Animal Technology - where good science communication is vital
Congress
2021
CONGRESS
9th25th March 2021
GENERAL INFORMATION
Welcome from the Congress Committee 2
Tech Month 4
General Information 5
AAALAC Fellowship Announcement 6
AS-ET Online Auction 7
Trade Partners Treasure Hunt 9
IAT Annual General Meeting Agenda 11
Andrew Blake Tribute Award 2020 12
Andrew Blake Tribute Award 2021 16
Animal Technology and Welfare Journal Prize 2020 19
Best Poster Prize 21
At A Glance – Full Programme 22
Tech Month Bingo 64
Index to Advertisers 78
AST2020 Sponsorship IBC
Congress 2022 OBC
SCIENTIFIC PROGRAMME
Paper Presentations 25
Kevin Dolan Memorial Lecture 44
Workshop Sessions 46
Poster Displays 56
TRADE EXHIBITION
Flash Trade Sessions 74
Trade Interactive Forums 75
Virtual Exhibition 79
Animal Technology
- where good science communication is vital
The IAT roundel logo is a registered trademark
of the Institute of Animal Technology
C21 e-Handbook Contents
2 General Information
WELCOME
Welcome from the IAT Congress Committee
Dear Delegate
Well, what a year!
This time last March we should have been in Edinburgh, enjoying the largest conference for
Animal Technologists in the UK. However, to quote Robert Burns, “the best-laid plans of mice
and men often go awry” and the plans were so well laid! We just had not taken into account
COVID-19.
We wish to say a big thank you to all those who have continued to support us through this
difficult year and to assure you that we do always try our best to make the annual conference,
be it an IAT or joint event, as successful as possible for all concerned.
As lockdowns and the after effects of the pandemic are still affecting the world, Congress 2021
will be our first virtual Congress. We will offer our usual mix of presentations and Workshops,
along with Poster Displays and the chance to receive the latest news from our Trade Partners.
Whilst virtual conferences are now more commonplace, we felt that we should spread out the
event during Tech Month this year. Hopefully by offering shorter sessions, evenly spaced over
a longer time frame, we can offer something for everyone.
Posters displays feature on the Congress 2021 website throughout the event.
You can watch the Paper Presentations live, or catch up on them via the website later on. They
will be available to watch throughout the month.
Workshops will be interactive.
Trade Exhibitors will be updating you on their latest innovations and products during the two
minute flash sessions, as well as via the timed Drop-In Forums.
For a quick At A Glance reference on the full programme, see pages 22-23.
There will also be a chance to win prizes with the Virtual Treasure Hunt competition. Details
are available on the Congress website.
We wish you a very enjoyable Congress 2021. As always, we are keen to receive your feedback
or any comments on this event. We will send out a survey at the end of the month. Please take
a few moments to complete this as it will help us to provide an improved event in future years.
We hope you find Congress 2021 interesting and stimulating, and we look forward to getting
back to a face-to-face Congress in 2022.
All information is included in this Handbook. For a quick guide, check out the website
https://eu.eventscloud.com/website/2712/home
IAT Congress Committee
Now more so than in previous years we would like to take time to recognise the important roles Technicians
perform within our industry and celebrate the huge efforts that have been made during this pandemic.
Tech Month is going to have a different feel this year due to the current climate we find ourselves in.
It will be running from the 1st of March and throughout the virtual Congress.
We will be running two national events. The IAT will be hosting an online quiz every week through March
2021 so make sure you go to the website to take part. There will be the choice of an IAT Hoodie or Polo
shirt for the weekly winners and an Amazon voucher worth £100 for the overall winner.
There will also be a new event running for 2021 called Technician Bingo. This will involve carrying out
certain challenges throughout March. There will be a weekly prize draw for all entries completing a bingo
line and an overall prize draw for all entries completing a Bingo Full House.
Check out the IAT website www.iat.org.uk for more information and to register for Technician Bingo.
Institute of
Animal Technology
IT’S HERE …
GENERAL INFORMATION
During Congress the Committee can be contacted via email congress@iat.org.uk or
telephone 0800 085 4380
Access all sessions on Tuesday, Wednesday and Thursday afternoons from 9th March to
25th March and join our trade partners in the mornings on those days in their interactive
sessions via the Virtual lobby for registered delegates.
https://eu.eventscloud.com/website/2712/
For a quick reference to check times/days, see the AT A GLANCE Full Programme on pages
22-23.
© Copyright Institute of Animal Technology 2021
This e-Handbook is subject to copyright with all rights reserved. No part may be
reproduced, by any means, without prior written permission of the Institute of Animal
Technology and the Publisher. Reproduction in whole or part without the express written
permission of the copyright holders is prohibited.
Registered Office:
Institute of Animal Technology, 5 South Parade, Summertown, Oxford OX2 7JL, UK
All information contained is correct at time of publication.
Published on behalf of the IAT by PRC Associates Ltd.
AGM
The 35th Annual General Meeting of the Institute of Animal Technology takes place at
14.00 hrs on Tuesday, 9th March.
President, Robin Lovell-Badge, CEO/Chair of Council, Linda Horan, Honorary Treasurer,
Glyn Fisher and Honorary Secretary, Simon Cumming will be in attendance.
A full Agenda appears on page 11 and attendance is open to ALL delegates.
PAPER SESSIONS
Paper Sessions commence with our Keynote Speaker, Wendy Jarrett from Understanding
Animal Research on Tuesday 9th March.
We also thank Will Reynolds, Head of ASRU, for joining us to give an update on Thursday
25th March.
Full details for all the papers and presenters appear on pages 25 to 43.
5General Information
Session sponsored by
General Information6
GENERAL INFORMATION
KEVIN DOLAN MEMORIAL LECTURE (KDML)
On the last day of Congress, Gerry Creighton, Global Elephant Care makes a welcome return
to talk to us about his extensive work with Asian elephants.
See the full details on pages 44-45.
WORKSHOPS
Nine workshops are taking place during Congress and attendance is IAT CPD accredited.
See the Workshops section starting on page …… for a full review and details on the
presenters.
Session sponsored by
AAALAC Fellowship – Coming soon!
The AAALAC Committee have made the very difficult decision
to postpone applications for the AAALAC Fellowship for
2021. Uncertainty about international travel restrictions and
whether facilities will be able to host visitors means that the
Fellowship programme has been paused for 2021.
However we are very excited to announce that when we return
to the programme in 2022, we will be launching our new
application process. This will be a simplified, online application
and will be accessed via the AAALAC website. Details on how
to apply can be found on the AAALAC website (www.aaalac.
org/awards/fellowship-award), as well as via links from the
AALAS (www.aalas.org) and IAT (www.iat.org.uk) websites.
GENERAL INFORMATION
General Information
7
POSTERS
View each, full poster on the Congress 2021 website.
Abstracts start on page 56.
PRIZES AND AWARDS
Featured in this Handbook are the Awards for the:
Andrew Blake Tribute Award - see pages 12-17 for further details.
ATW 2020 Journal Article Award - see page 19 for further details.
Congress 2021 Best Poster Award - see page 21 for further details.
Session sponsored by
AS-ET ONLINE AUCTION
There are many great items to choose from
Auction takes place throughout Congress
So start bidding!
https://auction.iat.org.uk/
Integrated services:
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GENERAL INFORMATION
General Information
9
TRADE PARTNERS
All details appear on the following pages:
BOTH FLASH Trade Sessions - page 74.
ALL INTERACTIVE 1 Hour Forums - page 75 onwards.
The full VIRTUAL Exhibition - page 79 onwards.
TRADE PARTNER TREASURE HUNT
Take part in our Trade Partner Treasure Hunt during Congress. Download the Treasure Map
and hunt for the answers to the questions.
You may find the answers on our Trade Partners websites, in the Virtual Exhibition, or
during one of their interactive sessions or within their product literature.
No prize for this extra question, except the satisfaction that you found it! Can you spot the
mistake on the treasure map?
Your answers can be submitted online via the Congress 2021 website and the winner of the
valuable treasure will be drawn after Congress.
Good luck!
Integrated services:
From custom
model generation,
to contract breeding,
to cryopreservation
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Preconditioning
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You won’t be when you watch our ash
trade presentation and then join IPS on
Wednesday 17th March 12pm -1pm!
Also, why not enter our IAT Congress Competition: “Guess the Number of Pandas”?
Your chance to win some of our new Bamboo Products for
your facility and a £50 voucher of your choice!
Visit our virtual trade stand for more details!
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General Information
11
Notice of AGM
THIRTY-FIFTH ANNUAL GENERAL MEETING
OF THE INSTITUTE OF ANIMAL TECHNOLOGY
To be held virtually at 14.00hr on Tuesday 9th March 2021
AGENDA
1. Apologies for absence
2. Minutes of the 34th Annual General Meeting of the Institute of Animal
Technology held virtually on Wednesday 8th July 2020
3. Matters arising from the Minutes, which were published in full on the
Members Section of the IAT website and an abridged version in the
Bulletin Vol 56 No: 8 August 2020
4. Correspondence
5. Annual Report / Council Objectives
6. Financial Report
7. Appointment of the Auditor
8. Election of Officers: (i) President
(ii) Vice Presidents
(iii) Council
9. Proposals for Honorary and Life Memberships
10. Any other business
THE AGM IS OPEN TO ALL DELEGATES
Voting rights are restricted to voting members only
1 Alan Thornhill
2 Alan Palmer
3 Nicky Gent
4 Sam Jameson
5 Theresa Langford
6 John Waters
7 Carole Wilson
8 Adrian Woodhouse
9 Carmen Abela
10 Di Hazlehurst
11 Robin Labesse
COUNCIL ELECTIONS 2020
As there were eleven nominations for the eleven vacancies on Council, no
ballot took place and therefore the following were elected to serve on
Council for a three year term as from May 2020.
Linda Horan
CEO & Chair of Council
Simon Cumming
Honorary Secretary
12 General Information
ANDREW BLAKE TRIBUTE AWARD 2020
As the planned AST2020 conference had to be cancelled
due to the COVID-19 outbreak in the UK, last year’s
winner did not have the opportunity to present.
We are therefore delighted he is able to take part in this
year’s programme.
The 2020 chosen winner was:
Stuart Mason BA MIAT RAnTech
Research Assistant/Primate Trainer, Department of
Experimental Psychology, Oxford University
For his paper:
‘Protective cranial implant caps for
macaques’
The paper will be presented on Tuesday 23rd March at 14.00.
See page 34 for his paper abstract.
Stuart receives an engraved glass plaque and a total cash
award of £250.00.
ANDREW BLAKE
TRIBUTE AWARD
ANDREW BLAKE
TRIBUTE AWARD
13General Information
ANDREW BLAKE TRIBUTE AWARD 2020
About the author:
Stuart graduated in 1993 with a Diploma in Business
Management, whilst living in New Zealand, and worked
in supermarket logistics and management. He moved to
the UK in 2004 and managed a sports retail store with a
£5 million turnover per annum. In 2009, Stuart started
working in the Department of Experimental Psychology
at Oxford University as a Manager and Primate trainer in
Professor Mitchell’s laboratory.
Professor Mitchell trained Stuart to work with the non
human primates on her Medical Research Council (UK)
funding (2009-2015). From 2014, he became the main
primate trainer on the Wellcome Trust Strategic Award in
Oxford and has now moved onto another Wellcome Trust
award with Professor Mitchell and continues to support
other Principle Investigators within the Oxford primate unit.
Over the past 10 years, Stuart has trained over 100
macaque monkeys. As part of his current role he now trains
researchers, technicians, and support staff to work with
the primates ensuring that all involved succeed with their
training each day.
Stuart delivers many presentations in his area of expertise
on primate training methods and renements, at UK and
international conferences. He also co-organises practical
primate neuroscience training and welfare workshops
in the Oxford primate unit. Participants have attended
these workshops from primate laboratories across the EU
and China. Stuart and Professor Mitchell’s lab are now
collaborating with colleagues at Newcastle University who
also use primates in vital neuroscience research to develop
the protective head cap renement for use after cranial
implant surgery at that establishment as well.
The Andrew Blake Tribute Award commemorates the work and life of Andrew
Blake, who suffered from Friedrich’s ataxia, a hereditary condition described as
one of the “worst of neurological diseases”. Andrew died in May 2002 aged 39.
Andrew was passionate about the need to support scientists in their work and
his commitment to speaking out against animal rights activists took up much of
the last ten years of his life. He died shortly before he was to collect his MBE.
find out more at
www.tecniplastuk.com
Or call us on 0345 050 4556
find out more at
www.tecniplastuk.com
Or call us on 0345 050 4556
16 General Information
ANDREW BLAKE TRIBUTE AWARD 2021
We all have a responsibility for the welfare of the animals in our care and it is
often the little things that make a signicant difference.
The Andrew Blake Tribute Award is awarded by the Institute of Animal Technology
and sponsored by The Association of the British Pharmaceutical Industry (the
ABPI) to an Animal Technologist at any level, judged to have made a signicant
contribution to improving laboratory animal welfare.
The judges were impressed with all of the applications received and renements
presented.
The 2021 chosen winner is:
Zoe Windsor MSc BSc(Hons)
MIAT NACWO
Senior Research Support Technician
Institute of Neurology, University College London
For her paper:
‘Renements in head plate mouse nesting: using composite
nests to enhance welfare’
The paper will be presented on Tuesday 23rd March at 14.30.
See page 35 for her paper abstract.
Zoe will receive an engraved glass plaque and a total cash award of £250.00.
ANDREW BLAKE
TRIBUTE AWARD
ANDREW BLAKE
TRIBUTE AWARD
17General Information
ANDREW BLAKE TRIBUTE AWARD 2021
About the author:
Zoe completed a BSc (Hons) in Animal Behaviour and Welfare and an MSc
in Conservation Biology. She has been a licenced Animal Technologist for
7 years. Her career began at King’s College London before moving to UCL,
where she currently works at the Institute of Neurology. She is passionate
about animal welfare and chairs UCL’s technician culture of care group:
Collective Laboratory Animal Welfare Society (CLAWS). Over the last few
years Zoe has worked closely with mice with head stages and implants and is
interested in investigating renements to improve their quality of life.
The Andrew Blake Tribute Award commemorates the work and life of Andrew
Blake, who suffered from Friedrich’s ataxia, a hereditary condition described as
one of the “worst of neurological diseases”. Andrew died in May 2002 aged 39.
Andrew was passionate about the need to support scientists in their work and
his commitment to speaking out against animal rights activists took up much of
the last ten years of his life. He died shortly before he was to collect his MBE.
ATW The Official Publication of The Institute of Animal Technology (IAT)
and European Federation of Animal Technologists (EFAT)
NOW PERMANENTLY FREE FOR EVERYONE TO READ AND DOWNLOAD
The implementation complies with Plan S, the multi-funder effort to
ensure immediate open access to scientific publications
www.atwjournal.com
IAT Journal
Animal Technology
and Welfare
ATW publishes peer-reviewed articles allied to
animal science and technology, management
and education
Particular encouragement is given to authors
submitting papers promoting the 3Rs leading
to improvements in environmental enrichment
and the care and welfare of genetically
altered animals
ATW facilitates the Marjorie (Sandiford)
Whittingham Memorial Prize awarded
annually to the author of the best original
peer-reviewed paper
ATW publishes technical notes describing
new products, new or refined techniques and
new developments
ATW publishes papers and posters presented
at international meetings, opinion articles,
book reviews and relevant texts
ATW promotes the dissemination of ‘good
practice’
ATW promotes the recognition of Animal
Technologists everywhere
ATW PROFILE
ATW aims to be the medium for Animal
Technologists and all those concerned with
the care and welfare of animals used for
research purposes to communicate ‘good
practice’.
ATW especially aims to promote
and develop the 3Rs particularly in respect
of Refinement. More importantly, ATW
promotes the generally accepted 4th R,
Responsibility. The responsibility that all
Animal Technologists have in ensuring
dissemination of ‘good practice’ to every
institution using animals in research.
ATW enjoys a unique position as the scientific
publication for the leading organisations for
the welfare of animals used in research.
NO fees are charged to authors for publishing
in ATW. Instructions to authors appear on the
website.
Editor: Jasmine Barley MSc FIAT RAnTech
Email: atweditor@iat.org.uk
GENERAL INFORMATION
Marjorie (Sandiford) Whittingham was a late arrival on Council in 1966 serving 11 years until
she retired from work in the late 1970s. For the 7 years prior to her retirement, she was
Secretary to the Institute and was also a Member of the Exam Board for all of those 11 years.
Marjorie’s husband, Dick Whittingham and Council set up the prize fund after her untimely
death in Kenya where they had retired to. The enormity of the amount of work that Marjorie
completed during that period made her shorter service even more exceptional.
19
General Information
Journal Article – Marjorie (Sandiford) Whittingham Prize 2020
Animal Technology and Welfare
Paper Abstract
The aim of the project was to explore the relationship between employee participation and job
satisfaction by carrying out four workshops relating to the implementation of the 3Rs and working
towards a Culture of Care with clearly defined shared values. The participants were members of the
Biological Services Unit at King’s College London, Guy’s Campus involved in the care of animals used
for medical research. The 3Rs are a set of principles that provide a framework for more ethical and
humane animal research. They stand for Replacement, Reduction and Refinement. Where possible,
the use of animals should be replaced by another method when they can provide the same quality of
research e.g. computer models. If it is not possible to replace animals, then all efforts should be made
to reduce the number of animals used. Refinement methods should be utilised to reduce the amount
of pain, suffering or lasting harm experienced by the animals. This can be obtained for example, by
improving housing, procedure methods and pain relief. Institutions that work with research animals
are highly regulated by legislation and guidelines. However, such institutions should endeavour to go
beyond the legal obligations and treat the animals with compassion and empathy by establishing a
Culture of Care. Improved animal welfare has continually been shown to increase the reproducibility
of research and promote good science. This culture should be extended to the people that work
with the animals where “Institutional culture influences the productivity and performance of many
enterprises”. Low morale and motivation in staff can be linked to low job satisfaction, increased
sickness and bad public perception of an organisation. According to the Chartered Institute of
Personnel and Development (CIPD) 2018 report, absences due to stress-related illness and mental
health issues including anxiety and depression had increased in nearly 40% and 55% of organisations
respectively.
Cheryl Yalden
Cheryl graduated from the University of Leeds in 2008 with a degree in Biology (Animal Science).
After graduating, she returned home to South London and started a career in Animal Technology as a
trainee Animal Technician at King’s College London and now holds an Advanced Animal Technologist
position. She is actively involved in the training of the new apprentices and with the implementation
of the new database. Cheryl is continuing her career path and has one more module to complete to
obtain her IAT level 6. Her interests in Culture of Care and staff morale were ignited during studying
these modules and became the topic of her level 6 project.
Cheryl receives a commemorative plaque and monetary gift of £250.00.
The IAT Editorial Board, chaired by Jas Barley, has selected
Cheryl Yalden BSc MIAT, King’s College London
as the 2020 winner of the Animal Technology and Welfare
Journal Prize for her paper ‘The relationship between employee
participation and job satisfaction’
published in the December 2020 issue Vol. 19.3 pp169-84 www.atwjournal.com
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General Information
21
GENERAL INFORMATION
BEST POSTER PRIZE 2021
An excellent variety of posters are being displayed virtually for you to browse
through during the whole of Congress.
The Best Poster is selected by a panel, nominated by the Congress Committee, who
judges each poster according to criteria for best content, clarity and quality of
science.
The criteria covers: improvement in animal welfare, innovation, ease of replication
of work, presentation and layout.
The 2021 winner, who will receive a cash award of £250.00, will be announced at
the Prize Giving on Thursday 25th March at 15.00 hrs.
Our thanks go to long-term generous sponsors
of this award, LBS Biotechnology for their support.
BEST POSTER WINNER
Congress
2019
BEST POSTER WINNER
Congress
2018
Best Poster Winner
Congress
2017
Best Poster Winner
Congress
2016
BEST POSTER WINNER
Congress
2021
Tel: +44 (0)1293 827940
Email: sales@lbs-biotech.com
Contact LBS - your trusted supplier, serving
the needs of the Biotechnology Industry
www.lbs-biotech.com
Enrichment Products
Designed to enhance your research
Our extensive product range gives your research
animals an active, stimulating and comfortable
environment.
DesRes
TM
Rodent Houses
Fun Tunnels
Toys, Balls and Chews
Treats & Rewards
Bedding & Nesting
Foraging
- just some of our quality assured products,
suitable for use in biotechnology conditions.
General Information22
AT A GLANCE FULL PROGRAMME
Tuesday
9
March
Thursday
11
March
Wednesday
17
March
Tuesday
23
March
Thursday
25
March
Agenda
Life Sciences
Sychem
RWD
Life Science
NKP-Isotec
Janvier Labs
TPS/
Gruenberg
Transnetyx
Trade 22
10:00
14:00
11:00 12:00 13:00
IAT 35th AGM
Tecniplast
UK
a-tune
Software
Trade 17
Avidity
Science
GVG
Diagnostics
GmbH
MMM
Medical
Equipment
Trade 20
Trade 23
Trade 6
Ewan
Smith
IPS Ltd
Natasha
Cartmell
Trade 18
ABTA 2020
Stuart Mason
Envigo UK
Ltd
Steve
Trim
Scionics
Saffron
Foster
Datesand
Ltd
Eilisha
Carlton
AS-ET
Carole
Wilson
Trade 24
Adrian
Smith
Wednesday
10
March
Tuesday
16
March
Thursday
18
March 2021
Wednesday
24
March
Presentations
KEY
Events
General Information
23
AT A GLANCE FULL PROGRAMME
14:00
14:30 15:00 16:00
IAT 35th AGM
Ewan
Smith
Flash Trade
Natasha
Cartmell
Elena
Mather
ABTA 2020
Stuart Mason
ABTA 2021
Zoe Windsor
Steve
Trim
Flash Trade
Saffron
Foster
Claire
Lathlean
Eilisha
Carlton
Joanna
Moore
Carole
Wilson
Maria
Sampieri
Adrian
Smith
Will Reynolds
ASRU
Prize Giving Kevin Dolan Lecture
15:30 16:00 16:30
Wendy
Jarrett
UAR
Animal
Research
Nexus
Francis
Crick
Jas
Barley
IAT
UAR
Francis Crick
Zebrafish
Association
NC3Rs
RSPCA
Culture of
Care
RSPCA
Zebrafish
IAT/HO/LAVA
Events Trade Sessions Workshops
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Scientific Programme
25
PAPER PRESENTATIONS
From awkwardness to openness: 15 years on the road to better understanding of
animal research
In January 2006 the Hall family closed their Darley Oaks Guinea pig farm in Staffordshire
following a sustained hate campaign which included threats of violence, thefts of animals
and a grave robbery. At the same time the building of a new animal facility in Oxford was
in jeopardy thanks to targeting by animal rights extremists.
Fifteen years on, animal research is credited in mainstream media with helping to
develop the vaccines that are allowing us to see a light at the end of the COVID tunnel.
Establishments share detailed information about their animal use publicly on their
websites and compete for Openness Awards. 92% of the public understands that animals
are used to try to develop new treatments for specific diseases and 79% believe that they
should be used for this purpose. New facilities are built and opened with minimal, if any,
attention from animal rights groups.
How did the UK bioscience sector succeed in creating such a supportive operating
environment for animal research? This presentation will look back at what our
community has achieved and what we need to persevere with in order to maintain public
understanding and acceptance.
Tuesday 9th March
15.00 – 16.00 hrs
Wendy Jarrett
Chief Executive
Understanding Animal Research
Wendy studied Classics at University but has focussed on
science and health communication for most of the past 30
years. Her work has included awareness programmes on the
risk factors for heart disease, male cancers and a campaign to
persuade the UK food industry to reduce the amount of salt
added to products. She is a trustee of the Blood Pressure Research Trust.
In 2004 Wendy joined the Coalition for Medical Progress (CMP), launching the People’s
Petition in support of animal research; creating an image and video library of research
animals and encouraging institutions to allow access to news cameras. She led on the
merger of CMP with the Research Defence Society to create Understanding Animal Research.
In late 2009 Wendy moved to the UK’s National Institute for Heath and Clinical Excellence
to introduce a more open approach to media relations, returning to UAR as Chief
Executive in November 2012. She led the development of the Concordat on Openness on
Animal Research in the UK, as well as helping to set up the European Animal Research
Association (EARA). Wendy is a Vice President of the Institute for Animal Technology. She
also sits on the UK’s Animals in Science Committee and the Board of EARA.
Session sponsored by
KEYNOTE SPEAKER
Scientific Programme26
PAPER PRESENTATIONS
Sneaky scorpions: husbandry of venomous armoured animals
Scorpions are relative newcomers to the laboratory environment and their unique biology
brings some fascinating challenges and observations. Venomtech have been caring for
scorpions in a laboratory environment for over 10 years and several of our scorpions have
been with us from the beginning and moved labs four times with us. Since the media has
grabbed the idea the scorpion venom is one of the most valuable liquids around there is a
real challenge to make sure these animals are well looked after and their natural populations
are protected.
Wednesday 10th March
14.00 – 14.30 hrs
Steve Trim
Founder, Chief Scientific Officer
Venomtech Ltd
Steve founded Venomtech Ltd in March 2010 after a ten-
year career as a molecular biologist at Pfizer. Approximately
eight of those years were studying the biology of pain and
neuroscience and this is where he gained an interest in toxins
from venoms as these have superior potency and selectivity
for ion channels compared with many small molecule drugs. Setting up a laboratory
housing nearly 140 species of venomous invertebrates, it was critical to understand more
about their welfare needs and potential veterinary care. The team also set up and work
with a separate facility that has approximately 60 species of venomous snake. In order to
do this we developed safe methods for working with venomous animals and even a patent
for a safe method of feeding venomous snakes. Venomtech won the 2012 Andrew Blake
Tribute Award, from the Institute for Animal Technology, for the most significant impact
on animal welfare with our paper demonstrating tarantulas (Theraphosids) respond to
environmental enrichment. Since 2014, Steve has co-led the Hazardous Invertebrate sub
group of the BIAZA terrestrial invertebrate working group. He was invited to join the
Veterinary Invertebrate Society in 2013 which he has chaired since early 2019. Thus in
addition to the collection of venom and the study of its components, Steve also researched
the biology and physiology of their venomous invertebrates to improve the veterinary care
potential for these animals and to maintain a healthy venom producing population.
Scientific Programme
27
PAPER PRESENTATIONS
The naked mole rat: blind and naked … but oh so cool!
Naked mole-rats (Heterocephalus glaber) are subterranean mammals that live in large
social colonies headed by a queen who is the sole breeding female, which makes them
one of very few eusocial mammals. In recent years, there has been much interest in the
unusual physiology of the naked mole-rat and how this could benefit biomedical research.
For example, naked mole-rats live healthily for over 30 years, therefore can this provide
insight into how to maintain health into old age? Moreover, naked mole-rats appear
highly resistant to cancer, have unusual pain behaviours and can withstand low oxygen
levels for prolonged periods of time.
Thursday 11th March
14.00 – 14.30 hrs
Ewan St. John Smith
Reader in Nociception
Department of Pharmacology,University of Cambridge
Following an undergraduate degree in Pharmacology at the
University of Bath and PhD in Neuropharmacology at the
University of Cambridge, Ewan conducted postdoctoral work
at the Max-Delbrück Centre for Molecular Medicine in Berlin
and the Skirball Institute of Biomolecular Medicine at New
York University School of Medicine.
In 2013, he took up a University Lectureship in Pharmacology, where his research group
focusses on understanding the molecular basis of pain, especially pain associated with
arthritis and disorders of the gastrointestinal tract. A second research focus is on the
unusual physiology of the naked mole-rat, i.e. its cancer resistance, longevity and unusual
pain sensitivity. He was promoted to Senior Lecturer in 2017 and Reader in 2019.
Ewan is also a Fellow of Corpus Christi College.
Session sponsored by
Scientific Programme28
Saffron Foster
Animal Technician
Brunel University
Saffron has been in the industry for almost three years and
started her career at The Francis Crick Institute. She is a Named
Animal Care and Welfare Officer (NACWO) and responsible
for the day-to-day animal management of mice, Zebrafish
and snails. She completed her level 2 IAT qualification and is
currently working for level 3. When not at work you can find Saffron drawing or making
various resin crafts. Thanks to her love for being creative, she recently won the IAT London
branch LOGO competition.
PAPER PRESENTATIONS
Snail husbandry: a technician’s perspective
This talk will provide a view on the use of snails (Lymnaea Stagnalis and Biomphalaria
glabrata) in research at Brunel University. I will discuss why they are useful research models
and briefly go into the work carried out on them at our establishment. I will also discuss
the fact that they are not protected and therefore an amazing replacement model. The
husbandry will be discussed along with enrichment that we provide and the obstacles we
have faced due to a lack of snail understanding in the research community.
Tuesday 16th March
14.00 – 14.30 hrs
Session sponsored by
Scientific Programme
29
PAPER PRESENTATIONS
Day to day care of opossums and their benefits to research
This presentation covers the day-to-day duties that are involved in looking after opossums
as well as some background on their natural habitat and what an opossum actually is. The
topics covered will include housing, handling, health, diet, breeding and the benefits of
using opossums in research.
Tuesday 16th March
14.30 – 15.00 hrs
Claire Lathlean
Research Scientist
The Francis Crick Institute
Claire has been in her current position for the last 9 years
and has been in the industry for 19 years. She started her
career working with mice for ICRF at Clare Hall, South Mimms
and went through multiple mergers with the company.
She works within a multi-species experimental unit and
directly supervises a team of research officers, training and mentoring them. Claire is also
responsible for certain areas within the unit and one of these areas is the opossums. The
multi-species include mice, rats, ferrets and opossums. The opossums are a favourite of
hers. She regularly takes part in procedural work and trains others in these techniques. She
is also trained in different containment levels. Animal welfare is a particularly important
part of her role. Claire achieved Registered Animal Technician (RAnTech) status and has
attended the NACWO training course. She also gained her level 4 IAT qualification. Claire
enjoys working with the more unusual animals and passing on her knowledge about these
species.
Scientific Programme30
PAPER PRESENTATIONS
Day to day care of the use of enrichment within a containment facility
When keeping animals in captivity, no matter what type of establishment they are being
housed in, whether it be a zoo, farm park or laboratory, the welfare of the animals takes
the highest priority. Besides food and water, it is also essential that enrichment is provided,
keeping all species of animals mentally and physically stimulated. Within a laboratory setting,
animals do not have the luxury of open space, which they perhaps would have in other
establishments. This is when enrichment makes all the difference. Focussing on pigs, cattle,
poultry, rabbits and ferrets, Natasha will be discussing the 5 main branches of enrichment,
and how they are implemented within a containment facility. Types of enrichment will be
discussed as well as the positive and negative impacts they can have on the animals, including
the considerations that need to be made and examples of enrichment used at the Animal
and Plant Health Agency (APHA).
Wednesday 17th March
14.00 – 14.30 hrs
Natasha Cartmell
Executive Officer Animal Technician
Animal and Plant Health Agency
Animals have always been Natasha’s passion. Her first paid
animal job was at the age of 14 as a kennel and cattery
assistant. After finishing school, she studied animal care,
followed by animal management, finally graduating with
an Honours degree in Animal Behaviour and Welfare.
Throughout her degree, Natasha was given the opportunity to work as a weekend Animal
Technician at Merrist Wood College in Guildford, Surrery. Her role was to maintain the
husbandry, care and welfare, of a variety of species including livestock, small mammals,
exotics and birds. On completing her degree, Natasha took this position on full time and
became more involved with lambing, the presentations’ teams, a member of the sheep
showing group and was part of the team for the rebuild of their new animal facility. As
she progressed, she became a tutor in animal husbandry, care and welfare. After working
at the college for 8 years, she fulfilled her desire to work in a zoo and became a zookeeper
at Chessington Zoo working with African hoof stock, small mammals and birds. From
there she moved to ZSL Whipsnade, working on their farm. Natasha then decided to gain
experience working with animals in science, which brings her to her current role as an EO
Animal Technician and Named Animal Care and Welfare Officer (NACWO) at APHA where
she works with livestock, small mammals and birds in high containment facilities.
Session sponsored by
Scientific Programme
31
PAPER PRESENTATIONS
A day in the life of a high containment technician working with poultry
This presentation provides a look into the daily life of an Animal Technician working
inside a high containment animal facility during an intensive study. It focusses on an
example of a study investigating highly pathogenic avian influenza virus in domestic
poultry and pheasants and discusses all aspects from ensuring the high containment suite
is safe to enter before any staff can begin work, to strict biosecurity, animal husbandry
and procedures during the day, concluding with the final facility checks that need to be
covered. Whilst the day-to-day work within a high containment animal facility can be
demanding, it is essential to understand the importance and the scientific need of the
work undertaken, and all the mechanisms in place to ensure the integrity of the work.
Wednesday 17th March
14.30 – 15.00 hrs
Elena Mather
Animal Technician
Animal and Plant Health Agency
Elena comes from Jersey in the Channels Islands and moved
to the UK when she was 18. She has always loved animals and
grew up with all sorts of creatures from birds to sheep. She
graduated from the Royal Veterinary College in 2019 with a
Masters degree in wild animal biology, having made a total
career change from social sciences. She worked at a wildlife park as an educator, delivering
talks on all things wildlife and then made a career move to APHA where she has worked
as an Animal Technologist for the past 18 months. Elena mainly works with mice, rabbits,
poultry, ferrets and pigs.
Session sponsored by
Scientific Programme32
PAPER PRESENTATIONS
Bovine husbandry, welfare challenges in SAPO ADCP containment
Pathogens that come under the Specified Animal Pathogens Order (SAPO 3) and acoustic
Doppler current profiler (ADCP 3) categories are interesting. However, they come with
their own challenges, when studied in their natural host. Adding the challenges of using
large livestock, such as cattle, as the subject of the study, leads to its own threats towards
husbandry, welfare and the safety of technicians. Through this presentation, we will, touch
upon what SAPO 3 ADCP 3 mean, discuss why cattle are used in high containment studies
and their husbandry and welfare needs as well as the challenges Animal Technicians face
when meeting these, for example, manual working in a bio hazardous environment, reduced
enrichment options and running a SAPO 3 ADCP 3 facility whilst meeting the needs of the
cattle.
Thursday 18th March
14.00 – 14.30 hrs
Eilisha Carlton
Animal Technologist
Animal Plant Health Agency
Eilisha has a Bachelor of Science degree in Veterinary Bioscience
and joined APHA in December 2020 as an Animal Technician.
Although ‘new’ in this industry, she is very enthusiastic about
it and has a passion for animal welfare and legislation.
Outside of work, Eilisha is devoted to her two dogs.
Session sponsored by
Scientific Programme
33
PAPER PRESENTATIONS
Using home cage monitoring during a time mating procedure to determine the
impact of swapping a female versus adding a female to an established pair
The use of sterile male mice to induce pseudopregnancy in female mice assigned for the
implantation of embryos is a vital component in the production of Genetically Altered
Animals (GAA). To achieve this, we use Protamine1 (Prm1) transgenic male Hemizygous
mice which are genetically sterile due to this mutation. These males are often kept for up
to nine months and are housed with a companion female. During the timed mating period
the companion is swapped for a new female.
We hypothesised that the addition of a new female to an established pair would cause
less disturbance for the male mouse, therefore activity would return to pre-change levels
in a shorter time frame compared to males that have their females substituted for a new
female.
We investigated what the disruption to the cage activity was like if - i) a new female was
added to the home cage compared to a group of control cages of trios, and ii) using a
normalisation of the data, we can estimate the difference in activity between the trio and
a group where the companion female was swapped. We used an established home-cage
monitoring (HCM) system to measure cage activity.
We found that there was widespread activity across the groups, however the activity of the
group where the female was added to the established pair was returned to pre-addition
levels sooner than the pairs where the female was swapped.
This presentation will discuss the results and the type of analysis we performed on the
data. Due to the complexity in comparing pairs of mice with trios in HCM, further studies
need to be designed to give us a clearer understanding and be confident that adding a
female to an established pair could reduce the impact of this intervention.
All animal studies were ethically reviewed and carried out in accordance with the Animals
(Scientific Procedures) Act 1986 and the GSK Policy on the Care, Welfare and Treatment
of Animals.
Thursday 18th March
14.30 – 15.00 hrs
Joanna Moore
Investigator and NIO
GlaxoSmithKline
Joanna has worked with laboratory animals for over 25 years
in a range of roles across different sectors. She has always
had a strong focus on welfare and enrichment and in 2018
she was awarded a PhD in Animal Sciences. More recently,
she has completed an assessment of the mouse DVC to
demonstrate the capabilities of this system in terms of what it can teach us to understand
the needs of the mouse.
Session sponsored by
Scientific Programme34
PAPER PRESENTATIONS
Andrew Blake Tribute Award Winner 2020
Protective cranial implant caps for macaques
Neuroscience studies with macaque monkeys may require cranial implants to stabilize the
head or gain access to the brain for scientific purposes. Wound management that promotes
healing after the cranial implant surgery in non-human primates can be difficult as it is not
necessarily possible to cover the wound margins. Here, we developed an easily modifiable
head cap that protects the sutured skin margins after cranial implant surgery and contributes
to wound healing. The protective head cap was developed in response to monkeys picking at
sutured skin margins around an implant, complicating healing. The user-friendly protective
cap, made from Klarity- R™ Sheet is affixed to the implant post-surgically. Once secured and
while the monkey is still anaesthetised, the plastic sheeting is moulded around the implant.
The protective head cap restricts the monkey’s finger access to its’ wound margins while
allowing air to circulate to promote wound healing. Across two UK primate facilities (Oxford
and Newcastle), the protective head cap promoted wound healing. In monkeys that did
not wear the head cap, re-suturing was necessary in ~30% of cases. In contrast, none of the
monkeys that wore the head cap required re-suturing. The monkeys wearing the head cap
also had reduced numbers of days of prescribed antibiotics and analgesia. This bespoken,
easily adaptable, protective head cap supports postoperative wound healing, and enhances
the welfare of monkeys involved in neuroscience research.
Reference:
Perry BAL, Mason S, Nacef J, Waddle A, Hynes B, Bergmann C, Schmid MC, Petkov CI, Thiele A, Mitchell AS. 2020.
Protective cranial implant caps for macaques. J Neurosci Methods, 108992. doi: 10.1016/j.jneumeth.2020.108992.
Further details on page 12-13.
(Original presentation postponed complying with lockdown restrictions in March 2020.)
Tuesday 23rd March
14.00 – 14.30 hrs
ANDREW BLAKE
TRIBUTE AWARD
The Andrew Blake Tribute Award is
generously sponsored by the Association
of British Pharmaceutical Industries
Scientific Programme
35
PAPER PRESENTATIONS
Andrew Blake Tribute Award Winner 2021
Refinements in head plate mouse nesting: using composite nests to enhance
welfare
Studies indicate that providing lab mice with choices which mimic the natural environment
allows them to build the best quality nests and mice have been shown to go to considerable
effort to gather and combine multiple nesting materials to construct a nest with. These types
of nests are referred to as composite nests and are typically higher quality nests than those
built of only one material. Many animal facilities commonly provide only one nesting material
due to ease, standardisation and costs. In many cases mice are observed to shred other
enrichment items within the cage such as cardboard tunnels and houses and incorporate
them into the nest, indicating a preference for additional or alternative materials. Head
plate mice however, face restrictions on enrichment items such as nesting material, as long
and fibrous products are liable to become tangled around the device and cause entrapment
or injury. It has been demonstrated that single short fibre materials are safe for head plate
mice and can be used to construct high quality nests, however it is not known whether a
combination of only short fibre materials can be used to construct a higher quality composite
nest than one single short fibre material. This study investigates whether composite nests
have the potential to be a beneficial refinement in head plate mouse husbandry with the
aim of improving welfare and in turn increasing the validity of the scientific output.
Further details on page 16-17.
Tuesday 23rd March
14.30 – 15.00 hrs
Session sponsored by
ANDREW BLAKE
TRIBUTE AWARD
The Andrew Blake Tribute Award is
generously sponsored by the Association
of British Pharmaceutical Industries
Scientific Programme36
PAPER PRESENTATIONS
Zebrafish – everyone’s poor relation
Over the last twenty years, Zebrafish (danio rerio) have seen a phenomenal rise as a model
for research, with their uses becoming many and varied across a wide range of scientific
disciplines. They are not, however wet mice, so does their small size, anatomical differences
and living environment make fish very difficult for humans to recognise and empathise with?
Home Office Guidance encourages the use of animals with the lowest capacity to experience
pain, suffering, distress or lasting harm. Do we really consider Zebrafish to be less sentient,
less able to feel pain, less able to feel or inspire emotion? Observation suggests the value put
upon a Zebrafish is considerably less than that put on a mouse.
Are we allowing these attitudes to contribute to the lack of husbandry standardisation
for Zebrafish? Do we even all agree what standardisation actually means in the context of
Zebrafish? The husbandry and welfare concerns of this species currently seem to be addressed
and driven by disparate groups and forces. In the interests of Zebrafish as a research model
and a sentient species, perhaps now is the time to start joining the dots of all this knowledge,
information and advice together and ask when will this Cinderella species go to the ball and
what will her fairy godmother look like?
Wednesday 24th March
14.00 – 14.30 hrs
Carole Wilson
Head of Fish Facility
University College London
Carole’s 30 year career as an Animal Technologist began
as a junior technician at the NIMR. She now sits on the IAT
Council and has been the IAT Bulletin editor for the past
3 years. Carole has spent the past 20 years as Head of the
UCL fish facility, the largest Zebrafish facility in the UK and
independent of UCL biological services platform. During this time, she has overseen
the expansion of the facility to four times its original size and increased its technical
complexity to include accredited training programmes, procedural programmes including
a large cryo-programme and is currently working on an improved and much expanded
health monitoring and screening programme. Carole has published on Zebrafish welfare
and husbandry issues in a variety of publications including Zebrafish, ILAR Journal
and AWT, as well as presenting at a broad range of conferences to a wide variety of
stakeholders, including research scientists, Home Office representatives, veterinarians and
Animal Technologists. She has also won several prizes for her work improving Zebrafish
welfare including the LASA Conference poster prize in 2014 for work on Zebrafish health
monitoring and the Andrew Blake Tribute Award in 2012 for the paper “Body condition
scoring for Zebrafish”.
Session sponsored by
Copies can be ordered via the
IAT website www.iat.org.uk/books
The last edition of this book, titled An Introduction
to Animal Technology was published in 2001. This
edition has been revised and enlarged to take account
of developments in the subject over the last 16 years.
It is well illustrated with most of the illustrations
being in colour.
The Animals (Scientific Procedures) Act 1986, as
Amended 2012 has been covered in detail as this
impinges on all aspects on the care and use of animals
used in science. Other topics covered include animal
health, housing and environment, routine care,
feeding and watering, breeding, ethics and welfare.
The text has been specifically prepared for staff
beginning their careers in Animal Technology and
closely follows the syllabus for the IAT level 2 Diploma
in Laboratory Animal Science and Technology. It is
also hoped it will be of interest to any other person
starting to work in establishments licenced under the
Animals (Scientific Procedures) Act 1986, as Amended.
l Paperback: 232 pages
l Publisher: Institute of Animal Technology (November 2017)
l Language: English
l ISBN-13: 978-1-9999168-0-0
l Cost: £20.00 (includes free p&p within the UK – overseas postage will be charged)
Introduction to
Laboratory Animal Science, Technology and Welfare
Scientific Programme38
PAPER PRESENTATIONS
Chilled storage of Zebrafish embryos, development and evolution of a promising
tool
Zebrafish embryo is a valid model already widely used thanks to its particular features
(ease of maintenance, small size, high fecundity, rapid development, optical transparency
of the embryo). Furthermore, according to the 3Rs principle (Replacement, Reduction
and Refinement), it is considered as a replacement method to animal experimentation.
Its widespread use in scientific research requires the development of techniques aimed at
preserving embryos. In fact, the availability of stored embryos would have an important
impact not only on the storage of genetically modified lines, but also on trade. Currently,
there is not a single and functional protocol aimed at preserving the structure, functionality
and morphology of the Zebrafish embryo. Therefore, the identification of a practical
procedure that can be used in different laboratories could broaden new horizons in a
collaborative context between scientific teams as well as in reaching an essential step for
understanding embryo preservation. The aim of the present investigation is to use Zebrafish
embryos as an alternative model to explore the development of a storage protocol and to
identify the limiting factors associated with fish embryo cryopreservation. Several variables
can play a key role in the identification of a cooling protocol for Zebrafish embryos: the
stage of embryo’s development is extremely important for its correct conservation. In
addition, further to identifying the exact time window, the choice of the more suitable
cryoprotective agent (CPA) should not be underestimated. To this, is added both the search
for the appropriate exposure time and the analysis of what could be the proper exposure
temperature at which the embryos would be incubated without undergoing alterations.
Furthermore, it is possible to set the same temperature for the whole cooling period,
otherwise it is possible to set a (more or less) rapid decrease of the thermal condition.
In this study embryos were obtained from a breeding stock of wild-type Zebrafish with
well-documented fertilisation rate (70 %). As preliminary experiments, the viability of
Zebrafish embryos was investigated in Dimethyl sulfoxide (DMSO) and Methanol (MeOH),
both at 1M concentration, while Embryo Medium (EM) was chosen as negative control.
Viable fertilised eggs correctly developed were divided into two experimental groups: 1)
embryos with chorion, 2) embryos treated with Pronase® (50 mg/mL) in order to remove
this protective barrier. Then, the two groups were exposed to CPAs as MeOH and DMSO
and to the negative control (EM). After 24 hours at 4°C, embryos were brought back to
room temperature for 2 hours and subsequently transferred in Embryo Medium at the
target development temperature of 28°C. A very high mortality was observed at 120
hours post fertilisation (hpf), especially for the dechorionated ones, thus it was decided to
continue testing only embryos with chorion and also to reduce the concentration of both
CPAs at 0.1M. The following experiment was carried out with the final concentration of
cryoprotectants halved to 0.05M and 0.1M of sucrose was added to all three solutions, in
order to verify its conservative function on the whole organism. This preliminary step was
followed by additional experiments: embryos at 24hpf and 48hpf were exposed for each
protocol devised, but further development stages will be investigated in order to find the
most applicable storage protocol. In conclusion, the results obtained so far are promising
and open up different possibilities in this under investigated area: additional targeted
experiments are needed for the optimization of a complete and feasible cooling protocol
of Zebrafish embryos.
Wednesday 24th March
14.30 – 15.00 hrs
Scientific Programme
39
PAPER PRESENTATIONS
Maria Sampieri
Biologist Research Fellow
IZSLER
Maria is a Research Fellow at the National Reference Center
for Alternative Methods, Welfare and Care of Laboratory
Animals at Istituto Zooprofilattico Sperimentale della
Lombardia e dell’Emilia Romagna (IZSLER) in Brescia, Italy.
In April 2017, a three year course in Life Sciences, Maria
graduated in Neurobiology at the University of Pavia, Bologna. Her chosen studies have
introduced her to a wide variety of subjects in the field of alternative methods, as she
was always curious about everything regarding the development and the application of
alternative approaches. Currently, Maria is working on projects including the detection
of neurotoxicity endpoints in Zebrafish embryos, the evaluation of the toxic effects of
different potential thyroid disruptors on Danio rerio larvae and finally she is working on
a project which purpose is to create an accurate and detailed protocol for the cooling
storage of Zebrafish embryos.
Scientific Programme40
PAPER PRESENTATIONS
Preparing, caring, sharing and flagging: tools for animal care staff
Managing accredited laboratory animal facilities for many years has taught me the crucial
role played by animal care staff in defining the quality of the research being carried
out there. For the last 13 years I have been Secretary of Norecopa, whose mission is to
disseminate resources for implementing the 3Rs (Replacement, Reduction and Refinement
of animal research). Refinement has also an important human component: maintaining
the physical and mental wellbeing of all those who are affected, directly or indirectly, by
the activities involving research animals - both in the field and in the laboratory.
Norecopa is involved in a number of strategies to improve the quality of the science, and
the quality of life of those involved in research:
The PREPARE guidelines (https://norecopa.no/PREPARE) were written to encourage
scientists - with good help from animal care staff - to plan more valid, reproducible and
translatable experiments which fully implement the 3Rs. PREPARE includes a 2-page
checklist, and a website with more information about all the topics on the checklist.
PREPARE helps scientists realise the importance of close collaboration with animal care
staff from day 1 of planning.
Norecopa also hosts the website of the International Culture of Care Network (https://
norecopa.no/CoC). This is a group of professionals, of all categories, who share ways in
which we can improve the support given to personnel in research facilities: recognising
efforts made to improve animal welfare, avoiding compassion fatigue and developing a
state of trust so that any member of the group has the confidence to raise an issue, or
challenge a proposed route of action without fear of reprisals.
In 2020, Norecopa launched a Refinement Wiki (https://wiki.norecopa.no), with the
aim of offering all animal care staff a portal where they can publish their experiences
in trying to refine animal experiments. The Wiki aims to be a halfway house between
scientific publications (which are time-consuming and which generally require detailed
investigations) and conversations on discussion forums (where many worthwhile ideas get
mentioned, only to be forgotten in time by most). Staff can either post ideas themselves,
or request Norecopa to publish them on their behalf.
Norecopa also encourages scientists to flag any 3R-advances which they have made within
the title and/or abstract of their papers. These are often the only sections of a paper which
get indexed by bibliographic databases, so it is crucial that they reflect these advances. The
commonly used reporting guidelines do not, unfortunately, make this important point.
PREPARE - CARE - SHARE - FLAG!
Thursday 25th March
14.00 – 14.30 hrs
Session sponsored by
Scientific Programme
41
Adrian Smith
Secretary to Norecopa
Norway
Adrian is a British veterinarian who graduated from
Cambridge University in 1979. After a year in mixed practice
in the UK he emigrated to Norway where he has lived since.
For much of this time he was employed by the Norwegian
School of Veterinary Science, where he defended his doctoral
thesis on the reproductive physiology of seasonal breeders. He held the Chair in Laboratory
Animal Science from 1988 and until he left the School in 2011. He was heavily involved in
the work of introducing mandatory training in Laboratory Animal Science in Norway, and
has arranged over 50 courses for all personnel categories. During this period he was also
a member of the National Animal Research Authority which oversaw all animal research
in Norway and served on the committee which created the curriculum for the Veterinary
Nurse programme in Norway. He has been the Secretary of Norway’s consensus-platform
for the 3Rs, Norecopa (https://norecopa.no) since it was established in 2007. He has had a
special interest in 3R resources for many years and has co-authored several databases in
this area which are now embedded in the Norecopa website. He is a Board Member of the
Danish 3R centre and a member of the National Committee for the protection of animals
used for scientific purposes in Denmark. He is lead author of the PREPARE guidelines for
planning animal experiments.
PAPER PRESENTATIONS
TRAIN
L
EARN
D
EVELOP
CPD courses with CPD points from
LASA and the IAT including:
Nominated Assessors course
Train the Trainer course
Contact us for more details:
ubstraining@admin.cam.ac.uk
More courses
coming soon!
Accredited by the IAT:
IAT Levels 2 and 3
NACWO Course
Accredited by University
Accreditation Group:
PIL Courses
PPL Course
Interactive
online
learning
Scientific Programme
43
PAPER PRESENTATIONS
ASRU update from the Home Office
Governance is central to the delivery of protection to animals in compliance with the
Animals (Scientific Procedures) Act. The Home Office will focus on how governance is at
the heart of delivery of the Act by ASRU itself, establishments and individuals. Join the
Head of ASRU for a presentation on how your role is integral to supporting compliance.
Thursday 25th March
14.30 – 15.00 hrs
Will Reynolds
Head of the Animals in Science
Regulation Unit
Home Office
Will Reynolds, Animals in Science Regulation Unit. Will began
his career as a marine biologist, gaining 10 years’ experience
in marine research for UK Government and internationally,
primarily in biological effects techniques. He was later an
adviser to the UK Department for Environment chief scientist
on animal health and welfare, before moving to the Home Office. Will has worked in
policy advice as secretary to the UK Advisory Council on the misuse of drugs and as head
of UK Advisory Bodies. This role included oversight of the advisory body for the use of
animals in science. Will subsequently took up a role as head of policy in the Animals in
Science Regulation Unit, and is now the head of the UK regulator.
TRAIN
LEARN
DEVELOP
CPD courses with CPD points from
LASA and the IAT including:
Nominated Assessors course
Train the Trainer course
Contact us for more details:
ubstraining@admin.cam.ac.uk
More courses
coming soon!
Accredited by the IAT:
IAT Levels 2 and 3
NACWO Course
Accredited by University
Accreditation Group:
PIL Courses
PPL Course
Interactive
online
learning
44 Scientific Programme
KEVIN DOLAN MEMORIAL LECTURE
Giant Footsteps
The Asian elephant is facing a very uncertain future in its natural habitat –
rapidly expanding human populations, poaching and habitat fragmentation
are putting remaining numbers of Asian elephants under extreme pressure.
This once wide-ranging species is now increasingly restricted to pockets of
habitat that can only sustain potentially unviable populations of animals.
This presentation will discuss the role that the modern Zoo can play in the
conservation of the world’s largest land mammal.
It will also describe key aspects of elephant wellness, husbandry, enrichment
and facility design that uses modern technology to enhance species specific
behaviour, with particular reference to the development of Dublin Zoo’s
ground breaking elephant programme.
Kevin Dolan 1926 - 2011
When Kevin Dolan died in 2011 at the age of 85, IAT Council wished to honour his memory in gratitude for the
contribution he had made to Animal Technologists and the industry in general and therefore fittingly, the Special
Guest Lecture given annually at Congress was renamed the Kevin Dolan Memorial Lecture.
Kevin’s contributions to the IAT included services on Council and for several years he was Editor of the IAT Journal,
only standing down on his retirement. He received his Fellowship in 1977 at the same time as attaining a Diploma
in Law. He was also made a Vice President of the IAT and latterly an Honorary Member.
Scientific Programme 45
KEVIN DOLAN MEMORIAL LECTURE
Gerry Creighton
Gerry has worked at Dublin Zoo since 1983 as a trainee
keeper before becoming a full time zoo keeper in 1986. He
subsequently worked as Team Leader for nearly ten years
responsible for large apes, carnivores and elephants, before
becoming Zoo Operations Manager in 2009, responsible for
all zoo animals and grounds.
He holds an advisory role acting as elephant consultant for
many international zoos. His career has spanned several
decades of exciting development, during which time, Dublin
Zoo has transformed from its Victorian beginnings in 1831
into a modern, vital and progressive European centre for
conversation, education and animal husbandry.
Gerry has spent over 30 years working with elephants, initially
under free contact management before moving progressively
to protective contact in 2006. After 36 years, Gerry took the
decision to leave Dublin Zoo at the beginning of this year, and
shares his vast expertise as an Elephant Care Consultant with
zoos across the world.
He also authored many distinguished books and articles on the subject of law and ethics using animals in
science but it was as a teacher that Kevin had most impact. He taught on the Postgraduate Diploma/MSc course,
the Medical Technology courses at City of Westminster and on Personal Licence Modular training courses. To
paraphrase one of his students ‘Kevin was a great teacher because he was passionate about the subject he was
dealing with and the people he was teaching to’.
Despite joining the world of animal technology somewhat later in life after many years in the ecclesiastical
domain, Kevin’s impact on our industry was outstanding. His was a life well lived in the service of others and in
recognition is remembered at Congress.
Scientific Programme46
CPD Workshop Sessions
Care-full stories? Introducing a training resource to explore the ‘culture of care’
from the perspective of different stakeholders
This workshop will offer a short preview of a new training resource being developed by
members of the Animal Research Nexus in collaboration with stakeholders in animal research.
The resource uses a series of fictional prompts (story scripts), which participants read out
during the session. The scripts are designed to encourage those involved to see a particular
scenario from multiple perspectives. Each script is accompanied by a series of discussion
points which are aimed at getting participants to share their own stories, and to use these
as a resource for reflecting on their institution’s culture of care.
This workshop would be of interest to those involved in training animal research staff, as
well as anyone with a broader interest in promoting continuing professional development
around the ‘culture of care’.
Wednesday 10th March
15.00 – 16.00 hrs
1 HOUR
CPD CREDIT
Beth Greenough
Associate Professor of Human Geography,
University of Oxford
Gail Davies
Professor in Human Geography,
University of Exeter
Dr Beth Greenhough’s research examines the social
implications of scientific innovations in the areas of health,
biomedicine and the environment. Along with Prof Davies,
she is one of the lead researchers on the Animal Research
Nexus project and has led the development of the Care-full
Stories training resource. She has published widely on topics including the culture of care
and everyday ethics in animal research. She is co-author of Bodies Across Borders (Ashgate)
Health Geographies: A Critical Introduction (Wiley-Blackwell) and Bioinformation (Polity).
Gail Davies is a social scientist whose work explores how we
understand and manage environments and animals, and seeks
to stage conversations between different kinds of knowledges.
Her past research has explored natural history filmmaking, the
changing spaces of scientific collaboration, and opportunities
for participatory decision-making in controversial issues in science and technology. She is
currently working on the interfaces between patient involvement and animal research.
She is part of the Wellcome Trust funded Animal Research Nexus Programme (2017-2022).
Professor Davies was appointed to the Animals in Science Committee from 2013-2019 and
chaired the 2017 review of Harm–Benefit Analysis in UK animal research.
Scientific Programme
47
CPD Workshop Sessions
Managing aggression in laboratory animal species
Aggression is a problem in many laboratory animal species. Aggressive behaviour can cause
stress and painful injuries, or lead to single housing, negatively affecting animal welfare.
Aggression is also undesirable from a scientific perspective, for example where it leads
to animals being culled or removed from studies, or where pain and distress introduce
variability into experimental results. It is therefore crucial to be able to detect aggressive
behaviour early on, understand the causes, and take steps to minimise its occurrence. In
this interactive workshop we will discuss the reasons why aggression may occur within the
animal facility, how this can affect animal wellbeing and science, and strategies and tips
for preventing and managing aggression in a range of mammalian species, from mice and
rats to dogs, pigs and non-human primates.
Participants will be able to share their experiences of reducing aggression and will receive
practical recommendations and handouts with sources of further advice.
Wednesday 10th March
16.00 – 17.00 hrs
1 HOUR
CPD CREDIT
Mark Prescott
Director of Policy and Outreach,
NC3Rs
Dimitra Schiza
Programme Manager - Animal Technology and Welfare,
NC3Rs
Dr Mark Prescott has worked at the NC3Rs since its
inception in 2004. Mark provides strategic oversight of the
Centre’s relationships with other research funders and the
academic community, including its peer review and advice
service, regional staff within UK universities, and office-led
programmes on animal welfare and experimental design. Mark trained as a zoologist and
primatologist, and has authored over 50 publications in primatology, animal behaviour
and animal welfare science. He serves on a number of ethics committees and scientific
advisory boards at project, institution, journal and governmental levels.
Dimitra manages the animal technology and welfare
programme and is a member of the Policy and Outreach
Group at the NC3Rs. She is involved in the NC3Rs peer
review service and office-led programmes on animal welfare.
Dimitra specialises in neuroscience and has obtained a PhD
from University College London. She has over 10 years of experience in animal work,
having worked as a researcher in the UK and abroad, before joining the NC3Rs.
Session sponsored by
Scientific Programme48
CPD Workshop Sessions
Improving the welfare of mice used in the study of ageing Introduction
Human lifespan is increasing globally whereas healthspan - the period of life free from
age-related diseases - is not increasing at the same rate. One consequence of this is that
we are witnessing a concerted research effort into the causes of ageing and the control
of its consequences, and this effort has resulted in an increase in the number of research
groups that use ageing rodents – particularly mice – in their scientific studies. As ageing is
universally associated with a general and progressive decline in organ systems, there are
some clinical/pathological manifestations that can be considered more or less typical in a
given species or strain. As mice age, many conditions develop slowly over extended periods
of time and the body adapts to them. However, a moment comes when an animal shows
clinical signs resulting from a decline in function that can no longer be compensated. In
this workshop we will explore what these signs might be, how best to “grade” them and
how best to tackle them. Another aspect we will explore is the interface between ageing
and experimental aims. For example, how can we gauge the cumulative harm in mice that
are being used to study the effects of age in the development of arthritis or of certain
forms of cancer? Following an introduction and explanation of the background, context
and aims, a breakout session into small focused groups will explore the more common
clinical signs of ageing and identify husbandry and care measures and humane endpoints.
Groups will also look into ways of assessing welfare and cumulative severity of mice that
are aged for scientific purposes.
Thursday 11th March
15.00 – 16.45 hrs
2 HOURS
CPD CREDIT
Linda Horan
Manager BPU
University of Strathclyde
Chair & CEO IAT
Linda is passionate about trying to improve the lives of the
animals we care for. She started her career at the University
of Liverpool as a junior Animal Technician, after completing
all the IAT Animal Technology exams she achieved a BSc
(Hons) in Applied Biomedical Sciences. Now working at The University of Strathclyde as
Manager of the Biological Procedure Unit, she has in excess of thirty-five years’ experience
in biomedical research and teaching. Linda is the current Chair and CEO of the Institute of
Animal Technology and an NC3Rs board member and impact panel member.
Scientific Programme
49
CPD Workshop Sessions
Michael Wilkinson
Named Veterinary Surgeon
University of Strathclyde
Norman Flynn
Home Office Inspector
Home Office
Dr Michael Wilkinson is a veterinary graduate from the
Autonomous University of Bellaterra (Barcelona). He also
holds a PhD from the University of Glasgow after completing
a programme of research at the Department of Veterinary
Medicine at the Glasgow Vet School. After a short spell in
general practice, he returned to the University of Glasgow to work as deputy Named
Veterinary Surgeon (NVS) in the Department of Biological Services and as NVS for the
University of Strathclyde. In 1994 he gained the Royal College of Veterinary Surgeons’
Certificate in Laboratory Animal Science (CertLAS) and in 2006 he gained Diplomate
status of the European College of Laboratory Animal Medicine (DiplECLAM), considered
to be the highest veterinary qualification in Europe in the specialty. Since 2010 he fulfils
a Named Veterinary Surgeon’s role for the University of Glasgow and still continues being
NVS for the University of Strathclyde.
Michael regularly lectures at training courses for scientists and animal care staff and
has published in various peer-reviewed journals on topics ranging from housing of
Monodelphis domestica to refinements in rodent models of arthritis. He has worked
with many different species in the biomedical research context and has a special interest
in animal welfare and refinements to experimental protocols. He is also very interested
in supporting veterinary colleagues in their efforts to specialise in the field and was a
co-founder of the ESLAV/ECLAM Summer School initiative. He heads the Mock Exam
Committee of ECLAM, is a member of the Council of Management of Laboratory Animals
Ltd (publishers of the Journal Laboratory Animals) and a member of a LAVA, LASA, ESLAV
and ECLAM.
Norman qualified as a vet from Glasgow University before
completing a PhD in immunology at Edinburgh University.
He worked as a research immunologist in Kenya, Scotland,
Italy and Switzerland before joining the Home Office in 2004.
Norman has been an Inspector in the Home Office for over 16
years and has undertaken several different roles in ASRU. His work-related interests are in
immunology, vaccine development, infectious disease and cancer.
Session sponsored by
CPD Workshop Sessions
Making the frame fit the picture: how should we talk about animal research?
Whether it is in a private conversation or at a public meeting, how we say something is
as important as what we say. If we want people to be receptive to our positive messages
about animal research, we need to communicate in ways that make the most impact. In
this session, UAR will share new techniques to frame your communications about animals
in science that will improve how your message is heard and help you to feel safer and more
confident when it comes to talking about your work in any context.
Tuesday 16th March
15.00 – 16.00 hrs
1 HOUR
CPD CREDIT
John Meredith
Head of Education and Outreach
Understanding Animal Research
Bella Williams
Head of Engagement
Understanding Animal Research
John Meredith is Head of Education and Outreach for
Understanding Animal Research where he manages a national
network of volunteers dedicated to talking about their work
with animals, and provides training and outreach activities at
laboratories, colleges and science fairs across the UK.
Bella has been exploring the relationship between science,
society and communication for over 20 years, working
through research in both natural and social sciences to
consider how ideas about science are communicated to the
public and their influencers such as media and policy makers.
As a facilitator Bella has developed and delivered workshops across many fields, with an
emphasis on communications, medical ethics and the use of animals in research.
Bella is currently Head of Engagement at Understanding Animal Research (UAR), and is
responsible for initiatives around member engagement and public engagement: both
helping UAR member and stakeholders with outreach and reactive initiatives on the use
of animals in research, and engaging directly with the public on this issue. She leads on
Openness at UAR, working with signatory institutions of the Concordat on Openness on
Animal Research to help them build openness into communications strategies.
Session sponsored by
50 Scientific Programme
Scientific Programme
51
CPD Workshop Sessions
The who, what, where, why and how of Zebrafish: introduction to popular
laboratory animals and the skills needed to work with them
Learn more about Zebrafish (Danio rerio) and why the species has become the second most
popular used animal in lab animal science. This workshop will include a brief introduction
to the zebrafish’s life history, what training and skills Animal Technicians need to work
with them, and good colony management practices.
Tuesday 16th March
16.00 – 17.00 hrs
1 HOUR
CPD CREDIT
Mollie Millington
Senior Research Scientist
The Francis Crick Institute
Mollie currently works as the Aquatics Unit Manager at The
Francis Crick Institute. She received a BA in Marine Biology
from Boston University and has a MSc in Zoo and Aquarium
Management from Michigan State University. Mollie holds
the Institute for Animal Technology level 2 diploma and is
currently enrolled in Level 3 for completion in 2021. She joined the executive board of the
Zebrafish Husbandry Association (zhaonline.org) in 2020 as president elect and is currently
serving as president.
Having always enjoyed working with aquatics species, Mollie has been fortunate enough
to work in both public (New England Aquarium, Alaska SeaLife Center and Mystic
Aquarium) and academia aquaria (Marine Biological Laboratory, Queen Mary University
of London, National Institute for Medical Research (NIMR) and The Francis Crick Institute)
during her career. Her experience with multiple species in these varied environments
gives her a wealth of knowledge to draw upon when troubleshooting system problems,
training animals, medical care, or establishing new systems. In October 2019, she won an
award with her colleagues for her 3Rs work in establishing a system to use lidocaine pre-
and post-fin clipping that did not impact the scientists’ research. She has also co-authored
several papers using Zebrafish as animal models and a methodology for environmental
screening Zebrafish systems for pathogens.
Session sponsored by
52
CPD Workshop Sessions
Best practice in breeding laboratory mice
This will be an interactive workshop for experienced (1 year+) junior technicians covering
the basics of mouse reproduction, inbred, outbred and GA strains. Looking at how to select
the best mice for breeding, which breeding systems to use and troubleshooting examples
of strains and breeders that are not producing litters.
You will come away from this with some pointers on best practice to take forward and
feeling more confident in your ability to manage your colonies or make suggestions on
how scientists could improve theirs.
Wednesday 17th March
15.00 – 16.00 hrs
1 HOUR
CPD CREDIT
Helen Bailey
BRF Training Manager
The Francis Crick Institute
Sarah Hart-Johnson
Head of Colony Management
The Francis Crick Institute
Helen Bailey is also Secondary NTCO at The Francis Crick
Institute with the responsibility of ensuring the training and
competency of over 170 members of the Biological Research
Facility. She is also the teacher/assessor for the accredited
Level 2 and 3 IAT Diplomas, taught in-house. Graduating
from DeMontfort University with a BSc(hons) in Animal Science, she joined the Imperial
Cancer Research Fund in 2001 as a junior Animal Technician, which then evolved into the
London Research Institute of Cancer Research UK. Progressing to become a Team Leader
and NACWO, she also gained MIAT and RAnTech status and 16 years’ experience as an
Animal Technologist before promotion in 2017 to her current role. Helen enjoys running
workshops and training the new generation of Animal Technologists.
Sarah previously led the Genetic manipulation team at The
Crick and prior to that at the MRC’s NIMR. She started in this
field because of a love of working with embryos and spent
many a year freezing and microinjecting mouse embryos,
with a little work in rats, fish and frogs thrown in too. She is
a section convenor for LASA’s animal science section and recently was part of an expert
working group to produce the NC3Rs Breeding and colony management hub. She holds a
MSc in Human Reproductive Biology and a BSc in Molecular Biology and Genetics.
Scientific Programme
Session sponsored by
Scientific Programme
53
CPD Workshop Sessions
How to help your AWERB promote a Culture of Care – including caring for you
The Animal Welfare and Ethical Review Body (AWERB) has a key task of helping to
promote a Culture of Care within the establishment and, as appropriate, the wider
community. Your AWERB should have a clear vision of the Culture of Care it wishes to
help achieve, and understand that this goes beyond caring for animals. A healthy Culture
also incorporates how staff treat one other and communicate, how effectively the 3Rs are
implemented, proper consideration of ethical issues and expectations for good quality
science. As an Animal Technologist, there is a lot you can do to help your AWERB fulfil
all these aspects of the task, whether or not you sit on the AWERB yourself. The Culture
of Care should also demonstrably care for you and your wellbeing. This workshop will
provide information and resources to help you assist the AWERB in this task and make sure
you are supported, whilst enabling you to share experiences and identify action points.
Thursday 18th March
15.00 – 16.00 hrs
1 HOUR
CPD CREDIT
Penny Hawkins
Head
Animals in Science Department, RSPCA
Penny graduated in biological sciences at the University
of Portsmouth in 1992 and completed her PhD in avian
physiology at the University of Birmingham in 1996. She
joined the RSPCA Animals in Science Department in 1996,
and has been Head of Department since 2015. The Animals
in Science Department works to implement the 3Rs and to ensure robust ethical review of
animal use in research and testing. Penny’s main area of work relates to supporting and
promoting ethics committees, including the UK Animal Welfare and Ethical Review Body
(AWERB). She has also been an independent member of four AWERBs, served three terms
on the Animal Procedures Committee/Animals in Science Committee and is currently one
of the IAT’s Vice Presidents.
Session sponsored by
Scientific Programme54
CPD Workshop Sessions
Why, how and what happened next - an introduction to scientific writing
Scientific writing, as opposed to writing about science, does not come naturally to most
people but it is a skill, some would say an art, that can be learnt. From deciding on your
audience through to checking the proofs, this workshop will cover the fundamentals of
an Animal Technologist’s first ventures in scientific reporting.
Tuesday 23rd March
15.00 – 16.00 hrs
1 HOUR
CPD CREDIT
Jas Barley
Editor, Animal Technology and Welfare
Institute of Animal Technology
Jas has had a long and varied profession in the industry,
working in both government and educational establishments
and finishing her career at the University of Southampton.
She has worked with a wide range of species and an even
wider range of researchers! Now technically retired, she
remains a member of IAT Council, chairing the IAT Editorial Board and has been Editor
of Animal Technology and Welfare, the official publication of the IAT and EFAT for over
10 years. In addition to her journal activities she lectures on the level 4 and 5 courses for
the IAT Higher Education programme. Jas enjoys many pursuits as well as teaching British
Sign Language and her hobbies include reading, gardening, various crafts and cookery.
Session sponsored by
Scientific Programme
55
CPD Workshop Sessions
Environmental enrichment for laboratory Zebrafish
Providing laboratory animals with appropriate environmental enrichment can promote
better welfare, encourage animals to express more natural behaviours, and help give
animals a better overall lifetime experience, but what counts as ‘appropriate’ enrichment
for Zebrafish? Lots of facilities may facilitate social behaviour by group housing, and give
live food to stimulate predatory behaviour, but beyond this there is great debate over
how best to provide enrichment for Zebrafish. This workshop will discuss different types
of environmental enrichment, and will then look at the evidence for how different types
of enrichment affect Zebrafish behaviour, physiology and welfare. We will also discuss
possible challenges to introducing more enrichment for Zebrafish and ways in which these
challenges might be addressed.
Wednesday 24th March
15.00 – 16.00 hrs
1 HOUR
CPD CREDIT
Chloe Stevens
Scientific Officer
RSPCA
Chloe works in the Animals in Science Department (formerly
the Research Animals Department) at the RSPCA. She primarily
works on improving the welfare of fish used in research and
testing, with particular focus on environmental enrichment
and the welfare of laboratory Zebrafish. Before joining the
RSPCA, Chloe completed an MBiolSci in Biology at the University of Sheffield, where she
studied the effects of social context on collective behaviour in Zebrafish, and a PhD in
Biology at the University of Exeter on stress, mortality and welfare in ornamental fishes.
Session sponsored by
Scientific Programme56
POSTER DISPLAYS
Karen Ekkelund Petersen
SCANBUR A/S
Karlslunde, Denmark
Controlling humidity – improved breeding
and validity of research
Regulatory guidelines for relative humidity (RH) when housing laboratory rodents are 55 ±
10%. These were set based on quite limited data and little is known on how fluctuations in
RH affects laboratory rodents, or how high versus low RH, within these boundaries affects
them. Studies through time have shown that RH has an impact on rodent health.
How relative humidity affects laboratory rodents is summarised below.
-
Puberty is delayed in female mice housed under 15-30% RH, whereas first estrus was
attained earlier when housed under a RH of 75% (1).
- At 35% RH compared to 75% rats consume 5% more food (2).
- Low RH has shown to increase activity in mice (2).
- RH impacts growth conditions for bacteria and fungus and transmission of virus (3-6).
We have set up several studies to investigate the effect of tighter control of RH on health
and physiology of research animals primarily by investigating the effect on breeding
performance. Additionally, the potential of uncontrolled RH to affect outcomes of studies,
and thus validity of research, has been part of our studies. We have specifically looked at
RH controlled accurately at 55% or above. These studies have shown that a controlled RH
improves breeding performance in different setups, and outcome of studies where for
example water intake is an outcome or thirst a motivator. We are continuously working on
additional studies to investigate effects of controlled RH on other research areas.
References:
(1) Drickamer, L. C. Environmental factors and age of puberty in female house mice. Developmental psychobiology
23, 63-73, doi:10.1002/dev.420230107 (1990)
(2) Clough, G. Environmental effects on animals used in biomedical research. Biological reviews of the Cambridge
Philosophical Society 57, 487-523 (1982)
(3) Arundel, A. V., Sterling, E. M., Biggin, J. H. et Sterling, T. D. Indirect health effects of relative humidity in indoor
environments. Environ Health Perspect 65, 351-361, doi:10.1289/ehp.8665351 (1986)
(4) Alsmo, T. et Alsmo, C. Ventilation and Relative Humidity in Swedish Buildings. Journal of Environmental Protection
05, 1022-1036, doi:10.4236/jep.2014.511102 (2014)
(5) Lowen, A. C., Mubareka, S., Steel, J. et Palese, P. Influenza virus transmission is dependent on relative humidity
and temperature. PLoS pathogens 3, 1470-1476, doi:10.1371/journal.ppat.0030151 (2007)
(6) Van Der Veen, J., Poort, Y. et Birchfield, D. J. Effect of Relative Humidity on Experimental Transmission
of Sendai Virus in Mice. Proceedings of the Society for Experimental Biology and Medicine 140, 1437-1440,
doi:10.3181/00379727-140-36691 (1972)
Scientific Programme
ADRIAN ZELTNER
Ellegaard Göttingen Minipigs
Dalmose, Denmark
ANN TURNER
American Association for Laboratory Animal Science (AALAS)
Memphis, USA
Taking blood from Göttingen Minipigs while
placed in a sling
Celebrate the Mouse
Traditionally Minipigs are placed in dorsal recumbency to have access to the blood vessels
in the neck. As this is not a position animals prefer to be in, it can evoke stress if they are
restrained in this way. The sling has been proven to be a valuable restraint for various
procedures with Minipigs. Most of them adapt to this form of confinement easily and are
quite content to hang in the sling.
A standard sling was modified and several options explored to find the most satisfying
design for the purpose. Two of the designs tested offered good access to the blood vessels
and, at the same time, enabled a calming effect on the Minipig during the procedure.
It is particularly helpful with larger Minipigs. We found that this way of blood sampling
reduces stress to a high degree and is therefore a valid refinement in the sense of the 3Rs.
Virtual Posters
There are 28 poster submissions being displayed throughout Congress and their abstracts
appear on the following pages. Delegates can download a pdf copy of the full poster in
the Poster Virtual Lobby on website by clicking the image or the poster’s title. There is also
a contact button for each author.
The Congress 2021 Poster Session is generously sponsored by LBS Serving Biotechnology.
The Foundation of the American Association for Laboratory Animal Science developed a
series of outreach programmes featuring a complete PowerPoint, script and giveaways
that can be distributed to provide information about how various animals are used to
find treatments and cures for disease. Breast cancer, heart disease, arthritis, transplants
and Alzheimer’s disease are currently available and can be downloaded and presented
to community groups, survivors’ groups and school classes. The poster will provide
information about the resource and how to obtain the materials free of charge.
POSTER DISPLAYS
57
Scientific Programme58
POSTER DISPLAYS
ANN MURRAY
Charles River Laboratories
Wilmington, USA
ADRIAN SMITH
Norecopa
Oslo, Norway
Innovative staffing strategies: a case study
on insourcing
PREPARE for better Science: Guidelines for
Animal Research
For any organisation, the most valuable resource is the people that work there. This
especially rings true for a laboratory animal facility, as having the right people in place
with the appropriate skills and qualifications is critical for such a busy and complex
environment. Finding, selecting, hiring and making sure people are happy and engaged is
a full-time job on its own. So imagine how much more productive a facility manager could
be if the staffing aspect was partially or completely taken care of? They could focus more
on other important aspects such as working with their research teams, regulatory issues,
taking care of equipment and consumables and ensuring the health status and wellbeing
of the animal models.
Insourcing provides that opportunity. A well-planned insourcing model offers a seamless
integration into a facility staffing model and provides the quality of service that allows for
increased productivity.
The current debate about “the reproducibility crisis” tends to focus on the ‘mathematical’
aspects of experimental design and statistical analysis but weaknesses in design can arise
from events throughout the animals’ lifetime. Close collaboration between scientists and
animal facilities is needed, from an early stage. There are many guidelines for reporting
experiments. Some have been endorsed by many journals but their impact has so far been
limited. The question remains as to whether these cover all aspects governing the quality
of preclinical research.
The PREPARE guidelines for planning animal experiments and their website (https://
norecopa.no) were developed in collaboration with scientists attending courses in
Laboratory Animal Science, with the aim of generating greater appreciation of the sum of
factors that influence the validity and translatability of animal studies.
Scientific Programme
59
POSTER DISPLAYS
ANDY DICKINSON
Surrey Diagnostics Ltd
Cranleigh, Surrey UK
ANDY DICKINSON
Surrey Diagnostics Ltd
Cranleigh, Surrey, UK
Contaminating DNA can give false positives
in ‘sentinel free’ health monitoring by PCR
on IVC exhaust air dust samples
Maximising efficacy of your health
monitoring programme
Following the introduction of ‘sentinel free’ animal health monitoring by polymerase chain
reaction (PCR) on the dust collected on filters in the exhaust plenums of IVC (Individually
Ventilated Cage) racks, we present a case where exhaust filters gave positives by PCR for
an infectious agent which had not previously been found by microbiological culture in that
colony on multiple live animal samples across the lifespan of the IVC exhaust filter.
Our own experience, along with other accounts of false positives from other users, possibly
due to the presence of contaminating DNA of an environmental source such as diet and
bedding, led us to the hypothesis that the sentinel free PCR method could be prone to
false positives due to the presence of contaminant DNA from infectious agents of mice.
This could be due to the ingress of wild rodents during the storage of raw materials prior
to the manufacturing process and in subsequent storage. The diet and bedding used in IVCs
both contribute to the dust collected on the plenum filters which will then be sampled and
tested, subsequently, any agents detected will be assumed to be present in the animals.
There may also be a concentrating effect in play if filters are left in situ for prolonged
periods.
Using Real-Time PCR for detection of the mouse Cox1 (Cytochrome Oxidase 1) gene, we
found that mouse DNA was indeed present in “clean” diet and bedding at a low level. This
therefore could be a mitigating factor in the reliability of health monitoring by PCR on
plenum filters alone.
These false positives on plenum filters cost the research facility a considerable amount of
time and money through subsequent extra testing to track down the source of the problem.
There are a multitude of health monitoring techniques/methods available to us. It can
be difficult to know which of these to use and when to use them. This is an attempt to
simplify, maximise the efficacy of, and ultimately reduce the number of animals used
in your health monitoring program. Whilst this is not exhaustive, and may not suit all
situations, it may provide some information that allows you to optimise your current
methods and give greater confidence in health monitoring results.
Scientific Programme60
POSTER DISPLAYS
FRANCESCA NUNN
Moredun Research Institute
Edinburgh, Scotland UK
SAMANTHA SHANKS
Charles River Laboratories Ltd
Tranent, Scotland, UK
Development of a feeding device to reduce
reliance on field trials to test novel poultry
red mite controls
Using physiotherapy to successfully manage
chronic atrophic hind limb lameness in the
Beagle dog
Poultry red mites (PRM) are small, mobile ectoparasites that feed on the blood of hens.
Testing of novel control methods uses mites in laboratory-based tests followed by field
trials. Field trials use large numbers of hens (~400) per experimental group, which are
then exposed to high numbers of mites for extended periods of time. (Bartley et al., 2017).
High background mortality and variable feeding rates of mites make in vitro testing
challenging and requires blood from hens. An ‘on-hen’ in vivo mite feeding device for
mites was developed and optimised for all blood feeding life stages of PRM. A mite
conditioning study to maximise feeding rates and evaluate baseline mortality was then
performed (Nunn et al., 2019).
Transient lameness in Beagle dogs is a familiar case in the research environment and can
be easily treated with short-term rest and medication. However, chronic lameness resulting
from malformation or injury, is much rarer and more challenging to treat.
Management of the chronic condition represents a scientific and ethical challenge; the
animal’s welfare and lifetime experience have to be considered when determining the
suitability of the treatment plan and its impact on any cumulative severity, against the
option of euthanasia as the best case for the animal.
This poster is a case study and refers to a purpose bred juvenile female Beagle dog
presenting with unilateral hind limb muscular atrophy and lameness.
Scientific Programme
61
POSTER DISPLAYS
WILLIAM ARCHIBALD
Charles River Laboratories
Tranent, Scotland, UK
HANS VAN WIJK
Covance Laboratories
Harrogate, UK
Refining cages for social housing of non-
human primates on absorption, distribution,
metabolism and elimination (ADME) studies
In respect of the 3Rs: do refinements affect
the surgery success rates in the bile duct
cannulation model?
The assessment and understanding of absorption, distribution, metabolism and elimination
(ADME) for new pharmaceuticals is required in regulatory submissions. Typically, ADME
studies are conducted using metabolism cages designed for the single housing of animals
to enable the quantitative collection of urine and faeces, normally over a 1 week period.
Social housing of animals such as Non-human primates has a significant positive impact
on the welfare of the animals. Charles River has successfully performed many ADME
studies with pair housed animals, with radioactivity recovery and plasma concentrations
comparable to single housing. As traditional single housing cages are relatively small, we
designed new and larger cages with improved features.
This poster describes some of the advantages of the enhancements we have made.
Bile duct cannulation is a relatively common procedure carried out in rats. Over the past
three decades many refinements have been made to the bile duct cannulation model. This
poster details the refinements made, the surgical success rates and the positive impacts
refinement has had on the model.
Scientific Programme62
POSTER DISPLAYS
MARK WHITE
University College London (UCL)
UK
IRENE LOPEZ JUARISTI
University College London (UCL)
UK
Pros and pros of selective cleaning
A comparison of enrichment items for the
promotion of natural gnawing behaviour in
laboratory mice
The Kathleen Lonsdale Building (KLB), is a high specification, high health status animal
facility that opened in 2011. It is a full IVC facility with an integral quarantine section.
It houses transgenic (TG) mice, inbred, outbred and immuno-suppressed mice and
occasionally rats and hamsters.
The reasons we decided to investigate included improving animal welfare with fewer
disturbances to the cage through reduced cleaning and with a 60% increase in bedding,
the ability for the mice to show some natural behaviours such as tunnelling, foraging and
digging. We also wanted to work ‘leanly’, save the College money in product and labour
time and create time for our Animal Technicians to do other things and provide much
needed planned preventative maintenance on IVC racks and cages. Time did not allow
this with the current system of cleaning. Of course, we were aware that reduced cleaning
may increase ammonia levels in the cage so we assessed the environment of the IVC during
the study with ammonia detectors to ensure cleaning took place at >25ppm but never
exceeded >50ppm which could damage the nasopharynx regions of our mice.
The Guide for the Care and Use of Laboratory Animals states the goal should always be to
maximise species specific behaviours and minimise stress-induced behaviours. Malocclusion
is a common problem within laboratory mice, which occurs when the incisors overgrow
because their jaws are misaligned and the mandibular and maxillary teeth do not properly
occlude. Basic requirements for good rodent housing and husbandry are to provide material
to gnaw such as wood blocks for maintaining general wellbeing. However, determining
the amount or form of environmental enrichment needed to produce a positive impact
without causing harm is a complex task. This study compares five different chew items to
decide which one is the most suitable as part of cage enrichment for fulfilling animals’
natural gnawing needs.
References:
Committee for the Update of the Guide for the Care and Use of Laboratory Animals, Institute for Laboratory Animal
Research, Division on Earth and Life Studies, & National Research Council. (2011). Guide for the care and use of
laboratory animals (8th ed.). National Academies Press. Washington (DC): National Academies Press (US); 2011. ISBN-
13: 978-0-309-15400-0ISBN-10: 0-309-15400-6
Scientific Programme
63
POSTER DISPLAYS
HEATHER CALLAWAY
University College London (UCL)
UK
PAUL BARWOOD
University College London (UCL)
UK
A comparison of Zebrafish embryo collection
using various methods
Refinement of water quality in Zebrafish
pair breeding
With the increase of scientific need for high volume output of good quality embryos from
Zebrafish has also come the rise of various breeding strategies and the development and
modification of tools in order to fulfil demand. Whilst much work has gone into this, the
welfare of both parent and progeny may come second to the production of the desired
embryo numbers. In order to determine if there is such a cost, a comparison was made
between five different spawning methods and the quality of embryos that each produced:
pairing, trays, and two types of mass embryo collection units, one of which was modified
to become a preference choice based unit.
These different methods and tools produced a variation of embryo volume as well as
quality, indicating that stress has a negative impact on embryo viability. From both a
scientific and welfare perspective, good breeding strategies are key; they should reduce
stress and allow fish to express mate preference, as well as to choose whether to spawn
or not. This type of refinement can aid in devising breeding strategies that can use fewer
numbers of fish and still produce a high volume of embryos.
Small containers with static water are commonly used for breeding Zebrafish when
knowledge of parental stocks and genetic lineage is required. The size of the breeding
chamber, age of the fish, frequency of pairing and stress are all factors which affect breeding
performance. The timing of feeding before breeding and water quality degradation, have
seen little investigation, with best practice varying from facility to facility and often relying
on anecdotal information. The breeding boxes assessed hold 650ml of water and have no
flow or filtration, meaning fish waste is not removed or broken down as in conventional
housing systems. This comparatively unstable environment has the potential to impact
breeding performance and can result in pain and suffering for the animal.
This poster aims to investigate the impact of feeding and time when holding Zebrafish in
breeding boxes.
Scientific Programme64
POSTER DISPLAYS
KAREN DUNFORD
University College London (UCL)
UK
Stiff as a board: handling frequency in
Zebrafish and its effect on rigor mortis
According to Schedule 1 in the Animals (Scientific Procedures) Act 1986, euthanasia must
include both a humane method of death and a confirmation of death. For Zebrafish,
anaesthetic overdose is the appropriate method of death, whilst confirmation of death can
be multiple options, including onset of rigor mortis (RM). Currently, the Code of Practice
advises minimising handling during euthanasia for all species, but does not quantify
this minimisation; this can and does lead to variations and interpretations of handling
frequency based on experience and logistics. We conducted an earlier trial that suggests
RM may be used as an index to comparatively indicate high levels of pre-mortem stress; in
that trial we found that the anaesthetic 2-Phenoxyethanol may cause more stress due to
its physiological mechanisms, as it resulted in faster onset of RM. With this background, we
conducted another trial to identify if pre-mortem stress due to frequency of handling can
also impact this onset. We tested multiple anaesthetic agents with three types of handling
(x1, x3, and x5) on two non-sacrificial wild type strains. These were then monitored in
timed intervals post-mortem in order to identify the rate of RM for each variable. The
resulting preliminary index of RM rates indicates how far to minimise handling and
therefore refine basic S1K protocols and minimise unnecessary pre-mortem stress.
IAT TECH MONTH 2021
Remember to join us throughout March to celebrate the work of
Animal Technologists with some fun quizzes, challenges and puzzles
Download Your Participation Plaque
Take part in our fun Tech Month BINGO Challenges to win great
prizes
To receive your BINGO card and submit your completed challenges
throughout March, register at
https://eu.eventscloud.com/website/2712/techmonth/
Scientific Programme
65
POSTER DISPLAYS
JACQUELINE GLOVER
King’s College London (KCL)
UK
CHLOE STEVENS
RSPCA
Southwater, UK
Shining a light on rearing pigment-less
Zebrafish
Enrichment for laboratory Zebrafish
Zebrafish strains expressing less pigmentation exhibit a lower survival rate during the early
rearing stages in comparison to wild type strains.
Light is one environmental factor which has been shown to influence the survival of wild
type Zebrafish larvae, however, research on its effect on other Zebrafish strains is limited.
At King’s College London, we compared the overall survival rate, spawning success, and
fertility of three strains of Zebrafish expressing varying pigment levels. Wild type, Albino
and Crystal strains were housed at three different light intensities (32, 128 and 259 LUX).
Zebrafish strain was found to have a significant effect on overall survival and spawning
success, but not on fertility. In contrast, light intensity was not found to significantly affect
any of the independent variables measured, suggesting that differences in survival may be
due to genetic rather than environmental factors.
The Zebrafish is one of the most commonly-used animals in scientific research and testing,
both in the UK and worldwide, but best practice for many aspects of Zebrafish husbandry
and care is still debated. One such aspect is the use of environmental enrichment in
Zebrafish tanks. Whilst most facilities provide social enrichment in the form of group
housing, and many provide live food to stimulate natural behaviour, generally little other
enrichment is used. However, there is a growing body of evidence to suggest that other
forms of enrichment, such as plants or substrate, are preferred by Zebrafish to barren
tanks and can improve Zebrafish welfare. This poster presents information on some of
the different forms of enrichment which could be used for laboratory Zebrafish and
summarises the welfare benefits these types of enrichment may be able to provide.
Scientific Programme66
POSTER DISPLAYS
LORNA CLEVERLEY
National Agri-Food Innovation Campus (NAFIC)
York, UK
Efficacy of Medola’s Blue stain in the
assessment of Syphacia muris egg viability
Syphacia muris (Nematoda: Oxyuridae); commonly known as the rat pinworm, is a parasite
of rodents. This ubiquitous nematode commonly infects laboratory rodents, primarily
rats, via direct and indirect transmission routes. Daily shedding of pinworm eggs in the
host results in ingestion of the eggs and contamination of water, food and bedding. This
provides a continual inoculum that results in frequent re-exposure of the host to the
parasite making the control of pinworms difficult.
The assessment of Syphacia muris egg viability following the disinfection of an infested
facility with an effective ovicidal agent can be costly and time consuming. Both viable
and non-viable eggs will persist following treatment. It is not possible to visually assess
the viability of eggs using standard microscopy. Therefore, to test the viability of eggs
following treatment with an ovicidal agent, traditionally, eggs are subjected to hatching
analysis using a suitable hatching media.
Most hatching media’s have a short shelf life and to ensure that unhatched pinworm
eggs are truly non-viable. It is advisable to test the hatching media on viable pinworm
eggs before analysing treated eggs. Further to this, using hatching media for the visual
assessment of hatched eggs is not ideal as juvenile nematodes are digested in the hatching
media within 30 minutes of hatching. Therefore, assessment is purely based on eggs being
correctly orientated on a Sellotape slide to allow the break in the egg cell wall that the
juvenile nematode has vacated, to be visible.
Medola’s Blue stain has been used in the viability assessment of plant-parasitic nematode
eggs for many years. We propose that this stain is a useful tool in determining the viability
of Syphacia muris ova in environmental and rodent samples when determining treatment/
decontamination efficacy in rodent facilities.
Scientific Programme
67
POSTER DISPLAYS
SELINA HOPKINS
Wellcome Sanger Institute
Cambridge, UK
JOE PEPLOE
University of Cambridge
UK
Cage side determination of post-mortem
interval in mice
Laboratory primate enCHEAPment!
Unexpected deaths in mice could be indicative of a potential welfare issue with
consequences ranging from data loss to compliance breach under A(SP)A. A robust post-
mortem interval scoring system in mice has yet to be developed, leaving this open to
educated opinions. The aim of this study is to develop a cage-side scoring system, relying
on mouse anatomical changes post-mortem, to provide a factual approximation of death
and reduce over-reporting.
In this study, we necropsied male C57BL6c-/ c- mice (6-8w), documented and scored the
appearance of key organs between 0 and 48h after Schedule 1 euthanasia. Preliminary
data confirm significant anatomical changes including skin elasticity, lividity within paws/
toes, liver, intestinal distension and composition changes between time points.
A catalogue of images and a drafted scoring system were created to assist technicians with
dating cadavers and the reporting process, where required.
There are a number of items we use regularly and often, in animal facilities that when
finished with are just thrown away. However many of these items come in packaging
that can be recycled to use as enrichment for our animals, particularly facilities housing
primates. The use of recycled packaging as enrichment for primates is especially useful
here in the UK because there are a limited number of suppliers of laboratory primate
enrichment and they only have a small range of variation available to buy. Furthermore,
along with supplier bought products, recycling materials such as plastic and cardboard for
use as enrichment is a far cheaper way of improving the lives of the primates we work
with (not to mention the boost our Animal Technicians have when they see our monkeys
using and enjoying them).
The ideas we have found to be most successful are when the enrichment is used in novel
and more challenging ways of presenting the monkeys with food. This poster shows a
number of enrichment ideas, using a range of common materials found in animal facilities,
that we at Cambridge have made use of for our monkeys and hope this will be of interest
to other similar facilities, to look at our enrichment ideas and create their own by recycling
such materials.
Scientific Programme68
ALISON RITCHIE
Biodiscovery Institute and the Centre of Cancer Sciences
Nottingham, UK
The jacket with pulling power(!) - a novel
approach to early stage evaluation of
magnetic nanoparticles
As a cancer research group, one of our aims is to develop more efficient methods
of compound delivery. One current area we are investigating is that of theranostic
nanoparticles, which combine a therapeutic agent with a diagnostic component and
directly target a tumour, thus reducing potential side effects from systemic therapies. In
order to deliver the nanoparticles to the tumour, they are magnetised during formulation
and, after injection, are exposed to a magnetic field located close to the tumour. In order
to study the targeting efficiency as well as the theranostic properties of these magnetised
nanoparticles, they need to be tested in vivo.
Other researchers have used a variety of methods to expose the particles to a magnetic
source, including:
- MRI which is expensive, therefore impractical for early stage testing, requires lengthy
anaesthesia and specialist equipment.
- Sticking a magnet to the animal’s skin with tape or superglue can damage the skin and
is difficult to remove.
- Surgically implanted subcutaneously requires full aseptic surgery and remains in place
until termination.
We wanted to develop an early stage testing system which would allow us to fine tune
the formulation of our nanoparticles prior to full translationally relevant testing, and
which would demonstrate the efficiency of the targeting without the need for invasive
or uncomfortable procedures. To this end, we decided to develop a novel, inexpensive
and non-harmful way to present the magnet to the tumour and took our inspiration
from the already widely available infusion jacket. Working with Lomir Biomedical, we
designed a Spandex jacket with a pocket to house the magnet and proceeded to test our
nanoparticles. While it was necessary to lightly sedate the mice in order to keep them still
and, therefore, the magnet in position during exposure, the jacket can easily be removed
and replaced according to the specifics of the experimental protocol. Thus, we hoped to
deliver the particles intravenously and then direct them towards the tumour with the
magnet. Preliminary data is very promising and, while we have identified some areas
for improvement, we believe this system can be used to quickly and easily test different
nanoparticle formulations, giving us the opportunity to improve and reformulate them
prior to taking them forward into more translationally relevant studies, while ensuring
high welfare standards for the mice throughout the procedure.
POSTER DISPLAYS
Scientific Programme
69
AIMEE BAINBRIDGE
The Pirbright Institute
Woking, UK
LOUIS KITCHENHAM
Sainsbury Wellcome Centre
London, UK
Improving welfare of cattle housed in a
high-containment facility using behavioural
analysis
Practical strategies to ensure the provision
of food and water for laboratory mice and
rats
Animal behaviour is an observable and quantifiable measure of the effects of various
factors on an animal, including the external environment. The relatively non-invasive
nature of behavioural analysis minimises the influence of human presence. The Pirbright
Institute (TPI) has been trialling the use of behavioural analysis of cattle to investigate
whether acclimatisation to a high-containment facility can be quantified and therefore
improved.
In this poster two approaches are described; CCTV recording and staff observations.
For the first approach, the room in which cattle were housed was recorded 24/7 using a
ceiling mounted 360° camera. This was carried out over nine days from the point of arrival.
An ethogram was formulated and a selection of locomotive behaviours were studied using
Observer XT (Noldus) software. It was observed that during the acclimatisation period, time
spent walking around the room decreased and time spent standing increased.
The preliminary data suggests that cattle at TPI acclimatise to their environment around 72
hours after their arrival.
The provision of food and water for laboratory animals, while being arguably the simplest
aspect of animal husbandry, is still a major cause of non-compliance issues within UK based
research establishments. According to the ASRU 2017 report, a failure to provide food
and water accounted for 20% of all non-compliance cases, a rather sizeable proportion
considering the necessity of the task. This problem is further exacerbated with the
introduction of permissible food and fluid restrictions.
At the Sainsbury Wellcome Centre, (SWC), approximately 180 experimental animals
would be on a restriction at any one time, including on bank holidays and at weekends.
To ensure all animals, be they on restriction or not, were provided with food and water,
and to address the danger of non-compliance, we successfully developed and introduced
a three-tier checking system. This poster looks at the development and implementation
of the checking and information system we now use to ensure compliance and welfare.
POSTER DISPLAYS
Scientific Programme70
POSTER DISPLAYS
IAN WILSON
Institute of Cancer Research (ICR)
London, UK
An electronic based experimental protocol
has “ARRIVED”
Historically Experimental Protocols for in vivo experiments have been paper based and
submitted for approval in person. A common drawback to this process is the many ‘copy
and paste’ errors that can occur during document creation, version control and insufficient
study information being supplied.
The publication of the Animal research: Reporting in vivo experiments: The ARRIVE
guidelines (Kilkenny et al 2010) is intended to improve the reporting of research using
animals – maximising information published and minimising unnecessary studies.
The aim of an electronic protocol is to directly integrate the values put forward by
the ARRIVE guidelines and standardise the various versions of paper based protocols
submitted. In turn this provides the submitter a platform to consider the wider health,
safety and welfare implications of their study.
Pre-scripted electronic layout guides encourage forethought around the 3Rs. Additionally
‘Dropbox’ functions for gathering information prompts the applicant to consider steps
involved within their experiment helping eliminate ‘copy and paste’ errors, as each
protocol becomes unique. In turn, this can dramatically reduce variability between
documents and make subsequent experiments more reproducible whilst still giving parity
to the ARRIVE guidelines.
The generation of documents on an electronic system enables submission and approvals
of protocols to be made remotely, ensuring the document reaches the correct person
immediately. Sequentially cross-referencing skills training, competence and compliance
can be made before the study commences.
A declaration statement is required prior to final submission. This requires the applicant to
review all aspects of legal compliance within the submission document.
Reference:
Kilkenny C, Browne WJ, Cuthill IC et al. (2010). Animal research: Reporting in vivo experiments: The ARRIVE
guidelines. Laboratory Animals 44(4):377-378
Scientific Programme
71
POSTER DISPLAYS
JOANNA MOORE
GlaxoSmithKline (GSK)
Stevenage, UK
Home caging monitoring – investing in the
future
Home cage monitoring is not a new technique, yet there is a long way to go before the
ideal system will be available. If indeed such a system could ever exist? Several criteria need
to be considered and a system that fits all situations may not be feasible. There are a few
‘off the shelf’ cage monitoring options available, each working in a different way to the
other. These differences may lead to some reproducibility difficulties as the ethograms of
observed behaviours may not map across from systems with cameras viewing cages from
different angles, or where behaviours have been defined by different research groups.
These observations must also be defined and inputted correctly in the first instance or
algorithms of behaviours will be flawed.
Better objectivity may therefore, be found in systems where cameras are not the primary
source of data, as these systems give a more definite answer in terms of movement: no
movement, heart rate up; heart rate down. However without some behaviour data to back
it up, subtle behavioural changes may be missed.
Another hurdle to overcome with any of the systems is group housing social animals
without using an invasive procedure to enable the system to recognise individuals. This
is likely to be insurmountable and microchips may always be needed to maintain social
housing during home cage monitoring. This may cause difficulties, for example, in areas
where MRI scans could be required as part of the study.
This poster gives a broad overview of the concept of Home Cage monitoring, the criteria
which could be used to assess a system, and the validation criteria used to determine which
system may best answer the scientific question being asked of it.
Scientific Programme72
JOANNA MOORE
GlaxoSmithKline (GSK)
Stevenage, UK
The use of home cage monitoring to
determine whether individual male mouse
activity patterns correlate with nest
complexity
It is well established that nesting materials are an important inclusion for mouse cages.
We wanted to determine whether there was a significant difference in mice activity when
offered three different material choices and whether there was any correlation between
activity in the cage and nest complexity. We individually housed nine adult male mice in
Digital Ventilated Cages (DVC), and offered each mouse one of three nesting options for
a seven-day period, either Lignocel Large, 9gms of shredded paper, or a combination of
Lignocel and shredded paper as well as a red igloo and fun tunnel. After seven days the nest
was given a score in terms of complexity using the method published by Jirkof et al (2013)
and the mice were moved to a clean cage with a different nesting option for a further
seven days until each mouse has been exposed to each option. We used the established
home-cage monitoring system to determine whether there were clear differences in the
activity pattern of mice depending on the nesting, and whether these were related to
the complexity of the nest. This poster discusses the results of our analysis and whether
the nesting offered to mice can reduce the disruption in their activity pattern. All animal
studies were ethically reviewed and carried out in accordance with Animals (Scientific
Procedures) Act 1986 and the GSK Policy on the Care, Welfare and Treatment of Animals.”
Reference:
Jirkof P, Fleischmann T, Cesarovic N, Rettich A, Vogel J and Arras M. (2013). Assessment of postsurgical distress and
pain in laboratory mice by nest complexity scoring. Laboratory Animals, 47(3), 153–161.
POSTER DISPLAYS
Scientific Programme
73
JOANNA MOORE
GlaxoSmithKline (GSK)
Stevenage, UK
Using home cage monitoring to determine
the impact of timed mating on male mouse
welfare
The use of sterile male mice to induce pseudopregnancy in female mice assigned for the
implantation of embryos is a vital component in the production of Genetically Altered
Animals (GAA). To achieve this we use Protamine1 (Prm1) transgenic male Hemizygous
mice which are genetically sterile due to this mutation. These males are often kept for
up to nine months and are housed with a companion female. During the timed mating
period the companion is swapped for a new female. We wanted to determine whether
there was a potential impact on male mouse welfare when their female companion was
swapped. We hypothesised that the impact in cage activity will significantly increase
when a companion female is replaced with a new naïve female. We used an established
home-cage monitoring system to determine how much disruption is created to the activity
pattern in cages when a companion female is swapped compared to when she is just
removed and replaced in the pair’s home-cage. We found that there is a potential impact
on the welfare of male mice as a result of timed mating which could lead to a decrease in
their wellbeing if they are used for repeated timed mating. The impact of this intervention
may be reduced if timed mating occurred in the late afternoon, closer to the naturally
active phase. Further studies will be designed to enable us to have a clearer understanding
of the activity and impact on these animals. All animal studies were ethically reviewed and
carried out in accordance with the Animals (Scientific Procedures) Act 1986 and the GSK
Policy on the Care, Welfare and Treatment of Animals.
POSTER DISPLAYS
TRADE EXHIBITION
74 Trade Exhibition
Always fast, sometimes furious and definitely fun!
Each company has only a few minutes to virtually enthral you with their services and
products. We have two sessions this year and here are the details on approximate timings
and participants.
Wednesday 10th March
Time
14:30 Alison Hopkins a-tune software AG
14:33 Nicky Windows and Ryan Hill Datesand Ltd
14:36 Sue Parker IPS Product Supplies Ltd
14:39 Anthony Iglesias LBS (Serving Biotechnology)
14:42 John Waters Impex
14:45 Melanie Klein and Paul Mackin NKP-Isotec
14:48 Debbie Carter Plexx BV
14:51 Marlene Mikkola SCANBUR
14:54 Andy Dickinson Surrey Diagnostics Ltd
14:57 Ian Fielding Tecniplast
Thursday 11th March
Time
14:30 Toby Sanders Agenda Life Sciences
14:33 Rachel Maylott Avidity Science
14:36 Olaf Gelsen GVG Diagnostics GmbH
14:39 Jon Faupel Janvier Labs
14:42 Alistair Vincent MMM Medical Equipment UK
14:45 Borja Gorbena NorayBio Software
14:48 Sara Wu RWD Life Science
14:51 Max Albring Scionics Computer Innovation GmbH
14:54 Dan Harding and Anais Eusebio Sychem
14:57 Robert Davis TPS/Gruenberg Dry Heat Sterilizers
15:00 David Porteous Transnetyx
Flash Trade Sessions
Animal Technology
- where good science communication is vital
TRADE EXHIBITION
Delegates are invited to join each of these interactive forums hosted by our industry
partners.
NKP-Isotec Wednesday 10th March 10.00 – 11.00 hrs
Join Melanie Klein and Paul Mackin for their very first IAT Interactive Trade Session. They
will be discussing some exciting topics including: biocontainment Level 3 and 4 isolators,
behaviour studies equipment, retrofitting of auto-watering systems and laboratory furniture
including the popular laptop trolleys.
If you are not able to join them, feel free to get in touch and they will be happy to provide
you with a copy of the presentation.
Avidity Science Wednesday 10th March 11.00 – 12.00 hrs
Join James Cardwell for this drop-in session where you will be able to meet your new UK/
Ireland contact, Rachel Maylott. Rachel will be talking about the one thing we all take for
granted - Water.
She will be demonstrating the variabilities you can find in water and how you can combat
these in your facility. There will also be a chance to ask her any questions you may have
about water or our products and services.
We will also be holding a special prize draw so don’t miss out!
Envigo UK Ltd Wednesday 10th March 12.00 – 13.00 hrs
What’s a health monitoring program got to do with it? Join Kelly Barnett and Ani Obaya
to find out.
Agenda Life Sciences Thursday 11th March 10.00 – 11.00 hrs
Join Ross Millard, Judith Fowlston, Laura Gilbey and Toby Sanders who will answer any
questions you may have about our products and services.
Trade Interactive Forums
75Trade Exhibition
TRADE EXHIBITION
Trade Exhibition76
Tecniplast UK Thursday 11th March 11.00 – 12.00 hrs
Innovation for your Laboratory Animal Facility
Do you want to know what products are available to make your like easier in your
laboratory animal facility?
Then why not join Carl Breacker, Fred Newborough, James Latta, Nick Bladon, Mike Rollings,
David Rooks, Sharon Sears, Simon Mizen, Clare Belton and Andy Humes.
During this session we will take you through the latest product innovations from Tecniplast
and show you how they can enhance your lab animal facility. Aquatics Solutions will
showcase the recently launched InterZebtec; the latest in aquatics environmental monitoring,
alongside the Z Park and 2.4 litre tank. From our Housing Division we will demonstrate the
Isolator P and show how this can support your Germ Free work.
Janvier Labs Tuesday 16th March 10.00 – 11.00 hrs
Join us for a drop-in session to ask any questions you may have.
GVG Diagnostics GmbH Tuesday 16th March 11.00 – 12.00 hrs
Join us to learn more about
l
our routine health screening programs – reliable service at competitive pricing
l
our new microbiome characterisation program per shotgun NGS
l
background checks and speed congenics through our panel of highly informative STR
markers
l
Snooplex kit for genotyping from swab samples
l
our target genotyping service for wt/mut
Scionics Computer Innovation GmbH Tuesday 16th March 12.00 – 13.00 hrs
Join us for a drop-in session to ask any questions you may have about our products and
services.
TRADE EXHIBITION
Trade Exhibition
77
Sychem Wednesday 17th March 10.00 – 11.00 hrs
Join us for a drop-in session to ask any questions you may have about our products and
services.
a-tune Software Wednesday 17th March 11.00 – 12.00 hrs
Connecting data, processes and people … please join us.
IPS Ltd Wednesday 17th March 12.00 – 13.00 hrs
Join the team for a drop-in session to ask any questions you may have about our products
and services.
TPS/Gruenberg Thursday 18th March 10.00 – 11.00 hrs
Join us to discover our dry heat sterilisers and to ask any questions you may have.
MMM Medical Equipment Ltd Thursday 18th March 11.00 – 12.00 hrs
Join Alistair Vincent, UK Sales Manager to ask any questions you may have about our
products and services.
Datesand Ltd Thursday 18th March 12.00 – 13.00 hrs
Join us for a drop-in session to ask any questions you may have about our products and
services.
TRADE EXHIBITION
Trade Exhibition78
RWD Life Science Tuesday 23rd March 10.00 – 11.00 hrs
Join us to discover how to quickly and precisely perform rodent surgery experiments.
Transnetyx Wednesday 24th March 10.00 – 11.00 hrs
Join Kanika Coleman, Manuel Vazquez and David Porteous.
Animals in Science Education Trust Wednesday 24th March 12.00 – 13.00 hrs
Join Wendy Steel for a drop-in session to ask any questions you may have about AS-ET.
AS-ET 7
Bell Isolation Systems Ltd 24
Datesand Ltd Inside Front Cover
Envigo 8
IPS Product Supplies Ltd 10
Institute of Animal Technology 4,18, 37, Back Cover
LBS Serving Biotechnology Ltd 20
R C Hartelust bv Inside Back Cover
Scionics Computer Innovation GmbH 3
Tecniplast 14-15
University of Cambridge 42
INDEX TO ADVERTISERS Page
Animal Technology
- where good science communication is vital
TRADE EXHIBITION
Trade Exhibition
79
Trade Partners Exhibition
Agenda Life Sciences
Choosing Agenda as your resourcing partner means that you receive a service which
provides you with choice, not compromise. Your business is unique and because of this,
we offer a bespoke service to each of our clients. We are the only life science recruitment
and temporary staffing provider that actively run our own research facilities. Working
with Agenda will mean you can take advantage of our unique position within the Life
Science industry. Our team fully understand the specific requirements of the sector and
develop a tailored approach to working with you. Our service offerings include permanent
recruitment, temporary staffing, and facility management.
Why choose Agenda for your recruitment?
You will benefit from our specialist recruitment team who have worked directly in life
sciences and are experts at understanding this sector’s very specific requirements, better
than anyone else. Specialist areas include: animal technology, histology, genetics, molecular
biology, immunology, neurology, oncology, pharmacology, toxicology and more.
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you gain access to our large database of technologists seeking career development
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360-degree support is provided by our experienced, friendly and professional
recruitment consultants who guide you through every step of the process
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detailed pre-employment screening (including our unique Animal Rights Connection
checks) and suitability interviews conducted before you interview
Do you need a temporary staffing solution?
Whether you need an additional resource for a specific research project, cover for long-term
absence, maternity or holiday cover, or just want the flexibility of a temporary staffing
solution, Agenda are perfectly placed to help.
All of the candidates we have on file have been specifically selected by us because they
have something special to offer your business. By carrying out rigorous and comprehensive
interviews and inductions we ensure that only the very best temporary candidates make it
through the process, with every technician boasting relevant qualifications and proven work
experience.
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short/long term cover offering greater flexibility - choose a bespoke solution that fits
your requirements
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you choose from our large pool of experienced technicians based nationwide, to fill
any gaps your resourcing may have
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solve your HR headaches. Agenda saves you time and money and ensures you have
peace of mind with our rigorous pre-employment screening process
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the only fast-start Licensed Technicians available on the market, allowing your team
the correct level of support right from the start
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our highly regarded Welfare First programme cares for the people who care for the
animals, including key elements such as a welfare contract, Welfare First e-newsletter,
training and development to provide the support to deliver great animal care and
welfare
Flexible Facility Management from Agenda
Research projects are unique and require a tailored Facility Management service which can
grow with your ever-changing requirements. Outsourcing your Facility Management needs
means that you are able to further your research success by centring your focus on your
projects and studies. Whether you need a full-service solution at a site of your choosing, or
want to conduct and control your research in one of our state-of-the-art facilities, Agenda
can provide a partnership approach to suit. Here are just some of the things we can help you
with as part of our facility management service -
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compliance and regulatory oversight
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animal Care and Welfare
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staffing solutions
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procurement and budgeting
hello@agendalifesciences.co.uk https://www.agendalifesciences.com/ +44 (0) 8456 445545
Animals in Science Education Trust
The Animals in Science Education Trust (AS-ET) is a charity registered under the UK Charities
Act 1993. The aim of the trust is to advance education and promote excellence in the care
and welfare of animals used in science.
It seeks to achieve this aim by:
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providing bursaries for course fees, travel and accommodation;
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providing funding to develop teaching packages;
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supporting the development of handbooks, DVDs and other course material;
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supporting the development of web based learning;
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supporting students with special needs
AS-ET was set up by the Institute of Animal Technology (IAT) but now operates as a
separate organisation. It is headed by two distinguished scientists; Professor Lord Naren
Patel KT (Patron) and Professor Sir Richard Gardner FIAT (Hon), FRS who chairs the board of
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four trustees. The trustees welcome applications from individuals for financial support for
activities that are in accordance with our aims.
Please visit the Auction Page on the website to browse the items and place your bids.
https://www.animalsinscienceeducationtrust.org.uk/ contact@as-et.org.uk
a-tune Software
Elevating Freedom to Conduct Research
Intuitive and easy to use, tick@lab centrally manages your animal records and enables the
management of your breeding colonies for all species including aquatics. Users working
with animals can securely access their required information in real time using any device
(notebook, tablet, PC...). Alerts and requests enhance communication between users. The
use of configurable forms allows any activity (experimental, health and treatment plans,
breeding, etc.) to be recorded directly into the animal profile making it searchable for
transparency and simplicity.
tick@lab integrates compliance management, facility and animal operations including
census/cage management, billing, and breeding into one central integrated platform. It
ensures data traceability as well as transparency while mitigating compliance risks.
tick@lab is designed to electronically manage the requirements of the Home Office and the
Directive 2010/63/EU by collecting data and generating the reports (Statistical returns and
EU Bred and un-used) required to meet the regulations.
In the background, tick@lab automatically applies compliance checks, tracks animal numbers
against protocols and collects costs associated to animal activities for billing purposes.
tick@lab also tracks compliance with training requirements for all personnel involved on a
protocol and manages training and competency information.
sales@a-tune.com https://www.a-tune.com/ +49 6151 95131-0
Avidity Science
Avidity Science is a water purification technologies company that is a trusted partner to the
global research industry. We are the world-leading supplier in automated animal watering
systems, water purification and treatment systems, environmental monitoring software, and
laboratory equipment. Our aim is to protect animal health and valuable research.
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Our Automated Watering Systems deliver purified water on demand, 24 hours a day,
eliminating ergonomic injuries and reducing the costs associated with bottle cleaning, filling
and manipulation. It’s never too late either, as our systems can be fitted in any facility and
are fully scalable. Our animal drinking valve technology is also the most reliable on the
market having been developed over the last 40 years.
Our Watchdog EX™ cloud-based control and monitoring software provides real-time data
readings, alarming, and reporting through an intuitive user interface that puts you in total
control of your facility’s data. From room and freezer temperatures to differential pressure
and humidity, customisable reports and alarm limits ensure your facility’s animals are safe.
UK.info@avidityscience.com https://www.avidityscience.com/en_gb/ +44 (0) 1844 201142
Charles River
For 70 years, researchers worldwide have trusted Charles River as their source for the
highest quality animal models and related services. Offering a broad selection of species
and strains, we support today’s most critical research with the timely delivery of study-ready,
preconditioned and genetically engineered animals.
Our leading scientists and global network of AAALAC-accredited vivaria and breeding
facilities provide clients with accessible, expert management of outsourced colonies, biology
services for line creation, maintenance and preservation, advanced diagnostics, and health
monitoring to guarantee the long-term success of their work.
Charles River: More than a mouse!
AskCharlesRiver@crl.com https://www.criver.com/rms
Datesand Ltd
With over 40 years of unrivalled experience, Datesand have always led the way when it
comes to meeting the supply needs of the world’s leading laboratories. Not to mention
continually pushing the boundaries of innovation within the Biotechnology sector.
The proud creators of the Janet Wood Award, Datesand provide Animal Technicians and
Industry Experts with the opportunity to design market-breaking products of tomorrow.
Datesand provide the widest range of husbandry and LAS critical consumables offered by a
single supplier.
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When you choose Datesand, you are choosing experience, quality, innovation and a
passionate, family-led team of professionals who will always put the customer first.
sales@datesand.com https://datesand.com/ 0800 161 5831
Envigo UK Ltd
Envigo provides the broadest range of research models and related services to the
pharmaceutical and biotechnology industries, government, academia, and other life science
organisations. As the largest organisation that is solely dedicated to providing research
models and related products and services, we are committed to helping researchers realise
the full potential of their critical R&D projects as we fulfill our mission to work together to
build a healthier and safer world.
In 2019, Envigo expanded our service offering by acquiring the assets of the research models
business unit of Horizon Discovery Group plc (“Horizon”, LSE:HZD). Horizon’s research
models business unit provides genetically engineered models and services from its locations
in St Louis, Missouri and Boyertown, Pennsylvania. The business unit uses gene-editing
technology and expertise to produce customised models with relevant gene deletions,
insertions and other modifications, which are then used as models for human disease during
drug discovery and development.
rms.uk@envigo.com https://www.envigo.com/ +44 (0) 1869 243241
GVG Diagnostics GmbH
In addition to the complete range of tests recommended by FELASA, GVG Diagnostics
also offers a raft of tests important and necessary for the health monitoring of laboratory
animals. Our test routines include testing of live animals, in vivo and environmetal samples
(through PCR). Our latest product is the complete in-house microbiome characterisation by
shotgun NGS.
GVG Genetic Monitoring offers a range of molecular genetic services including mouse
genotyping for genetic background checks, accelerated marker-assisted back-crossing
projects(“Speed Congenics“) and our fully comprehensive target genotyping service.
Feel free to get in touch with us.
+49 341 3929869-0 info@gvg-diagnostics.de www.gvg diagnostics.de
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Impex
Impex have successfully transported livestock on a worldwide and domestic basis for over
20 years. We are Europe’s largest specialist livestock courier and market leaders in the
transportation of non-agricultural animals and delicate or endangered species.
Our service extends throughout the UK, Europe and the rest of the World, making us a truly
Global Courier. Our friendly and dedicated team are waiting to offer you a service second
to none.
Impex have developed strategic relationships with international air couriers to provide door-
to-door, seamless Domestic, European and Global controlled transportation.
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international and domestic licensed aircraft operators
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security cleared air and ground crews
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transcontinental availability to and from most major airports world-wide
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accompanied door-to-door export/import capability
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full, fast freight clearance at all locations
info@impex-uk.com http://www.impex-uk.com/ +44 (0) 8456 021662
IPS International Product Supplies Ltd
We can all do our bit for the environment
IPS is a leading supplier of high quality and ethically sourced products and brands including
LabDiet®, TestDiet®, Lignocel Bedding, BenchGuards®.
For IAT Congress 2021 we are delighted to be launching a new range of eco-friendly
BenchGuard® clinical hygiene products which are made from Bamboo and are 100%
biodegradable. The strength and absorbency of these products will knock your bamboo
socks off and they will soon become your go-to wipes and absorption products for your
procedure and animal holding rooms, isolators and perhaps even your staff rooms!
For more information and samples for this green solution please visit us during Congress or
join our interactive session
benchguard@ipsltd.biz customers@ipsltd.biz http://www.ipsltd.biz/ +44 (0) 870 600 1616
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Janvier Labs
As an international player of biomedical research, JANVIER LABS supplies experimental
models with the highest standards.
JANVIER LABS takes care of your models to allow you to devote yourself fully to your
research projects.
Thanks to its unique site, the largest and most modern in Europe, JANVIER LABS provides
you with experimental models with the highest level of quality.
We assure you of rigorous breeding conditions essential to the homogeneity and
reproducibility of your experimental results: health status (SPF and SOPF), genetic stability,
a single microbiota, animal welfare.
A family-owned and independent company, JANVIER LABS ensures availability, responsiveness,
excellence and transparency on the quality of its models, products and services.
Discover our new NXG model as well as our 360 ° range of immunodeficient models.
We offer comprehensive support for your models by our experts, from creation to delivery,
including the preparation of your models in the laboratory.
Throughout the year, you will discover our new models and services which will complement
our offer to best meet your needs. Contact Jon Faupel at jonathan.faupel@janvier-labs.com
or 07507 363717 for more information.
contact@janvier-labs.com https://immunoonco.janvier-labs.com/en/
https://www.janvier-labs.com/ +33 (0) 2 43 02 11 91
Laboratory Animal Science Association (LASA)
The UK society for scientists and laboratory animal professionals with an interest in animal
research, 3Rs, care and welfare, education and training, ethics and policy and regulation of
animal research.
LASA was founded in 1963 by a consortium of industrial, university, ministry and research
council representatives – a breadth of interest which is still typical of the LASA membership
today. Through our mission statement ‘To advance scientific understanding and knowledge
of the use, care and welfare of laboratory animals and promote refinement, reduction
and replacement’ we aim to encourage and facilitate education and training in laboratory
animal science.
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LASA promotes the interchange of information through meetings, lectures, discussions and
publications. There are seven specialist sections of LASA which together provide a forum to
discuss the latest developments in the areas of specialised scientific interest.
We welcome applications of membership from Individuals and Organisations.
info@lasa.co.uk https://www.lasa.co.uk/ +44 (0) 8456 711956
LBS Biotech
As an independent family run business since 1939, where integrity still counts, heritage
and tenacity runs through the very veins and DNA of LBS. These have played no small
part in its success as a leading supplier of diet, bedding, consumables and services to the
biotech industry as we head into our 82nd year. Whilst the company takes immense pride
in its heritage we recognise that it is only through a relentless and a consistent focus on
meeting and exceeding the requirements of our domestic and international customers in
the biotechnology industry that we maintain this position.
We offer a combination of tried and tested products and through a continual process of
product development, new innovative product solutions. All of this is backed through our
commitment to ISO 9001:2015 quality assurance, customer service and logistics management.
This is further underpinned and developed through a process of working closer with the
understanding of our customers’ needs, at which we aim to excel.
Contact us for expert advice on:
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research and zoo diets
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research bedding and nesting material
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environmental enrichment products
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PPE including clothing and footwear
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AniBio animal facility management software – covers all your essential needs
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disinfectants and all allied products
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bespoke irradiated packaging and supplies
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specialist vacuum / floor care products
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broad range of specialist equipment and products for Animal Technologists
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price promise
sales@lbs-biotech.com http://www.lbs-biotech.com/ +44 (0) 1293 827940
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Marshall BioResources
Marshall UK is a division of Marshall BioResources Inc., and our Home Office designated
breeding and supplying facilities are located in Grimston, near Hull, East Yorkshire and
Wyton in Cambridgeshire. We supply Marshall Beagles® and have full barrier facilities for
the production of ‘Influenza-free’ ferrets and SPF Guinea pigs and mice. Using flexible film
isolators, we breed the IFNAR type 1 and type 2 interferon receptor KO mice (A129 and AG129)
as well as the wild type control (129 SvEv). Our SPF Dunkin Hartley Guinea pigs have a high
health status and remain negative for many pathogens including Guinea pig CMV and PI3.
Marshall UK also offers Contract Services including small research projects and animal
breeding and housing of customers’ own strains.
Our Scientific Services team offers a highly regarded Animal Health Monitoring Service and
we are able to perform health screening at your site or, using our collection service, your
samples can be brought to Grimston for testing.
Biological matrices from a range of donors (rodents, Marshall Beagles®, rabbits, humans,
NHP’s and farm animals) are also available. We offer a very quick turnaround of your orders
for whole blood, plasma, serum, tissues and many other bioproducts.
BNKsales@marshallbio.com https://www.marshallbio.com/ +44 (0) 1964 527555
MMM Medical Equipment Ltd
Total Solutions for Infection Control Units
The MMM Group founded in 1954 in Munich, Germany has supplied sterilizing equipment
to both laboratories and research centres for over sixty six years and is one of the strongest
manufacturing groups in Europe.
MMM Sterilizers are designed with reliability built in, offering you peace of mind for
your animal facility. Each stage of manufacture, installation and after-sales care is quality
controlled to provide the long-life cycle you need. This level of reliability and continued after-
sales and service support has earned us ‘preferred supplier status’ with many of our clients.
MMM in the UK is centrally located in Leeds and was founded in 1997. Since that time we
have worked hard to earn and maintain our excellent reputation for autoclave quality and
reliability in both the UK and Ireland. This has been achieved by providing the following:
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our own PRINCE2® qualified project management team to deliver you a stress-free
project on budget, on time
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factory trained team of service engineers based at locations throughout the country
(UK & Ireland)
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factory trained systems and installation personnel enable us to work closely with your
Architects, Design teams and Planning Departments
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ISO Quality standards in 9001, 14001 and 45001
This allows us to take full control of projects as a sub or principal contractor from the initial
concept through to installation, commissioning, final validation and successful handover to
our clients.
Contact Alistair and the MMM UK team to discuss your requirements and we will be happy
to help with any assistance you require.
enquiries@mmm-group.co.uk https://www.mmmgroup.com/en/products
+44 (0) 113 3910717
NKP-Isotec
Since the 1950s NKP has had a strong relationship with the research industry, developing
plastic caging and housing systems worldwide. Through recent years, NKP-Isotec has
developed a wide range of Flexible Film Isolators for various species, bio-safety cabinets and
associated sundry items. With the help of our trusted Research partners, we have established
a reputable line of products that have animal welfare, user satisfaction and eco-friendly
solutions at their core. Customer requirements and services are at the heart of our business,
and we therefore offer support, training and bespoke manufacturing in order to meet our
client’s requests.
Our interactive session will discuss the following topics:
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biocontainment Level 3 & 4
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lab furniture from laptop trolleys through to sinks and work benches
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behavioural studies equipment
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retrofitting auto-watering systems in partnership with Avidity Science
Your ideas drive us forward
sales@nkpisotec.com https://nkpisotec.com/ +44 (0) 1530 510113
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NorayBio
AniBio is an easy-to-use software solution designed to improve the management of the
animal facility and its animals, facilitating the daily tasks and activities of each user and
ensuring the traceability of data.
This year, NorayBio launches a new version of AniBio with a completely evolved and adapted
interface that allows each user total navigability over the application modules.
anibio@noraybio.com https://www.noraybio.com/en/ +34 94 403 6998
Orbit Search
Established in 2018, Orbit Search has grown and developed to become one of the leading
agencies in the Life Sciences field. We pride ourselves in connecting high calibre talent to
leading organisations globally.
We are passionate about the life sciences industry, and we aim to provide truly comprehensive
recruiting solutions to both jobseekers and employers alike.
With over twenty-five years of combined recruitment experience, whether it will be for
entry level or executive level positions; you are in safe hands whilst we provide you with an
‘out of this world’ recruitment experience at competitive rates.
hello@orbitsearch.co.uk https://orbitsearch.co.uk/ +44 (0) 20 7965 7799
Plexx BV
Plexx BV is the sole European representative for BioMedic Data Systems, Lab Products Inc,
E-Z Systems/Euthanex and as of last year, Iwaki Aquatic Systems. With nearly 30 years of
experience in the pharmaceutical and biomedical industry, we have a proven track record
of providing high quality products and outstanding customer service.
Animal Identification - Injectable transponders give the option to program unique
identification codes as well as reading body temperature. Additional data can also be
collected by connecting weighing scales and tumour measurement devices.
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Individually ventilated Micro Isolator systems - Protect both your staff and animals with our
positive cage in a negative rack design.
Zebrafish and Xenopus Housing Systems - Newly designed tanks and racks with high quality
components and remote access and control.
Hydropac - An innovative way to deliver water to rodents using on-site produced pouches
and drip-free single use valves.
Anaesthesia equipment - User friendly, simple operation equipment with a level of precise
automation that minimises operator error.
Automated Home Cage Euthanasia Systems - Humane gradient CO
2
systems for small,
medium and large numbers of cages at the press of a button.
Enrichment, Treats and Special Diets for all laboratory animal species.
info@plexx.eu https://www.plexx.eu/ +31 481 377 797
RWD Life Science
Founded in 2002 and headquartered in Shenzhen, China, RWD Life Science specialises in life
science, animal healthcare and medical devices. With more than 600 employees and over
100 R&D engineers, RWD has offered high quality products and service to more than 2,000
laboratories in 100 countries all over the world.
RWD is committed to innovation based on global customer needs by providing smart
solutions of respiratory anaesthesia, neuroscience research, animal behaviour research,
surgery and nursing, and pathological analysis. RWD products are more innovative, more
efficient and more reliable, easy to install, creating value for customers to achieve better
research with higher quality and lower maintenance cost. Looking into the future, we
shall adhere to the core values of quality, integrity, responsibility and contribute to the
advancement and development of pre-clinical and medical clinic applications across an
international market.
rwd@rwdmall.com https://www.rwdstco.com/ +86 7558 6111 286
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S3 Science
Making permanent and temporary Animal Technician placements at all levels nationwide
since 2002
Our background - S3 has been placing new and experienced Animal Technicians within
clients animal facilities for almost 2 decades. With over 25 years combined recruitment
experience we are the sole or preferred supplier to many clients, with recruitment solutions
that deliver on time and on budget.
Our candidates - We have a passion for sourcing candidates with good animal welfare and
a desire to work with laboratory animals at the heart of their career aspirations. We find
local talent, with the right skills for the role on offer. We don’t believe in placing expensive
temporary workers to work far from home, or in a role above or below their experience level.
Our Animal Technician Development Programme (ATDP) ensures a steady stream of trained
and available technicians 24/7, 365 days a year. The programme enroles new technicians for
basic training, having completed their animal related studies at college or university. Our
inhouse Animal Technician trainers work with the new technicians through several industry
specific online study modules before finally matching them up to a local clients animal
facility for 12 weeks work experience. ATDP partner employers can go onto employ their
newly trained technician either permanently, as a temporary worker at not-for-profit charge
rates, or to further their development via an apprenticeship programme. Our creation of the
ATDP has changed the face of new technician recruitment and achieved an amazing into
work ratio of 96% for the past 3 years.
Our recruitment methods - We are excited to announce a new recruitment tool for busy
hiring managers. Our candidate presentation platform lets hiring managers see and hear
prospective candidates discussing working for them and answering clients pre-set questions
to the role they are hiring for, whilst presenting their skills and work history.
Finding the right candidate has never been easier - Clients set the questions, and the
candidate records their answers within 48 hours of the vacancy going live. No need to book
a meeting room or wait for a colleague to share their availability to attend the interview.
Forward the candidate presentation to your colleagues or manager for their feedback too.
Replay the candidates presentation and answers, whenever and wherever you like, if you
are home working, at the office, or on the go from your mobile device, laptop or computer.
Click on the links below to view some of our recent placements. View the interview
questions on the left and watch the candidate present their answer on the right. Click on
each question in turn to view the complete presentation.
-
Video Interview Review For Sophie Wildman – we utilised the video interview process
ourselves when hiring for our Training Manager vacancy. On the back of our questions,
Sophie recorded a great presentation and landed the job.
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-
Video Interview Review For Amy Sizer – our client, Royal Free hired Amy after viewing
her presentation.
Talk to us today to arrange a demonstration of our innovative candidate presentation
platform, or to discuss your recruitment strategy and see how we can help realise your
recruitment goals.
CVs say nothing, let your next hire really impress you
+44 (0) 203 924 0166 info@s3science.com www.ATDP.org www.s3science.com
www.s3discovery.com
Scanbur
It is SCANBUR’s mission to successfully and innovatively develop, produce and sell equipment
for in vivo medical research and cleanroom production globally hence contribute to
preventing and curing diseases: Improving Life Sciences.
ScanClime for Scantainer and IVC - a compact and mobile plug and play air handling,
humidification and dehumidification unit for animal housing systems. Provides humidity
control with unrivalled accuracy, promoting better breeding performance, animal welfare,
increased validity of research and improved flexibility. In addition humidification cost can
be reduced by up to 80%.
Scantainer – if draught inside IVC cages is a concern, when housing e.g. pups or nude mice,
Scantainer is a great alternative. Also, considering that rodents are social animals, if more
rodents should be allowed to smell or hear each other, a Scantainer could be a preferred
housing solution. A very flexible housing system. Can hold many different cages sizes
allowing for housing of rodents to be applied for many different types of studies.
Animal Welfare | Allergen/Disease Control | Ergonomics | Green Solutions
jow@scanbur.com www.scanbur.com +44 (0) 7923 320 519
Scionics Computer Innovation GmbH
Scionics has provided computer solutions for scientists for 20 years and is the maker of the
PyRAT line of animal facility software products. PyRAT is used for the storage, sharing,
and management of animal facility data and increases facility efficiency, work flow, and
governmental compliance. The PyRAT Transgenic edition includes additional functionality
tailored to the needs of transgenic facilities, tracking sperm, embryos, and oocytes, their
genetic modifications, and the life history of the resulting animals. PyRAT Aquatic makes
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managing your fish colonies easier than ever, saving you both time and money.
Development for all products is done in close collaboration with our clients and is governed
by our ISO9001:2015 certified Quality Management System (QMS).
The web interface is easy to learn and accessible from any device (computer, tablet, smart
phone) with a web browser. Data can be stored on-site or in the cloud.
Accessible in several languages, our PyRAT products are used worldwide by clients with
a diverse set of regulatory requirements. Customization of our PyRAT products is also
available. Please contact us for a demonstration.
A list of PyRAT’s features include but are not limited to:
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full history tracking
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location management including graphical rack display
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cage card, cage label printing
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breeding management
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animal and line/strain pedigrees
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expanded line/strain management including line/strain severity assessment
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importing genotyping results
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authorisation tracking and reporting
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animal ordering
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work request management
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real-time reporting including alerts system
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budgeting and invoices
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user management including Active Directory / LDAP integration
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training records
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SOP management
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document uploads
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configurable views and advanced filters
The PyRAT Transgenic edition has all of the features of PyRAT but also includes:
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a cryopreservation database for sperm and embryos with a detailed representation of
tanks
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complete embryo cell tracking system, from isolation and preservation, to thawing,
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fertilisation, transfer, and transgenic offspring
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complete sperm cell tracking, allowing the import, isolation, freezing, and revitalizing
of sperm
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colony statistics that enable line and stock management at a glance
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user-configurable views (embryos, animals, transfers) and advanced filters to support
your workflows
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transgenic features seamlessly integrated with PyRAT
PyRAT Aquatic borrows the easy-to-use interface of PyRAT but with new logic and reports
for tank based operations. Some of its features include:
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full history tracking
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location management including graphical rack display
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crossing management
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tank label printing
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cage level management
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authorisation tracking and reporting
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work request management
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real-time information on stocks
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average mortality rate and related reports
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user management including Active Directory / LDAP integration
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training records
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configurable views and advanced filters
Contact us for a free demo.
products@scionics.com https://www.scionics.com/ +49 351 202 707 00
Surrey Diagnostics Ltd
HEALTH MONITORING (Microbiology, Serology, PCR, Parasitology, Necropsy and Histology)
SDL understands the importance of developing and maintaining a robust health monitoring
programme for laboratory animals and recognise that it is a fundamental part of successful
research.
Our aim is to give customers the best, scientifically accurate Health Monitoring Service on
the market at a fair price. We use the latest appropriate and proven technologies, such as
bead based SEROLOGY and REAL-TIME PCR and Microbiological Culture to achieve this.
SDL offer Combined Health Monitoring (CHM) using destructive and non-destructive
methods where fewer animals are used, but confidence in results is maintained.
ENVIRONMENTAL MONITORING (Allergens, Microbiology, Particulates)
SDL’s ENVIROSCREEN is a full environmental monitoring service including surfaces, air,
water, consumables and Laboratory Animal Allergen (LAA) monitoring.
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DECONTAMINATION VALIDATION - Biological Indicator analysis service to validate
fumigation/VHP/steam sterilisation processes.
AIR QUALITY MANAGEMENT through technology PROVEN to reduce Laboratory Animal
Allergens (LAAs), odours, micro-organisms, volatile organic compounds (VOCs) and any
airborne pathogens in an indoor environment. Please call Mark on +44 (0) 1483 266533 or
email marks@sdlab.co.uk for further information.
Surrey Diagnostics Ltd is an ISO9001:2015 accredited company
andy@sdlab.co.uk or alistair@sdlab.co.uk www.sdl.uk.net +44 (0) 1483 268300 /
+44 (0) 787 053 4617 / +44 (0) 7778 010184
Sychem
Founded in 1982, Sychem is a leading provider for disinfection, sterilisation, and
decontamination solutions. Operating predominantly within life sciences, healthcare
settings and laboratories, Sychem provides a true variety of capital equipment, vapour-phase
hydrogen peroxide solutions, infection control consumables, disinfection chemicals and
customisable servicing packages to fit your facilities requirements.
Sychem Airflow Range NEW - Sychem provides a comprehensive range of animal care
solutions, services, and consumables to support and assist research facilities in providing
the best conditions possible for all animals within their care. Innovation is at the heart of
everything Sychem do and 2020 marked the arrival of the all-new Sychem Airflow Range.
Three unique work stations, all designed to help and assist research facilities in maximising
animal welfare, protect animal technicians and advance biomedical research.
SychemCHANGE NEW - SychemCHANGE is a dual access station designed to protect your
animals during cage changing and minor procedures. You are further protecting your users
from exposure to Laboratory Animal Allergens (LAAs) through Sychem’s Active Airflow
Technology.
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unrivalled height adjustment
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multi configuration work surface
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red light mode
SychemWASTE NEW – the stand-alone waste disposal unit protects the user against LAAs.
Sychem’s Active Airflow Technology enhances protection for users, even when replacing
waste bags. Standard features include a single chute and tabletop, providing a spacious
working area.
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unrivalled cleanability
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three stage filtration
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double chute option
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SychemFILL is a clean bedding dispensing system, providing the ideal solution for modernising
your cage change process. The design features various easily adjustable programs, ensuring
that you can fill any rodent cage on the market.
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class-leading accuracy (+/- 4%)
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intuitive user interface
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compatible with all free flowing bedding
Steelco S.p.A – Sychem has worked together with Steelco since 2008 to support facilities
across the UK. They are a leading Italian manufacturer of equipment and systems
for washing, disinfection, sterilisation, and decontamination. Steelco provides medical
instrument and ultrasonic washers, glassware washers and steam sterilisers, and a range of
cage and bottle washing and automated systems. Together we support hospitals, research
facilities and laboratories.
Service and Testing – Sychem provides a comprehensive range of servicing solutions
which range from validation, testing, PPM packages, breakdown support and cloud-based
asset management software, SychemEye, all to enable facilities to minimise the risks of
contamination on-site and keep staff and visitors safe.
Infection Control Consumables – Sychem is the exclusive partner for Terragene in the UK
providing a range of consumables for use in life sciences. These range from rapid-readout
biological indicators and process challenge devices for validating sterilisation cycles.
Hand Sanitisers & Disinfectants – At Sychem, we work with some of the most prestigious
healthcare and research facilities in the UK, supplying them with our range of hand
sanitisers and surface cleaner disinfectants. Our products enable effective and prolonged
antimicrobial protection against harmful bacteria and viruses minimising the risk of
infection posed to staff, public and visitors.
hello@sychem.co.uk https://www.sychem.co.uk/ +44 (0) 845 644 6824
Tecniplast UK
Since our inception in 1949, Tecniplast has been building its global reputation for creating
the best designed, best built, highest quality animal housing and washing solutions. At
Tecniplast, our primary objective is simple: to keep your animals safely cared for, reliably
and economically.
Tecniplast have been at the heart of creating innovative solutions for over 70 years. We have
an acute awareness of the continuous evolution of biomedical facilities and are proud to
have the capability to design and develop products in-house.
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We are able to offer a wide range of integrated solutions for your lab animal facility, here
are details of just some of the Tecniplast/IWT product range on offer:
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the world leading range of IVC systems, including the latest jewel in our crown:
Emerald Line
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washing, disinfection and logistics equipment including bottle washers and fillers, rack
washers, cabinet washers and decontamination locks
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laminar airflow technology including: cage changing stations, bio safety stations,
downflow booths, bedding disposal systems and air showers
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conventional caging for all laboratory species
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automation: from partial to fully automated robotic systems to assist with ergonomics,
standardisation of process and throughput
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digitally ventilated caging (DVC), the latest home cage data capture technology
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biocontainment and bio-exclusion caging
info@tecniplastuk.com www.tecniplastuk.com +44 (0) 345 050 4556
TPS/Gruenberg
Gruenberg Steri-Dry - Dry Heat Lab Animal Science Sterilisers
Gruenberg’s Steri-Dry™ sterilisers use dry heat instead of steam to sterilise laboratory animal
cages and other lab equipment in research and laboratory settings. Not only is dry heat
sterilization most effective, but it is lower in both cost and energy consumption. Our wide
variety of dry heat Steri-Dry™ sterilisers are available custom designed and built in any size
and are designed in modules for ease of installation.
Dry heat sterilisers require no pit, no drain, no water, no steam and are light enough that
they typically do not require structural reinforcement of the building to hold their weight.
Since they do not utilise a pressure vessel, there is no need for annual pressure testing.
Maintenance is minimal – even after many years of use, our typical customer requires no
unscheduled or emergency maintenance.
bdavis@process-info.com http://www.steri-dry.com +1 5083414363
TRADE EXHIBITION
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Transnetyx
Our Transnetyx suite of services allows labs and facilities to focus on efficiently and
responsibly progressing their research while effectively saving valuable time and resources.
Transnetyx Automated Genotyping service eliminates human error and accelerates research
through our fast, easy and accurate approach. Since 2000, Transnetyx has genotyped more
than 25 million samples with 99.97% accuracy. We have built an inventory of more than
35,000 assays which includes more than 15,000 MGI and JAX lines.
IAT 2021 Virtual Congress exclusive - 50 FREE Genotyping Sample offer for all new
customers, register at www.transnetyx.com.
Transnetyx Genetic Monitoring services help you characterise the background of your mouse
strains and/or reach full congenic strain status, supporting your marker assisted breeding
program. Supporting the reproducibility of your research with our in-depth MiniMUGA
panel, including 10,000 SNP’s across 241 strains at a cost of only $40 USD per/sample.
Transnetyx Microbiome service supports researchers and LAS in the characterization of the
Microbiome to ensure research reproducibility. Enabling monitoring of shifts in the gut
microbiome, utilizing gold-standard interactive bioinformatics, deep insights from shotgun
sequencing, easy sample shipping and all at a cost of only $150 USD per/sample. 50%
Discount on first 10 samples.
dporteous@transnetyx.com help@transnetyx.com https://www.transnetyx.com/
+1 888 321 2113
Vet-Tech Solutions Ltd
The “Go to“ and only company to manufacture, supply, service and repair all types of
equipment from our own premises. We custom-build anaesthesia and surgery equipment,
euthanasia systems, heating and down flow equipment, supply a wide range of biomedical
research equipment and consumables. Specialists in manufacturing items made in stainless
steel, acylics, perspex, polycarbonate and trespa, we can assist with design options and
bespoke solutions. Innovators of the first home cage euthanasia system built to include
either a pre anaesthetic cycle or CO
2
only and smaller Pre Set CO
2
Systems which can be used
with either chambers or home-cage lids.
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heated bench top system NEW
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3Rs CurVet™ Rat and Mimicky Mouse™ Training Aids
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Dycem decontamination flooring system
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Ethicon sutures
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PPE
+44 (0) 1260 274333 info@vet-tech.co.uk https://www.vet-tech.co.uk/
a-tune software AG
Water Bottles
Envigo
Pens
IPS Product Supplies Ltd
Notebooks and Bags
Scionics
Mugs
And thanks also goes to Hartelust bv who kindly
sponsored the wine planned for the Gala Dinner.
AST2020 SPONSORS
The AST2020 Conference Committee is immensely grateful to the
companies who had sponsored delegate giveaways. Needless
to say, all of these branded items will not go to waste as they
will be ‘saved’ for the next face-to-face IAT Congress and LASA
Winter Conference.
Hartelust B.V.
Phone: +31 13 4555189
Email: info@hartelust.net
We proudly present our company as an important provider of
non human primates for research only.
Our animals are selected, monitored and shipped out right from the source,
prior to our quarantine facilities in the Netherlands.
From there they can be shipped to any destination worldwide. We have all permits
to meet the regulations in the EU regarding quarantine and transport.
Please feel free to contact us for your requirements and we will make a suitable
offer to meet your protocol and individual wishes.
Hartelust B.V.
Phone: +31 13 4555189
Email: info@hartelust.net
We proudly present our company as an important provider of
non human primates for research only.
Our animals are selected, monitored and shipped out right from the source,
prior to our quarantine facilities in the Netherlands.
From there they can be shipped to any destination worldwide. We have all permits
to meet the regulations in the EU regarding quarantine and transport.
Please feel free to contact us for your requirements and we will make a suitable
offer to meet your protocol and individual wishes.
Enquiries to Congress Committee via congress@iat.org.uk
Congress
CONGRESS 2022
Come and join us at
Congress 2022
29th March - 1st April
NORTH EAST UK VENUE
Delivering a Full Scientific Programme addressing current themes
Attend the wide range of Scientific Papers and Poster Displays
Visit one of the largest Trade Exhibitions in the UK
The event will take place in a tried and tested conference venue
We will also host the legendary
‘Ken’s Quiz Evening’ – never to be missed!
Details for Congress 2022 will be available on the IAT website
www.iat.org.uk and published in the monthly Bulletin
Bookings will open September 2021
The largest UK event run entirely for
Animal Technologists and Technicians