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CUFFLESS BLOOD PRESSURE, AMBULATORY PROFILING, AND PATIENT MONITORING SOLUTIONS OPRHealth 303‐332‐5363

simplifying IT  CUFFLESSBLOODPRESSURESENSOR DEDICATEDHYPERTENSIONPROFILES EASYTOUNDERSTANDREPORTS COMFORTABLEANDPAINLESS IMPROVESDOCTOR‐PATIENTRELATIONS PROMOTESPATIENTCOMPLIANCE FAST,ACCURATEDIAGNOSIS ELIMINATESWHITECOATSYNDROME ENABLESPATIENT‐SPECIFICTREATMENTS FASTEFFICACYASSESSMENTS INSURANCEBILLABLE FINANCIALLYSUSTAINABLE INEXPENSIVE IDEALFORUNDESERVEDCOMMUNITIES SUPPORTSTELEMEDICINE NOIT/INFRASTRUCTUREUPGRADES NOEXTENSIVESTAFFTRAININGEXTENSIVE LIST OF BENEFITS CUFFLESS SENSOR BREAKTHROUGH Biobeat’scardiovasculartechnologiescenteronrevolutionarysensorsmeasuring3.3x3.3‐inchesandweighinglessthanoneounce.TheyarethefirstFDAclearedsensorsformeasuringbloodpressureusingphotoplethysmography(PPG)only.PPGisanopticaltechniqueusedtodetectbloodvolumechangesinthemicro‐vascularbedoftissues.Itswaveformincludesapulsative(‘AC’)physiologicalwaveformcausedbycardiacsynchronouschangesinbloodvolumeconnectedtoeachheartcontraction,superimposedonaslowlyvarying(‘DC’)baselinewithlowerfrequencycomponents.Thelowerfrequenciesareattributedtophysiologi‐calmeasuresincludingrespiration,sympatheticnervoussystemactivity,andthermoregulation1.Sensordataareprocessedthroughadvancedanalyticsandartificialintelligencetoextractoveradozenvitalsincludingbloodpressure,heartrate,heartratevari‐ability,pulsepressure,cardiacoutput(CO),strokevolume,systemicvascularresistance(SVR),bloodoxygensaturation(SPO2),andbodytemperature.Thesearedisplayedandreportedclinician‐patientfriendlyformats.Ambulatory blood pressure monitoring (ABPM) Sensors eliminate known barriers including paƟent noncompliance Patientnoncompliancehaslonghamperedhypertensioncontrolefforts.Studieshavefoundthatabout30%ofpatientsquitwhattheydescribeascumbersomeandpainfulcuff‐basedABPMprotocolsbeforecompletingthemandanaddi‐tional50%stoptakingtheirmedicationswithinayearofbeingprescribed.Legacycuff‐basedinstrumentsonlymeasureandtrendbloodpressureandheartrates.Theseareusefulwiththeapproximately40%ofpatientswhoquicklyre‐spondtostandardpharmacologicalstrategies,buthaveprovenlesseffectivewithothers.Bycontrast,Biobeat’sABPMdeliversthemostcomprehensivehy‐pertensiondiagnosticpanelavailable,includingbloodpressure,heartrate,meanarterialpressure,cardiacoutput(CO),andsystemicvascularresistance(SVR)trends.Itcalculatesday‐nightdippingandbreaksdownbloodpressuretrendsbytimeofday,evening,andovernightaverages.Biobeat’sABPMallowsclinicianstoevaluatetheunderlyingdriversofbloodpressure(COandSVR).Thedetailedreportshelpthemdevelopandtunepatient‐specifictreatmentstrategiesbasedonquantitativemeasuresandtrendsthathaveneverbeenpreviouslyavailable.Theyareidealforquicklyevaluatingtreat‐mentefficacyandmakingadjustmentsbasedonquantifiablemeasures.Biobeatsensorsalsoeliminatewhitecoatsyndrome,aknownbarriertorepre‐sentativebloodpressuremeasurementsandprofiling.Patientsoftenreportfor‐getingthattheyarewearingasensor,can’tfeelwhenreadingsarebeingtaken,andcangoabouttheirlivesundisturbedbytheprocess.3.3x3.3‐inchesWeighslessthanoneounce!OPRHealth 303‐332‐5363

LOW ENTRY COSTS Biobeat’s ABPM does not require specialequipment and upgraded IT infrastructure.Thekitsandsensorsareconsumablesthataredisposed after use. The management consoleis an easy to use, cloud‐based, applicationaccessible through connected devices. Stafftraining is minimal anddoes not require thedevelopmentofnewskillsets.FINANCIALLY SUSTAINABLE ABPM is insurance billable and is an idealtoolfor advancedblood pressure related ser‐vices. These include patient‐specific treat‐mentstrategiesandlong‐termbloodpressuremanagement.ABPMhelpscliniciansimprovetreatment efficiency and efficacy, which al‐lows providers to serve more patients withtheirexistingstaffandinfrastructure.PATIENT FRIENDLY Biobeat’ssmallcufflessbloodpressuresensorissocomfortablethatpatientsforgettheyarewearing them. They also can’t feel whenmeasurements are being taken, which helpsreduce diagnostically induced elevated bloodpressure, i.e., white coat syndrome.Theysimilarly prevent diagnostically induced low‐erbloodpressuremeasurements.Thesechar‐acteristicsmakeABPMapracticalcomponentofpatientcollaborationandcompliance.ABPM REPORT OPRHealth 303‐332‐5363

FLEXIBLE DEPLOYMENT MODELS Biobeat’sfamilyofambulatorybloodpressureprofiling solutions cover a broad range ofclinical and extended patient monitoring so‐lutions.24BPwasdesignedasalessexpensivediagnostic tool for profiling patient bloodpressure. ABPM delivers comprehensive pro‐filesthatincludecardiacoutputandsystemicvascularresistance.Continuousremotemon‐itoring solutions are designed for long termcardiovascularmonitoring.IDEAL FOR WELLNESS PROGRAMS 24BPempowerscommunityhealthinitiativesthat target underserved communities. Localprovidersfrequentlystrugglewithlegacyam‐bulatory blood pressure evaluations. Cuffbased legacy methods are expensive and re‐quiremoreextensivesupport.24BP’safforda‐bility, easy deployment and use make it anidealtoolforcommunityhealthprograms.IMPROVES COMMUNICATIONS ABPM and 24BP were designed with doctor‐patient communication and collaboration inmind. Their affordability, convenience, andpatient friendly reports help doctors explainthe factors affecting each patient’s bloodpressure, the importance of complying withprescribedtreatments,andtheresultsoftheireffortstokeepbloodpressureundercontrol. 24BP REPORT OPRHealth 303‐332‐5363

ADOPTED BY LEADING PROVIDERS Biobeattechnologiesandsolutionshavebeeninternationallyadopted.Over50internation‐alhealthcareproviderscurrentlyuseBiobeatproducts,systems,andservices.Theirad‐vancedmeasurementsandanalyticsarehelp‐ingprovidersdeployinnovativecaredeliverymodelsincludingHospitalAtHomeservices.PEER-REVIEWED PUBLICATIONS Thereisagrowinglistofpaperspublishedinpeer‐reviewedjournalsontheperformance,applicability,andclinicalbenefitsofBiobeat’scufflesscardiovascularsensorsandtechnolo‐gies.Morestudiesareon‐goingandaddition‐alpapersarebeingsubmittedforreview.Thesewilladdtothepublishedexperientialbaseandhelpprovidersshareimportantin‐sightsandbestpractices.CONTINUING IMPROVEMENTS Biobeatsensorsandsystemsarebeingcon‐tinuouslyimproved.NewvitalsincludingbloodCO2areundergoingtestingandauto‐matic/dynamictriagecapabilitiescontinuetoevolvebasedonoperationalexperience.Theseeffortsaddtotheirgrowingcompellingvalueandhelpprotectproviderinvestments.EMBRACED BY CLINICAL INNOVATORS AND EARLY ADOPTERS Biobeat’srevolutionarytechnologiesareinusethroughouttheworldincludingtheUnitedStates,Canada,Europe,MiddleEast,andAustralia.TheyhavebeentestedacrossoperationalenvironmentsincludingremotepatientmonitoringandtelehealthsupportbyIsraelidoctorsforUkrainianrefugeesinfieldhospitals.PUBLISHED PAPERS AND STUDIES There are numerous papers published in peer-reviewed journals covering Biobeat’s technologies, their use, and benefits. They can help clinicians appreciate how the products are being deployed and specific clinical applicaƟons. THE FUTURE OF DIGITAL HEALTH Biobeat’stechnologiesareattheforefrontofdigitalhealth.Itsfamilyofsensorsdeliverunpresentedmeasurementsofpatients’cardiovascular,respiratory,andrelatedsystems.Artificialintelligenceandadvancedanalyticstranslaterawmeasurementsintointelligible,actionableinformationpresentedinclinicianfriendlyformats.LocalandRemotePatientMonitoring(RPM)includecontinu‐ousvitalsevaluation,patientscoring,andprioritymanagement.Theseserveasresourcemultipliersbyautomatingmanytimeconsumingfunctionsandreduc‐ingbureaucraticoverheads.Bloodpressureprofiling,detailedhypertensiondiag‐nosis,andRPMworkhandinhandtosupportspecificclinicalpracticesinareaslikepreeclampsiadiagnostics,at‐homemonitoringandcare.Thesebenefitsaredeliveredwithoutsacrificingclinicians’specialrolepatientrelationships.OPRHealth 303‐332‐5363

Biobeat’sinnovativetechnologiesofferscalablesolutionsfromadvancedambulatorybloodpressureprofiling(24BPandABPM)toremotecardiovascularmonitoringandtelemedicine.Biobeatproductsandservicessupportcaredeliverysolutionsacrossopera‐tionalenvironmentsfromlargemetropolitanareastoremoteruralcommunities.Theirefficiency,efficacy,andlowcostsmakethemidealforprogramstargetingunderservedcommunities.Biobeatsolutionscanhelpproviderscopewithnursingshortagesbyimprovingefficiency,workforceproductivity,andretention.Theyarecompatiblewithinsuranceandofferfinanciallysustaina‐blesolutionsforlargeandsmallproviders,includingindependentdoctorpractices.WehelpprovidersdeployBiobeattechnologiesandsolutions.Ourteamsworkcloselywithclinicalandadministrativestaffstotunebusinessandcaredeliverymodelstoexploittheseremarkabletechnologies.Checkourblogfortechnicalpostsandarticles.Callustoarrangeapresentationanddemonstrationoftheseinno‐vativetechnologies:ozzie@oprhealth.com/1+303‐332‐5363. BIOBEAT DISTRIBUTOR AND SOLUTIONS PROVIDER BIOBEAT SOLUTIONS OzziePaezOPRHealth303‐332‐5363ozzie@oprhealth.comReferences:1.CastanedaD,EsparzaA,GhamariM,SoltanpurC,NazeranH.Areviewonwearablephotoplethysmographysensorsandtheirpotentialfutureapplicationsinhealthcare.IntJBiosensBioelectron.2018;4(4):195‐202.doi:10.15406/ijbsbe.2018.04.00125.Epub2018Aug6.PMID:30906922;PMCID:PMC6426305.OPRHealth 303‐332‐5363