July 2021, has taken the role of CEO to work full time on bringing the technology to the thousands of cancer research institutions worldwide.PAPER PRESENTATIONS LECTURE THEATRE - QUEEN’S SUITEChair: Ken Applebee, Life Member, Institute of Animal TechnologyThursday 31st March09.00 – 10.00Home Ofﬁce Update and Q&A SessionThe Home Ofﬁce will present on key aspects of its regulatory reform programme through the lens of what is needed for modern regulation.Subjects to be addressed: structural alignment of the Regulator to a policy function and a sponsoring Department; an operating model aligned to leading regulatory strategy;and, an organisational design which has the capability and capacity to deliver the required outcomes.

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Scientiﬁc Programme52PAPER PRESENTATIONS AND MAIN PROGRAMMEWill ReynoldsHead of the Animals in ScienceRegulation Ofﬁce, Home Ofﬁce Will Reynolds, Animals in Science Regulation Unit. Will began his career as a marine biologist, gaining 10 years’ experience in marine research for UK Government and internationally, primarily in biological effects techniques. He was later an adviser to the UK Department for Environment chief scientist on animal health and welfare, before moving to the Home Ofﬁce. Will has worked in policy advice as secretary to the UK Advisory Council on the misuse of drugs and as head of UK Advisory Bodies. This role included oversight of the advisory body for the use of animals in science. Will subsequently took up a role as Head of Policy in the Animals in Science Regulation Unit. 10.00 – 10.30Veterinary care of invertebrate laboratory animalsInvertebrate medicine is still a niche area both in research and veterinary care, despite dedicated specialist publishing for many decades. Part of this is probably due to the complexity of answering simple questions of the invertebrate lab animal, such as, is the animal sick? is it in pain and how do I tell if the subject is dead? These all make the invertebrate lab animal a challenging proposition. Many tarantulas (properly called Theraphosids) can live much longer than many other lab animals and thus can become very long-term research subjects. However, because it is not yet commonplace to see invertebrates in veterinary care scientists need to search further aﬁeld for invertebrate medical advice. This is one area where the Veterinary Invertebrate Society (VIS) can get involved and connect technicians and scientists with vets with experience of invertebrates. The new frontiers in invertebrate medicine presented here show the progress being made in diagnosis, management and treatment of invertebrates with a bias towards large arachnids. This presentation will also deliver novel data from researching these fascinating lab animals and related information. This is part our memorandum of understanding between the VIS and the IAT to share expertise and improve the care for the animals we work with.Steven TrimFounder, Chief Scientiﬁc OfﬁcerVenomtech Ltd Steve founded Venomtech Ltd in March 2010 after a ten-year career as a molecular biologist at Pﬁzer. Setting up a lab housing over 100 species of venomous invertebrates it was critical to understand more about their welfare needs and potential veterinary care. We gained early recognition of our novel, safe methods for working with venomous animals. Our team won the 2012 Andrew Blake Tribute Award, from the IAT, for the most signiﬁcant impact on animal welfare with our paper demonstrating how tarantulas (Theraphosids) respond to environmental enrichment. Steve also led the team that developed a novel method of terrestrial arthropod euthanasia which is now part of the BIAZA guidelines. Since 2013 he has been one of the few non-vet members of the Veterinary Invertebrate Society and in 2019, was asked to Chair the VIS.

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Scientiﬁc Programme5310.30 – 11.00Refreshments served in Hall C Dining AreaChair: Ken Applebee, Life Member, Institute of Animal Technology11.00 – 11.30The evolution of the rat playroomOver the years the Culture of Care and welfare for laboratory animals has improved signiﬁcantly. We at the MSRU are constantly changing and adapting to provide the best possible welfare for the animals under our care. So we decided to set-up a rat playroom within our unit, it has developed over time and proven to be valuable in many circumstances. This includes socialisation with humans before re-homing, introducing adult rats before they are housed together and most importantly it allows the animals in our facility the ability to explore and exhibit their natural behaviours such as running, climbing, and foraging in a secure area. Despite being away from the conﬁnes of their cage, the rats desire for human interaction was something we weren’t expecting, but fully embraced. The difference in behaviour between strains was also something we weren’t expecting but we found quite fascinating. We understand that we are quite lucky to be able to provide our animals with such a space and that other units may not, so we have also investigated and experimented with different ways to provide the same level of welfare and enrichment in a much more conﬁned area. This presentation will explain more about the playroom and cage adaptations we have undertaken.Joanne MainsSenior Animal TechnicianUniversity of Dundee Joanne Mains is a Senior Animal Technologist. She graduated from the University of Abertay with a BSc(Hons) in Biomedical Science prior to joining the University of Dundee in 2014 as a junior Animal Technician. Since then she has gained her MIAT, is a PIL holder, Deputy NACWO and more recently she has become a Research Technician in a division of systems medicine with the focus of pathogenesis of insulin resistance and metabolic diseases. Joanne is an active member of the IAT at Branch level. In 2020 she became secretary of the West of Scotland Branch. Joanne is dedicated to promoting the 3Rs and enhancing Animal Welfare. She has been published in ATW Journal and contributed to the IAT Bulletin, as well as presenting at AWERB meetings and as a former Congress presenter, on changes and improvements in Animal Welfare and enrichment she and her team have developed over the past few years.WORKSHOPS11.00 – 12.30Why, how, what happened next: an introduction to scientiﬁc writing – details on page 64.Managing aggression in laboratory animal species – details on page 70.Care-full stories? Introducing a training resource to explore the ‘Culture of Care’ from the perspective of different stakeholders – details on page 72.How to help your AWERB promote a Culture of Care – including caring for you – details on page 73.PAPER PRESENTATIONS AND MAIN PROGRAMME

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Scientiﬁc Programme54PAPER PRESENTATIONS AND MAIN PROGRAMMEPAPER PRESENTATIONS11.30 – 12.00Creating specialised antibodies from llamasCamelid species (including llamas, alpaca and camels) are known to produce small, specialised antibodies called nanobodies as well as conventional antibodies. There is a growing scientiﬁc interest in the potential therapeutic utility of using nanobodies as alternatives to conventional antibodies and other biological or small molecule drugs. Nanobodies are potentially more immunogenic, have improved efﬁcacy, are more economic and easier to deliver to their target than larger conventional antibodies. The ﬁrst nanobody drug, caplacizumab, was introduced in 2019 to treat a rare bleeding disorder. Interest in nanobody technology has been further enhanced during the on-going COVID-19 pandemic, with several research institutes seeking to develop nanobodies from camelids. Llamas are social, pack animals and can be kept as part of a herd. The University of Reading has maintained a herd of llamas at its Centre for Dairy Research (CEDAR) farm facility since 2014. We currently have over 20 male and female llamas working with project partners from the pharmaceutical industry and research institutes such as Pirbright, The Crick Institute and the Rosalind Franklin Institute (RFI) in Oxford. We have recently worked with RFI to generate nanobodies against the SARS-CoV-2 virus.Antibodies are raised in llamas by injecting isolated protein (such as the SARS-CoV-2 ‘spike protein’ responsible for mediating the binding of the virus to human host cells), together with a suitable adjuvant. Llama are held in a secure ‘crush’ for primary immunisation whereby antigen/adjuvant are injected intramuscularly at up to 4 sites on the llama shoulder/neck. Booster immunisations (typically 2-4) are given every 3 weeks. Blood samples (~500 ml) containing antibodies/nanobodies to the antigen are taken at the end of the procedure. The blood is processed to isolate, select and expand suitable nanobody populations.Work with RFI in our llama, Fiﬁ, has generated nanobodies that have been shown to neutralise SARS-CoV-2 virus and variants in vitro (Huo et al., 2021); moreover, a mixture of these nanobodies showed potent therapeutic efﬁcacy in the in vivo Syrian hamster model of COVID-19, via both respiratory and intraperitoneal injection.Work with the isolated SARS-CoV-2 virus spike protein provides a compelling example of the utility of using llamas to provide potentially life-saving medical interventions. The technical team involved in the procedures described, and their management of the llama herd at CEDAR further illustrates, the positive use of animals in research, for which the University of Reading was awarded Understanding Animal Research Openness Awards in 2019 and 2020. RFI and the University of Reading will also showcase this work at the Royal Society Summer Exhibition in July 2022.ReferenceHuo et al (2021) A potent SARS-CoV-2 neutralising nanobody shows therapeutic efﬁcacy in the Syrian golden hamster model of COVID-19. Nature Communications 12(1):5469Gary StephensProfessor of PharmacologyUniversity of Reading Gary Stephens is Professor of Pharmacology within the School of Pharmacy, University of Reading and Programme Director of the Pharmacology programme at Reading. His scientiﬁc expertise is in the pharmacology and physiology of ion channels and receptors. Gary’s work has a focus on models of disease, namely ataxia, pain and epilepsy. He was

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Scientiﬁc Programme55PAPER PRESENTATIONS AND MAIN PROGRAMMEpart of a team awarded the Sir James Black Award for Contribution to Drug Discovery in 2019 and a Guardian University Award for Research Impact runner-up award in 2020 for work on cannabidiol for treatment of childhood epilepsy. An experienced pharmacologist, Gary is also a Senior Editor for the British Journal of Pharmacology and Editor-in-Chief for the Pharmacology section of Pharmaceuticals journal. In terms of animal work, he is the Home Ofﬁce Licence holder for the project ‘Antibody Production’ at the University of Reading. Working with staff at the Centre for Dairy Research (CEDAR), this licence permits procedures to raise conventional and specialised antibodies in a range of species including llamas, cows, and sheep. Such specialised antibodies include nanobodies directed against coronavirus proteins.12.00 – 12.30The trials and tribulations of setting up a Chick Embryo Facility (CEF) as a replacement modelI’ll tell you what I want, what I really, really, want … and that is to see more replacements used before researchers move into protected animals. I became an NC3Rs Board member in 2019. Part of this role means I attend selected mid-term grant meetings. It was at one of these meetings that I met Dr Anne Herrmann who was an NC3Rs grant holder running a Chick Embryo Facility at the University of Liverpool.The chick embryo model is an excellent tool and I was fascinated by the model as it seemed to have so many potential applications from cancer research to drug discovery / toxicity, it also appeared to be relatively simple in its set-up. Further advantages over murine models include its cost effectiveness, its simplicity and immunodeﬁciency, which allows the engraftment of any xenogenic material. As the experiments are terminated at E14, the model is classiﬁed as non-protected under the AnimalsScientiﬁc Procedures Act 1986 (amended 2012) and hence it is a valid animal reduction as well as replacement technique. Moreover, the chick embryo has the potential to be readily imaged in vivo.I engaged with some of my researchers and they were sold on the idea. We put in an application for an NC3Rs Skills and Knowledge Transfer grant, to set-up the technique at Strathclyde, and we were successful. This presentation will give an overview of the set-up of the facility at The University of Strathclyde, demonstrate a commonly used method in cancer research, as well as provide some information about the beneﬁts and limitations of this model.Linda HoranManager BPUUniversity of StrathclydeChair & CEO IAT Linda is passionate about trying to improve the lives of the animals we care for. She started her career at the University of Liverpool as a junior Animal Technician and after completing all the IAT Animal Technology exams she achieved a BSc (Hons) in Applied Biomedical Sciences. Now working at The University of Strathclyde as Manager of the Biological Procedure Unit, she has in excess of thirty-ﬁve years’ experience in biomedical research and teaching. Linda is the current Chair and CEO of the Institute of Animal Technology and an NC3Rs Board member and impact panel member.

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Scientiﬁc Programme56PAPER PRESENTATIONS AND MAIN PROGRAMME12.30 – 13.00POSTER PRESENTATIONS LECTURE THEATRE - QUEEN’S SUITESee page 74 for details.13.00 – 14.00LUNCH – meals and refreshments served in Hall C Dining AreaChair: Penny Hawkins, Vice President, Institute of Animal Technology14.00 – 14.30Managing moral stress: Learning from the use of ethical discussion groups and ethical decision making tools in veterinary practice Less than half of the 48 People’s Dispensary for Sick Animals (PDSA) UK hospitals are completely satisﬁed with the level of staff discussion about ethically challenging cases (Wensley et al 2020). In this presentation I share the progress of a collaborative project which aims to evaluate the use of ethical discussion groups and ethical tools to reduce moral stress in PDSA veterinary teams. I highlight how such approaches might also prove beneﬁcial in the laboratory animal setting. Through preliminary ﬁndings from an analysis of focus groups and individual interviews I identify the role of practical and relational barriers in creating veterinary moral stress (Reynolds et al, 2012). I highlight the complexity of relationships and responsibilities between humans in the veterinary setting, which may become better understood through sociological research. I show how these relationships may challenge current veterinary ethical approaches (Grimm et al 2018). Finally I illustrate some of the ways in which formal ethical discussion may beneﬁt PDSA veterinary staff, even when it does not change clinical outcomes for animal patients. ReferencesGrimm, H. Bergadano, A. Musk, G.C. Otto, K. Taylor, P.M. Duncan, J.C. (2018) Drawing the line in clinical treatment of companion animals: recommendations from an ethics working party. Veterinary Record 182(23):664Reynolds, S.J., Owens, B.P. & Rubenstein, A.L. Moral Stress: Considering the Nature and Effects of Managerial Moral Uncertainty. J Bus Ethics 106, 491–502 (2012).Wensley, S., Betton, V., Martin, N. and Tipton, E. (2020), Advancing animal welfare and ethics in veterinary practice through a national pet wellbeing task force, practice-based champions and clinical audit. Veterinary Record, 187: 316-31614.30 – 15.00Vanessa AshallManager BPUUniversity of York Vanessa is an interdisciplinary health researcher and qualiﬁed veterinary surgeon. She is interested in the meaning and signiﬁcance of human-animal relationships in the context of health and medicine. Vanessa is a Member of the Royal College of Veterinary Surgeons and a European Specialist in Animal Welfare Science, Ethics and Law. With 15 years’ of clinical experience working as a veterinary surgeon in the clinic and in the laboratory, Vanessa has published on the ethics and regulation of animal research, veterinary involvement in animal research, informed consent and sociological and ethical aspects of human and animal blood donation. She has inﬂuenced policy and practice within the UK and EU through the provision of expert opinion and the development of ethical decision making tools.

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Scientiﬁc Programme57PAPER PRESENTATIONS AND MAIN PROGRAMME14.30 – 15.00Andrew Blake Tribute Award Winner 2022Exploring environmental enrichment as a tool for assessing cognitive degeneration in ageing miceEnvironmental enrichment is used to improve animal welfare, but could it be used for more? As mice age, their cognitive abilities decrease. We looked at our ageing colony and how mice at different life stages and of different genetic backgrounds interact with environmental enrichment. We evaluated not only the preference for different EE items, but also if the preference for EE items changes in different age groups. We also trialled the use of an EE strategy and evaluated the potential effect of routine exposure to EE on the level of interaction in different age groups. Our ﬁndings suggest that the use of repetitive EE doesn’t affect the interaction level in adult and middle age mice, but it decreases signiﬁcantly in the old groups over time.Also, interaction with EE item decreased signiﬁcantly at an earlier stage (middle age) in some knockout lines and especially in one particular strain of mice whose phenotype has synaptic plasticity and memory lesions. This could suggest that standardised evaluation of EE interaction level has the potential to be used as an alternative method to assess cognitive impairment in mice.Our ﬁndings conﬁrm the preference of mice for foraging and nesting EE items, as reported in literature, but add that preference doesn’t change with age. They also indicate that the level of interest with repetitive EE items decreases in old mice, while it is unaffected in younger animals. This seems to suggest that an adequate and varied EE programme should be put in place and monitored for ageing colonies to be effective and maintain adequate enrichment standards.Rosie PayneFaculty of Health and Medical Science, University of Surrey Further details on page 16-17.ANDREW BLAKETRIBUTE AWARDThe Andrew Blake Tribute Award is generously sponsored by the Association of British Pharmaceutical Industries

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Scientiﬁc Programme58PAPER PRESENTATIONS AND MAIN PROGRAMME15.00 – 15.30AAALAC Fellowship Winner - Reﬂections of 30 years in Laboratory Animal Science The ﬁeld of laboratory science although enjoyable and highly satisfying, comes with its fair share of heartbreak and stress. The ﬁeld has also had many positive changes and challenges over these past three decades.Come along with me on this incredible journey of 30 years in the ﬁeld!Kelly PattersonManager II - Rodent Toxicology and Sample Processing LabCorp Further details on page 27.15.30 – 16.00Refreshments served in the Queen’s Suite FoyerChair: Linda Horan, CEO and Chair Institute of Animal Technology16.00 – 17.00KEVIN DOLAN MEMORIAL LECTURETHE LIVING BIOBANKAnimal Cell & Tissue Preservation for Future RegenerationDetails on pages 60 and 61.Session sponsored by IPS17.00PRIZES AND AWARDS FOLLOWED BY CLOSE OF CONGRESSTHE STEPHEN BARNETT FIRST TIME PRESENTERS’ SESSIONfor the Annual Jack Mundy PrizeSponsored by Marshall BioResourcesThe annual Jack Mundy prize has previously been awarded at Congress for the best Junior Technician paper, but the competition is now opened up to include anyone who has not formally given a presentation before at a conference. Arthur Edward “Jack” Mundy FIAT was thought of by his peers as the founder of the Animal Technicians Association (ATA) in 1950. During the early years as Honorary Secretary, he worked very hard to make the Association work and raise the original membership of 200. By 1960, it had doubled to 400 members.When the Laboratory Animal Centre (LAC) discontinued their support of an annual Congress, it was Jack who petitioned for the ATA to take over and he organised the ﬁrst one in Bangor with the help of his wife, Mimi. The following year, it was held at the Royal Veterinary College where he worked as Chief Technician and there were two exhibitors! When the organisation became too big for two people to manage, the Congress Committee was formed.On his retirement, Jack was awarded Life Membership of the IAT.

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60 Scientiﬁc ProgrammeIn the UK, there are over 847,000 horses, with the equine industry worth over £4.7 billion in consumer spending. This excludes the racing sector, which alone adds a further £4.1bn annually and supports tens of thousands of jobs. As such, the equine breeding industry is of notable size and importance, not only in the UK, but also across Europe and beyond.Over the last 40 years, the industry has revolutionised from natural cover only, to improvised methods of semen collection, to the present-day advanced techniques. While natural service remains predominant in the racing sector, other industries have almost completely converted to artiﬁcial insemination. In the 1980s, up to 80% of horses were bred by natural methods. Now up to 90% are bred via artiﬁcial insemination, with only 10% via natural cover.This presentation will provide an overview of equine breeding and a look to the past, present and future of the industry. Technologies include standard AI, ICSI, embryo transfer, cloning, genetics and fertility, genomics and genetic modiﬁcation. It will also explore the transfer of equine AI technology to other species, including to aid in conservation of wild and endangered animals, with coverage of exotic species semen collection and the work of charity Nature’s SAFE in biobanking to Save Animals From Extinction.THE LIVING BIOBANKAnimal Cell & Tissue Preservation for Future RegenerationKevin Dolan 1926 - 2011When Kevin Dolan died in 2011 at the age of 85, IAT Council wished to honour his memory in gratitude for the contribution he had made to Animal Technologists and the industry in general and therefore ﬁttingly, the Special Guest Lecture given annually at Congress was renamed the Kevin Dolan Memorial Lecture.Kevin’s contributions to the IAT included services on Council and for several years he was Editor of the IAT Journal, only standing down on his retirement. He received his Fellowship in 1977 at the same time as attaining a Diploma in Law. He was also made a Vice President of the IAT and latterly an Honorary Member.KEVIN DOLAN MEMORIAL LECTURE

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Scientiﬁc Programme 61He also authored many distinguished books and articles on the subject of law and ethics using animals in science but it was as a teacher that Kevin had most impact. He taught on the Postgraduate Diploma/MSc course, the Medical Technology courses at City of Westminster and on Personal Licence Modular training courses. To paraphrase one of his students ‘Kevin was a great teacher because he was passionate about the subject he was dealing with and the people he was teaching to’.Despite joining the world of animal technology somewhat later in life after many years in the ecclesiastical domain, Kevin’s impact on our industry was outstanding. His was a life well lived in the service of others and in recognition is remembered at Congress.TULLIS MATSON FRAgSTrustee, Chair and Founder, Nature’s SafeTullis Matson has practiced Artiﬁcial Insemination (AI) in stallions and freezing semen for over 30 years. He began running the small natural covering stud at the family farm in 1989. In 1990 he went to New Zealand to learn the practice of AI before returning home to set up one of the ﬁrst equine AI only units in the UK.Tullis formed Stallion AI Services Ltd in 2000 which is one of the most successful stallion collection centres in Europe, offering semen collection services, fertility assessment and worldwide semen export. Collections have been made from over 1100 stallions, across 51 different breeds. Tullis pioneers and implements new advanced techniques, such as Post Castration, Epididymal Sperm Harvesting, using different gradients and specialises in handling and collection from sub fertile stallions. He has carried out research into semen collection, stallion fertility and cryopreservation methods of equine semen and embryos. He has developed bespoke extenders for stallions and harvested semen from post castration testicles. Tullis also works with organisations such as Chester Zoo to help cryopreserve semen from endangered species, for example, rhinos and lions. He also visited South Africa in 2019, where he was working with elephants and rhinos. Using knowledge and technology from his lab, semen and tissue samples were collected from 8 elephants and stored in South Africa using the latest technology.Tullis has been working with the Rare Breeds Survival Trust since 2002, being made a Trustee of the Society in 2015. In 2011 Tullis received the Marsh Christian Award for Conservation in Genetic Bio-Diversity. He has been given the award for the technological advances he has brought to the ﬁeld of equine semen freezing which has enabled some rare breeds to be collected from and frozen successfully for the ﬁrst time. The award, run in conjunction with the Rare Breeds Survival Trust, recognises signiﬁcant technical, scientiﬁc and practical contributions to the ﬁeld of genetic bio-diversity. In 2019, Tullis also received the Fellowship of the Royal Agricultural Societies (FRAgS) award in the House of Lords for his success in land-based industries.In 2020 Stallion AI Services foaled the ﬁrst Suffolk Punch foal in the UK to have been born using sex-sorted semen. Their technology is a major step towards securing the future for all critically endangered breeds currently nearing extinction.Over the past two years Tullis has been working on his idea to create a cryopreservation biobank in the UK which specialises in storing living regenerative material from animal species threatened with extinction. From this idea Tullis founded the charity, Nature’s SAFE in December 2020, a living biobank on a mission to save animals from extinction by indeﬁnitely preserving live cells from endangered species. On a personal note, in 2020 Tullis accepted the commission of Deputy Lieutenant of Shropshire to support the work of the Lord-Lieutenant of the county. With a history of serving the community and living in the local area, Tullis as a Deputy Lieutenant will assist in carrying out engagements and visits on behalf of the Lord-Lieutenant. Tullis is also an avid skydiver, carrying out over 1,600 skydives!

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Scientiﬁc Programme62CPD WORKSHOP SESSIONS3 CPDPOINTSImproving the welfare of mice used in the study of ageingAs ageing is universally associated with a general and progressive decline in organ systems, there are some clinical/pathological manifestations that can be considered more or less typical in a given species or strain. As mice age many conditions develop slowly over extended periods of time and the body adapts to them. However, a moment comes when an animal shows clinical signs resulting from a decline in function that can no longer be compensated. In this workshop we will explore what these signs might be, how best to ‘grade’ them and how best to tackle them. Another aspect we will explore is the interface between ageing and experimental aims. For example, how can we gauge the cumulative harm in mice that are being used to study the effects of age in the development of arthritis or of certain forms of cancer?Tuesday 29th March 14.00 – 15.30 Room 2 Queen’s SuiteAndWednesday 30th March 11.00 – 12.30 Room 1 Queen’s SuiteLinda HoranManager BPUUniversity of StrathclydeLinda is passionate about trying to improve the lives of the animals we care for. She started her career at the University of Liverpool as a junior Animal Technician, and after completing all the IAT Animal Technology exams she achieved a BSc (Hons) in Applied Biomedical Sciences. Now working at The University of Strathclyde as Manager of the Biological Procedure Unit, she has in excess of thirty-ﬁve years’ experience in biomedical research and teaching. Linda is the current Chair and CEO of the Institute of Animal Technology and an NC3Rs board member and impact panel member.

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Scientiﬁc Programme63CPD WORKSHOP SESSIONSMichael Wilkinson Named Veterinary SurgeonUniversity of StrathclydeMichael has been an NVS for almost 30 years. He is a veterinary graduate from the Autonomous University of Bellaterra (Barcelona) and also holds a PhD from the University of Glasgow after completing a programme of research at the Department of Veterinary Medicine at the Glasgow Vet School. He holds the Royal College of Veterinary Surgeons’ Certiﬁcate in Laboratory Animal Science (CertLAS) and is a Diplomate of the European College of Laboratory Animal Medicine (DiplECLAM) since 2006.Michael has worked with many different species in the biomedical research context and has a special interest in animal welfare and reﬁnements to experimental protocols. He has published in topics ranging from improvement of animal housing to reﬁnements in rodent models of arthritis. He is also very interested in supporting veterinary colleagues in their efforts to specialise in the ﬁeld: he was a co-founder of the ESLAV/ECLAM Summer School initiative and leads the Mock Exam Committee of ECLAM. Michael is also a member of the Council of Management of Laboratory Animals Ltd (publishers of the international journal Laboratory Animals) and a member of LAVA, LASA and ESLAV.Gillian BorlandResearch AssociateUniversity of GlasgowGillian is a post-doc working at the University of Glasgow with a particular interest in mouse models of ageing and disease. She has a PhD in Immunology from the University of Glasgow and has worked at the National Institute of Medical Research in London and the University of Glasgow. Gillian has extensive experience of mouse models of cancer and is currently investigating ageing and healthspan in an RNA polymerase III knockout mouse model.3 CPDPOINTSTuesday 29th March 14.00 – 15.30 Room 2 Queen’s SuiteAndWednesday 30th March 11.00 – 12.30 Room 1 Queen’s Suite

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Scientiﬁc Programme64CPD WORKSHOP SESSIONS3 CPDPOINTSTuesday 29th March 14.00 – 15.30 Room 3 Queen’s SuiteAndThursday 31st March 11.00 – 12.30 Room 3 Queen’s SuiteWhy, how and what happened next - an introduction to scientiﬁc writingScientiﬁc writing, as opposed to writing about science, does not come naturally to most people but it is a skill, some would say an art, that can be learnt. From deciding on your audience through to checking the proofs, this workshop will cover the fundamentals of an Animal Technologist’s ﬁrst ventures in scientiﬁc reporting.Jas BarleyEditor, Animal Technology and WelfareInstitute of Animal TechnologyJas has had a long and varied profession in the industry, working in both government and educational establishments and ﬁnishing her career at the University of Southampton. She has worked with a wide range of species and an even wider range of researchers! Now technically retired, she remains a member of IAT Council, chairing the IAT Editorial Board and has been Editor of Animal Technology and Welfare, the ofﬁcial publication of the IAT and EFAT for over 10 years. In addition to her journal activities she lectures on the Level 4 and 5 courses for the IAT Higher Education programme. She has also been a Trustee of AS-ET since 2017. Jas enjoys many pursuits as well as teaching British Sign Language and her hobbies include reading, gardening, various crafts and cookery.Animal Technology and WelfareIAT Journal

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ATW The Ofﬁcial Publication of The Institute of Animal Technology (IAT)and European Federation of Animal Technologists (EFAT)NOW PERMANENTLY FREE FOR EVERYONE TO READ AND DOWNLOADThe implementation complies with Plan S, the multi-funder effort to ensure immediate open access to scientiﬁc publicationswww.atwjournal.comIAT JournalAnimal Technology and WelfareATW publishes peer-reviewed articles allied to animal science and technology, management and educationParticular encouragement is given to authors submitting papers promoting the 3Rs leading to improvements in environmental enrichment and the care and welfare of genetically altered animals ATW facilitates the Marjorie (Sandiford) Whittingham Memorial Prize awarded annually to the author of the best original peer-reviewed paperATW publishes technical notes describing new products, new or reﬁned techniques and new developmentsATW publishes papers and posters presented at international meetings, opinion articles, book reviews and relevant textsATW promotes the dissemination of ‘good practice’ATW promotes the recognition of Animal Technologists everywhereATW PROFILEATW aims to be the medium for AnimalTechnologists and all those concerned withthe care and welfare of animals used forresearch purposes to communicate ‘goodpractice’. ATW especially aims to promoteand develop the 3Rs, particularly in respectof Reﬁnement. More importantly, ATWpromotes the generally accepted 4th R,Responsibility - the responsibility that allAnimal Technologists have in ensuringdissemination of ‘good practice’ to everyinstitution using animals in research. ATW enjoys a unique position as the scientiﬁcpublication for the leading organisations forthe welfare of animals used in research.NO fees are charged to authors for publishing in ATW. Instructions to authors appear on the website.Editor: Jasmine Barley MSc FIAT RAnTech Email: atweditor@iat.org.uk

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CPD WORKSHOP SESSIONS66 Scientiﬁc ProgrammeBest practice in breeding laboratory miceThis will be an interactive workshop for experienced (1 year+) junior technicians covering the basics of mouse reproduction, inbred, outbred and GA strains. Looking at how to select the best mice for breeding, which breeding systems to use and troubleshooting examples of strains and breeders that are not producing litters.You will come away from this with some pointers on best practice to take forward and feeling more conﬁdent in your ability to manage your colonies or make suggestions on how scientists could improve theirs.Helen BaileyBRF Training ManagerThe Francis Crick InstituteClive Da CostaSenior Colony Manager, BRF Colony Management TeamThe Francis Crick InstituteHelen Bailey is also Secondary NTCO at The Francis Crick Institute with the responsibility of ensuring the training and competency of over 170 members of the Biological Research Facility. She is also the teacher/assessor for the accredited Level 2 and 3 IAT Diplomas, taught in-house. Graduating from DeMontfort University with a BSc(hons) in Animal Science, she joined the Imperial Cancer Research Fund in 2001 as a junior Animal Technician, which then evolved into the London Research Institute of Cancer Research UK. Progressing to become a Team Leader and NACWO, she also gained MIAT and RAnTech status and 16 years’ experience as an Animal Technologist before promotion in 2017 to her current role. Helen enjoys running workshops and training the new generation of Animal Technologists.Clive completed his PhD at St George’s Hospital Medical School, University of London and also carried out his postdoctoral studies there before joining Axel Behrens’ laboratory at the Cancer Research UK London Research Institute (now part of The Francis Crick Institute) in 2001. Work centred around studying how stem cells regenerate to repair the body and how faulty stem cells can lead to cancer using primarily mouse models.In 2019 he joined the Colony Management Services team headed by Sarah Hart-Johnson in the Biological Research Facility (BRF) at The Francis Crick Institute. Core aims are assistance and advice for research groups to manage their mouse colonies to best practice standards and colony management of core central BRF lines.3 CPDPOINTSTuesday 29th March 14.00 – 15.30 Room 1 Queen’s SuiteAndWednesday 30th March 14.00 – 13.30 Room 4 Queen’s Suite

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Scientiﬁc Programme67CPD WORKSHOP SESSIONSAntony HorwoodBRF Research ScientistThe Francis Crick InstituteAntony Horwood is a BRF Research Scientist working in the multi-species Experimental Unit at The Francis Crick Institute. He began working at Cancer Research UK in 2007 as an Animal Technician, gaining valuable experience and responsibility until being promoted to BRF Research Scientist at the Crick in 2019. Antony currently supervises a team of Research Ofﬁcers working with the neurophysiology research groups and is also responsible for the Quarantine room. His 15 years’ knowledge and experience includes managing GA breeding colonies in a rodent SPF barrier unit, immunocompromised mice in isolators and experimental work with different species. Antony is very passionate about animal welfare and enjoys working with the several different species within his unit including mice, opossums and ferrets.3 CPDPOINTSTuesday 29th March 14.00 – 15.30 Room 1 Queen’s SuiteAndWednesday 30th March 14.00 – 13.30 Room 4 Queen’s Suite

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68CPD WORKSHOP SESSIONSScientiﬁc ProgrammeEnvironmental enrichment for laboratory ZebraﬁshProviding laboratory animals with appropriate environmental enrichment can promote better welfare, encourage animals to express more natural behaviours, and help give animals a better overall lifetime experience, but what counts as ‘appropriate’ enrichment for Zebraﬁsh? Lots of facilities may facilitate social behaviour by group housing, and give live food to stimulate predatory behaviour, but beyond this there is great debate over how best to provide enrichment for Zebraﬁsh. This workshop will discuss different types of environmental enrichment, and will then look at the evidence for how different types of enrichment affect Zebraﬁsh behaviour, physiology and welfare. We will also discuss possible challenges to introducing more enrichment for Zebraﬁsh and ways in which these challenges might be addressed. Chloe StevensScientiﬁc OfﬁcerRSPCAChloe works in the Animals in Science Department (formerly the Research Animals Department) at the RSPCA. She primarily works on improving the welfare of ﬁsh used in research and testing, with particular focus on environmental enrichment and the welfare of laboratory Zebraﬁsh. Before joining the RSPCA, Chloe completed an MBiolSci in Biology at the University of Shefﬁeld, where she studied the effects of social context on collective behaviour in Zebraﬁsh, and a PhD in Biology at the University of Exeter on stress, mortality and welfare in ornamental ﬁshes.3 CPDPOINTSTuesday 29th March 14.00 – 15.30 Room 5 Queen’s SuiteAndWednesday 30th March 11.00 – 12.30 Room 5 Queen’s Suite

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Scientiﬁc Programme69CPD WORKSHOP SESSIONS3 CPDPOINTSTuesday 29th March 14.00 – 15.30 Room 4 Queen’s SuiteAndWednesday 30th March 11.00 – 12.30 Room 3 Queen’s SuiteTime to get schooled: an introduction to ZebraﬁshLearn more about Zebraﬁsh (Danio rerio) and why the species has become the second most popular used animal in laboratory animal science. This workshop will include a brief introduction to the Zebraﬁsh’s life history, what training and skills Animal Technicians need to work with them, and good colony management practices.Mollie MillingtonSenior Research ScientistThe Francis Crick InstituteMollie currently works as the Aquatics Unit Manager at The Francis Crick Institute. She received a BA in Marine Biology from Boston University and has a MSc in Zoo and Aquarium Management from Michigan State University. Mollie holds the Institute for Animal Technology Level 2 Diploma and is currently enrolled in Level 3 for completion in 2021. She joined the executive board of the Zebraﬁsh Husbandry Association (zhaonline.org) in 2020 as president elect and is currently serving as president.Having always enjoyed working with aquatics species, Mollie has been fortunate enough to work in both public (New England Aquarium, Alaska SeaLife Center and Mystic Aquarium) and academia aquaria (Marine Biological Laboratory, Queen Mary University of London, National Institute for Medical Research (NIMR) and The Francis Crick Institute) during her career. Her experience with multiple species in these varied environments gives her a wealth of knowledge to draw upon when troubleshooting system problems, training animals, medical care, or establishing new systems. In October 2019, she won an award with her colleagues for her 3Rs work in establishing a system to use lidocaine pre- and post-ﬁn clipping that did not impact the scientists’ research. She has also co-authored several papers using Zebraﬁsh as animal models and a methodology for environmental screening Zebraﬁsh systems for pathogens.

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Scientiﬁc Programme70CPD WORKSHOP SESSIONSManaging aggression in laboratory animal speciesAggression is a problem in many laboratory animal species. Aggressive behaviour can cause stress and painful injuries, or lead to single housing, negatively affecting Animal Welfare. Aggression is also undesirable from a scientiﬁc perspective, for example where it leads to animals being culled or removed from studies, or where pain and distress introduce variability into experimental results. It is therefore crucial to be able to detect aggressive behaviour early on, understand the causes, and take steps to minimise its occurrence. In this interactive workshop we will discuss the reasons why aggression may occur within the animal facility, how this can affect animal wellbeing and science, and strategies and tips for preventing and managing aggression in a range of mammalian species, from mice and rats to dogs, pigs and non-human primates.Participants will be able to share their experiences of reducing aggression and will receive practical recommendations and handouts with sources of further advice.Joanna Stanley Regional Programme Manager, North West and YorkshireNC3RsKhia DobbinsonScience Manager, Animal WelfareNC3RsJo is a Regional Programme Manager with the NC3Rs, working with the Universities of Liverpool, Manchester and Shefﬁeld. Jo received her PhD from the University of Manchester before completing postdoctoral positions in Canada and New Zealand, where she focussed on animal models of pregnancy complications. As a Regional Manager, Jo provides 3Rs advice and training and shares best practice across her 3 institutions.Khia is Science Manager for Animal Welfare at the NC3Rs. She is involved in the NC3Rs peer review service and ofﬁce-led programmes on Animal Welfare. Khia obtained a PhD and MSc (by research) from the University of Hull, where she trained in zoology with a focus on behavioural ecology. Alongside her research, Khia worked as a aquaria technician, caring for aquatic species. Outside of a research environment, she has experience in the care and behavioural rehabilitation of domestic and wild animals.3 CPDPOINTSWednesday 30th March 11.00 – 12.30 Room 4 Queen’s SuiteAndThursday 31st March 11.00 – 12.30 Room 2 Queen’s Suite

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Scientiﬁc Programme71CPD WORKSHOP SESSIONS3 CPDPOINTSWednesday 30th March 11.00 – 12.30 Room 2 Queen’s SuiteAndWednesday 30th March 14.00 – 15.30 Room 1 Queen’s SuiteMaking the frame ﬁt the picture: how should we talk about animal research?Whether it is in a private conversation or at a public meeting, how we say something is as important as what we say. If we want people to be receptive to our positive messages about animal research, we need to communicate in ways that make the most impact. In this session, UAR will share new techniques to frame your communications about animals in science that will improve how your message is heard and help you to feel safer and more conﬁdent when it comes to talking about your work in any context.John MeredithHead of Education and OutreachUnderstanding Animal ResearchBella WilliamsHead of EngagementUnderstanding Animal ResearchJohn Meredith is Head of Education and Outreach for Understanding Animal Research. He works with young people in classrooms across the UK to help them better understand animal research and provides support and training in communications and outreach for scientists and animal technicians. He previously developed educational programmes and materials for a wide range of clients including the Army, BT and Marks and Spencer and was an educational adviser to the Commission for Architecture and the Built Environment.Bella has been exploring the relationship between science, society and communication for over 20 years, working through research in both natural and social sciences to consider how ideas about science are communicated to the public and their inﬂuencers such as media and policy makers. As a facilitator Bella has developed and delivered workshops across many ﬁelds, with an emphasis on communications, medical ethics and the use of animals in research.Bella is currently Head of Engagement at Understanding Animal Research (UAR), and is responsible for initiatives around member engagement and public engagement: both helping UAR member and stakeholders with outreach and reactive initiatives on the use of animals in research, and engaging directly with the public on this issue. She leads on Openness at UAR, working with signatory institutions of the Concordat on Openness on Animal Research to help them build openness into communications strategies.

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Scientiﬁc Programme72CPD WORKSHOP SESSIONSCare-full stories? Introducing a training resource to explore the ‘Culture of Care’ from the perspective of different stakeholdersThis workshop will offer a short preview of a new training resource being developed by members of the Animal Research Nexus in collaboration with stakeholders in animal research.The resource uses a series of ﬁctional prompts (story scripts), which participants read out during the session. The scripts are designed to encourage those involved to see a particular scenario from multiple perspectives. Each script is accompanied by a series of discussion points which are aimed at getting participants to share their own stories, and to use these as a resource for reﬂecting on their institution’s Culture of Care.This workshop would be of interest to those involved in training animal research staff, as well as anyone with a broader interest in promoting continuing professional development around the ‘Culture of Care’.Beth GreenoughAssociate Professor of Human GeographyUniversity of OxfordReuben MessagePostdoctoral Research AssistantUniversity of OxfordDr Beth Greenhough’s research examines the social implications of scientiﬁc innovations in the areas of health, biomedicine and the environment. She is one of the lead researchers on the Animal Research Nexus project and has led the development of the Care-full Stories training resource. She has published widely on topics including the Culture of Care and everyday ethics in animal research. She is co-author of Bodies Across Borders (Ashgate) Health Geographies: A Critical Introduction (Wiley-Blackwell) and Bioinformation (Polity).Dr Reuben Message is a postdoctoral research assistant based at the School of Geography and the Environment, Oxford. Working on the Animal Research Nexus project alongside Dr Beth Greenhough, he is interested in the intersections between animals, technology, law and discourse - and particularly in all things ﬁshy. His work on the AnNex project has focussed mainly on the use of Zebraﬁsh in laboratories and what their growing prominence in science means for practices of ethical review, the 3Rs, animal care and public engagements with animal research.3 CPDPOINTSWednesday 30th March 14.00 – 15.30 Room 5 Queen’s SuiteAndThursday 31st March 11.00 – 12.30 Room 1 Queen’s Suite

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Scientiﬁc Programme73CPD WORKSHOP SESSIONS3 CPDPOINTSWednesday 30th March 14.00 – 15.30 Room 2 Queen’s SuiteAndThursday 31st March 11.00 – 12.30 Room 4 Queen’s SuiteHow to help your AWERB promote a Culture of Care – including caring for youThe Animal Welfare and Ethical Review Body (AWERB) has a key task of helping to promote a Culture of Care within the establishment and, as appropriate, the wider community. Your AWERB should have a clear vision of the Culture of Care it wishes to help achieve, and understand that this goes beyond caring for animals. A healthy Culture also incorporates how staff treat one other and communicate, how effectively the 3Rs are implemented, proper consideration of ethical issues and expectations for good quality science. As an Animal Technologist, there is a lot you can do to help your AWERB fulﬁl all these aspects of the task, whether or not you sit on the AWERB yourself. The Culture of Care should also demonstrably care for you and your wellbeing. This workshop will provide information and resources to help you assist the AWERB in this task and make sure you are supported, whilst enabling you to share experiences and identify action points.Penny HawkinsHead, Animals in Science DepartmentRSPCAPenny graduated in biological sciences at the University of Portsmouth in 1992 and completed her PhD in avian physiology at the University of Birmingham in 1996. She joined the RSPCA Animals in Science Department in 1996, and has been Head of Department since 2015. The Animals in Science Department works to implement the 3Rs and to ensure robust ethical review of animal use in research and testing. Penny’s main area of work relates to supporting and promoting ethics committees, including the UK Animal Welfare and Ethical Review Body (AWERB). She has also been an independent member of four AWERBs, served three terms on the Animal Procedures Committee/Animals in Science Committee and is currently one of the IAT’s Vice Presidents.

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Scientiﬁc Programme74POSTER PRESENTATIONSLet us choose which food enrichment we prefer - enrichment from a mouse’s perspectiveTom FewlassUniversity of York A reﬁnement in hamster breeding – creating a sustainable colony for vaccine researchMelanie DavenportEnvigo This study focusses on rodents, speciﬁcally looking at food preferences as a source of rodent enrichment. The study method used will be the preference test using pasta, sunﬂower seeds or standard diet. The study will be conducted by giving separate cages access to the speciﬁc enrichment or a choice of multiple types of food enrichment.The animals will be given access to this enrichment 3 times per week after handling. The rodent preference test will be monitored by visual observation to record the amount of time spent with each type of enrichment. The rodents will be weighed and will have their teeth checked weekly to assess whether these types of enrichment have an impact on behaviour, and health.The beneﬁt of giving the animals food enrichment may allow the animals to express natural behaviours of storing food within their nest and reduce stress and stereotypic behaviours. The enrichment may also be seen as a reward after handling and will aid technicians and researchers train the animals in our care.As a commercial breeder, Envigo had a requirement to relocate a hamster breeding colony from the US to the UK Contract Breeding Services (CBS) Facility. Due to Code of Practice speciﬁcations, there was a necessity to amend the established mating regime from trios (2 males, 1 female) to monogamous pairs. On implementing this regime, the number of successful matings was inconsistent and litter sizes were below the expected output. Consequently, the current breeding program required review. Due to the lack of relevant literature, we had to establish a novel colony plan based on our existing data and expertise as breeders. This poster demonstrates an alternative scheme to produce a sustainable colony, with a reduction in numbers of breeders used and increased productivity.

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Scientiﬁc ProgrammePOSTER DISPLAYS75Zebraﬁsh (Danio rerio) housing, improving welfare with environmental enrichmentPaul BarwoodUniversity College London Does colour matter?Ryan GoldsmithUniversity College London The design of the aquaria that Zebraﬁsh are typically housed in was devised to provide a practical and space efﬁcient means of housing the animals for scientiﬁc study. These tanks are typically small, barren environments that would normally be considered unsuitable for animals kept as pets or in zoos. Environmental enrichment provides welfare beneﬁts - allowing the ﬁsh to better express natural behaviours, remain healthy, and maintain a positive mental state. In recent years it has become clear that to improve the welfare of Zebraﬁsh in our care we must view environmental enrichment as a necessary provision. However, this cannot be considered in isolation and should be reviewed in combination with potential impacts to scientiﬁc reliability, as well as the resources available to implement and maintain any changes, but should this be the case? Studies carried out to assess the suitability of various enrichments, such as the presence of other ﬁsh, tank colour, and the use of plants have yielded conﬂicting results. Differing views and pressures of stakeholders including veterinarians, scientists, legislators and technicians have limited the use of environmental enrichment for Zebraﬁsh. Here we review the literature and consider practical ways in which we can move forward and encourage the uptake of environmental enrichment.With an increased use of Zebraﬁsh (Danio rerio) as a popular scientiﬁc model in research, their welfare and care must be under constant improvement. Most setups have Zebraﬁsh in transparent tanks on a rack system potentially with a clear view of their surroundings, which can lead to heightened levels of stress, health complications and inconsistent behaviour patterns. With many behavioural studies being done involving colour preference in Zebraﬁsh, we wanted to try and understand how this could be used in practical ways.Three sets of coloured tanks – green, blue and black in an opaque matt ﬁnish giving complete coverage were used along with a transparent control group. These colours were used because they are within the Zebraﬁsh’s visual range, found in natural environments and frequently used in mass aquaculture. Additionally, the intensity of the lighting the growing ﬁsh were exposed to was measured by a LUX reading.We used 30 ﬁsh of UCL AB/TL hybrid in each tank and measured their lengths, these were recorded at 28 and 56 days past fertilisation, as well as their growth rate and survivability in each environment.

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Scientiﬁc Programme76POSTER DISPLAYSValidating in-cage mouse enrichmentZoe Beresford, Chelsea Burbidge and Valentina Serrano-GallegoUniversity of Birmingham Culture of Care during COVID-19: Animal Technicians’ perspectivesAmy Brogden and Katy Moskot-BrettellUniversity of Birmingham There is a wide variety of different types of mouse enrichment currently available, some items of which are more practical than others. Validating items as providing enrichment can be time consuming and costly. Nevertheless, it is important to ensure that any objects being provided for this purpose are truly offering enrichment opportunities for the animals.The purpose of this study was to demonstrate how a quick and simple cage side assessment can be undertaken to identify which items are most effective as enrichments and whether they offer short- or long-term solutions. The study compared four different types of enrichment, all of which are easily available, in ﬁve cages of pair housed 6-month-old CD1 mice.Through this approach, we found that the mice preferred items suspended from the cage lid. Using this information, we have identiﬁed a practical and cost effective solution, and conﬁrmed that it retains novelty over longer periods. This validated enrichment is now being used routinely in the Biomedical Services Unit at the University of Birmingham.Over the last 18 months, COVID-19 has affected everyone, both at work and in their personal life. Within the space of a week, new work routines, home routines, and general every day practices had to be altered or cancelled all together. The world of Biomedical Research, and in particular that of animal technologists, was no exception to this. Staff in animal facilities were required to rapidly adapt, including having to reduce animal numbers, undergo changes in working patterns, and work with restrictions on the number of people entering what used to be a busy, fast paced environment.There have been many presentations and discussions reﬂecting on how the pandemic affected Culture of Care in animal facilities, but very few have been from the perspective of the technicians themselves. As Animal Technicians, we have undertaken a small survey at the University of Birmingham to investigate, and reﬂect upon, how individuals coped during this challenging period, and how the Culture of Care for both staff and animals was affected. As part of our ﬁndings, we will present how the pandemic has taught us to be more aware of compassion fatigue, and how we can use what we have learnt over this difﬁcult period going forward.

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Scientiﬁc Programme77POSTER DISPLAYSDigital photography and the care and welfare of African Clawed Frogs (Xenopus laevis)Rue Jones-GreenUniversity of Cambridge African Clawed Frog (Xenopus laevis) diseases and interesting clinical signs in photographsRue Jones-GreenUniversity of Cambridge How to breed African Clawed Frogs (Xenopus laevis)Rue Jones-GreenUniversity of Cambridge Not everyone likes bubbles!Paul Haskings and Keith SavillUniversity of Cambridge Digital photography has been used at The Gurdon Institute, Cambridge University, since 2016, primarily as an identiﬁcation aid. We have found it to be: non-invasive, quick, cheap, reliable and accessible. We also discovered it to be advantageous in monitoring the health and body condition of our large colony of over 600 Xenopus laevis frogs. This has been an excellent reﬁnement in their welfare and care.Many diseases in Xenopus laevis have been described in literature. However, it is often difﬁcult to ﬁnd images which clearly demonstrate any clinical signs. This poster is designed to bridge that gap using photographs taken of these frogs, with clinical signs, in a licenced establishment. We hope by sharing our experiences and images, we will help to improve the welfare and husbandry of this species and open up the dialogue to a wider audience so they can also share theirs.This is an instructional poster on how to breed Xenopus laevis in the laboratory. The many challenges in 2020 have had a negative impact on xenopus suppliers, predominantly the closure of the world’s largest supplier NASCO. Other suppliers available are Portsmouth UK (EXRC) and Xenopus1 USA. However with the increase in demand on both companies, in-house breeding may be needed to supplement stock and decrease stress from transport. In-house breeding is also an excellent reﬁnement in animals’ welfare as it eliminates the stress caused by travel and the animals are acclimatised to the facility. It’s also very cheap!Following the deep clean and fumigation of a new bio facility at the University of Cambridge, numerous patches of bubbled/blistered paintwork were observed throughout the building. The paint had been selected as it was known to be used in other facilities regularly fumigated using hydrogen peroxide (H2O2) in vapour form, but upon investigation we learned that the formulation of the paint had recently changed to remove volatile organic compounds (VOCs) and, even more recently the data sheet had been revised listing only 3 compatible H2O2 fumigation systems – the system we had used was not on the list. This poster details the trials and tribulations we experienced in ﬁrstly ﬁnding a new and suitable system and then developing effective fumigation cycles.

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Scientiﬁc Programme78POSTER DISPLAYSThe evolution of how guinea pigs are housed at high containment in the Biological Investigations GroupJo Heydon and Leilah EmmUK Health Security Agency, Porton Down Hopping madMichael WebbCancer Research UK Exploring treatments for Idiopathic Chronic Diarrhoea (ICD) in Rhesus Macaques (Macaca mulatta): A Systematic ReviewHayley RobinsonUK Health Security Agency, Porton Down When housing any species within the facility, we always consider the 3Rs – which are Reduce, Replace and Reﬁne. Improving the caging system will allow us to promote improved animal welfare and consider the 3Rs. Improvements to the caging system will allow the animals to express their natural behaviours such as foraging, which keeps them active, alert and makes them feel happier in their environment. Historically, TB studies are carried out in ﬂexible ﬁlm isolators, which allow us to house a large number of guinea pigs in pairs. Due to changes in housing requirements within the Code of Practice, we reassessed how guinea pigs are housed for long term studies due to their increased size as they get older. We took this opportunity to explore changes that will positively inﬂuence the welfare of the guinea pigs.Mice that display an abnormal gait or an unusual way of walking would usually be concerning through the eyes of an Animal Technician, however, these mice that show a ‘bunny hop’ are something that we look for. In this speciﬁc line of mice used by the De la Roche lab at CRUK Cambridge Institute, we see mice with this unusual trait of hopping rather than walking, much like how a rabbit would move. We decided to investigate this by performing CT scans on the GliKO mice to see if this has anything to do with bone structure in the leg – speciﬁcally the femur. These GliKO homozygous mice are usually born small and runty, but with extra care from the technicians we can see these mice through to 6 weeks of age so they can be used in research studies.Idiopathic Chronic Diarrhoea (ICD) is an intestinal disorder prevalent in captive Non-human primates (NHPs). It is characterised by recurrent loose stool in the absence of classically presented diarrheal causing pathogens (Westreich et al., 2019). Annually, ICD affects upwards of 15% of NHPs in a colony, posing a serious clinical threat disturbing both research and stock (Blackwood et al., 2008). Monkey’s experiencing ICD are likely to suffer from severe dehydration, weight loss, and poor body condition, often leading to a rapid decline in individual welfare accounting for 33% of euthanasia unrelated to research (Blackwood et al., 2008).

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Scientiﬁc Programme79POSTER DISPLAYSGreen clay - not just a pretty faceHannah BissmireCancer Research UK Reﬁnement of handling and dosing methods for rats and miceJulia BartlettUniversity of Bristol Green Clay is often bought by people and used to improve skin. Generally it is used to assist with skin healing and improve skin appearance due to its nutrient content. It has also been used on mice to alleviate skin lesions. This poster will describe its use on mice housed at CRUK at Cambridge University.Many scientiﬁc procedures involving animals require the administration of test substances. This almost always requires the animal to be restrained which is known to cause stress. Our research group has developed and implemented several techniques to reduce the stress caused during substance administration.Oral dosing of rats and mice is commonly carried out using an oesophageal cannula. This procedure is distressing for the animals requiring physical restraint. There are also risks of adverse events including incorrect placement and tracheal dosing and oesophageal trauma. This method also requires the researcher to have a PIL which can leave studies vulnerable to disruption due to staff absences. An alternative approach is to use voluntary ingestion of test substances in palatable solutions. Although this approach has previously been reported by several research groups, it is still not widely used. Our own experience has been that rats and mice readily take palatable solutions from a syringe but can quickly form negative associations with ingestion of some drug solutions which we hypothesise arises from conditioned aversion. To reduce the potential for this to develop, we have developed a modiﬁed protocol. Animals are ﬁrst trained to ingest a 10% condensed milk solution from a syringe (0.5ml rat, 0.2ml mice). Following 5 days of training all animals ingested the required volume and in a time period of <30sec. We then continue to provide animals with the same volume and solution at least 5 days in 7 irrespective of whether they are in a study or not to reduce the potential for animals to develop conditioned aversion. For the purposes of drug administration, the drug is ﬁrst dissolved in water and then mixed with condensed milk to a ﬁnal dilution of 10%. Mice (10ml/kg or rats 1ml/kg) voluntarily ingest the drug solution in their home cage at the appropriate volume and pre-treatment time followed by a small volume of the vehicle solution to further minimise any aversion associated with the taste of the drug solution.For the purposes of injections, we have modiﬁed our handling techniques for rats and mice to eliminate the need for “scrufﬁng” in rats or tail handling in mice prior to injecting the animal. We have been able to use objective measures of affective state and the stress response to show that these methods offer signiﬁcant improvements in welfare. Importantly, these techniques have been taught to and used by researchers with a range of prior experience levels and all have demonstrated competency within a short period of time. These methods offer both welfare and scientiﬁc beneﬁts and could reduce variability between subjects and improve the quality and reproducibility of scientiﬁc studies.

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Scientiﬁc Programme80POSTER DISPLAYSThe use of portable ultrasound imaging to reﬁne the technique of tumour detection in neuroblastoma mouse modelsClaire DobinsonBiological Services Unit, Institute of Cancer Research Sensory enrichment for the common marmoset (Callithrix jacchus)Millie FullerDstl Investigating a reﬁned method for identifying domestic chickens (Gallus gallus domesticus)Paul SmithThe Pirbright Institute Prior to using a portable ultrasound unit, we would abdominally palpate mice to detect tumours. This was never an accurate technique and has the potential to cause internal injury. We now use portable ultrasound imaging to reﬁne the tumour detection technique. This poster compares palpation of the animals with the use of ultrasound in the early detection of neuroblastoma in transgenic mice.Common marmosets (Callithrix jacchus) are new world primates that are found within the coastal rainforests of NE Brazil. They are a multisensory species, relying on all their senses to survive. It is the duty of all animal carers to fulﬁl the 5 needs of captive animals, one of which being the need to express natural behaviours. Apart from the environmental enrichment that is placed in a primate’s home cage, the majority of enrichment ideas used usually involve hiding foods and sweet treats encouraging the sense of taste to keep the animals engaged for longer. Within the marmoset breeding colony, at Porton Down, a form of enrichment that would encourage the primates to use sense of smell was trialled. To do this the hammock within the marmoset’s home cage was soaked in other scents to encourage a use of the sense of smell. This poster will explore the trial designed to assess 2 different scents on one of the breeding families.The Pirbright Institute undertakes research into various infectious diseases of birds, with the aim of preventing and controlling these diseases in the ﬁeld both in the UK and overseas. A key part of this research is the use of domestic chicken models of disease to understand key areas such as transmission, pathogenesis, and vaccine efﬁcacy against the pathogens of interest.Many of these studies require regulated procedures to be applied to the birds from a young age (from day old) and a widely accepted approach for identifying these animals has been to apply a numbered plastic tag (wing band) through the webbing of one wing. This method is permanent, reliable, and is compatible with the rapid growth rate of the birds.This poster describes the approach taken to validate a non-invasive method of bird identiﬁcation (leg band) to replace the use of the invasive wing band.

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Scientiﬁc Programme81POSTER DISPLAYSMedicated jelly as a replacement for injectables and the use of Maropitant to manage itchy skin in miceMark Donaldson-WingMedical Research Council, Babraham Institute Maximising efﬁcacy of your health monitoring programmeAndy DickinsonSurrey Diagnostics Ltd It is desirable to administer drugs by the least invasive route to (1) optimise welfare, (2) reduce the risk of injury to animal handlers, and (3) minimise the impact of restraint and transient pain on physiological and experimental readouts. We tested whether commonly used drugs provided in Electro-Gel™ would be effective and tolerated by mice as a replacement to injectable versions, and to reduce the need for handling of mice.A previous study (Williams-Fritz et al., 2011) showed that the anti-emetic maropitant citrate was an effective anti-pruritic for mice suffering with ulcerative dermatitis. We decided to trial Maropitant and Enroﬂoxacin (antibiotic) versions of strawberry Electro-Gel™ for managing post-surgical pruritus and infection in implanted mice.There are a multitude of health monitoring techniques/methods available to us. It can be difﬁcult to know which of these to use and when to use them. This is an attempt to simplify, maximise the efﬁcacy of, and ultimately reduce the number of animals used in your health monitoring program. Whilst this is not exhaustive, and may not suit all situations, but may provide some information that allows you to optimise your current methods and give greater conﬁdence in health monitoring results.

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SOCIAL PROGRAMME19.30DINNERServed in Hall D and remember your TICKET for admittanceFollowed by KEN’S LEGENDARY CONGRESS QUIZOur very own Quiz Master, the incomparable Ken Applebee makes this evening one to always remember!Don’t forget, the Notebook and App both have maps showing all locationsBars will be open throughout the evening and there are plenty of quiet areas for a good chat and catch up.20.00 – 02.00GALA DINNER DANCESmart dress required (No jeans, t-shirts, trainers or fancy dress please)Held in The Royal Hall (Map location in the Notepad and on the App)Rock, indie, pop, soul … HARD TO HANDLE … play it ALL! They will also man a DISCO to complete a great night(Bar areas will be open for those who prefer a quieter end to the evening) Congress Badges must be worn by EVERYONEWednesday30MarchThursday31March83Social ProgrammeTHE LEGENDARY CONGRESS QUIZAfter a good day of learning and networking, there’s nothing better than an evening ﬁlled with the CONGRESS QUIZ – so if you think it’s an evening of sit back and relax – forget it!It’s the equivalent of the KINGDA KA roller coaster… very fast and furious!HARD TO HANDLEAnd to quote their own publicity “are absolutely, positively one of the most amazingly awesome three piece acts performing at parties and business events around the UK.Hard to Handle are the full package playing instantly recognisable friendly classic and contemporary live music.”Well let’s put them to test and spend a great few hours on the dance ﬂoor!

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2332393738403556343320473642411LUNCH AND REFRESHMENTS - HALL C DININGEXHIBITIONENTRANCEEXITEMERGENCYGOODSDOORSESCALATORSESCALATORSLIFT14 1113 12891017161518192425222321303129282627EXITEMERGENCYEXITEMERGENCYFIREDOORSCATERINGCompany / Institute Stand NoAS-ET 1LASA 2IAT 3UNO BV 4MMM Medical Equipment UK 5Inotiv 6Sychem 7Fera Science 8MRC Harwell Advance 9SAFE 10LBS (Serving Biotechnology) 11Transnetyx 12Impex Services International Ltd 13Vet-Tech Solutions Ltd 14Marshall BioResources 15Aston Pharma 16TPS/Gruenberg 17a-tune software AG 18CLAST 19Tecniplast 20Linton Instrumentation 21Kent Scientiﬁc 22Plexx BV 23Datesand Ltd 24Janvier Labs 25Ellegaard Göttingen Minipigs 26Dortek 27Carﬁl Quality 28Positive Weighing Solutions Ltd 29Innotec Hygiene Solutions Ltd 30Surrey Diagnostics Ltd 31IPS Product Supplies Ltd 32Charles River 33Allentown 34Agenda Life Sciences 35Avidity Science 36NKP-Isotec 37Castium Ltd 38SCANBUR 39S3 Science Recruitment 40Clinipath Limited 41Lomir Biomedical 42Exhibitors’ Index by Stand No.Congress 2022CONGRESS86 Trade ExhibitionTRADE EXHIBITION HALL

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Company / Institute Stand NoAgenda Life Sciences 35Allentown 34AS-ET 1Aston Pharma 16a-tune software AG 18Avidity Science 36Carﬁl Quality 28Castium Ltd 38Charles River 33CLAST 19Clinipath Limited 41Datesand Ltd 24Dortek 27Ellegaard Göttingen Minipigs 26Fera Science 8Impex Services International Ltd 13Innotec Hygiene Solutions Ltd 30Inotiv 6Institute of Animal Technology 3IPS Product Supplies Ltd 32Janvier Labs 25Kent Scientiﬁc 22LASA 2LBS (Serving Biotechnology) 11Linton Instrumentation 21Lomir Biomedical 42Marshall BioResources 15MMM Medical Equipment UK 5MRC Harwell Advance 9NKP-Isotec 37Plexx BV 23Positive Weighing Solutions Ltd 29S3 Science Recruitment 40SAFE 10SCANBUR 39Surrey Diagnostics Ltd 31Sychem 7Tecniplast 20TPS/Gruenberg 17Transnetyx 12UNO BV 4Vet-Tech Solutions Ltd 14Exhibitors’ Index by Name2332393738403556343320473642411LUNCH AND REFRESHMENTS - HALL C DININGEXHIBITIONENTRANCEEXITEMERGENCYGOODSDOORSESCALATORSESCALATORSLIFT14 1113 12891017161518192425222321303129282627EXITEMERGENCYEXITEMERGENCYFIREDOORSCATERINGTrade Exhibition 87TRADE EXHIBITION HALL

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TRADE EXHIBITIONTrade Exhibition89Trade Partners ExhibitionAgenda Life Sciences Stand 35Choosing Agenda as your resourcing partner means you receive a service which provides you with choice, not compromise.As the only life science recruitment agency that actively run our own research facilities, working with Agenda means you take advantage of our unique position within the industry. Our team fully understand the speciﬁc requirements of the sector and develop a bespoke service for each of our clients’ needs.Our service offerings include permanent recruitment, temporary stafﬁng, and facility management.Why choose Agenda for your recruitment?You will beneﬁt from our specialist recruitment team who have worked directly in life sciences and are experts at understanding this sector’s very speciﬁc requirements.l you gain access to our large database of technologists seeking career developmentl 360-degree support is provided by our experienced, friendly, and professional recruitment consultants who guide you through every step of the processl detailed pre-employment screening (including our unique Animal Rights Connection checks) and suitability interviews conducted before you interviewLooking for a temporary stafﬁng solution?If you need extra resource for a speciﬁc research project, cover for sickness, maternity or holiday cover, Agenda are perfectly placed to help. Every technician holds relevant qualiﬁcations and proven experience to provide you with the perfect stafﬁng solution.l solve your HR headaches with a short- or long-term cover offering you ﬂexibility l save time and money, ensuring peace of mind with our rigorous pre employment screening processl the only fast start Licensed Technicians available on the market, allowing your team access to the right level of supportFlexible Facility Management from AgendaResearch projects are unique and require a tailored Facility Management service to grow with your ever-changing requirements. Outsourcing your Facility Management means you further your research success by centring your focus on your projects and studies. Whether you need a full-service solution at a site or want to control your research in one of our state-of-the-art facilities, Agenda provide a partnership approach to suit. Here are just some of the things we can help you with as part of our service.

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TRADE EXHIBITIONTrade Exhibition90l compliance and regulatory oversightl animal care and welfarel stafﬁng solutionsl procurement and budgetinghello@agendalifesciences.co.uk https://www.agendalifesciences.com/ +44 (0) 8456 445545Allentown Stand 34Allentown is a leading global provider in Life Science solutions. In nearly 55 years of operation, dedicated exclusively to the life science industry, we are proud to have played our part in heroic research that continues to save lives around the world every day. We earn the highest trust of the biomedical research community by providing critical services with integrity and care. To this day, care is at the heart of everything we do. Care for each product that rolls off our factory ﬂoor; care for our customers and the patients that ultimately beneﬁt from their work; care for the welfare of the animals whose health and comfort are critical to the success of the research. Our success is based on precision-engineering of equipment that lasts longer and performs more efﬁciently, accurately and humanely; on our corporate culture that focusses on personal service and delivering peace of mind to our customers; and on lasting relationships with leading institutions that enable us to inﬂuence and accommodate new trends in laboratory housing.infoUK@allentowninc.com https://www.allentowninc.com/Animals in Science - Education Trust Stand 1AS-ET is a charity registered under UK Law with the objective of advancing education and promoting excellence in the care and welfare of animals used in science.The trust’s main activity is providing bursaries to enable technical staff who are involved in the care and welfare of laboratory animals to attend training courses and to undertake educational study. In 2021 the trustees awarded £15,000 in bursaries, many of which enabled applicants to obtain co-funding from their employers. In addition to providing bursaries AS-ET has awarded grants to support the development of new courses and educational meetings. We provide three annual educational prizes for each level of the

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TRADE EXHIBITIONTrade Exhibition91IAT higher education qualiﬁcations, a LASA 3Rs prize and a prize for the best Tech-2-Tech article in Animal Technology and Welfare – IAT Journal.In order to be able to fund these activities we rely on generous donations. The trustees are extremely grateful to our corporate sponsors who give great support to AS-ET, as do our ambassadors including the IAT and the IAT West Middlesex Branch. We also organise fund-raising activities and beneﬁt from IAT branches who hold events for us. We have a good number of individual supporters who share our objectives but we are always in need of more.Donations can be made by standing order if an individual wishes to donate a minimum of £25 a year to AS-ET.Please do visit our stand to ﬁnd out more about AS-ET, how you or a colleague might beneﬁt from a bursary and how you can help support our work. Visit our website for more information and access to the bursary application process.contact@as-et.org.uk www.animalsinscienceeducationtrust.org.ukAston Pharma Stand 16Founded in 2006, Aston Pharma is the wholesale personal protective equipment (PPE) supplier of choice for the Healthcare, Biotechnology and Veterinary industries. With an extensive product range including a huge range of protective clothing, disposable visitor coats and coveralls, powered respirators, pin worm detergents, disposable nitrile, latex and vinyl gloves, our aim is to assist you, ensuring you are compliant with all health and safety regulations.With a thorough understanding of our customers’ needs we aim to excel in every aspect of what we do, from initial customer contact through to delivery and beyond to after sales care. Our huge stocks and regular deliveries ensure that you get what you want, when you want it.Our specialist customer service team is dedicated to sourcing and selling the best range of products and they will be happy to help you ﬁnd suitable items for your speciﬁc requirements. With over 16 years of experience, Aston Pharma is one of the leading suppliers of clothing and textiles to the healthcare industries in the UK, building upon this, 2019 saw the launch of Chameleon Scrubs www.chameleonscrubs.co.uk Chameleon Scrubs aims to be the place to shop for cotton scrubs in whatever colour, size, brand and style you need, contact the team today sales@chameleonscrubs.co.uk for more information.

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TRADE EXHIBITIONTrade Exhibition92Aston Pharma is your one-stop shop for PPE with easy and secure online ordering for busy professionals – view our extensive product range on our website or contact our team today.info@aston-pharma.com www.aston-pharma.com + 44 (0) 207 419 5907a-tune Software Stand 18tick@lab animal research facility software helps organisations effectively manage animal care, operations, and compliance processes. Get the power of a single and secure access point to the information and functionality needs of each stakeholder – from researchers and facility staff to compliance personnel and management.tick@lab includes:l management of Project and Personal Licensesl management of training and competency records l animal orderingl colony and breeding management l aquatic management l animal facility managementl animal and animal health management l task managementl Home Ofﬁce documentation and reportingl AWERB review and document managementl cost accounting tick@lab offers:– Built-in Flexibility - The tick@lab framework enables administrators to conﬁgure templates, forms, cage cards, reports and even the user interface including labels, grid views and ﬁeld properties.– Integration Capabilities - tick@lab has been built for integration with the existing application landscape, offers a variety of (web service) interface and supports diverse integration technologies.– Browser independent web application – ready for mobile use, no client installation required, support for all standard browsers on all types of client devices including tablets.– Audit Trail - Full audit trail capability to fulﬁl CFR21 Part 11 requirements and to enable GLP validation.

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TRADE EXHIBITIONTrade Exhibition93– tick@lab from the Cloud - tick@lab is available as a secure, fully managed cloud service reducing infrastructure requirements to the browser and the internet connection.In synergy with our clients business objectives we:l optimise work and data ﬂows l create transparency for users (supporting the 3Rs)l guarantee governance, compliance and best practice l lower expenses and risksResearch-Driven Organisations rely on a-tune50,000+ Users Worldwide5 / 7 Top Pharmaceuticals140+ Research Institutions100+ World-Renowned Universities20+ Countriessales@a-tune.com https://www.a-tune.com/ +49 6151 95131-0Avidity Science Stand 36Avidity Science is proud to offer the biomedical research community modern alternatives to bottled water with – Edstrom Automated Watering Systems delivering animal water 24-hours a day – eliminating repetitive, laborious, and time-consuming tasks while efﬁciency creating cost savings. Our Water Puriﬁcation and Treatment Systems ensure that Edstrom systems deliver consistent water quality with Reverse Osmosis (RO) puriﬁcation, clean system design principles, and automated ﬂushing.For those needing an individual cage watering solution, Hydropac® is a convenient, reliable, and economical alternative to bottled watering. It reduces ergonomic injury potential and costs associated with bottle cleaning, ﬁlling and manipulation and can produce up to 600 pouches an hour, with treated pouches supplying bacteria-free water for two weeks between cage changes.Similarly, Sipper Sack is an Ergonomically Smart System for Individual Cage Watering using reusable drinking valves and pouches.State-of-the-art RFID technology from BMDS automates the gathering, recording, and validating of data crucial for quality research, ﬁnd out more from PLEXX BV.Enabling science to improve the quality of lifeEMEA.info@avidityscience.com www.avidityscience.com +44 (0) 1844 201142

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TRADE EXHIBITIONTrade Exhibition94Carﬁl Quality Stand 28Carﬁl Quality has been operating in the industry as a total supplier for research centres, universities and pharmaceutical companies for more than 40 years.It started out as a family business and has now become a household name in the life science sector. Company manager Philippe Huybrechts and his team attach great importance to personal contact with customers, quick service and high quality.The product range consists of consumer and investment goods like diets, bedding, environmental enrichment, housing, disinfection machines and detergent for cleaning housing. In recent years we have also been able to offer SPF NZW rabbits and conventional Aachen mini pigs to our customers. Our focus is always on the welfare of animals. All products are under permanent quality control with regard to the legal standards and regulations: ISO 9001 and the GMP directives.Carﬁl also focusses on the circular economy. You can also buy second-hand equipment for your animal facility such as conventional cages, IVCs, drinking bottles and much more through a sister company, Life Science Equipment. Life Science Equipment stands for: saving on your budget, saving in time and recycling.Carﬁl Quality delivers worldwide and is mainly specialised within Europe.admin@carﬁl.be https://www.carﬁl.eu/enhttps://www.lifescienceequipment.eu/en +32 (0) 14 45 13 10Castium Stand 38Castium Ltd provide Expert Decontamination Services to the Academic and Pharmaceutical Research, LAS, Health & Clinical environments with continued investment in the latest technologies to ensure we are able to deliver cleaning and decontamination services which are best suited to our clients requirements.We provide our clients and partners with expert, dedicated and bespoke In-house and offsite cleaning, disinfection and sterilisation programmes.

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TRADE EXHIBITIONTrade Exhibition95Castium’s programmes and projects are validated, certiﬁed and carried out by our highly trained and skilled professional teams. From commissioning projects to daily contract cleaning services, our clients are able to control and eliminate risks to their operations.Castium Specialise in Microbial and Parasitic elimination including PinWorm.Castium also manufacture and install LabTACKTM Environmentally Friendly Tack-Regenerating Contamination Control Flooring.Please visit our Stand at Congress 2022 for further details!enquiries@castium.co.uk www.castium.co.uk +44 (0) 345 900 3767Charles River Stand 33For 70 years, researchers worldwide have trusted Charles River as their source for the highest quality animal models and related services. Offering a broad selection of species and strains, we support today’s most critical research with the timely delivery of study-ready, preconditioned and genetically engineered animals.Our leading scientists and global network of AAALAC-accredited vivaria and breeding facilities provide clients with accessible, expert management of outsourced colonies, biology services for line creation, maintenance and preservation, advanced diagnostics, and health monitoring to guarantee the long-term success of their work.Charles River: More than a mouse!AskCharlesRiver@crl.com https://www.criver.com/rmsClinipath Stand 41Clinipath Equipment has been manufacturing, distributing and servicing a complete range of veterinary and laboratory equipment since the company was founded in 2011. Our mission is to provide quality products at competitive prices with timely deliveries and our goal is to become one of your valued suppliers. We support advances in the technology of science, whilst respecting the impact on our environment. We provide problem-solving solutions, quality products, superior customer service, and support to our clients through the complete understanding of their business objectives and needs.

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TRADE EXHIBITIONTrade Exhibition96Clinipath has remained a company with family at its heart, keeping the core values of animal welfare & customer satisfaction a top priority, without being affected by year on year expansions.Our core products include anaesthesia, culling and warming, fume containment, infection control and laboratory equipment. www.clinipathequipment.com +44 (0) 7554 957336College of Laboratory Science and Technology (CLAST) Stand 19CLAST is the organiser of ﬂexible modular training courses aimed at providing accredited and relevant continued professional development (CPD) in Laboratory Animal Science and Technology. Our courses are for enthusiastic scientiﬁc and technical staff who wish to increase their knowledge in many aspects for laboratory animal research including preparing for more senior, professional roles.To support employers and learners under COVID restrictions, we are offering most of our units via our bespoke Virtual Learning Environment to reduce the need to travel and be away from the workplace.The courses can be used to attain IAT higher education qualiﬁcations in Laboratory Animal Science and Technology. Within this Higher Education programme there are three levels:CLAST unitsIAT Level 4 Diploma in Laboratory Animal Science and Technologyl Unit 1 - Applied learning and development for sciencel Unit 2 - Animal facility supervisory management skillsl Unit 3 - Biological sciencel Unit 4 - Control and identiﬁcation of diseaseIAT Level 5 in Diploma in Laboratory Animal Science and Technologyl Unit 5 - Animal law and ethicsl Unit 6 - Experimental designl Unit 7 - Toxicologyl Unit 8 - Reproduction and genetic alterationIAT Level 6 Diploma in Laboratory Animal Science and Technologyl Unit 9 - Project planningl Unit 10 - Project

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TRADE EXHIBITIONTrade Exhibition97l Unit 11 - Animal facility management and designl Unit 12 - Physiology of stress and painThe Level 6 is 1st Degree equivalent, allowing successful students to apply for election to the Fellowship of the IAT and subject to entry requirements, Higher Degrees e.g., Masters For more information on what career developing opportunities we can offer you, or those you employ, please visit our stand.info@clast.org www.clast.org.uk https://portal.clast.org.uk/Datesand Ltd Stand 24With over 40 years of unrivalled experience, Datesand have always led the way when it comes to meeting the supply needs of the world’s leading laboratories. Not to mention continually pushing the boundaries of innovation within the Biotechnology sector. Datesand provide the widest range of husbandry and LAS critical consumables offered by a single supplier. This ranges from animal bedding, nesting, enrichment & caging to PPE and beyond.The proud creators of the Janet Wood Award, Datesand provide Animal Technicians and Industry Experts with the opportunity to design the market-breaking products of tomorrow. As well as offering the highest quality products at the best available prices, Datesand also offer the most sustainable options such as biodegradable and compostable bedding and nesting as well as several nesting and enrichment items made from recycled paper pulp, rather than virgin paper.Our new e-commerce website has also been designed to support our mission of becoming a carbon neutral business, as we are now planting a tree for every online order.When you choose Datesand, you are choosing experience, quality, innovation and a passionate, family-led team of professionals who put the customer and the planet ﬁrst.sales@datesand.com https://datesand.com/ +44 (0) 161 274 1080

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TRADE EXHIBITIONTrade Exhibition98Dortek Stand 27Dortek is one of the world’s leading manufacturers of hygienic timber-free door solutions for the research and bioscience sectors. Our innovative product range is designed and engineered to satisfy end-user needs for safe, secure and reliable access. Dortek has over 50 years’ experience in door manufacture and speciﬁcation, with our dedicated in-house project management team delivering complex, bespoke door packages from initial design to ﬁnal commissioning across the UK and worldwide. We have produced and installed more than 250,000 door sets for clients in over 60 countries.We provide a range of integrated access solutions which are individually tailored to meet client’s speciﬁcations. This includes key performance requirements like hygiene, ﬁre protection, radiation shielding, intelligent automations, access control, sound reduction and air-pressure control. Our hygienic door systems are constructed with a smooth, seamless surface designed to prevent bacteria from harbouring. They’re exceptionally strong, lightweight and proven to maximise efﬁciency in the most demanding environments.Dortek door sets are designed, tested and certiﬁed by recognised independent third parties to meet stringent ﬁre and acoustic certiﬁcations.Products/Services:– Dortek design, manufacture and install specialist hygienic timber-free doors and automation systems.– Other products include; glass doors, hermetic sealing sliding doors, transfer hatches and windows.– We offer a range of speciﬁcation services including; project advice, product design, drawings, speciﬁcation writing, BIM objects, data sheets and compliance documents. Our products are also listed on NBS Source. info@dortek.com https://dortek.com +44 (0) 1482 226848EGM – Ellegaard Göttingen Minipigs A/S Stand 26Ellegaard Göttingen Minipigs is the breeder of Göttingen Minipigs founded on the idea of offering a well-deﬁned non-rodent model with a high translational value. Göttingen Minipigs are bred in our AAALAC accredited barrier facility in Denmark focussing on our core values; Animal welfare, respect, collaboration and quality. We deliver animals to most

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TRADE EXHIBITIONTrade Exhibition99of the world with dedicated partners supplying the markets in North America, Japan, Taiwan and South Korea, and our Göttingen Minipigs are also available to customers in India and China. Furthermore, we provide animals with e.g. permanent catheters, VAP ports, or telemetry devices plus surgically or diet induced disease models and provide exploratory pharmacology studies as well as ‘open lab’ set-ups; all in addition to the collaborative development of transgenic Göttingen Minipigs.ellegaard@minipigs.dk www.minipigs.dk +45 58 18 58 18Fera Science Stand 8We create and deliver integrated, innovative and expert research services and products for our partners in crop protection, chemical and animal health companies, as well as food producers and growers, manufacturers, distributors and retailers. We also support and work closely with governments, academia and leading research organisations. Situated within the York Biotech Campus, our state-of-the-art facilities provide us with the tools to complete complex analytical activities across all of our business areas. Five years ago we turned our expertise and innovation into ways to support the medical research community in animal health. Fera now provide a successful laboratory animal health monitoring service for mice, rats, hamsters, gerbils, rabbits and Zebraﬁsh. In addition, we offer a suite of biological materials testing, water microbiology, water pollutant testing and mite trapping services.animalhealth@fera.co.uk www.fera.co.uk +44 (0) 1904 462724Impex Stand 13At Impex, Animal Welfare is as important to Us … as it is to You!Whether transporting large or small consignments we go to great lengths to ensure your shipment is safe, secure and stress free. Impex understand the importance of animal welfare and providing a service that reduces stress to your animals, is our number one priority. Impex understands how much time, care and dedication is afforded to laboratory animals and we extend those values whilst under our care.

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TRADE EXHIBITIONTrade Exhibition100Our dedicated team work 24 hours a day, 7 days a week to provide a world-wide, fully validated courier service working with our associates on all continents. Our in-depth knowledge gained from over 25 years’ experience within laboratory animal sciences, means we have the skills to meet your high expectations, in every shipment we carry out. Our ﬂeet of ministry approved vehicles are operated solely by trained, security cleared technicians. We have access to dedicated aircraft, increasing reliability and decreasing journey times. Our budget shipping options for smaller consignments offer customers a cost effective alternative whilst maintaining a high-quality service. We are fully compliant with all import / export licencing and documentation requirements. Our operations team can assist with this to ensure a seamless door to door service. But that’s not all - our other speciality services for shipping bio products and specialist equipment makes us your total logistics solution.info@impex-uk.com www.impex-uk.com +44 (0) 8456 021662Innotec Hygiene Solutions Stand 30Innotec Hygiene Solutions are delighted to introduce the Oxy’Pharm NOCOTECH concept; the powerful automated whole-room disinfection system for Life Science & Veterinary professionals. Sold in 120+ countries worldwide, the NOCOTECH system is an advanced technology for disinfecting surfaces, the airspace and sensitive electronic equipment, utilising a highly potent dry gas of Hydrogen Peroxide (HPV). Validated to the highest international standards, the process delivers up to a log 7 reduction. The entry-level device, Nocospray 2, is remarkably portable, weighing just 6kgs, yet has a capacity to treat areas up to 1,000mᶟ. The range topping Nocomax Easy has been devised for larger areas still, having the capability of treating up to 20,000mᶟ. With a comprehensive range of three disinfectants and two insecticides, the NOCOTECH concept offers complete material compatibility. Please visit us at our stand to ﬁnd out more details of our exciting IAT Launch Offer. sales@innotechygienesolutions.com www.innotechygienesolutions.com +44 (0) 7599 480 490

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TRADE EXHIBITIONTrade Exhibition101Inotiv Stand 6Inotiv Inc., is a leading contract research organisation dedicated to providing nonclinical and analytical drug discovery and development services and research models and related products and services. The company’s products and services focus on bringing new drugs and medical devices through the discovery and preclinical phases of development, all while increasing efﬁciency, improving data, and reducing the cost of taking new drugs to market. Inotiv is committed to supporting discovery and development objectives as well as helping researchers realise the full potential of their critical R&D projects, working together to build a healthier and safer world. https://www.inotivco.com/Aston Pharma 14 / 24BDT Animal Transport 32Bell Isolation Systems Ltd 38Datesand Ltd IFC / 3IPS Product Supplies Ltd 28Institute of Animal Technology 65 / IBCLBS Serving Biotechnology Ltd OBCR C Hartelust BV 9Tecniplast UK 22-23University of Cambridge / University of Oxford 41INDEX TO ADVERTISERS PageAnimal Technologists – the key workers for medical research

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TRADE EXHIBITIONTrade Exhibition102Institute of Animal Technology (IAT) Stand 3The Institute of Animal Technology (IAT) was founded in 1950 and its purpose is to advance knowledge and promote excellence in the care and welfare of animals in science. The IAT recognises and supports the beneﬁts arising from research involving animals and its members are committed to the principle that excellence in animal care and welfare is essential for excellence in science. Representing Animal Technologists both within the United Kingdom, and around the world, the IAT has over 2500 members, which includes the vast majority of the UK’s Named Animal Care and Welfare Ofﬁcers (NACWOs) for which the Institute awards the accredited training on behalf of the Home Ofﬁce. Education, qualiﬁcation and continuous professional development for Animal Technologists is the primary role of IAT Education, whose website www.iateducation.co.uk was successfully launched in early 2021. The website has all the resources that members need when considering furthering their education, whether they’re considering a diploma or apprenticeship. IAT Education continues to be recognised by Ofqual as an Awarding Organisation, awarding diploma qualiﬁcations, FE and HE Levels 2 through to 6 qualiﬁcations in Laboratory Animal Science and Technology. Last year our scope of recognition was extended to include the End Point Assessments (EPA) for Level 2 and 3 apprentices. IAT members are now able to access and apply for these courses through the mySociety member page which launched in February 2021. The IAT’s award winning Career Pathway www.iat.org.uk/pathway for Animal Technologists is now widely recognised throughout the UK and has been adopted as a template by other countries.admin@iat.org.uk www.iat.org.uk www.iateducation.co.uk

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TRADE EXHIBITIONTrade Exhibition103IPS International Product Supplies Ltd Stand 32It’s so good to be back!IPS is a leading supplier of high quality and ethically sourced products and brands including LabDiet®, TestDiet®, Lignocel Bedding and BenchGuard®. For IAT Congress 2022 we are delighted to be launching a new product within our BenchGuard® range. SafeGuard is a revolution in the world of hand and small object sanitising and it really must be seen to be believed! Visit the IPS stand and see for yourself what a game changer this is to the extent that everyone will want at least one within their facility! If that does not tempt you then join Becky, Mirren, Senga and Sue for some fun competitions as we celebrate not only being back at IAT Congress but IPS’ 20th birthday too!customers@ipsltd.biz http://www.ipsltd.biz/ +44 (0) 870 600 1616Janvier Labs Stand 25JANVIER LABS takes care of your models so you can devote yourself fully to your research projects!Thanks to its unique site, the largest and most modern in Europe, JANVIER LABS provides you with experimental models of the highest level of quality.We assure you of rigorous breeding conditions essential for uniformity and reproducibility of your experimental results: health status (SPF and SOPF), genetic stability, microbiota and animal welfare.With more than 60 years dedicated to breeding and developing research models, JANVIER LABS ensures availability, responsiveness, and excellence, as well as transparency on the quality of its models, products and services.In addition to our 360° range of immunodeﬁcient models, in particular the NXG (NODSCID Gamma) mouse and its humanised counterpart the NXG-HIS, you will also be able to discover our range of metabolic models. These are ideal for all projects dedicated to the study of obesity and metabolic disorders, such as NAFLD, diabetes, diabetic nephropathies and many more.With JANVIER LABS, you beneﬁt from a complete support which extends from the creation of your new models, their characterization by our experts and the breeding of preclinical cohorts, the preparation of your models in the laboratory, until their delivery by our dedicated carriers.

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TRADE EXHIBITIONTrade Exhibition104Throughout the year, you will discover the beneﬁts of JANVIER LABS Innovation through our new models and services, which will complement our offer to best meet your needs.Jon is looking forward to welcoming to the stand!jonathan.faupel@janvier-labs.com +44 (0) 7507 363717Kent Scientiﬁc Stand 22Drawing on more than 30 years of experience, Kent Scientiﬁc Corporation serves medical and research scientists worldwide as a provider of innovative integrated solutions for pre-clinical research and drug discovery advancement.As the world leader in non-invasive blood pressure, physiological monitoring and anaesthesia systems for mice and rats, Kent Scientiﬁc enables their customers to achieve results that are fast, consistent, and exceedingly accurate. They provide the latest technological advances in research products at the best prices.Widely regarded as a trusted and reliable partner, Kent Scientiﬁc has come to be known as an integral member of the research community, committed to investing resources toward improving lab animal and researcher safety and research results.marketing@kentscientiﬁc.com kentscientiﬁc.com +1 860 626 1172Laboratory AnimalScience AssociationLaboratory Animal Science Association (LASA) Stand 2The UK society for scientists and laboratory animal professionals with an interest in animal research, 3Rs, care and welfare, education and training, ethics and policy and regulation of animal research.LASA was founded in 1963 by a consortium of industrial, university, ministry and research council representatives – a breadth of interest which is still typical of the LASA membership today. Through our mission statement ‘To advance scientiﬁc understanding and knowledge of the use, care and welfare of laboratory animals and promote reﬁnement, reduction and replacement’ we aim to encourage and facilitate education and training in laboratory animal science.

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TRADE EXHIBITIONTrade Exhibition105LASA promotes the interchange of information through meetings, lectures, discussions and publications. There are seven specialist sections of LASA which together provide a forum to discuss the latest developments in the areas of specialised scientiﬁc interest.We welcome applications of membership from Individuals and Organisations. info@lasa.co.uk https://www.lasa.co.uk/ +44 (0) 8456 711956LBS Biotech Stand 11As an independent family run business since 1939, where integrity still counts, heritage and tenacity runs through the very veins and DNA of LBS. These have played no small part in its success as a leading supplier of diet, bedding, consumables and services to the biotech industry as we head into our 82nd year. Whilst the company takes immense pride in its heritage we recognise that it is only through a relentless and a consistent focus on meeting and exceeding the requirements of our domestic and international customers in the biotechnology industry that we maintain this position.We offer a combination of tried and tested products and through a continual process of product development, new innovative product solutions. All of this is backed through our commitment to ISO 9001:2015 quality assurance, customer service and logistics management. This is further underpinned and developed through a process of working closer with the understanding our customers’ needs, at which we aim to excel.Contact us for expert advice on:l research and zoo dietsl research bedding and nesting materiall environmental enrichment productsl PPE including clothing and footwearl AniBio animal facility management software – covers all your essential needsl disinfectants and all allied productsl bespoke irradiated packaging and suppliesl specialist vacuum / ﬂoor care productsl broad range of specialist equipment and products for Animal Technologistsl price promisel LBS owned and run logistics sales@lbs-biotech.com http://www.lbs-biotech.com/ +44 (0) 1293 827940

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TRADE EXHIBITIONTrade Exhibition106Linton Instrumentation Stand 21Linton Instrumentation is an independently owned company specialising in the supply, maintenance and support of laboratory instrumentation and consumables for the life sciences. We distribute innovative products and solutions from market leading manufacturers as well as our own branded products. Our product range includes physiological and behavioural recording systems (human and animal), anaesthetic and surgical products, drug delivery technologies, micropipette pullers, microdialysis systems, ﬂowmeters and actigraphy systems and much more besides. At this conference we will be showcasing some exciting new products from Instech Laboratories and Kent Scientiﬁc.Linton Instrumentation are UK and Ireland distributors for Biopac Systems Inc., BodyCap, Cedrus, CMA Microdialysis, CWE, Instech Laboratories, KD Scientiﬁc, Kent Scientiﬁc, M-Dialysis, New Era, North-Coast Medical, Philips Respironics (Actigraphy Products), Physitemp, Primetech (iPRECIO implantable drug delivery systems), Sutter Instrument Co., Transonic Systems, TSE and Ugo Basile.mail@lintoninst.co.uk www.lintoninst.co.uk +44 (0) 1379 651344Lomir Stand 42No further details available at time of printing.Marshall BioResources Stand 15Marshall UK is a division of Marshall BioResources Inc., and our Home Ofﬁce designated breeding and supplying facilities are located in East Yorkshire near Hull and at Wyton in Cambridgeshire. We supply Marshall Beagles® and have full barrier facilities for the production of ‘Inﬂuenza-free’ Marshall Ferrets® and SPF Guinea pigs and mice. Using ﬂexible ﬁlm isolators, we breed the IFNAR type 1 and type 2 interferon receptor KO mice (A129 and AG129) as well as the wild type control (129 SvEv). Our SPF Dunkin Hartley Guinea pigs have a high health status (being free of CMV and PI3). Our Scientiﬁc Services team offers a highly regarded animal Health Monitoring Service and we are able to carry out health screening at your site or, using our collection service, your sentinels can be brought to Grimston for testing.

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TRADE EXHIBITIONTrade Exhibition107Biological matrices from a range of donors (rodents, Marshall Beagles®, rabbits, humans, NHP’s and farm animals) are also available. We offer a very quick turnaround of your orders for whole blood, plasma, serum, tissues and many other bioproducts.Visit our stand to pick up a set of current literature or contact us after the event.BNKsales@marshallbio.com https://www.marshallbio.com/ +44 (0) 1964 527555MMM Medical Equipment Ltd Stand 5Complete Solutions for Infection ControlMMM have supplied Sterilising Equipment to both Laboratories and Research Centres for over sixty-eight years and are one of the strongest manufacturing groups in Europe. MMM Sterilisers are designed with reliability built in offering you peace of mind for your facility. Each stage of manufacture, installation and after sales care is quality controlled to provide the long-life cycle you need. This level of reliability and continued after sales and Service support has earned us preferred supplier status with many of our clients. MMM Equipment – All MMM equipment complies with all relevant European standards and directives.– Steriliser chamber sizes from 150 to 9000+ litres – our comprehensive range is sized to allow easy access for single and double sided IVCs.– Single sided or double door pass-through options available. – Sterilisers are installed within a single or double skinned airtight barrier; double skinned being preferred by many for its dramatic improvement to both sound and heat insulation. – We offer our own compatible electric or steam to steam generators should a suitable external supply be unavailable. – Standard loading heights of 390mm, 625mm, 850mm and ﬂoor level are available or individually set to client requirements. – MMM can include H2O2 (VHP) generators as part of an automated process cycle to meet each individual client reprocessing requirements.enquiries@mmm-group.co.uk https://www.mmmgroup.com/en/products+44 (0) 113 3910717

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TRADE EXHIBITIONTrade Exhibition108MRC Harwell Advance Stand 9What is Advance?Advance is a state-of-the-art scientiﬁc training centre dedicated to training and skills transfer within the life sciences. Located at MRC Harwell, Advance offers a mixture of practical and theoretical courses in laboratory animal science and genetics to the research community worldwide.The centre is purpose built to deliver high-quality scientiﬁc training. The centre brings together some of the country’s experts in laboratory animal science to provide engaging training courses in mouse genetics, genome editing, pathology and laboratory skills. Our goal is to address the vital need to develop skills in life sciences by expanding training and education opportunities for researchers and technicians. We aim to deliver quality training courses that develop the expertise that scientists can offer in a competitive global research industry, whilst maintaining a strong emphasis on animal welfare.As a wide-reaching knowledge and research base, we aim to develop links with external training providers, including academic organisations, societies and commercial companies, to support, collaborate and produce bespoke training courses. Advance also offers unique facilities, including laboratory space equipped to support in vivo techniques alongside seminar rooms and modern meeting spaces for workshops and training courses.training@harmrc.ack.uk www.har.mrc.ac.uk/training +44 (0) 1235 841438NKP-Isotec Stand 37Your Ideas Drive Us Forward Since the 1950s NKP has had a strong relationship with the research industry, developing plastic caging and housing systems worldwide.Through recent years, NKP-Isotec has developed a wide range of Flexible Film Isolators for various species, bio-safety cabinets and associated sundry items. With the help of our trusted research partners, we have established a reputable line of products that have animal welfare, user satisfaction and eco-friendly solutions at their core. Customer requirements and services are at the heart of our business, and we therefore offer support, training, and bespoke manufacturing to meet our client’s requests. Furthermore, our experienced team of Servicing Technicians are on hand to ensure all of your equipment is running efﬁciently. Working With You for Better Solutionssales@nkpisotec.com https://nkpisotec.com/ +44 (0) 1530 510113

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TRADE EXHIBITIONTrade Exhibition109Plexx BV Stand 23Plexx BV is the sole European representative for BioMedic Data Systems, Lab Products LLC., Hydropac, E-Z Systems/Euthanex and Iwaki Aquatic Systems. With nearly 30 years of experience in the pharmaceutical and biomedical industry, we have a proven track record of providing high quality products and outstanding customer service. Animal Identiﬁcation Injectable transponders give the option to program unique identiﬁcation codes as well as reading body temperature. Additional data can also be collected by connecting weighing scales and tumour measurement devices.Individually ventilated Micro Isolator systems Protect both your staff and animals with our positive cage in a negative rack design. Zebraﬁsh and Xenopus Housing SystemsNewly designed tanks and racks with high quality components and remote access and control.Hydropac An innovative way to deliver water to rodents using on-site produced pouches and drip-free single use valves.Anaesthesia equipmentUser friendly, simple operation equipment with a level of precise automation that minimises operator error.Automated Home Cage Euthanasia SystemsHumane gradient CO2 systems for small, medium and large numbers of cages at the press of a buttonEnrichment, Treats and Special DietsFor all laboratory animal species.uk@plexx.eu https://www.plexx.eu/ +31 481 377797

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TRADE EXHIBITIONTrade Exhibition110Positive Weighing Solutions Stand 29Positive Weighing Solutions are one of the country’s leading suppliers of weighing scales, systems and equipment. At Positive Weighing Solutions we offer a wide range of services including the sale of quality weighing equipment, reliable servicing and maintenance of your scales and weighing equipment and calibration of your scales.Positive Weighing Solutions will always endeavour to provide you and your company with excellent service and the weighing solution that suits you.At Positive Weighing Solutions we pride ourselves on our face-to-face, traditional style.– You will always receive expert advice and a fast response to any enquiries.– You will never have to try numerous times to get through to one of our team.– We will never substitute our team for an automated telephone system.– You will never have to search around for the right number or get passed from department to department.You can be conﬁdent that when you call us you will speak to one of our friendly reliable team members and you won’t be kept waiting.info@positiveweighing.co.uk www.positiveweighing.co.uk +44 (0) 1684 561002S3 Science Stand 40Why use S3 Science Recruitment?– Largest preferred supplier of Animal Technicians and research staff since 2002.– Expert solution providers for permanent and temporary recruitment. – Security and Occupational Health screened and competency tested candidates.– Highly acclaimed and industry recruitment leaders. – 24/7 support from recruitment consultants for both clients and candidates.Supporters of the Animal Technician Program (ATP), a social enterprise delivering excellent new animal technicians on a not-for-proﬁt basis. For ATP Training and Development contact us via info@s3science.comwww.atdp.org info@s3science.com www.s3science.com +44 (0) 203 924 0166

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TRADE EXHIBITIONTrade Exhibition111Safe Stand 10Your System Partner for Laboratory Animal ScienceWe offer complete solutions for your research work. We supply diets, custom diets, bedding and environmental enrichment, in a range of packaging formats, delivered to you from our new UK warehouse.All our products and processes are independently certiﬁed for provenance, traceability, quality and environmental sustainability.Our products are available irradiated to 10kGy, 25kGy or 40kGy if required.To discuss your speciﬁc requirements, contact: Brian Young, UK Business ManagerBrian.Young@rettenmaier.eu www.safe-lab.com Scanbur Stand 39It is SCANBUR’s mission to successfully and innovatively develop, produce and sell equipment for in vivo medical research and cleanroom production globally hence contribute to preventing and curing diseases: Improving Life Sciences.ScanClime for Scantainer and IVC - a compact and mobile plug and play air handling, humidiﬁcation and dehumidiﬁcation unit for animal housing systems. Provides humidity control with unrivalled accuracy, promoting better breeding performance, animal welfare, increased validity of research and improved ﬂexibility. In addition humidiﬁcation cost can be reduced by up to 80%.Scantainer – if draught inside IVC cages is a concern, when housing e.g. pups or nude mice, Scantainer is a great alternative. Also, considering that rodents are social animals, if more rodents should be allowed to smell or hear each other, a Scantainer could be a preferred housing solution. A very ﬂexible housing system. Can hold many different cages sizes allowing for housing of rodents to be applied for many different types of studies.Animal Welfare | Allergen/Disease Control | Ergonomics | Green Solutionsjow@scanbur.com www.scanbur.com +44 (0) 7923 320 519

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TRADE EXHIBITIONTrade Exhibition112Surrey Diagnostics Ltd Stand 31We specialise in providing independent screening services in laboratory animal health monitoring. Our staff have a wealth of experience in microbiology, serology, molecular biology and veterinary pathology. Through this expertise, SDL can provide consultancy services in all aspects of laboratory animal science.Here at Surrey Diagnostics, we understand the importance of developing and maintaining a comprehensive health monitoring programme as a fundamental part of successful research. It’s our aim to give clients the most scientiﬁcally accurate health monitoring service on the market, at a fair price, with customer service which is second to none. We use the latest appropriate and proven technologies. We advocate a highly ﬂexible multi-disciplinary approach to health monitoring, using both conventional necropsy and non-destructive sampling techniques in combination, which we call ‘Combined Screening’. This allows a signiﬁcant reduction the numbers of animals used whilst maintaining a reliable, robust health screening programme. As a complementary service to health monitoring we offer full environmental testing including surfaces, air, water, consumables and Laboratory Animal Allergen (LAA) monitoring. We also provide possible solutions to any problems arising. We also have room sanitising systems available.If you would like any further information on the services and products we can supply, please do get in touch and we will be very happy to help in any way we can.andy@sdlab.co.uk / alistair@sdlab.co.uk (Health Monitoring) www.sdl.uk.net mark@sdlab.co.uk (Environmental)

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TRADE EXHIBITIONTrade Exhibition113Sychem Stand 7Providing industry-leading animal care solutions Sychem is leading UK provider for sterilisation and decontamination solutions, equipment servicing, and infection control consumables. Offering a range of high-quality products and services across Life Sciences, Laboratory and Healthcare Sectors. Services include decontamination equipment, infection solutions, and tailored service contracts.Steeclo S.p.A Partners We work with Steelco S.p.A, to provide a range of decontamination equipment to facilities across the UK. These include variously sized washer-disinfectors, automated tunnel washing systems, and a range of steam sterilisers designed to aid Biomedical sites in breakthrough research.Animal Containment Workstations At Sychem, innovation is a fundamental quality found in every machine manufactured, and 2020 celebrated the launch of the AirFlow Range. Made up of three unique workstations, SychemCHANGE, WASTE and FILL are manufactured in the UK, and are designed with ergonomic advantages to protect users in their daily routine.Servicing With a team of 23+ service and test people based throughout the UK, Sychem offers a range of comprehensive service solutions. Our services include validation and testing, equipment servicing, PPM and emergency breakdown support assisted by our Sychem Eye customer service portal.hello@sychem.co.uk https://www.sychem.co.uk/ +44 (0) 845 644 6824

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TRADE EXHIBITIONTrade Exhibition114Tecniplast UK Stand 20Since our inception in 1949, Tecniplast has been building its global reputation for creating the best designed, best built, highest quality animal housing and washing solutions. At Tecniplast, our primary objective is simple: to keep your animals safely cared for, reliably and economically.Tecniplast have been at the heart of creating innovative solutions for over 70 years. We have an acute awareness of the continuous evolution of biomedical facilities and are proud to have the capability to design and develop products in-house. We are able to offer a wide range of integrated solutions to our clients, here are details of just some of the Tecniplast/IWT product range on offer:– A world leading range of IVC systems, including the latest jewel in our crown - Emerald Line, now available to house both mice and rats.– Digitally Ventilated Caging (DVC): the latest home cage data capture technology.– Biocontainment and bio-exclusion caging.– Laminar Flow technology including cage changing stations, bio-safety cabinets, downﬂow booths, bedding disposal systems and air showers.– Washing, decontamination and logistics equipment ranging from bottle washers and ﬁllers, rack washers, cabinet washers and decon locks.– Automation: from partial to fully automated robotic systems to assist with ergonomics, standardisation of process and throughput.As a complete solutions provider, Tecniplast offer a wide range of Service Options for the care and maintenance of your equipment. With Silver, Gold, Platinum, and bespoke packages available – the optimum solution is available for your facility.For more information regarding any of our products or services either pop by our stand or visit our website.info@tecniplastuk.com www.tecniplastuk.com +44 (0) 345 050 4556

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TRADE EXHIBITIONTrade Exhibition115TPS/Gruenberg Stand 17Gruenberg Steri-Dry Heat Lab Animal Science SterilisersTPS/Gruenberg manufactures a wide range of lab-animal science dry heat sterilizers for the decontamination and sterilisation of animal-habitat cages and equipment. Available in cabinet and truck in styles in a variety of conﬁgurations, Gruenberg Steri Dry heat sterilisers can meet any throughput and architectural requirements without the need for a pit, drain, water, steam or structural reinforcement of the building to hold the weight. Each steriliser is designed in modules, sized to ﬁt the move in path through the building without the need for construction. The steriliser modules are then assembled in place and each cycle is carefully validated by our team of experienced Project Managers.Please visit our stand to meet Robert Davis, our Steri Dry Sales Manager.bdavis@process-info.com http://www.steri-dry.com +1 508 341 4363Transnetyx Stand 12At Transnetyx, we are passionate about serving researchers worldwide to help them advance human health. Our suite of services (Automated Genotyping, Microbiome Analysis, Genetic Monitoring, and Colony + AMI) is dedicated to supporting efﬁcient and reproducible research -- with a relentless focus on accuracy and responsible lab animal care.Our partnership with the global research community empowers them to outsource critical research tasks to conﬁdently focus on their next discovery.dporteous@transnetyx.com help@transnetyx.com https://www.transnetyx.com/ +1 888 321 2113

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TRADE EXHIBITIONTrade Exhibition116UNO BV Stand 4UNO – Life Science is a well-known supplier of housing products and research equipment for laboratory animal research. UNO has a wide range of standardised products and also the knowledge and experience in the development of customised solutions for research equipment as well as the design of complete animal facilities. Our products and solutions facilitate the complete process cycle of laboratory animal science. UNO provides solutions for your research and supports you with our quick response by skilled and experienced staff, offering efﬁcient and cost saving solutions. Innovative designs and high-quality project management is our speciality.Since 2018, UNO Life Science has added the products and designs of Arrowmight to our portfolio.info@unobv.com www.unobv.com +31 316 524451Vet-Tech Solutions Ltd Stand 14Vet-Tech Solutions Ltd the “Go to“ company unique in our ﬁeld. The only company to manufacture, supply, service, and repair all types of equipment from our premises in the UK.We’ve grown in size yet still keep that important personal approach with our Customers.We custom-build anaesthesia and surgery equipment, euthanasia systems and down ﬂow tables and supply a wide range of biomedical research items and hold a range of consumables in stock.Specialists in manufacturing items from stainless steel, acrylics, perspex, polycarbonate and trespa using our own in-house creative team to assist with design and bespoke solutions working alongside our dedicated engineers. All the items we supply are ﬁt for purpose.Talk to us about our Servicing Contracts if you are looking to make cost savings.Innovators of the ﬁrst home cage euthanasia system to include a pre anaesthetic cycle or just CO2. We supply smaller Pre Set CO2 Systems which can be used with either chambers or home-cage lid attachments.All our CO2 Systems are AVMA compliant.– Developers of the CurVet Rat and we stock the Mimicky Mouse Model.– Represent Dycem decontamination ﬂooring system.info@vet-tech.co.uk https://www.vet-tech.co.uk/ +44 (0) 1260 274333