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2016 Annual Report

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On our 70th Anniversary, we asked today’s Damon Runyon scientists how they think cancer will be prevented, diagnosed, and treated dierently in our lifetimes and our children’s. Their fascinating responses give us great optimism. DAMON RUNYON CANCER RESEARCH FOUNDATION ANNUAL REPORT 2016

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President & CEO01

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WE ALL DREAM ABOUT THE FUTURE, a time when fewer cancers will be diagnosed and every cancer patient can be effectively treated. That has been our goal since our founding 70 years ago. Over that time, our thinking about cancer has evolved from viewing it as a mysterious killer into a beer understood disease, driven by genetic mutations that cause cells to multiply and spread in an uncontrolled manner. We have more recently witnessed the application of this knowledge to new ways to prevent, diagnose and cure many forms of cancer. Today, novel therapies are saving the lives of those who likely would not have even survived if they were diagnosed in the year 2000. We want this outcome — continued health and survival—to be true for all cancer patients regardless of cancer type. This progress would not be possible without brilliant scientists fully dedicated to this work, which is why the Damon Runyon Cancer Research Foundation remains so vitally important. Our unique role is to recruit the best emerging talent to cancer research—young scientists with the creativity, passion and innovative spirit needed to make the next breakthroughs—and keep them there. In the pages that follow, a few of these exceptional Damon Runyon scientists share their vision for the future. Our goal is to give them the resources they need to make these predictions a reality.02Lorraine W. Egan President and Chief Executive Officer Damon Runyon Cancer Research Foundation

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SCREENING AT OUR FINGERTIPS A patient will have the ability to screen for signs of cancer from their home, providing the opportunity for early diagnosis. Catching cancer in its earliest stages can vastly improve outcomes for patients, and great effort is put toward encouraging the public to undergo regular screening tests such as mammograms, prostate examinations and colonoscopies. If discovered, benign lumps and polyps can then be safely removed before they turn malignant. Ideally, everyone should have the opportunity to be routinely screened for signs of cancer, but the financial burden and available resources make this a tremendous challenge. In the future, screening will be carried out by the patient with the same device they use to schedule meetings—the smartphone.Revolutionizing Cancer ScreeningFaster processors and increased functionality from handheld devices will give individuals the equivalent of a lab computer in their pockets. Additionally, nanotechnology and microfluidic advances have shrunk the equipment needed to test blood or other bodily fluids for biomarkers of cancer into miniature sensors that can be pluged into phones like a memory card. In a few years, people will routinely test themselves at home. Any changes in cancer biomarkers will be detected early and the results emailed to oncologists for a treatment strategy to be organized. Along with technological advances, basic biological research to uncover “early-tumor” biomarkers and enhance the understanding of cancer progression will be equally critical. With twin breakthroughs in technology and biology, ubiquitous smartphone screening can be at the forefront of fighting this disease.WILLIAM RAZZELL, PhD Damon Runyon Fellow, Memorial Sloan Keering Cancer Center, New YorkWrien byA look into the future04

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“Illness is the night-side of life, a more onerous citizenship,” wrote Susan Sontag in 1977. Twenty-seven years later, Sontag died of myelodysplastic syndrome (MDS), a subtype of myeloid blood cancers, which are the focus of the research in my laboratory at Harvard. Sontag’s words remind us that we as physician-scientists have a solemn responsibility to never give up in our efforts to develop beer treatments for our patients and to lessen the burden their illness imposes on them and on their families. In the twelve years since Sontag’s death, we’ve made enormous advances in understanding how myeloid blood cancers develop. We’ve defined the causative mutations and have developed the ability to sequentially track the genetic evolution of leukemia in real time in patients. We can even detect leukemia-initiating mutations in the blood of normal individuals before they are aware of any symptoms or signs of disease. Armed with this knowledge, we are poised to prevent myeloid blood cancers, to diagnose them earlier and to treat them more selectively and effectively. In the next 10–20 years, we will screen for these cancers using blood testing, much as we currently screen for diabetes. We will intervene before full-blown cancer develops using either targeted drug therapies or gene editing technology to correct specific cancer- causing mutations.In patients who present with cancer, we will exploit precision medicine to tailor our treatment to the mutational spectrum of their individual cancer, and we will target their own immune system against specific mutant proteins in their cancer.A look into the futureCancer Treatment As Unique As Each Patient ANN MULLALLY, MD Damon Runyon Clinical Investigator Brigham and Women's Hospital, BostonWrien by05

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Luckily for the cancer research community, science has arrived in the era of genomics. This is what we’ve been waiting for, and it is the key to the future of cancer diagnosis and treatment. Through deep sequencing of cancer genomes we can now appreciate the tremendous diversity of cancers and the combinations of mutations that drive them. It will take a village of cancer researchers (and computers—lots of computers) to tenaciously hash out the functions of cancer-associated genes, and the consequences of mutations within them, to precisely pinpoint a cancer’s weaknesses. Ten to fieen years from now, cancer patients should expect to have their tumors fully sequenced aer biopsy. A unique disease deserves a unique treatment—sequencing a patient’s tumor genome will reveal the specific mutations that are driving his or her cancer. Pluging these mutations into computational models will enable doctors to prescribe treatment combinations that are as unique as the patient. Perhaps that will include a vaccine developed from the tumor’s own mutated proteins to train the patient’s immune system to recognize and destroy it. Or perhaps a drug schedule targeting molecules upon which the cancer uniquely relies, but not normal cells. We’ll gradually transition away from the “one-size-fits-all,” blunt instrument chemothera-peutics of the past toward the sophisticated custom-tailored therapies of the future. PRECISION & TARGETED TREATMENTS Cancer treatments will be tailored to the individual, providing treatment options that are less toxic and more effective. EMMA WATSON, PhD Damon Runyon Fellow, Brigham and Women’s Hospital, BostonWrien by06

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ANALYZING THE EARLY STAGES Understanding how a cell transforms into a cancer cell will help scientists create therapies for disease prevention.Biomedical scientists and physicians are extremely adept at curing cancers through chemical, surgical, or immunological interventions. While this broad and desirable statement applies to certain patients with treatable cancers, it does not apply to enough. Furthermore, rates of cancer incidence and prevalence continue to increase. What is the cause of the disparity between failure in prevention and success at treatment, and how can we address this challenge? While cancer immunotherapy has already heralded the era of treatment-based precision medicine that will dominate the next decade, I predict that the most significant impact of patient-specific medicine will come from a Prevention through Greater Knowledgegreater understanding of the unique path that each patient’s cells take to transform a healthy tissue into a malignant tumor. By systematically character-izing, defining, and testing cell networks within individuals, we will not only understand what precipitates cancer but also identify how we can reset the balance of these cellular ecosystems to inhibit the initiation of cancer. It is with great hope that I consider the possibility that the next decade of precision therapies will not be targeted at cancer treatment, but rather at prevention.JOSE M. ORDOVAS-MONTANES, PhD Damon Runyon Fellow, Massachuses Institute of TechnologyWrien byA look into the future08

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I treat children with brain tumors, a resilient patient population that suffers not only from the direct effects of cancer but also the deleterious effects of the toxic treatments we must give them to try to achieve cures. More children die from brain tumors than from any other type of cancer. This must and will change. We are on the cusp of a scientific revolution. As we begin to unravel the genome, epigenome, and transcriptome of these devastating tumors, we are also removing the academic roadblocks that have stymied research for so long. I am collaborating with a scientific community that understands we must not just stand on our academic laurels but that we must make “significant” and “meaningful” discoveries. In the past, there have been many smart, well-meaning scientists devoted to pediatric neuro-oncology research; however, they were missing a research infrastructure that brought scientists and patients together. They were missing a research platform in which the massive amounts of biological data (petabytes) could be openly shared in real-time. As a scientific community we now have the technology, the perseverance, and the cultural academic shi to find cures. We are no longer conducting research in scientific silos. In the future, children with a devastating brain tumor, no maer where they live, will be able to have their tumor molecularly analyzed, and a treatment tailored to provide them with the best chance possible for a long, healthy, productive life. A look into the futureChanging the Way Science is DoneANGELA J. WAANDERS, MD, MPH Damon Runyon-Dale F. Frey Breakthrough Scientist, Children’s Hospital of PhiladelphiaWrien byCREATING A DATABASE OF KNOWLEDGE With scientists working together across multiple disciplines and sharing research data, patients will see more effective and creative treatments developed at a rate never before seen. 09

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With brilliant scientists working in collaboration, developing new technologies, and seeking even greater understanding of cancer, these visions of the future will become a reality—for us, and certainly for our children.12

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Damon Runyon Cancer Research Foundation Board of DirectorsCHAIR MR. ALAN M. LEVENTHAL Chairman and Chief Executive Officer Beacon Capital Partners, LLC Boston, MassachusettsVICE CHAIR Scientific Programs WILLIAM G. KAELIN, JR., MD Howard Hughes Medical Institute Investigator Professor of Medicine Harvard Medical School Dana-Farber Cancer Institute Boston, MassachusettsVICE CHAIR Investments and Treasurer MR. LEON G. COOPERMAN Chairman and Chief Executive Officer Omega Advisors, Inc. New York, New YorkVICE CHAIR Audit and Secretary SANFORD W. MORHOUSE, ESQ. Of Counsel Schulte Roth & Zabel LLP New York, New YorkVICE CHAIR Board Development MR. MICHAEL L. GORDON Chief Executive Officer Angelo, Gordon & Co. New York, New YorkVICE CHAIR Development and Marketing MR. DAVID M. BEIRNE Chairman Fantex Holdings, Inc. Coral Gables, FloridaSTEVEN J. BURAKOFF, MD Director, The Tisch Cancer Institute Icahn School of Medicine at Mount Sinai Mount Sinai Health System New York, New York MS. DEBORAH J. COLEMAN Legal Counsel Convexity Capital Management LP Boston, MassachusettsMS. ROBYN COLES President TRATE Properties Boston, MassachusettsMR. GARY E. ERLBAUM President Greentree Properties Ardmore, PennsylvaniaTHOMAS J. FAHEY, JR., MD Senior Vice President Emeritus Memorial Sloan Kettering Cancer Center New York, New York MR. BUCK FRENCH Co-Founder and Chief Executive Officer Fantex Holdings, Inc. San Francisco, CaliforniaELAINE V. FUCHS, PhD Rebecca C. Lancefield Professor Howard Hughes Medical Institute Investigator Head, Laboratory of Mammalian Cell Biology and Development The Rockefeller University New York, New YorkRICHARD B. GAYNOR, MD Senior Vice President Global Product Development/ Medical Affairs Oncology Business Unit Eli Lilly and Company Indianapolis, Indiana TODD R. GOLUB, MD Chief Scientific Officer Director, Cancer Program The Broad Institute of MIT and Harvard Charles A. Dana Investigator in Human Cancer Genetics at the Dana-Farber Cancer Institute Professor of Pediatrics at Harvard Medical School Howard Hughes Medical Institute Investigator Cambridge, MassachusettsMR. SCOTT GREENSTEIN President and Chief Content Officer SiriusXM New York, New YorkMR. STEVE HAYDEN Vice Chairman and Chief Creative Officer (Retired) Ogilvy & Mather Worldwide New York, New York MR. JAY W. IRELAND President and Chief Executive Officer GE Africa General Electric Nairobi, Kenya 13

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MORANA JOVAN-EMBIRICOS, PhD Managing Partner F2 Capital Ventures, LLP London, United KingdomMR. STEVEN A. KANDARIAN Chairman, President and Chief Executive Officer MetLife, Inc. New York, New York MR. NOAH KNAUF General Partner Kleiner Perkins Caufield & Byers San Francisco, California GABRIELLE LAYTON, PhD Palo Alto, CaliforniaDAVID M. LIVINGSTON, MD Deputy Director Dana-Farber/Harvard Cancer Center Emil Frei Professor of Genetics and Medicine Harvard Medical School Boston, Massachusetts MR. DAVID G. MARSHALL Chairman and Chief Executive Officer Amerimar Realty Company Philadelphia, Pennsylvania MR. JOHN H. MYERS Senior Advisor Angelo, Gordon & Co. New York, New York RICHARD J. O’REILLY, MD Chief, Pediatric Bone Marrow Transplant Service Claire L. Tow Chair in Pediatric Oncology Research Memorial Sloan Kettering Cancer Center New York, New YorkMR. ANDREW S. RACHLEFF Executive Chairman Wealthfront Faculty, Stanford Graduate School of Business Palo Alto, CaliforniaMR. WILLIAM RAVEIS, JR. Founder, Chairman and CEO William Raveis Real Estate, Mortgage & Insurance Southport, ConnecticutMICHAEL V. SEIDEN, MD, PhD Senior Vice President and Chief Medical Officer McKesson Specialty Health US Oncology Network The Woodlands, Texas MS. KAREN D. SEITZ Founder and Managing Director Fusion Partners New York, New YorkNANCY SIMONIAN, MD Chief Executive Officer Syros Pharmaceuticals Cambridge, MassachusettsMS. CYNTHIA F. SULZBERGER Palm Beach, FloridaMR. PETER VAN CAMP Executive Chairman Equinix, Inc. Redwood City, CaliforniaJAMES A. WELLS, PhD Chair, Department of Pharmaceutical Chemistry Professor, Cellular and Molecular Pharmacology University of California, San Francisco San Francisco, California MS. LORRAINE W. EGAN President and Chief Executive Officer Damon Runyon Cancer Research FoundationSIDNEY ALTMAN, PhD Sterling Professor of Molecular, Cellular and Developmental Biology Professor of Chemistry Yale University, Department of Chemistry New Haven, ConnecticutDAVID BALTIMORE, PhD P r e s i d e n t E m e r i t u s Robert Andrews Millikan P r o f e s s o r o f B i o l o g y C a l i f o r n i a I n s t i t u t e o f T e c h n o l o g y Pasadena, CaliforniaRONALD LEVY, MD Professor of Medicine Division of Oncology Stanford University School of Medicine Stanford, CaliforniaMRS. CONNIE LURIE Atherton, California I. GEORGE MILLER, MD John F. Enders Professor of Pediatrics P r o f e s s o r o f E p i d e m i o l o g y Molecular Biophysics and Biochemistry Yale University School of Medicine New Haven, ConnecticutHENRY C. PITOT, MD, PhD Professor Emeritus of Oncology, Pathology and Laboratory M e d i c i n e McArdle Laboratory for Cancer Research University of Wisconsin- Madison School of Medicine and Public Health Madison, WisconsinMRS. KATHARINE F. PLUM Hobe Sound, Florida SAMUEL C. SILVERSTEIN, MD John C. Dalton Professor a n d C h a i r m a n , D e p a r t m e n t o f Physiology and Cellular B i o p h y s i c s P r o f e s s o r o f M e d i c i n e College of Physicians and Surgeons of Columbia University New York, New YorkCRAIG B. THOMPSON, MD President and Chief Executive Officer Memorial Sloan Kettering Cancer Center New York, New YorkMS. VIRGINIA UEBERROTH Chairman, The Ueberroth Family Foundation Corona del Mar, CaliforniaMR. ROBERT C. WRIGHT Senior Advisor Lee Equity Partners, LLC New York, New York ROBERT C. YOUNG, MD Former Chancellor Fox Chase Cancer Center President RCY Medicine Philadelphia, Pennsylvania EMERITUS BOARD MEMBERS14

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The Damon Runyon Cancer Research Foundation was deeply saddened by the passing of Dale F. Frey, past Chairman of its Board of Directors, one of its greatest champions and a dear friend. Through his vision, passion and relentless dedication to cancer research, Dale had a lasting impact on human life. Under his leadership for over 16 years, the Foundation grew exponentially and funded top young scientists in cancer research whose discoveries have dramatically advanced progress against cancer. In 2010, the Dale F. Frey Award for Breakthrough Scientists was established in his honor to support the most outstanding young cancer researchers in the nation.Remembering Dale F. Frey, 1932-2016ANGELA N. BROOKS, PhD ROBERT K. MCGINTY, MD, PhD MICHAEL J. SMANSKI, PhDANGELA J. WAANDERS, MD, MPH ARUN P. WIITA, MD, PhDSelect Damon Runyon-Dale F. Frey Breakthrough Scientists15

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Damon Runyon-Rachle Innovation AwardSupports the next generation of exceptionally creative thinkers with high-risk, high-reward ideas that have the potential to significantly impact our understanding of and approaches to the prevention, diagnosis or treatment of cancer.TWO-YEAR AWARD: $300,000, with possibility of extension up to an additional $300,000 Damon Runyon Clinical Investigator AwardSupports early career physician-scientists conducting patient-oriented research. The goal of this innovative program is to increase the number of physicians capable of moving seamlessly between the laboratory and the patient’s bedside in search of breakthrough treatments.THREE-YEAR AWARD: $450,000 plus up to $100,000 for medical school loan repaymentDamon Runyon Clinical Investigator Continuation GrantSupports Damon Runyon Clinical Investigators who are approaching the end of their original three-year awards and need extra time and funding to complete a promising avenue of research or initiate/continue a clinical trial.TWO-YEAR AWARD: $300,000Damon Runyon Fellowship AwardSupports the training of the brightest postdoctoral scientists as they embark upon their research careers. This funding enables them to be mentored by established investigators in leading research laboratories across the country.FOUR-YEAR AWARD: $231,000Damon Runyon-Sohn Pediatric Cancer Fellowship AwardSupports dedicated basic scientists and clinicians who conduct research with the potential to significantly impact the prevention, diagnosis or treatment of one or more pediatric cancers.FOUR-YEAR AWARD: $231,000Damon Runyon-Dale F. Frey Award for Breakthrough Scientists Supports a select few Damon Runyon Fellows who have greatly exceeded the Foundation’s highest expectations. This additional investment in these exceptional individuals will help catapult their research careers and their impact on cancer.TWO-YEAR AWARD: $100,000Damon Runyon Physician-Scientist Training AwardSupports and encourages outstanding recent medical school graduates to pursue cancer research careers by providing them with the opportunity for a protected research training experience under the mentorship of a highly qualified and gifted mentor. FOUR-YEAR AWARD: $460,000 plus up to $100,000 for medical school loan repaymentDamon Runyon Award Programs*Increased award amount effective July 1, 2016Damon Runyon Physician-Scientist MICHAEL DRAZER, MDDamon Runyon Fellow KYLE G. DANIELS, PhD16

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CHAIRKENNETH W. KINZLER, PhD Professor of Oncology Director, Ludwig Center for Cancer Genetics and Therapeutics Johns Hopkins University Kimmel Cancer Center Baltimore, MarylandDAFNA BAR-SAGI, PhD Senior Vice President Vice Dean for Science Chief Scientific Officer NYU Langone Medical Center New York, New YorkMICHAEL A. CALIGIURI, MD Director, Comprehensive Cancer Center CEO, James Cancer Hospital and Solove Research Institute JL Marakas Nationwide Insurance Enterprise Foundation Professor of Cancer Research Professor, Departments of Internal Medicine and Molecular Virology, Immunology, and Medical Genetics Columbus, OhioABBY F. DERNBURG, PhD Howard Hughes Medical Institute Investigator Professor of Cell and Developmental Biology University of California, Berkeley Lawrence Berkeley National Lab Berkeley, CaliforniaSANJIV SAM GAMBHIR, MD, PhD Director, Molecular Imaging Program Head, Nuclear Medicine Division Professor of Radiology, Bioengineering and Engineering Materials Science Stanford University School of Medicine Stanford, CaliforniaTODD R. GOLUB, MD Chief Scientific Officer Director, Cancer Program The Broad Institute of Harvard and MIT Charles A. Dana Investigator in Human Cancer Genetics at the Dana-Farber Cancer Institute Professor of Pediatrics at Harvard Medical School Howard Hughes Medical Institute Investigator Cambridge, MassachusettsTARUN M. KAPOOR, PhD Pels Family Professor Head, Laboratory of Chemistry and Cell Biology The Rockefeller University New York, New YorkDAVID G. KIRSCH, MD, PhD Professor of Radiation Oncology Professor of Pharmacology and Cancer Biology Duke University Medical Center Durham, North CarolinaRICHARD L. KLEMKE, PhD Professor, Department of Pathology University of California, San Diego Moores Cancer Center La Jolla, CaliforniaLEWIS L. LANIER, PhD American Cancer Society Research Professor Chair, Department of Microbiology and Immunology J. Michael Bishop, MD, Distinguished Professor University of California, San Francisco Leader, Cancer, Immunity and Microenvironment Program UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, CaliforniaSTEVEN M. LARSON, MD Member and Lab Head Molecular Pharmacology and Chemistry Program Sloan Kettering Cancer Center Donna and Benjamin M. Rosen Chair in Radiology Memorial Sloan Kettering Cancer Center New York, New YorkRONALD LEVY, MD Professor of Medicine Division of Oncology Stanford University School of Medicine Stanford, CaliforniaJOSHUA T. MENDELL, MD, PhD Howard Hughes Medical Institute Investigator Professor, Department of Molecular Biology University of Texas Southwestern Medical Center Dallas, Texas STEPHEN R. QUAKE, DPhil Howard Hughes Medical Institute Investigator Lee Otterson Professor of Bioengineering and Applied Physics Department of Bioengineering Stanford University Stanford, CaliforniaDamon Runyon-Rachle Innovation Award CommitteeDamon Runyon-Rachleff Innovator ROBERTO ZONCU, PhDDamon Runyon-Rachleff Innovator CHRISTIN E. BURD, PhD17

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CALIFORNIASCOTT J. DIXON, PhD* “Exploring the role of a toxic endogenous glycolytic metabolite in tumor suppression and chemotherapy action” at Stanford University, StanfordNICHOLAS T. INGOLIA, PhD “Cis-regulatory code for the translational control of gene expression” at the University of California, BerkeleyGUILLEM PRATX, PhD “Adding a new dimension to flow cytometry: radionuclide-activated cell sorting” at Stanford University School of Medicine, StanfordPETER J. TURNBAUGH, PhD*, Nadia’s Gift Foundation Innovator “The gut microbiome: an unexpected contributor to cancer drug resistance” at the University of California, San FranciscoELÇIN ÜNAL, PhD “Reducing cancer susceptibility by attenuating cellular aging” at the University of California, BerkeleyROBERTO ZONCU, PhD* “Dissecting and disabling the glucose-mTORC1 signaling axis in cancer growth” at the University of California, BerkeleyCONNECTICUTJASON M. CRAWFORD, PhD* “Elucidating the bacterial determinants of colorectal cancer” at Yale University, New HavenMARYLANDCHRISTOPHER M. JEWELL, PhD “Harnessing intra-lymph node controlled release to study and enhance tumor immunity” at the University of Maryland, College ParkMASSACHUSETTSEMILY P. BALSKUS, PhD “Understanding and preventing carcinogenesis caused by the human microbiota” at Harvard University, CambridgeNEW YORKPIERO D. DALERBA, MD* Island Outreach Foundation Innovator “Using single-cell genomics to resolve the molecular identity of cancer stem cells and guide their pharmacological eradication” at Columbia University, New YorkARVIN C. DAR, PhD “Targeting allosteric control in the Ras-MAPK pathway for cancer therapy” at the Icahn School of Medicine at Mount Sinai, New YorkMORITZ F. KIRCHER, MD, PhD “Raman-MRI nanobeacons: towards a universal cancer theranostic agent” at Memorial Sloan Kettering Cancer Center, New YorkEIRINI P. PAPAPETROU, MD, PhD Edward P. Evans Foundation Innovator “Dissecting chromosome hemizygosity with human pluripotent stem cells” at the Icahn School of Medicine at Mount Sinai, New YorkOHIOCHRISTIN E. BURD, PhD* “Exploiting mutational specificity to target RAS-driven melanoma” at The Ohio State University, ColumbusOREGONSUMMER L. GIBBS, PhD and XIAOLIN NAN, PhD “Studying spatial regulation of HER2 tumorigenesis with multispectral super resolution microscopy (MSSRM)” at Oregon Health and Science University, PortlandTEXASNING JENNY JIANG, PhD “A single cell integrated system to dissecting cancer immunoediting in humans” at The University of Texas, AustinWASHINGTONBRIAN H. SHIRTS, MD, PhD “Participatory genetics for defining genotype-phenotype associations of rare cancer variants” at the University of Washington, SeattleWISCONSINPHILIP A. ROMERO, PhD* “Digital circulating tumor cell detection using scalable molecular logic” at the University of Wisconsin, Madison*Initial YearDamon Runyon-Rachle Innovation AwardsDamon Runyon-Rachleff Innovator NING JENNY JIANG, PhDDamon Runyon-Rachleff Innovator PHILIP A. ROMERO, PhD18

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CHAIRWILLIAM G. KAELIN, JR., MD Howard Hughes Medical Institute Investigator Professor of Medicine Harvard Medical School Dana-Farber Cancer Institute Boston, MassachusettsCHAIR ELECTCHARLES L. SAWYERS, MD Chair, Human Oncology and Pathogenesis Program The Marie-Josée and Henry R. Kravis Chair Howard Hughes Medical Institute Investigator Memorial Sloan Kettering Cancer Center New York, New YorkKARLA V. BALLMAN, PhD Chief of the Division of Biostatistics and Epidemiology Department of Healthcare Policy and Research Weill Cornell Medicine New York, New YorkDAVID P. CARBONE, MD, PhD Professor, Division of Medical Oncology Director, Thoracic Oncology Center Comprehensive Cancer Center The Ohio State University Columbus, OhioDENNIS A. CARSON, MD Professor Emeritus Department of Medicine Moores Cancer Center University of California, San Diego La Jolla, CaliforniaBRUCE A. CHABNER, MD Professor of Medicine Harvard Medical School Director of Clinical Research Massachusetts General Hospital Cancer Center Boston, MassachusettsNANCY E. DAVIDSON, MD Director, University of Pittsburgh Cancer Institute UPMC Cancer Centers Associate Vice Chancellor for Cancer Research Professor of Medicine Division of Hematology/ Oncology University of Pittsburgh School of Medicine Pittsburgh, PennsylvaniaS. GAIL ECKHARDT, MD Professor and Head of the Division of Medicine Oncology Stapp/Harlow Endowed Chair in Cancer Research University of Colorado Denver and Health Sciences Center Senior Associate Director of Translational and Collaborative Research University of Colorado Cancer Center Aurora, ColoradoHOWARD A. FINE, MD Director, Weill Cornell Brain Tumor Center Associate Director of Translational Research Meyer Cancer Center Weill Cornell Medicine New York, New YorkPATRICIA A. GANZ, MD Professor, Schools of Medicine and Public Health Director, Division of Cancer Prevention and Control Research Jonsson Comprehensive Cancer Center University of California, Los Angeles Los Angeles, CaliforniaAMATO J. GIACCIA, PhD Jack, Lulu and Sam Willson Professor in Cancer Biology Director, Division of Radiation and Cancer Biology Department of Radiation Oncology Stanford University School of Medicine Stanford, CaliforniaCARL H. JUNE, MD Richard W. Vague Professor in Immunotherapy Department of Pathology and Laboratory Medicine Director Center for Cellular Immunotherapies Director Translational Research Program Abramson Cancer Center Perelman School of Medicine University of Pennsylvania Philadelphia, PennsylvaniaANDREW L. KUNG, MD, PhD Chair and Professor Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New YorkDREW M. PARDOLL, MD, PhD Director, Cancer Immunology Program Sidney Kimmel Comprehensive Cancer Center Abeloff Professorship in Oncology Johns Hopkins University School of Medicine Baltimore, MarylandDAVID R. PIWNICA-WORMS, MD, PhD Professor and Chair, Department of Cancer Systems Imaging Deputy Division Head, Research Affairs, Division of Diagnostic Imaging The University of Texas M.D. Anderson Cancer Center Houston, TexasKORNELIA POLYAK, MD, PhD Professor of Medicine Department of Medical Oncology Dana-Farber Cancer Institute Harvard Medical School Boston, MassachusettsNORMAN E. SHARPLESS, MD Director, Lineberger Comprehensive Cancer Center Wellcome Distinguished Professor of Cancer Research Departments of Medicine and Genetics University of North Carolina School of Medicine Chapel Hill, North CarolinaDamon Runyon Clinical Investigator Award Committee19

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CALIFORNIAARASH ASH ALIZADEH, MD, PhD “Targeting the malignant reprogramming of early hematopoietic progenitors to mature aggressive human B-cell lymphomas” with Ronald Levy, MD, Stanford University School of Medicine, StanfordAMI S. BHATT, MD, PhD* “Applying microbiome-based therapeutics in cancer patients” with Linda Boxer, MD, PhD, and Michael Snyder, PhD, Stanford University School of Medicine, StanfordL. ELIZABETH BUDDE, MD, PhD Damon Runyon-Jake Wetchler Foundation for Innovative Pediatric Cancer Research Clinical Investigator “Targeting CD123 using chimeric antigen receptor T cells for treatment of acute myeloid leukemia” with Stephen J. Forman, MD, FACP, City of Hope, DuarteFLORIDAMARCO L. DAVILA, MD, PhD “The development and clinical translation of an armored CAR T cell therapy for immune-resistant B cell malignancies" with Michel Sadelain, MD, PhD, Memorial Sloan Kettering Cancer Center, New York, and Claudio Anasetti, MD, Moffitt Cancer Center, Tampa ILLINOISJAEHYUK CHOI, MD, PhD* Doris Duke-Damon Runyon Clinical Investigator “Identification of genetic basis of altered T cell receptor signaling in cutaneous T cell lymphoma” with Stephen D. Miller, PhD, and John D. Crispino, PhD, Northwestern University, ChicagoMASSACHUSETTSPRISCILLA K. BRASTIANOS, MD “Investigation of novel targeted therapeutic approaches for brain metastases” with Keith T. Flaherty, MD, and Tracy T. Batchelor, MD, Massachusetts General Hospital, BostonALEJANDRO GUTIERREZ, MD “Mechanisms and therapeutic targeting of EZH2-dependent chemoresistance in T-ALL” with Stuart H. Orkin, MD, and Anthony G. Letai, MD, PhD, Boston Children’s Hospital, BostonPETER S. HAMMERMAN, MD, PhD “Development of personalized cancer immunotherapy” with Kwok-Kin Wong, MD, PhD, F. Stephen Hodi, Jr., MD, and Glenn Dranoff, MD, Dana-Farber Cancer Institute, BostonGEOFFREY R. OXNARD, MD* Gordon Family Clinical Investigator “Noninvasive genotyping of cell free plasma DNA (cfDNA) as a tool for guiding personalized lung cancer care” with Pasi A. Janne, MD, PhD, Dana-Farber Cancer Institute, BostonELIEZER M. VAN ALLEN, MD* “Dissecting response to conventional and emerging DNA damage and repair therapies” with Levi A. Garraway, MD, PhD, and Philip Kantoff, MD, Dana-Farber Cancer Institute, BostonMISSOURIVIVEK K. ARORA, MD, PhD* “Defining a targetable oncogenic dyad in bladder cancer” with Lee Ratner, MD, PhD, Washington University, St. LouisSTEPHEN T. OH, MD, PhD Doris Duke-Damon Runyon Clinical Investigator “Targeting aberrant signaling pathways in myeloproliferative neoplasms” with Daniel C. Link, MD, Washington University, St. LouisNEW YORKCHRISTOPHER E. BARBIERI, MD, PhD* MetLife Foundation Clinical Investigator “Presurgical trials to target distinct subclasses of localized prostate cancer” with Mark A. Rubin, MD, Weill Cornell Medicine, New YorkJOSHUA BRODY, MD “Flt3L-primed ‘in situ’ vaccination for low-grade lymphoma-Phase I/II study of intratumoral injection of rhuFlt3L and poly-ICLC with low-dose radiotherapy [NCT01976585]” with Nina Bhardwaj, MD, PhD, and Miriam Merad, MD, PhD, Mount Sinai Hospital, New YorkDamon Runyon Clinical Investigator AwardsSANDRA L. WONG, MD, MS Chair, Department of Surgery Senior Vice President of the Surgical Services Line Dartmouth-Hitchcock Medical Center The Greisel School of Medicine at Dartmouth Lebanon, New HampshireFounding Member RICHARD J. O’REILLY, MD Chief, Pediatric Bone Marrow Transplant Service; Claire L. Tow Chair in Pediatric Oncology Research Memorial Sloan Kettering Cancer Center New York, New YorkDamon Runyon Clinical Investigator Award Committee (Continued)20

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Damon Runyon Clinical Investigator Awards (Continued)Damon Runyon Clinical Investigator Award Continuation GrantsALEX KENTSIS, MD, PhD* Richard Lumsden Foundation Clinical Investigator “Mechanism and function of regulatory signaling in acute myeloid leukemia” with Scott A. Armstrong, MD, PhD, Dana-Farber Cancer Institute, Boston, and Ross Levine, MD, Memorial Sloan Kettering Cancer Center, New York LUC G. MORRIS, MD “Functionalizing tumor suppressor gene mutations and deletions in head and neck cancer” with Timothy A. Chan, MD, PhD, and James A. Fagin, MD, Memorial Sloan Kettering Cancer Center, New YorkHEATHER L. YEO, MD* “Use of mobile applications to evaluate post surgical recovery in aging patients with GI cancer” Manish A. Shah, MD, and Deborah Estrin, PhD, MS, Weill Cornell Medicine, New YorkWASHINGTONAUDE G. CHAPUIS, MD “To specify the requirements of CD8+ and CD4+ T cells for successful adoptive transfer in solid tumors” with Philip D. Greenberg, MD, Fred Hutchinson Cancer Research Center, Seattle*Initial YearMASSACHUSETTSRYAN B. CORCORAN, MD, PhD “Defining novel targeted therapy combination strategies for BRAF V600 mutant colorectal cancer” with Jeffrey A. Engelman, MD, PhD, and Keith T. Flaherty, MD, Massachusetts General Hospital, CharlestownANN MULLALLY, MD* “Peptide vaccination to target mutant calreticulin in myeloproliferative neoplasms” with Benjamin L. Ebert, MD, and Jerome Ritz, MD, Brigham and Women’s Hospital, BostonNORTH CAROLINAOREN J. BECHER, MD “Regional differences in central nervous system gliomagenesis” with Darell D. Bigner, MD, PhD, Katherine E. Warren, MD, and Michael B. Kastan, MD, Duke University, DurhamNEW YORKSARAT CHANDARLAPATY, MD, PhD Patterson Trust Clinical Investigator “Therapeutic approaches to PI3K-AKT-mTOR feedback pathways in breast cancer” Neal Rosen, MD, PhD, and Clifford A. Hudis, MD, Memorial Sloan Kettering Cancer Center, New YorkTENNESSEECHRISTINE M. LOVLY, MD, PhD* “Developing novel therapeutic strategies for ALK-fusion positive lung cancer” with David P. Carbone, MD, PhD, The Ohio State University, Columbus, and Pierre P. Massion, MD, Vanderbilt University, NashvilleTEXASDEEPAK NIJHAWAN, MD, PhD* “Developing the anti-tumor toxin CD437 into a new cancer therapy” with Steve L. McKnight, PhD, and David Johnson, MD, University of Texas Southwestern Medical Center, Dallas*Initial YearSARAT CHANDARLAPATY, MD, PhD CHRISTINE M. LOVLY, MD, PhDHEATHER YEO, MDSelect Damon Runyon Clinical Investigators21

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Damon Runyon Fellowship Award CommitteeCHAIRSUSAN L. ACKERMAN, PhD Howard Hughes Medical Institute Investigator Steven W. Kuffler Chair of Biology Professor Neurobiology Section and Cell and Molecular Medicine University of California San Diego Medical School La Jolla, California VICE CHAIRPHILIPPE M. SORIANO, PhD Professor of Developmental and Regenerative Biology Professor of Oncological Sciences Mount Sinai School of Medicine New York, New YorkGREG BARTON, PhD Professor of Immunology and Pathogenesis Class of 1936 Chair, Department of Molecular and Cell Biology University of California, Berkeley Berkeley, CaliforniaSHARON Y.R. DENT, PhD Professor and J. Ralph Meadows Chair Department of Molecular Carcinogenesis Director, Science Park Director, Center for Cancer Epigenetics The University of Texas MD Anderson Cancer Center Smithville, TexasADOLFO A. FERRANDO, MD, PhD Associate Professor of Pediatrics and Pathology Director, WOLF Foundation Leukemia/Lymphoma Laboratory Institute for Cancer Genetics Columbia University Medical Center New York, New YorkJENNIFER GERTON, PhD Investigator Associate Professor, Department of Biochemistry and Molecular Biology The University of Kansas School of Medicine Stowers Institute for Medical Research Kansas City, Missouri ANTONIO J. GIRALDEZ, PhD Investigator Professor of Genetics Director of Graduate Studies Yale University School of Medicine New Haven, ConnecticutLUCY A. GODLEY, MD, PhD Professor, Department of Medicine Section of Hematology and Oncology Cancer Research Center The University of Chicago Medicine Chicago, IllinoisRACHEL GREEN, PhD Howard Hughes Medical Institute Investigator Professor of Molecular Biology and Genetics Johns Hopkins University School of Medicine Baltimore, MarylandRICHARD GREGORY, PhD Professor, Department of Biological Chemistry and Molecular Pharmacology, and Department of Pediatrics Harvard Medical School Harvard Stem Cell Institute The Stem Cell Program at Boston Children’s Hospital Boston, MassachusettsSUSAN KAECH, PhD Associate Professor Department of Immunobiology Yale University School of Medicine New Haven, ConnecticutALEX L. KOLODKIN, PhD Howard Hughes Medical Institute Investigator Professor The Solomon H. Snyder Department of Neuroscience Johns Hopkins University School of Medicine Baltimore, MarylandCHRISTINA LESLIE, PhD Associate Member and Laboratory Head Computational Biology Program Memorial Sloan Kettering Cancer Center New York, New York ERIK A. LUNDQUIST, PhD Professor, Department of Molecular Biosciences University of Kansas Lawrence, KansasLYNNE E. MAQUAT, PhD J. Lowell Orbison Endowed Chair and Professor Department of Biochemistry and Biophysics School of Medicine and Dentistry Director, University of Rochester Center for RNA Biology Chair, University of Rochester Graduate Women in Science University of Rochester Rochester, New YorkTOBIAS MEYER, PhD Chair, Department of Chemical and Systems Biology Mrs. George A. Winzer Professor in Cell Biology Stanford University School of Medicine Stanford, CaliforniaPHILIP A. NEWMARK, PhD Howard Hughes Medical Institute Investigator Professor of Cell and Developmental Biology University of Illinois Urbana, IllinoisELAINE A. OSTRANDER, PhD * Chief and NIH Distinguished Investigator Cancer Genetics and Comparative Genomics Branch Head, Comparative Genetics Section National Human Genome Research Institute Bethesda, Maryland *Dr. Ostrander is serving in her personal capacity.JOEL ROTHMAN, PhD Professor and Wilcox Family Chair in Biotechnology University of California, Santa Barbara Santa Barbara, CaliforniaDAVID RUGGERO, PhD Professor Helen Diller Family Endowed Chair in Basic Research University of California San Francisco School of Medicine Member, UCSF Comprehensive Cancer Center San Francisco, California 22

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Damon Runyon Fellowship Award Committee (Continued)Damon Runyon Fellowship AwardsCALIFORNIA Gladstone InstitutesCASEY A. GIFFORD, PhD HHMI Fellow “Dissecting the role of pioneer transcription factors in cancer progression” with Deepak Srivastava, MDSalk InstituteCORINA E. ANTAL, PhD* “Stromal reprogramming as a therapeutic approach in pancreatic cancer” with Ronald M. Evans, PhDJEANINE L. VAN NOSTRAND, PhD “Elucidating the AMPK-dependent regulation of mTOR signaling in the metabolic checkpoint of tumorigenesis” with Reuben J. Shaw, PhDScripps Research InstituteLIRON BAR-PELED, PhD Lallage Feazel Wall Fellow “Identification of cysteine liabilities in NRF2-driven cancers” with Benjamin F. Cravatt, PhDEVGENIA N. NIKOLOVA, PhD Robert Black Fellow “Recognition of methylated and specific DNA sequences by the zinc finger transcriptional repressor Kaiso and modulation by other nuclear factors” with Peter E. Wright, PhD JOSEPH D. SCHONHOFT, PhD Merck Fellow “Probing the relation between sequence, aggregation and proteotoxicity in cardiac amyloidoses caused by free antibody light chains” with Jeffery W. Kelly, PhDStanford UniversityCHRISTOPHER J. CAMBIER, PhD* HHMI Fellow “In vivo characterization of mycobacterial cording” with Carolyn R. Bertozzi, PhDStanford University School of MedicineANUPAM K. CHAKRAVARTY, PhD HHMI Fellow “Investigating the phenomenon of epigenetic inheritance mediated by non-amyloid protein aggregates” with Daniel F. Jarosz, PhDKEREN I. HILGENDORF, PhD Layton Family Fellow “Role of ciliary IGF-1/AKT signaling in ciliogenesis, adipogenesis, and tissue regeneration” with Peter K. Jackson, PhDKATHRIN LEPPEK, PhD Layton Family Fellow “Mechanistic characterization of 5’UTR RNA elements that confer translational specificity to shape vertebrate embryonic development” with Maria Barna, PhD YIN LIU, PhD Layton Family Fellow “Sensing lung tumors by pulmonary sensory neurons” with Mark A. Krasnow, MD, PhDANDREW R. NAGER, PhD Fayez Sarofim Fellow “Dissecting the mechanism of selective diffusion into the primary cilium” with Maxence V. Nachury, PhDROHITH K. SRIVAS, PhD “Longitudinal profiling of host-microbiome interactions in obese patients during drastic weight loss” with Michael P. Snyder, PhDALBERT G. TSAI, MD, PhD*† “Diagnosis of hematologic malignancies from paucicellular aspirate material using highly multiplexed single cell analysis” with Sean C. Bendall, PhDUniversity of California, BerkeleyJUSTIN M. CREST, PhD “Cells, ECM, and the mechanical forces that regulate organ shape” with David Bilder, PhDFUGUO JIANG, PhD Merck Fellow “Molecular mechanisms of guide RNA: target dsDNA binding and PAM recognition by CRISPR/Cas9” with Jennifer A. Doudna, PhD JULIEN SAGE, PhD Professor, Department of Pediatrics (Hematology/ Oncology) and Genetics Stanford University School of Medicine Stanford, California SOHAIL TAVAZOIE, MD, PhD Leon Hess Assistant Professor Head, Elizabeth and Vincent Meyer Laboratory of Systems Cancer Biology The Rockefeller University New York, New York MATTHEW G. VANDER HEIDEN, MD, PhD Eisen and Chang Career Development Professor Associate Professor of Biology Koch Institute for Integrative Cancer Research at MIT Cambridge, Massachusetts AMY WAGERS, PhD Professor of Stem Cell and Regenerative Biology Harvard University Cambridge, Massachusetts HONGTAO YU, PhD Howard Hughes Medical Institute Investigator Professor, Department of Pharmacology The University of Texas Southwestern Medical Center Dallas, Texas23

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STEVEN LIN, PhD HHMI Fellow “Biochemical characterizations and optimization of CRISPR/Cas9 for genome engineering” with Jennifer A. Doudna, PhD MANDY M. MULLER, PhD HHMI Fellow “Widespread RNA destruction and selective preservation during viral infection” with Britt Glaunsinger, PhDNEEL H. SHAH, PhD “Interrogating ZAP-70 substrate recognition using high-throughput mutant screening” with John Kuriyan, PhDNIRANJAN SRINIVAS, PhD* “Mutual repression, bistability, and switch-like decisions during development” with Hernan G.Garcia, PhD, and Adam P. Arkin, PhDDAVID W. TAYLOR, PhD “Structures of the RNA-targeting CRISPR-Cas complex Cmr” with Eva Nogales, PhDUniversity of California, Los AngelesMAGDALENA E. POTOK, PhD HHMI Fellow “The relationship between epigenetic gene silencing, nuclear architecture, and genome stability” with Steven E. Jacobsen, PhDMICHAEL A. CIANFROCCO, PhD HHMI Fellow “How does dynein achieve processivity?” with Andres Leschziner, PhD, and Samara L. Reck-Peterson, PhDERIC L. VAN NOSTRAND, PhD Merck Fellow “Improved RNA binding protein target identification by eCLIP-seq and integrative analysis of RNA regulatory networks across neuronal differentiation and medulloblastoma” with Eugene Yeo, PhD University of California, San FranciscoBRITTANY ADAMSON, PhD HHMI Fellow “Comprehensive characterization of the integrated networks that regulate protein homeostasis within the mammalian endoplasmic reticulum” with Jonathan S. Weissman, PhDTRACY T. CHOW, PhD “Investigating and engineering non-canonical telomere maintenance mechanisms in human cells” with Elizabeth H. Blackburn, PhDKYLE G. DANIELS, PhD* “Controlling T cell signaling and fate choice using synthetic receptors” with Wendell A. Lim, PhDALBA DIZ MUÑOZ, PhD “How neutrophils convert changes in membrane tension to changes in intracellular signaling during chemotaxis” with Orion D. Weiner, PhD, and Daniel A. Fletcher, PhDMARY W. ELTING, PhD “Probing how kinetochore-fibers anchor to spindles to robustly and accurately segregate chromosomes” with Sophie Dumont, PhDQI HU, PhD “Design of inhibitors of cancer-associated mutant GNAS” with Kevan M. Shokat, PhDJEFFREY A. HUSSMANN, PhD* Rebecca Ridley Kry Fellow “Genome-wide measurement of ribosome spacing on individual transcripts” with Carol A. Gross, PhDANKUR JAIN, PhD “Formation and function of mRNA processing bodies” with Ronald D. Vale, PhDBRIAN J. LAIDLAW*, PhD “Role of EBI2 in the regulation of lymphocyte migration during viral infection and cancer” with Jason G. Cyster, PhDJESSICA P. LAO, PhD “Identifying metabolic targets of the DNA damage checkpoint” with David P. Toczyski, PhDWENYU LUO, PhD “A Drosophila model to study resilience to social stress and depression-like behavior” with Yuh-Nung Jan, PhDGABRIELA C. MONSALVE, PhD Robert Black Fellow “Identification and characterization of plasma membrane transporters for glucocorticoids” with Keith R. Yamamoto, PhDLYNDSAY M. MURROW, PhD “Fate specification of mammary stem cells by cell self-sorting” with Zev J. Gartner, PhDDUY P. NGUYEN, PhD Connie and Bob Lurie Fellow “Genome editing via an engineered RNA-guided nuclease to create cancer genetic models” with James A. Wells, PhDTHOMAS M. NORMAN, PhD “Identifying the stochastic determinants of drug resistance” with Jonathan S. Weissman, PhDBEVERLY J. PIGGOTT, PhD Lefkofsky Family Fellow “Brain tumor suppression by mutation(s) of the voltage-gated sodium channel Para” with Yuh-Nung Jan, PhDALEX POLLEN, PhD “Regulation of proliferation, migration and angiogenesis by genes uniquely expressed in human neural stem cells” with Arnold R. Kriegstein, MD, PhDERIN F. SIMONDS, PhD “Single-cell analysis and targeting of signaling networks in glioblastoma tumor-initiating cells” with William A. Weiss, MD, PhDJAKOB VON MOLTKE, PhD HHMI Fellow “Innate type II cells and wound healing” with Richard Locksley, MDVICTORIA E. WANG, MD PhD† “The role of the c-Met/Hepatocyte growth factor (HGF) pathway in drug resistance and tumor metastasis” with Frank McCormick, PhD24

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Damon Runyon Fellowship Awards (Continued)ANDREW L. WOLFE, PhD “The therapeutic potential and biological effects of targeting oncogenic KRAS” with Frank McCormick, PhDJIAXI WU, PhD* “Mechanism of dendritic cell missing-self recognition and migration to activate CD4 T cell responses” with Jason Cyster, PhDCOLORADOUniversity of Colorado, BoulderJENS C. SCHMIDT, PhD Merck Fellow “Single-molecule analysis of telomerase recruitment to telomeres” with Thomas R. Cech, PhDCONNECTICUTYale School of MedicineZHUOBIN LIANG, PhD* “Mechanistic dissection of the Fanconi anemia pathway in coordinating R-loop processing and DNA repair” with Patrick Sung, DPhil, and Gary M. Kupfer, MDSEYED FAKHREDDIN TORABI, PhD* “Evolution of triplex-forming RNAs from random sequences: a search for additional MALAT1-like triplex motifs” with Joan A. Steitz, PhDILLINOISThe University of ChicagoJOHN D. LEONARD, PhD* “Self-antigen recognition by regulatory T cells” with Erin J. Adams, PhD, and Peter A. Savage, PhDSIGRID NACHTERGAELE, PhD HHMI Fellow “The dynamic N1-methyladenosine methylome in eukaryotic mRNA” with Chuan He, PhD University of IllinoisSARAH Z. TASKER, PhD* HHMI Fellow “Synthesis and evaluation of a collection of complex molecules biased for penetration of the blood-brain barrier” with Paul J. Hergenrother, PhDMARYLANDJohn Hopkins University, BaltimoreDANIEL H. GOLDMAN, PhD * Merck Fellow “Elucidating the role of the exon junction complex in regulating translation of spliced mRNA” with Rachel Green, PhDCHIH-YUNG LEE, PhD HHMI Fellow “Regulation of primordial germ cell fate in Caenorhabditis elegans” with Geraldine Seydoux, PhDVU QUANG NGUYEN, PhD “Role of chromatin organization in dynamics of transcription initiation” with Carl Wu, PhDHANJING PENG, PhD “Targeting the proteasome using a hybrid, combinatorial rapafucin library” with Jun O. Liu, PhDBORIS ZINSHTEYN, PhD* HHMI Fellow “Mechanisms of splicing-independent nonsense-mediated mRNA decay” with Rachel Green, PhDNational Institutes of HealthDANFENG CAI, PhD “Protein crowding and protein folding landscapes as predictors of healthy and diseased cell states” with Jennifer Lippincott-Schwartz, PhDDANIEL E. WEBSTER, PhD Philip O’B Montgomery, Jr., MD, Fellow “Identification and analysis of LncRNAs regulating diffuse large B cell lymphoma” with Louis M. Staudt, MD, PhD MASSACHUSETTSBoston Children’s HospitalMEGAN L. INSCO, MD, PhD*† “Investigating transcriptional cyclin dependent kinases as novel melanoma drug targets” with Leonard I. Zon, MD Brigham and Women’s HospitalEMMA WATSON, PhD* Suzanne and Bob Wright Fellow “Metabolic stress response: Exploring transcript-level regulation of metabolic feedback” with Stephen Elledge, PhDTIMOTHY D. MARTIN, PhD Marion Abbe Fellow “Investigating the role of aneuploidy and haploinsufficiency in driving tumorigenesis” with Stephen J. Elledge, PhDDana-Farber Cancer InstituteDENNIS L. BUCKLEY, PhD Merck Fellow “Development of selective brodomain inhibitors from dual brodomain-kinase inhibitors for the treatment of neuroblastoma” with James E. Bradner, MDSERKAN KIR, PhD Robert Black Fellow “Identification of factors that induce brown fat activity in cancer cachexia” with Bruce M. Spiegelman, PhDNEIL T. UMBREIT, PhD HHMI Fellow “Elucidating the mechanism of chromosome bridge resolution” with David S. Pellman, MDERIC S. WANG, PhD* “Enhancing anti-tumor immunity via pharmacological inhibition of kinases” with Nathanael S. Gray, PhD 25

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Harvard T.H. Chan School of Public HealthCAITLIN A. BRENNAN, PhD Dennis and Marsha Dammerman Fellow “Mechanisms underlying Fusobacterium nucleatum-driven colorectal cancer” with Wendy S. Garrett, MD, PhDHarvard Medical SchoolRYAN D. BALDRIDGE, PhD Fraternal Order of Eagles Fellow “Investigating the mechanism of retro-translocation by ERAD” with Tom A. Rapoport, PhDJUSTIN A. BOSCH, PhD* “Elucidating the biological functions of polypeptide transfer between animal cells” with Norbert Perrimon, PhDIVANA GASIC, DrSc* Merck Fellow “Molecular elucidation of the interphase microtubule integrity response (MIR)” with Timothy J. Mitchison, PhDNATASHA M. O’BROWN, PhD* “Molecular and cellular mechanisms of transcytosis regulation in blood-brain barrier function” with Chenghua Gu, PhDNIKHIL SHARMA, PhD* “Neural control of breathing” with Stephen Liberles, PhDJUSTIN L. SPARKS, PhD “Replicative helicase bypass of bulky DNA adducts?” with Johannes C. Walter, PhDBENJAMIN M. STINSON, PhD* “Mechanism of DNA processing during non-homologous end joining” with Johannes C. Walter, PhD, and Joseph L. Loparo, PhDHUME A. STROUD, PhD HHMI Fellow “Understanding the mechanism and roles of changes in chromatin composition in the brain” with Michael E. Greenberg, PhDTONY Y. TSAI, MD, PhD Kenneth G. and Elaine A. Langone Fellow “Cell sorting in zebrafish neural tube development” with Sean G. Megason, PhDTHOMAS S. VIERBUCHEN, PhD HHMI Fellow “Understanding the developmental programming and function of the enhancers that control activity-regulated transcription in the mammalian cortex” with Michael E. Greenberg, PhDHarvard UniversityPHILIP B. ABITUA, PhD* “Functional characterization of signaling molecules during zebrafish embryogenesis” with Alexander F. Schier, PhDBRIAN J. BELIVEAU, PhD* HHMI Fellow "Decoding Polycomb-mediated gene regulation in single cells with single-molecule super resolution imaging and synthetic biology" with Peng Yin, PhDAVINASH KHANNA, PhD Rebecca Ridley Kry Fellow “Disrupting the protein-protein interactions of CDK8 to target cancer” with Matthew D. Shair, PhDSUMMER B. THYME, PhD HHMI Fellow “Chromatin modifications and pioneer transcription factors in development” with Alexander F. Schier, PhDERIC M. WOERLY, PhD Suzanne and Bob Wright Fellow “Accessing new cancer therapeutics via an intermolecular fluorofunctionalization reaction” with Eric N. Jacobsen, PhDSUNGWOOK WOO, PhD HHMI Fellow “Crystal-free crystallography using programmable 3D DNA crystal frameworks” with Peng Yin, PhDMassachusetts General HospitalKAI MAO, PhD “Mechanisms of xenobiotic surveillance and regulation” with Gary Ruvkun, PhDIVA A. TCHASOVNIKAROVA, PhD* “Deciphering the role of chromatin remodeling in epigenetic repression by the HUSH complex” with Robert E. Kingston, PhD OZLEM YILDIRIM, PhD HHMI Fellow “Role of LncRNAs in inheritance of chromatin states during self-renewal and differentiation” with Robert E. Kingston, PhDMassachusetts Institute of TechnologyALLISON N. LAU, PhD Robert Black Fellow “Understanding metabolic heterogeneity in pancreatic cancer” with Matthew G. Vander Heiden, MD, PhDJOSE M. ORDOVAS-MONTANES, PhD* HHMI Fellow “Single-cell genomic approaches for tracing the contribution of inflammation to human colon cancer” with Alex K. Shalek, PhDCHENXI TIAN, PhD Sherry and Alan Leventhal Family Fellow “Understanding the roles of extracellular matrix proteins in pancreatic ductal adenocarcinoma progression” with Richard O. Hynes, PhDPETER M. WESTCOTT, PhD* “Exploiting endogenous mutational processes in cancer to enhance response to immunotherapy” with Tyler Jacks, PhDUniversity of Massachusetts Medical SchoolGINA V. CALDAS, PhD “Analysis of CSR- function in C. elegans embryonic cell division” with Craig C. Mello, PhDWhitehead Institute for Biomedical ResearchWENWEN FANG, PhD HHMI Fellow “Mechanism and regulation of primary-microRNA processing” with David P. Bartel, PhDJUNJIE U. GUO, PhD Dale F. and Betty Ann Frey Fellow “Charting the in vivo landscape of RNA-RNA interactions” with David P. Bartel, PhDALEXANDER M. JAEGER, PhD* HHMI Fellow “Surveying the chromatin architecture shaped by HSF1 in cancer” with Susan Lindquist, PhD26

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XIAOXIAO S. LIU, PhD “Examining the biological function of 5-hmC modification in the mammalian genome” with Rudolf Jaenisch, MDMARIA M. MIHAYLOVA, PhD Robert Black Fellow “Examining how nutrient state dependent metabolic reprogramming in adult stem cell niches controls cell renewal, differentiation and tumorigenesis” with David M. Sabatini, MD, PhDMICHIGANUniversity of MichiganSWATHI YADLAPALLI, PhD HHMI Fellow “Neural and genetic basis of metabolic regulation” with Orie T. Shafer, PhD, and Edgar Meyhofer, PhDNEW YORKCornell UniversitySUDEEP BANJADE, PhD* HHMI Fellow “Division of labor in ESCRT-III proteins during polymer assembly and membrane remodeling” with Scott D. Emr, PhDCold Spring Harbor LaboratoryCHRISTINE I. CHIO, PhD Shirley Stein Fellow “Regulation of the global redox landscape: Investigating the role of Nrf2 in pancreatic cancer development” with David A. Tuveson, MD, PhDMemorial Sloan Kettering Cancer CenterNICHOLAS ARPAIA, PhD Robert Black Fellow “The role of microbiota-derived metabolic signals in shaping the intestinal immune landscape” with Alexander Y. Rudensky, PhDHARIHAR BASNET, PhD* “Identifying determinants of latency in brain metastatic breast cancer cells” with Joan Massague, PhDLYDIA FINLEY, PhD Jack Sorrell Fellow “Regulation of cancer cell growth and survival by the propionate catabolic pathway” with Craig B. Thompson, MDBRYAN C. KING, PhD Berger Foundation Fellow “AMPK-induced catabolism of extracellular proteins: a novel survival mechanism for nutrient-deprived cancer cells” with Craig B. Thompson, MDWILLIAM RAZZELL, PhD HHMI Fellow “The role of tension in Hippo pathway signaling” with Jennifer A. Zallen, PhDAARON D. VINY, MD† William Raveis Charitable Fund Fellow “Role of the cohesin complex in oncogenic transformation of AML” with Ross L. Levine, MDDMITRIY ZAMARIN, MD, PhD† Dr. Bart A. Kamen Fellow “Immunotherapeutic approach to cancer treatment integrating oncolytic virotherapy and immune checkpoint regulation” with Jedd D. Wolchok, MD, PhDNew York University School of MedicineLACY J. BARTON, PhD “Mechanisms of directed cell migration in a complex in vivo environment” with Ruth Lehmann, PhDJUNE-YONG LEE, PhD HHMI Fellow “Investigation of potential roles of serum amyloid A in peripheral Th17 cell pathogenicity” with Dan R. Littman, MD, PhDThe Rockefeller UniversityCHAO LU, PhD Kandarian Family Fellow “Understanding the mechanism of histone H3 mutation in cancer initiation and maintenance” with C. David Allis, PhDRAND M. MILLER, PhD Illini 4000 Fellow “Chemistry-based dissection of multidrug resistance efflux pump mechanisms in living cells” with Tarun M. Kapoor, PhD SHRUTI NAIK, PhD “Immune and epidermal stem cell cross talk in skin inflammation” with Elaine V. Fuchs, PhDALEXEY A. SOSHNEV, MD, PhD HHMI Fellow “The study of linker histone H1 in transcriptional regulation and genome organization” with C. David Allis, PhDJONATHAN R. WHICHER, PhD GE Asset Management Fellow “Structure and mechanism of the voltage-gated potassium channel hEag1” with Roderick MacKinnon, MDLINGHE XI, PhD* Dale F. and Betty Ann Frey Fellow “WNT signaling and fate specification of normal versus tumorigenic stem cells” with Elaine V. Fuchs, PhDTEXASBaylor College of MedicineCHRISTINE R. BECK, PhD HHMI Fellow “Mechanisms underlying copy number gain in cancer and genomic disorder-associated complex rearrangements” with James R. Lupski, MD, PhDUniversity of Texas Southwestern Medical CenterLINDSAY B. CASE, PhD* “Regulation of integrin clustering on supported lipid bilayers” with Michael K. Rosen, PhDELISE C. JEFFERY, PhD* “Characterizing a new hematopoietic stem cell niche factor” with Sean J. Morrison, PhD Damon Runyon Fellowship Awards (Continued)27

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Damon Runyon-Sohn Pediatric Cancer Fellowship Award CommitteeCHAIRWILLIAM L. CARROLL, MD Julie and Edward J. Minskoff Professor of Pediatrics and Professor of Pathology Director, Division of Pediatric Hematology/Oncology Associate Chair, Clinical and Translational Research Stephen D. Hassenfeld Children's Center for Cancer and Blood Disorders New York University Langone Medical Center New York, New YorkCHAIR ELECTSCOTT A. ARMSTRONG, MD, PhD Chair, Department of Pediatric Oncology Dana-Farber Cancer Institute David G. Nathan Professor of Pediatrics, Harvard Medical School Associate Chief of the Division of Hematology/Oncology at Boston Children's Hospital Boston, MassachusettsPATRICK A. BROWN, MD Director, Pediatric Leukemia and Lymphoma Program Associate Professor, Department of Oncology Johns Hopkins University School of Medicine Baltimore, MarylandPETER D. COLE, MD Associate Professor, Department of Pediatrics Albert Einstein College of Medicine Montefiore Medical Center Bronx, New YorkLISA R. DILLER, MD Chief Medical Officer Dana-Farber Children’s Hospital Cancer Center Clinical Director, Pediatric Oncology Dana-Farber Cancer Institute Boston, MassachusettsADOLFO A. FERRANDO, MD, PhD Associate Professor of Pediatrics and Pathology Director, WOLF Foundation Leukemia/Lymphoma Laboratory Institute for Cancer Genetics Columbia University Medical Center New York, New YorkJAMES M. OLSON, MD, PhD Member Division of Clinical Research Fred Hutchinson Cancer Research Center Seattle, WashingtonMARTINE F. ROUSSEL, PhD Member and Endowed Chair in Molecular Oncogenesis Co-Director, Cancer Center Signal Transduction Program Department of Tumor Cell Biology and Genetics St. Jude Children’s Research Hospital Memphis, Tennessee (Adjunct Professor, The University of Tennessee Health Science Center)UTAHUniversity of Utah School of MedicineALESIA N. MCKEOWN, PhD* HHMI Fellow “Novel roles for retrogenes in host immunity” with Nels C. Elde, PhD, and Cedric Feschotte, PhDVIRGINIAHoward Hughes Medical Institute Janelia Research CampusALBERT TSAI, PhD “Single-molecule imaging of transcription factors binding dynamics in Drosophila embryos” with Robert H. Singer, PhD *Initial Year † Physician Scientist WASHINGTONFred Hutchinson Cancer Research CenterTERA C. LEVIN, PhD HHMI Fellow “Master microbial manipulators: how Wolbachia subvert Drosophila development” with Harmit S. Malik, PhDMATTHEW P. MILLER, PhD HHMI Fellow “Regulation of kinetochore assembly” with Susan Biggins, PhDANTOINE MOLARO, PhD “Evolutionary and functional consequences of genetic conflicts between KRAB-Zinc-Fingers and endogenous retroviruses in primate genomes” with Harmit S. Malik, PhD ALISTAIR B. RUSSELL, PhD Merck Fellow “Impact of heterogeneity on the cellular recognition of influenza infection” with Jesse D. Bloom, PhDYING QI SHIRLEEN SOH, PhD* “Mapping paths and mechanisms of virus-host adaptation” with Jesse D. Bloom, PhDUniversity of WashingtonRONALD J. HAUSE, PhD “Function dissection of the effects of variants of uncertain significance in TPMT in response to thiopurine anticancer agents” with Jay A. Shendure, MD, PhDYI YIN, PhD* William Raveis Charitable Fund Fellow “Global analysis of DNA break repair by single-cell sequencing” with Jay A. Shendure, MD, PhD 28

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Damon Runyon-Dale F. Frey Awards for Breakthrough ScientistsGIRA BHABHA, PhD* “High-resolution studies of dynein structure and mechanism” at New York University Medical School, New York, New YorkALISTAIR N. BOETTIGER, PhD* “Using super resolution imaging to probe molecular mechanisms of Polycomb silencing” at Stanford University, Stanford, CaliforniaMINGYE FENG, PhD* “Macrophage-mediated immunosurveillance in metastasis” at Stanford University, Stanford, CaliforniaRALPH E. KLEINER, PhD* “Investigating the importance of post-translational microtubule modification using recombinant acetylated tubulin” at Princeton University, Princeton, New JerseyDamon Runyon-Sohn Pediatric Cancer Fellowship AwardsCALIFORNIAÖZLEM AKSOY, PhD “Understanding the role of translational control in humanized mouse models for medulloblastoma” with Davide Ruggero, PhD, University of California, San FranciscoZHIPENG LU, PhD Layton Family Fellow of the Damon Runyon-Sohn Foundation Pediatric Cancer Fellowship Award “Elucidating the role of dynamic RNA structures in cancer” with Howard Y. Chang, MD, PhD, Stanford University School of Medicine, StanfordAMIT J. SABNIS, MD† “Exploiting chaperone dependence as a novel therapeutic strategy in alveolar rhabdomyosarcoma” with Trever G. Bivona, MD, PhD, University of California, San FranciscoMARYLANDSTACY L. COOPER, MD† “The Cebpa +37kb enhancer is a critical target of transformation in acute myeloid leukemia” with Alan D. Friedman, MD, Johns Hopkins University, BaltimoreMICHAEL A. KOLDOBSKIY, MD, PhD*† “DNA methylation stochasticity in pediatric pre-B cell acute lymphoblastic leukemia” with Andrew P. Feinberg, MD, Johns Hopkins University, BaltimoreCARA A. RABIK, MD, PhD*† “Determination of the role of WT1 in hematopoiesis and leukemogenesis” with Patrick A. Brown, MD, Johns Hopkins University, BaltimoreMASSACHUSETTSAMANDA L. BALBONI, PhD “Targeting the EWS-FLI oncoprotein in Ewing sarcoma with CDK12/13 inhibitors” with Kimberly Stegmaier, MD, Dana-Farber Cancer Institute, BostonHAIHUA CHU, PhD “The role of DOT1L in pediatric leukemias” with Scott A. Armstrong, MD, PhD, Dana-Farber Cancer Institute, BostonSHUIBIN LIN, PhD “Molecular and cellular characterization of a novel LincRNA in neuroblastoma” with Richard Gregory, PhD, Boston Children’s Hospital, BostonMARK W. ZIMMERMAN, PhD “Elucidating the mechanism of CHD5-mediated tumor suppression in neuroblastoma” with A. Thomas Look, MD, Dana-Farber Cancer Institute, BostonMICHIGANCHALLICE L. BONIFANT, MD, PhD*† “Dual-antigen targeting by ENG-T cells as improved anti-AML therapy” with Pavan Reddy, MD, University of Michigan, Ann ArborNEW YORKLY P. VU, PhD “Uncovering the role of RNA-binding protein Syncrip in acute myeloid leukemia (AML)” with Michael G. Kharas, PhD, and Ross L. Levine, MD, Memorial Sloan Kettering Cancer Center, New YorkPENNSYLVANIATAMARA P. MILLER, MD*† “Improving adverse event reporting on cooperative oncology group trials” with Richard Aplenc, MD, PhD, Children’s Hospital of Philadelphia, PhiladelphiaTENNESSEEDAVID W. WOESSNER, PhD “Discovery of new driver alterations in childhood ALL” with Charles G. Mullighan, MBBS, MD, St. Jude Children’s Research Hospital, Memphis*Initial Year † Physician ScientistDamon Runyon-Dale F. Frey Scientist GIRA BHABHA, PhD29

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CHAIRWILLIAM G. KAELIN, JR., MD Howard Hughes Medical Institute Investigator Professor of Medicine Harvard Medical School Dana-Farber Cancer Institute Boston, MassachusettsDAVID P. CARBONE, MD, PhD Professor, Division of Medical Oncology Director, Thoracic Oncology Center Comprehensive Cancer Center The Ohio State University Columbus, OhioPATRICIA A. GANZ, MD Professor, Schools of Medicine and Public Health Director, Division of Cancer Prevention and Control Research Jonsson Comprehensive Cancer Center University of California, Los Angeles Los Angeles, CaliforniaLUCY A. GODLEY, MD, PhD Professor Department of Medicine Section of Hematology and Oncology The University of Chicago Medicine Chicago, IllinoisPETER S. NELSON, MD Member Program in Prostate Cancer Research Division of Human Biology Fred Hutchison Cancer Research Center Professor, Division of Medical Oncology Adjunct Professor, Genomic Sciences and Pathology University of Washington School of Medicine Seattle, WashingtonKORNELIA POLYAK, MD, PhD Professor of Medicine Department of Medical Oncology Dana-Farber Cancer Institute Harvard Medical School Boston, MassachusettsJEREMY N. RICH, MD Chair, Department Stem Cell Biology and Regenerative Medicine Lerner Research Institute The Cleveland Clinic Foundation Cleveland, OhioNORMAN E. SHARPLESS, MD Director, Lineberger Comprehensive Cancer Center Wellcome Distinguished Professor of Cancer Research Departments of Medicine and Genetics University of North Carolina School of Medicine Chapel Hill, North Carolina CASSIAN YEE, MD Professor, Department of Melanoma Medical Oncology Professor, Department of Immunology Division of Cancer Medicine Director, Solid Tumor Cell Therapy Center for Cancer Immunology Research The University of Texas M.D. Anderson Cancer Center Houston, TexasDamon Runyon Physician-Scientist Training Award CommitteeDamon Runyon Physician-Scientist Training AwardsPAVAN BACHIREDDY, MD “Coevolution of tumor and T cell heterogeneity following immunotherapy” with Catherine J. Wu, MD, at Dana-Farber Cancer Institute, Boston, MassachusettsGIADA BIANCHI, MD* Damon Runyon-Celgene Physician-Scientist “Molecular mechanisms of ROBO1 in multiple myeloma pathogenesis” with Kenneth C. Anderson, MD, Dana-Farber Cancer Institute, Boston, MassachusettsKRISTOPHER R. BOSSE, MD* “GPC2 as an oncogene and immunotherapeutic target in high-risk neuroblastoma” with John M. Maris, MD, Children’s Hospital of Philadelphia, PennsylvaniaJULIA C. CARNEVALE, MD* “Developing new therapeutic approaches for pancreatic cancer with homologous recombination repair defects” with Alan Ashworth, PhD, University of California, San Francisco, CaliforniaMICHAEL W. DRAZER, MD* “Defining leukomogenic mechanisms in hereditary hematologic malignancies” with Lucy A. Godley, MD, PhD, The University of Chicago Medicine, Chicago, IllinoisCAROLYN C. JACKSON, MD, MPH “Genetic dissection of pediatric classic Kaposi sarcoma” with Jean-Laurent Casanova, MD, PhD, at Memorial Sloan Kettering Cancer Center, New York, New YorkDAVID M. KURTZ, MD* “Response prediction and personalized therapy from mathematical modeling of circulating tumor DNA in non-Hodgkin lymphoma” with Arash A. Alizadeh, MD, PhD, Stanford University School of Medicine, Stanford, CaliforniaLORETTA S. LI, MD “Mechanisms of disease and resistance in CRLF2-rearranged B-cell acute lymphoblastic leukemia” with David Weinstock, MD, at Dana-Farber Cancer Institute, Boston, Massachusetts*Initial Year30

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EventsDAMON RUNYON BROADWAY TICKETS offers premium seats to all of Broadway’s hits, including sold-out shows like Hamilton (shown above). We are especially grateful to the Shubert Organization, Nederlander Productions, Jujamcyn Theaters, and Disney Theatrical Productions for making this program possible. To purchase tickets and gift certificates, please call (212) 455-0550.IN NOVEMBER 2015, THE DAMON RUNYON 5K AT YANKEE STADIUM drew more than 2,700 participants and raised nearly $500,000. The 2015 Runyon 5K was presented by MetLife Foundation, with additional support from NYSID, Poland Spring, KRAVE Jerky, Bigelow, Frito Lay, New Era, 24 Hour Fitness, NBC 4 New York, New York Post, SiriusXM Satellite Radio and the New York Yankees.OUR 2016 ANNUAL BREAKFAST RAISED MORE THAN $1.4 MILLION. Tom Daniel, MD, Chairman, Celgene Research and Bob Hugin, Executive Chairman, Celgene Corporation were honored and introduced by NBC News Special Correspondent and author Tom Brokaw. THE WILLIAM RAVEIS CHARITABLE FUND HOSTED TWO RAVEIS RIDE + WALK EVENTS in the northeast, raising $550,000 for Damon Runyon scientists. Thank you to everyone at William Raveis for their partnership and support!31

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Your support this year enabled us to fund $17 million of research by the next generation of leading cancer researchers exploring bold new ideas. Since our founding in 1946, in partnership with donors across the nation, Damon Runyon has invested nearly $320 million and funded more than 3,550 young scientists.Thank You to Our DonorsAward SponsorsAccelerating Cancer CuresWe are grateful to our individual, foundation and corporate sponsors who have partnered with us to launch new programs or are funding one or more of our scientists. Donors are able to choose scientists to fund based on location, institution, research focus or cancer type, and the award can be named in recognition of their gi. Award sponsors are listed on pages 33-35. Thank you to Eli Lilly and Company, Celgene, Genentech, Merck, Takeda Pharmaceu-ticals International, and Pfizer for partnering with us to support the Damon Runyon Clinical Investigator Award and for helping to foster communication and collaboration between our scientists and the biopharmaceutical industry.PETER J. TURNBAUGH, PhD Laura and Peter Van Camp have sponsored three Damon Runyon Innovators through Nadia's Gift Foundation. They are pictured here with Peter J. Turnbaugh, PhD, at the University of California, San Francisco, one of their sponsored scientists. 32

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Sponsored AwardsDAMON RUNYON-RACHLEFF INNOVATION AWARDS This award was established thanks to the vision and generosity of Debbie and Andy Rachleff.EDWARD P. EVANS FOUNDATION INNOVATOR Eirini P. Papapetrou, MD, PhD Icahn School of Medicine at Mount SinaiISLAND OUTREACH FOUNDATION INNOVATOR Piero D. Dalerba, MD Columbia UniversityNADIA’S GIFT FOUNDATION INNOVATOR Peter J. Turnbaugh, PhD University of California, San FranciscoCLINICAL INVESTIGATOR AWARDS This award was initially established in partnership with Eli Lilly and Company. In addition to the named awards, it is supported by Accelerating Cancer Cures, a collaboration between Damon Runyon and leading biopharmaceutical companies.GORDON FAMILY CLINICAL INVESTIGATOR Geoffrey R. Oxnard, MD Dana-Farber Cancer InstituteJAKE WETCHLER FOUNDATION FOR INNOVATIVE PEDIATRIC CANCER RESEARCH CLINICAL INVESTIGATOR L. Elizabeth Budde, MD, PhD City of Hope METLIFE FOUNDATION CLINICAL INVESTIGATOR Christopher E. Barbieri, MD, PhD Weill Cornell MedicineRICHARD LUMSDEN FOUNDATION CLINICAL INVESTIGATOR Alex Kentsis, MD, PhD Memorial Sloan Kettering Cancer CenterCLINICAL INVESTIGATOR CONTINUATION GRANT Follow-up funding for select Clinical Investigators has been provided thanks to the generosity of the William K. Bowes, Jr. Foundation.PATTERSON TRUST CLINICAL INVESTIGATOR Sarat Chandarlapaty, MD, PhD Memorial Sloan Kettering Cancer CenterFELLOWSHIP AWARDS The following awards are funded by donors who have generously endowed an award in perpetuity or sponsored an individual Fellow.DR. BART A. KAMEN FELLOW Dmitriy Zamarin, MD, PhD Memorial Sloan Kettering Cancer CenterBERGER FOUNDATION FELLOW Bryan C. King, PhD Memorial Sloan Kettering Cancer CenterCONNIE AND BOB LURIE FELLOW* Duy P. Nguyen, PhD University of California, San FranciscoDALE F. AND BETTY ANN FREY FELLOW* Linghe Xi, PhD The Rockefeller University DENNIS AND MARSHA DAMMERMAN FELLOW* Caitlin A. Brennan, PhD Harvard T.H. Chan School of Public HealthFAYEZ SAROFIM FELLOW* Andrew R. Nager, PhD Stanford University School of MedicineFRATERNAL ORDER OF EAGLES FELLOW Ryan D. Baldridge, PhD Harvard Medical SchoolGE ASSET MANAGEMENT FELLOW Jonathan R. Whicher, PhD The Rockefeller UniversityHOWARD HUGHES MEDICAL INSTITUTE (HHMI) FELLOWS Brittany Adamson, PhD University of California, San FranciscoSudeep Banjade, PhD Cornell UniversityBrian J. Beliveau, PhD Harvard UniversityChristopher J. Cambier, PhD Stanford UniversityAnupam K. Chakravarty, PhD Stanford University School of MedicineCasey A. Gifford, PhD Gladstone InstitutesAlexander M. Jaeger, PhD Whitehead Institute for Biomedical ResearchJune-Yong Lee, PhD New York University School of MedicineTera C. Levin, PhD Fred Hutchinson Cancer Research CenterWe are fortunate to have individual, foundation, and corporate sponsors who have partnered with us to launch or provide continuing support for specific award programs. We thank them for their vision.33

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Alesia N. McKeown, PhD University of Utah School of MedicineMatthew P. Miller, PhD Fred Hutchinson Cancer Research CenterMandy M. Muller, PhD University of California, BerkeleySigrid Nachtergaele, PhD The University of ChicagoJose M. Ordovas-Montanes, PhD Massachusetts Institute of TechnologyMagdalena E. Potok, PhD University of California, Los AngelesWilliam Razzell, PhD Memorial Sloan Kettering Cancer CenterAlexey A. Soshnev, MD, PhD The Rockefeller UniversityHume A. Stroud, PhD Harvard Medical SchoolSarah Z. Tasker, PhD University of IllinoisNeil T. Umbreit, PhD Dana-Farber Cancer InstituteThomas S. Vierbuchen, PhD Harvard Medical SchoolSungwook Woo, PhD Harvard UniversitySwathi Yadlapalli, PhD University of MichiganBoris Zinshteyn, PhD Johns Hopkins University School of MedicineILLINI 4000 FELLOW Rand M. Miller, PhD The Rockefeller UniversityJACK SORRELL FELLOW Lydia Finley, PhD Memorial Sloan Kettering Cancer CenterKANDARIAN FAMILY FELLOW Chao Lu, PhD The Rockefeller UniversityKENNETH G. AND ELAINE A. LANGONE FELLOW* Tony Y. Tsai, MD, PhD Harvard Medical School LALLAGE FEAZEL WALL FELLOW* Liron Bar-Peled, PhD Scripps Research InstituteLAYTON FAMILY FELLOWS Keren I. Hilgendorf, PhD Stanford University School of MedicineKathrin Leppek, PhD Stanford University School of MedicineYin Liu, PhD Stanford University School of MedicineLEFKOFSKY FAMILY FELLOW Beverly J. Piggott, PhD University of California, San FranciscoMARION ABBE FELLOW* Timothy D. Martin, PhD Brigham and Women’s HospitalMERCK FELLOWS Dennis L. Buckley, PhD Dana-Farber Cancer InstituteIvana Gasic, Dr.Sc. Harvard Medical SchoolDaniel H. Goldman, PhD Johns Hopkins School of MedicineFuguo Jiang, PhD University of California, BerkeleyAlistair B. Russell, PhD Fred Hutchinson Cancer Research CenterJoseph D. Schonhoft, PhD Scripps Research InstitutePHILIP O’BRYAN MONTGOMERY, JR., MD, FELLOW Daniel E. Webster, PhD National Institutes of HealthREBECCA RIDLEY KRY FELLOW* Jeffrey A. Hussmann, PhD University of California, San FranciscoROBERT BLACK FELLOWS Nicholas Arpaia, PhD Memorial Sloan Kettering Cancer CenterSerkan Kir, PhD Dana-Farber Cancer InstituteAllison N. Lau, PhD Massachusetts Institute of TechnologyMaria M. Mihaylova, PhD Whitehead Institute for Biomedical ResearchGabriela C. Monsalve, PhD University of California, San FranciscoEvgenia N. Nikolova, PhD Scripps Research InstituteSHERRY AND ALAN LEVENTHAL FAMILY FELLOW Chenxi Tian, PhD Massachusetts Institute of TechnologySHIRLEY STEIN FELLOW Christine I. Chio, PhD Cold Spring Harbor LaboratorySUZANNE AND BOB WRIGHT FELLOW* Emma Watson, PhD Brigham and Women’s HospitalWILLIAM RAVEIS CHARITABLE FUND FELLOWS Aaron D. Viny, MD Memorial Sloan Kettering Cancer CenterYi Yin, MD University of Washington DAMON RUNYON-SOHN FOUNDATION PEDIATRIC CANCER FELLOWSHIP AWARDS This award program was launched in partnership with the generous support of the Sohn Conference Foundation. DAMON RUNYON-SOHN FOUNDATION PEDIATRIC CANCER FELLOWS SUPPORTED BY THE SOHN CONFERENCE FOUNDATIONÖzlem Aksoy, PhD University of California, San FranciscoAmanda L. Balboni, PhD Dana-Farber Cancer InstituteChallice L. Bonifant, MD, PhD University of MichiganHaihua Chu, PhD Dana-Farber Cancer InstituteStacy L. Cooper, MD Johns Hopkins University 34

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$1,000,000 + **Howard Hughes Medical Institute$500,000 TO $999,999Anonymous**William K. Bowes, Jr. Foundation **Mr. Michael L. Gordon The Layton Family Fund **MetLife Foundation **Sohn Conference Foundation William Raveis Charitable Fund $100,000 TO $499,999 Anonymous**Terry and David Beirne**Robert Black Charitable FoundationAntoinette & Herman Boehm FoundationCelgene Corporation**Estate of Adrienne & Harry Chamberlain**Leon & Toby Cooperman FoundationEdward P. Evans FoundationFidelity Investments Charitable Gift Fund **Genentech, Inc. Estate of Stephanie GoldmanMr. Robert J. Hugin**Island Outreach Foundation**Sherry and Alan Leventhal Family Foundation**Lilly Oncology**Merck & Company, Inc. **Nadia’s Gift FoundationRussel H. Norberg Trust Louis and Rachel Rudin Foundation, Inc.Select Equity Group Silicon Valley Community FoundationThe Varelas Family Fund$50,000 TO $99,999Angelo, Gordon & Co.Sol and Margaret Berger FoundationEstate of Ernest Bittler Ms. Deborah Coleman and Mr. Timothy Diggins Estate of John W.M. Fitton HHMI Janelia Farm Research Campus The Illini 4000 for Cancer Lefkofsky Family FoundationMetLifeThe Jake Wetchler Foundation for Innovative Pediatric Cancer Research$25,000 TO $49,999 AnonymousBeacon Capital Partners, LLC Mr. and Mrs. Lawrence A. BossidyCommunities Foundation of Texas (CFT)Judy Angelo Cowen FoundationEstate of Rita EisenbergErlbaum Family Foundation **Grand Aerie Fraternal Order of EaglesHettinger Foundation Our ContributorsThe Damon Runyon Cancer Research Foundation acknowledges the generosity and support of the many individual, corporate and foundation donors who supported our brilliant researchers through gis to the Foundation from July 1, 2015 to June 30, 2016. Those whose individual lifetime giving is $100,000 or more are in bold, and those whose lifetime giving exceeds $1 million are noted with two asterisks.** We are especially grateful to these extraordinarily generous and commied donors.Michael A. Koldobskiy, MD, PhD Johns Hopkins University Cara A. Rabik, MD, PhD Johns Hopkins University Amit J. Sabnis, MD University of California, San FranciscoLy P. Vu, PhD Memorial Sloan Kettering Cancer Center David W. Woessner, PhD St. Jude Children’s Research Hospital Mark W. Zimmerman, PhD Dana-Farber Cancer InstituteLAYTON FAMILY FELLOW OF THE DAMON RUNYON-SOHN FOUNDATION PEDIATRIC CANCER FELLOWSHIP AWARD Zhipeng Lu, PhD Stanford University School of MedicineDAMON RUNYON PHYSICIAN-SCIENTIST TRAINING AWARDS This award was established thanks to the generosity of Damon Runyon Board Members Leon G. Cooperman and Michael L. GordonDAMON RUNYON-CELGENE PHYSICIAN-SCIENTIST Giada Bianchi, MD Dana-Farber Cancer Institute *In perpetuity Sponsored Awards (Continued)*Our donor lists are checked carefully. However, if you have any corrections or questions, please call 877.722.6237. The full pledge amount is listed in the year the pledge is made. In subsequent years, actual pledge payments are listed.35

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Mr. Ray Hunt Independent Charities of AmericaEstate of Walter E. KelleyThe Muriel and Norman B. Leventhal Family Foundation Mr. and Mrs. David G. Marshall Gordon H. & Karen M. Millner Family FoundationEugene & Mary Murphy Charitable Gift FundThe Pew Charitable Trusts Mr. Roy PfautchThe Frances and Abraham Reichman Charitable Trust The Bruce Robert Reid Family Foundation The San Francisco Foundation Fred and Donna Seigel Ms. Karen D. Seitz The Richard C. and Theresa P. Smith Memorial FundMs. Cynthia F. Sulzberger and Mr. Steven B. Green Tzedakah Foundation UBS Financial Services, Inc.$10,000 TO $24,999 Abide Therapeutics Alexandria Real Estate Equities, Inc.AnonymousAtlantic Health SystemAyco Charitable Foundation Barthold Family FoundationCiti Deutsche Bank Securities Inc.Mr. and Mrs. Frank DoyleEchlin FoundationLorraine and Bill Egan Mr. and Mrs. Steven Esrick The Fine & Greenwald Foundation, Inc. GE Asset Management General Electric FoundationGoldman, Sachs & Co.Mr. and Mrs. James GouldMr. and Mrs. Scott Greenstein Mr. Steve HaydenEstate of Irma T. Hirschl Ms. Solange and Mr. Michael Hommel Ms. Sandra J. Horbach and Mr. Steven Skoler Mr. and Mrs. Wayne M. HummelValerie and Jay Ireland Jewish Communal FundJones DayJ.P. MorganMr. Steven A. Kandarian**Mr. and Mrs. Kenneth G. LangoneCharles and Margaret Levin Family Foundation Estate of Laurie D. LimaMr. and Mrs. Henry Mannix III Ms. Lynn L. MarksJoe & Pasena Maroun Family FoundationMr. and Mrs. Gerald M. Marshall Northern BiologicsPerrigo Company Foundation Pfizer Inc. Pharmaceutical Research and Manufacturers of America (PhRMA) ProskauerPyramid Hotel GroupQuinn Emanuel Urquhart & Sullivan, LLP Mr. and Mrs. Arthur J. Samberg Schulte Roth & Zabel LLP Schwab Charitable Michael V. Seiden, MD, PhDHenry J. & Kathleen Singer Family FoundationGerri and Andrew Sommers Family FundThe Symonds Foundation Vanguard Charitable Endowment Program Mr. and Mrs. John F. Welch, Jr. Mr. and Mrs. Gary WolfMr. Peter J. Worth, Alliant Insurance Services $5,000 TO $9,9995AM Ventures Mrs. Carolyn R. AllerThe Allergan Foundation AnonymousBarclays Barnett Family Philanthropic FundMrs. Barbara Lieb BaumsteinBaupost Group, LLCThe Howard Bayne FundBenevity Community Impact Fund Mr. and Mrs. Steven H. BergMr. Frank M. Bumstead Lewis C. Cantley, PhDEstate of Laurelia M. CliffordMr. and Mrs. Martin J. CohenRobyn and Tony ColesCommunity Health Systems, Inc. C.R. Bard, Inc. Ms. Elizabeth B. Dater and Mr. Mitchell JenningsMr. and Mrs. Larry D. DroppaMr. and Mrs. Lawrence Foley Dale & Betty Ann Frey Family Foundation Friedman Family Foundation Ms. Erica Evans-Gioffre and Mr. Michael GioffreTodd R. Golub, MDHeitman LLCMr. and Mrs. Robert M. Hess Mr. Clair Howey Interco Charitable Trust Mr. Scott R. Isdaner Mrs. Carolyn June Kaplan Mr. and Mrs. Michael M. Kassen Mr. Richard A. Konigsberg Ms. Patty Kosion Mr. and Mrs. Jeremy R. Kramer Ms. Ann E. Levine The Lichtenberger Foundation Ms. Susan Lipton Kenneth J. Livak, PhD Loynd Family Foundation **Connie and Bob Lurie Mr. and Mrs. James I. Magid Ms. Jami W. McKeonThe Leo Model Foundation, Inc.Alfred L. Morse and Annette S. Morse FoundationMr. and Mrs. Warren K. MyerMr. and Mrs. John H. MyersNasdaq Inc.The New York Community TrustNew York State Industries for the Disabled (NYSID) Palisade Capital ManagementThe Penates FoundationMr. and Mrs. Rahn PitzerMr. Sheldon PresslerMr. and Mrs. Michael ReppergerRose Family FundMrs. Elizabeth B. RossDr. Lief Sannen and Mr. Lawrence Wieman Sanofi GenzymeMrs. Mikell M. SmithMr. Wayne T. SmithMr. Jonathan SonnebornMs. Robie E. SpectorMr. James D. StaleyStewart Senter, Inc.Mrs. Barbara S. StraussMr. and Mrs. John M. TraniThe Turk Family FoundationUeberroth Family FoundationUnited Way of Metropolitan ChicagoMr. and Mrs. E. Scott UrdangMr. Jon VogelVoya FoundationMr. and Mrs. Peter J. WassermanDr. and Mrs. Victor J. WeinsteinMr. and Mrs. David A. Weiss$1,000 TO $4,999 AgiosMr. David AltshulerMs. Velma M. AndersonAnonymous (4)Mr. and Mrs. Joel AppelApple Lane FoundationDr. Shelly ArtzAurora Capital Group36

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Our Contributors (Continued)Mr. Arthur S. BahrMs. Susannah BailinAlan P. Baker, PhDMs. Patricia A. BaranMr. Richard BarnettMr. Tim BartonMr. F. Harlan BatrusMr. and Mrs. Roger BaumannBDMs. Jill C. BeeMs. Robin BellMr. Norman C. BenderMr. James BennettMs. Sandye BergerThe Len & Laura Berlik Foundation, Inc.Ms. Bonnie BernardMrs. Beth BernsDonald P. Biek, PhDMs. Mindee BlancoBLL FoundationMr. Frederic L. BlochMr. David S. BlueMr. William BoehMr. and Mrs. Eugene K. BoltonMs. Lisa BoncoskyMr. Brett BorettiMr. and Mrs. Thomas J. BrackenMr. John BreslowMs. Gloria P. BriggsMrs. Samantha BrousMr. and Mrs. Richard E. BruceRev. and Mrs. C. Frederick BuechnerSteven J. Burakoff, MDBurlingame FoundationMr. and Mrs. Arthur B. CalcagniniMr. and Mrs. Patrick J. CallanMr. Joseph Carrabino, Jr. CharityBuzzMs. Mary F. CherifMs. Sheila A. ChervinMs. Elizabeth M. ChristiansenMs. Deborah Clayman and Mr. Lawrence Raiman Mr. Paul CocoMr. John T.J. CoeMr. and Mrs. Jay L. CohanMs. Irene CohenMr. Samuel T. CohenMr. Frank ContiRobert N. Cooney, MD and Ms. Lorrie M. CooneyProf. and Mrs. Daniel R. CoopermanMr. Howard J. CoopermanCORAL Investment PartnersMr. and Mrs. Michael J. CosgroveMr. and Mrs. Jonathan CrawfordMs. Maureen CreasonMs. Dorothy D’AmatoMr. and Mrs. Pierre J. de VeghMr. Jerome H. Debs IIMr. and Mrs. Michael DeDomenicoMs. Michelle DelongMs. Allyson DematteoMs. Lisa DeslauriersMr. and Mrs. Philip DeToledoMr. Herb DeuschelBarbara G. Deutsch, MDMs. Cynthia W. DeVineMr. and Mrs. John DilleyMs. Marjorie DonigerRonald I. Dozoretz, MDMr. Paul DuhaimeMs. Josephine J. DummMr. and Mrs. Dexter D. EarleMr. and Mrs. Don C. EddingtonMitzi & Warren Eisenberg Family FoundationEOG Resources, Inc.Ms. Julia EspelMr. Robert EttlMr. Robert EvansThomas J. Fahey, Jr., MDMrs. Roberta FineMs. Leah FinkelsteinFINRARobert F. Fisher, PhDMr. and Mrs. Mark FishmanOlivia E. and Adam R. FlattoMr. Thomas FlorkowskiFORMA TherapeuticsMs. Linda FrankelFranklin & Marshall CollegeMs. Mary Ann FrenzelMs. Effie FribourgMrs. Mary Ann FribourgMs. Terri FriedmanElaine V. Fuchs, PhDGabelli FundsMr. Leonard R. GanzMr. and Mrs. Robert W. Garthwait, Sr.Richard B. Gaynor, MDMr. Ken GlobusMrs. Isobel GloverMr. Steve GoldbergMs. Lois GoldringMr. Carl GolubGoulston & StorrsGrabe FoundationMs. Elizabeth A. GrayPatrick William Gray, PhDMrs. Ina Haas and Dr. Jerome Haas John W. Hadden IIMr. and Mrs. Tarek HallabaMr. Ira HammermanMr. Stephen L. HammermanHanover-Horton SchoolsMr. Stephen HansonMr. Ronald F. HartenbaumMs. Elizabeth HazardMs. Alexes HazenHealey Family FoundationMr. and Mrs. Gary Hellinger Mr. Richard A. Hoffman and Ms. Lisa GrossMr. and Mrs. Edward E. Hood, Jr.Mr. and Mrs. Daniel HuberMs. Mary I. HullMr. and Mrs. Kevin HungateMr. Andre HunterDr. Phyllis HydeIndeedMrs. Randi InfusinoJ.I. Foundation, Inc.Jewish Community FederationJohnson-Miller FoundationWilliam G. Kaelin, Jr., MDMrs. Ellen Schwarzman KatzMr. and Mrs. Jordan KatzMr. Samuel L. KatzMr. and Mrs. James H. KimenkerMs. Kathleen KingMs. Kathryn KingMs. Sue F. KingMr. and Mrs. Douglas M. KinneyMr. Gerold F.L. KlauerKlingenstein FundMr. and Mrs. Noah J. KnaufMr. John KnopfMs. Abby KohnstammMs. Brenda KorffMr. Kyle S. KozloffMr. Lawrence J. KramerMs. Wendy KreegerH. Frederick Krimendahl II FoundationEstate of Marie KronmanMrs. Rebecca R. KryMr. Bryan LabellaJeremy D. Lack, DPhilMs. Janice R. LaneWilliam D. & E.M. Lane FoundationMr. and Mrs. Mark and Elizabeth LazarusMr. and Mrs. Steven LazarusLevin Capital Strategies, LPMs. Ann E. LevineMr. Gilbert LevineMr. Daniel LevyMr. Tom LevyMr. and Mrs. William Guy LevyLevy Family Philanthropic FundThe Edward F. Limato FoundationMr. Peter P. LindleyDavid M. Livingston, MDAnthony F. LoFrisco, Esq.Mr. and Mrs. J. Donald LongeneckerMr. and Mrs. Curtis Louie37

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Frank E. & Miriam Loveman Foundation Inc.Ms. Leslie LynchMr. and Mrs. Timothy MacdonaldMrs. Barbara MackloweMr. and Mrs. Richard H. MaidmanMr. and Mrs. James S. MamaryMs. Marianne ManzolilloMr. David MarcusEstate of August Mattheyses Fund MB Real EstateMr. Christopher McGarrigalMr. and Mrs. William S. McKiernanMs. Christine McManusMr. James K. McMorrowMr. John McStayMr. Gary MeaderMr. Asheet MehtaThe Messinger Foundation, Inc.Mr. and Mrs. Fred MiddletonMr. John MikhailMs. Laura MillerMr. and Mrs. Russell C. MinkoffThe Minneapolis FoundationSanford W. Morhouse, Esq.MorphotekMr. Bruce MoslerNational Mah Jongg League, Inc.Dr. Herbert E. NatofMr. and Mrs. James L. NeislossNetwork For GoodMrs. Dorothy NeustadterNew Crossways FoundationPhillip A. Newmark, PhDMr. Timothy O’ConnorOdyssey Reinsurance CompanyMrs. Paula K. OppenheimMr. and Mrs. Peter Busch OrthweinMs. Megan PaceMr. and Mrs. Ronald E. ParrMr. Stephen PattersonMs. Cindy PearlsteinMs. Agnes PeelleMr. and Mrs. Jack O. PeifferPells Mayton Foundation, Inc.Mr. and Mrs. Robert M. PennoyerMr. and Mrs. Charles H. PerlmanPerrigo CompanyMr. Fabio D. PetruzzielloMs. Elizabeth M. Portland and Mr. Thomas ToceDr. and Mrs. Max ProffittMs. Elaine C. Pulk and Mr. James WesmanMr. and Mrs. James M. PulkMr. and Mrs. Robert P. QuinnMr. Robert L. RattetMs. Meghan Raveis and Mr. Ryan RaveisMr. Michael RaynesDr. Garrett ReismanMr. and Mrs. Douglas C. Renfield- MillerMr. Peter E. RickerMr. and Mrs. D. Paul RittmasterMrs. Sheila RobbinsMr. and Mrs. Gary R. RockholdMs. Elizabeth RoddinMr. Steven D. RossMrs. Miriam K. RothenbergMr. Philip R. RotnerMr. Joseph D. RoxeMs. Julia A. RubinMs. Patricia RyanMr. and Mrs. Donald SageMr. and Mrs. Eric & Corinne SamsonMr. and Mrs. Richard L. SandersonMs. Ilene SandsMr. Gary SaretskyMs. Linda SaslowMs. Alisa SavitzMr. and Mrs. Anand R. SavurDr. David SchenkeinMr. Norman R. SchlangerMs. Tracy SchmidtMr. Paul SchnellMendon F. Schutt Family FundMr. Cary M. SchwartzMr. and Mrs. David G. SchwartzMs. Madeline SchwartzMr. Marvin C. SchwartzMr. and Mrs. Philip C. SchwartzMr. Robert D. ScintoMs. Amy SegalRobert J. Seifer Cancer Research FoundationWilliam R. Sellers, MDMr. and Mrs. Theodore M. SerureMs. Nancy ShapiroMr. Steven L. ShapiroMs. Victoria ShattnerMr. Keith S. SherinMs. Lois SherwinMr. Ed ShoganThe Sidewater Family Foundation, Inc.Ms. Patricia SilversteinSamuel C. Silverstein, MDNancy Simonian, MDMs. Paullina SimonsMr. Alfred J. SmithMr. and Mrs. Jeffrey Q. SmithMr. Joseph SmithEstate of Mildred A. SmithMs. Susan L. SolomonPhilippe Soriano, DSc, PhDMr. Walter C. SquireMr. and Mrs. Kenneth M. StablerMr. Rocco A. StainoMr. and Mrs. Alex StankevichMr. Irving StennMr. Seth F. SternMr. and Mrs. Adam StrumMr. Martin J. SullivanMr. Selby SullivanSutro BiopharmaMr. Steven TawMr. and Mrs. Sanford V. TeplitzkyThe David B. Terk FoundationMr. J. Ronald TerwilligerMr. and Mrs. Ellias TheodoropoulosMr. Joseph M. ThomasCraig B. Thompson, MDMr. John L. TishmanMr. and Mrs. Donald W. ToreyMr. Daniel TracyMs. Dina Treanor and Mr. Jeffrey TaschlerMr. Eddie TrumpMr. Jeffrey TuckerDaniel P. and Grace I. Tully Charitable TrustUnited Way of Central MarylandUnited Way of Martin CountyUnited Way of New York CityMr. Craig VarrelmanMr. Sheldon VidiborMs. Kay E. WagnerMr. Robert WaldbauerMs. Joni L. Walser and Mr. Andrew B. ChurchMr. and Mrs. Frank J. Walter IIIMr. and Mrs. John T. Walter, Jr.Warburg Pincus, LLCMs. Louise WassoMr. and Mrs. Donald C. WeedenMs. Terry Wegner and Mr. Robert WegnerMr. Edwin A. Weiller IIIDavid and Candace Weir FoundationJames A. Wells, PhDMs. Dudley B. WhiteDr. Janet M. WidraEstate of Winifred WiederkerrMr. and Mrs. Frank H. WildtMr. and Mrs. Benjamin J. WinterMr. James L. WinterMr. Seth WolchokMr. Rod WoodWoodrow Wilson SchoolMrs. Betty G. YoungMr. Seymour W. Zises38

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Damon Runyon Advisors The Damon Runyon Advisors act as special advisors to the Foundation in their areas of expertise and are committed to expanding awareness about our important work to the next generation of supporters.JILL E. BARGONETTI, PhD Professor of Biological Sciences Hunter College and The Graduate Center City University of New YorkMS. ERICA EVANS Managing Director, Sales Strategy & Institutional Partnerships The Hartford FundsMS. KAREN FANG Managing Director, Head of Americas FICC Sales, Global Banking and Markets Bank of America Merrill Lynch JEREMY D. LACK, DPhil Partner Athyrium CapitalMR. GERALD M. MARSHALL Co-Chairman and CEO Amerimar Enterprises, Inc. MS. ANNEMARIE NORRIS SVP, Group Director, Behavioral Planning BBDOMS. CHRISTINE L. O’DONNELL Senior Vice President, Market Philanthropic Director U.S. Trust, Bank of America Private Wealth ManagementMR. JOHN M. OLIVIERI Partner White & Case LLP MR. JAMES C. RIVIEZZO Client Director AIGMARCEL R. M. VAN DEN BRINK, MD, PhD Head, Division of Hematologic Oncology Alan Houghton Professor in Immunology | Member, Memorial Sloan Kettering Cancer Center Professor of Medicine and Immunology, Weill Cornell MedicineMR. GARY I. WOLF Managing Director Angelo, Gordon & Co.Broadway Premier Circle The Broadway Premier Circle is a group of loyal Damon Runyon Broadway Tickets customers who have made a special donation in support of cancer research. The Premier Circle offers members priority access to tickets and other benefits.Mr. David AltshulerMr. and Mrs. Joel AppelMrs. Barbara Lieb BaumsteinMs. Jill C. BeeMs. Robin BellMr. Norman C. BenderMr. James BennettMr. and Mrs. Robert S. BirchMs. Mindee BlancoMs. Lisa BoncoskyMrs. Samantha BrousMr. Frank M. BumsteadMs. Mary F. CherifMs. Sheila A. ChervinMr. Samuel T. CohenRobyn and Tony ColesMs. Maureen CreasonMr. Jerome H. Debs IIMs. Michelle DelongMs. Allyson DematteoMr. and Mrs. Philip DeToledoMr. Herb DeuschelMr. and Mrs. Larry D. DroppaMrs. Carol Dubron-Witlin Mr. Paul DuhaimeMr. and Mrs. Dexter D. EarleMr. and Mrs. Warren EisenbergMr. Robert Ettl Mr. and Mrs. Mark FishmanMs. Linda FrankelMs. Mary Ann FrenzelMs. Effie FribourgMs. Terri FriedmanMr. Leonard R. GanzMrs. Isobel GloverMr. William GrabeMr. Ira HammermanMs. Alexes HazenMr. Andre HunterDr. Phyllis Hyde Mrs. Randi InfusinoMr. Scott R. Isdaner Mrs. Carolyn June KaplanMrs. Ellen Schwarzman KatzMr. Samuel L. KatzMr. and Mrs. James H. KimenkerMs. Kathleen KingMs. Kathryn KingMs. Sue F. KingMr. and Mrs. William B. KingMs. Abby KohnstammMr. Richard A. Konigsberg Mr. Kyle S. KozloffMr. and Mrs. Jeremy R. Kramer Mr. Lawrence J. KramerMs. Wendy KreegerMs. Ellen S. LaneMr. and Mrs. Mark and Elizabeth LazarusMs. Ann E. LevineMr. Doug Levine Mr. and Mrs. William Guy LevyMr. Daniel Levy Ms. Susan Lipton Kenneth J. Livak, PhD Mr. and Mrs. James I. MagidMr. and Mrs. Henry Mannix IIIMr. David MarcusMs. Jami W. McKeonMr. John MikhailMs. Kimberly Terk MurphyMr. and Mrs. James L. NeislossMr. and Mrs. Peter Busch OrthweinMs. Megan PaceMs. Cindy PearlsteinMs. Agnes PeelleMr. Sheldon PresslerMs. Elaine C. Pulk and Mr. James WesmanMrs. Sheila Robbins39

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Discovery Society Discovery Society members are valued supporters who have provided for the Damon Runyon Cancer Research Foundation through planned gifts. These donations provide a vital source of support and fuel future breakthroughs against cancer. Mr. Philip R. RotnerMr. Joseph D. RoxeMs. Julia A. RubinMs. Ilene SandsMrs. Jane SantinelliMr. Gary SaretskyMs. Linda SaslowMs. Tracy SchmidtMr. and Mrs. Philip C. SchwartzMrs. Cipora Schwartz Ms. Madeline SchwartzMs. Nancy ShapiroMr. Steven L. ShapiroMs. Elaine M. AddisAnne C. Burkholder, PhD, and Stephen P. Eisenberg, PhDMr. and Mrs. Martin J. CohenMs. Ann K. CoteMrs. Phyllis FarleighRobert F. Fisher, PhDMs. Mary Ann FrenzelRichard B. Gaynor, MDMr. Rick J. GovernMr. and Mrs. William C. HinesMrs. Rebecca R. KryBroadway Premier Circle (Continued)Ms. Victoria ShattnerMs. Barbara ShermanMs. Lois SherwinThe Sidewater Family Foundation, Inc.Mr. Alfred J. SmithDr. David Hamilton SmithMs. Susan L. SolomonMr. Jonathan SonnebornMr. Walter C. SquireMr. Selby SullivanMr. Steven TawMr. J. Ronald TerwilligerMr. Joseph M. ThomasMr. Jeffrey TuckerMr. and Mrs. E. Scott UrdangMs. Kay E. WagnerMr. and Mrs. Peter J. WassermanMr. Edwin A. Weiller IIIMr. and Mrs. David WeinerDr. and Mrs. Victor J. WeinsteinDr. Janet M. WidraOwen N. Witte, MDMr. and Mrs. Gary WolfLewis L. Lanier, PhDMr. and Mrs. Leo LoFriscoMr. D.G. MitchellMr. and Mrs. Ronald E. ParrMr. and Mrs. Rick RobinsonMr. Seymour RosenheckMrs. Esther E. SchwartzMs. Phoebe H. ShowersMrs. Carol H. StixMs. Rose VaccarielloMr. and Mrs. Arthur WalkerAladdinBeautiful-The Carole King MusicalThe Book of MormonA Bronx TaleChicagoThe Color PurpleDear Evan HansenThe EncounterFalsettosFiddler on the RoofTICKETS AVAILABLE FORThe Front PageHamiltonThe HumansIn TransitJersey BoysKinky BootsLes Liaisons DangereusesThe Lion KingMatilda Natasha, Pierre & The Great Comet of 1812Oh, Hello on BroadwayOn Your FeetPhantom of the OperaSchool of RockSomething Rotten!WaitressWickedDamon Runyon Broadway TicketsSupport cancer research from the best seats in the theater. Your purchase includes a voluntary tax-deductible donation. Our gift certificates are perfect for friends and loved ones this holiday season. We'll send a card on your behalf—they can choose the show and date at their convenience, even Hamilton! To find out more, call 212.455.0550 or visit

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DAMON RUNYON CANCER RESEARCH FOUNDATION ANNUAL REPORT 2016Ways to GiveDONATE ONLINE BY VISITING USAT DAMONRUNYON.ORG/DONATE. CALL US AT 1.877.7CANCER OR 1.877.722.6237, 9AM – 5PM ET, MONDAY TO FRIDAYDAMON RUNYON CANCER RESEARCH FOUNDATION55 BROADWAY, SUITE 302 NEW YORK, NY 10006Please remember us in your will or trusts. Visit WWW.DAMONRUNYON.ORG/GET-INVOLVEDfor more information about planned giving.ONE HUNDRED PERCENT of your donation is tax-deductible. Many companies match the gifts of employees, spouses and retirees. 41

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OUR OVERHEAD IS PAID FROM OUR ENDOWMENT AND DAMON RUNYON BROADWAY TICKETS, ALLOWING 100% of your donation to support cancer research. Financial SummaryFiscal Year 2016REVENUE AND APPROPRIATION FROM ENDOWMENTEXPENSESAward Programs 87.1% Fundraising 10.4% General Administration 2.5%$22.1MILLION$22.1MILLIONContributions 45% Appropriation from Endowment 45.9% Bequests & Trusts 3.4% Misc. Income 3.6% Damon Runyon Broadway Tickets 2.1% In Fiscal Year 2016, based on a comprehensive review of our award programs by the Scientific Committee of our Board of Directors, we continued the implementation of several changes to our programs, substantially increasing the duration, dollar amount, and number of awards. These changes were a result of a strategic decision to utilize our endowment, as well as increase donations, to fund new opportunities in cancer research and accelerate progress. In FY2016, we used $10 million from our endowment to support our work. As in previous years, the financial activities of the Damon Runyon Cancer Research Foundation were audited by RMS US LLP. Below is a snapshot of FY2016. For our complete audited financial statements, please visit our website at OF BALANCE SHEETS42$145,440,975 $135,646,786$25,930,143 $29,816,543$119,510,832 $105,830,243Total Assets Total Liabilities Total Net Assets 2015 2016

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ONE EXCHANGE PLAZA55 Broadway, Suite 302New York, New York 100061.877.7CANCERT 212.455.0500 F 212.455.0509www.damonrunyon.orgTo accelerate breakthroughs, the Damon Runyon Cancer Research Foundation provides today’s best young scientists with funding to pursue innovative cancer research. Our goal is to foster the talent capable of revolutionizing the prevention, detection, and treatment of all forms of cancer.