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Prion  diseases  or   transmissible  spongiform encephalopathies   TSEs
TSE   a family of rare progressive neurodegenerative disorders that affect both humans  and  animals. Distinguished     by...
     PrPc     present  in  the  cell  surface    when transform  to  PrP sc  causes  cell  toxicity  and  cell damage
TSE Human  Prion  Diseases                          Creutzfeldt-Jakob Disease   CJD  Variant  CreutzfeldtJakob  Disease   ...
Spongiform   vacuolation  degeneration  of  grey  matter neuropil
PrP   Sc   plaques  -   A   PrP  Sc  deposits  vary  from  small,  diffuse  aggregates  to  dense plaques,  often  occurri...
Scrapie  in  goats                     First  case  scrapie  in  goats  in  France  in  1942  Vaccari  et  al.,  2009 . In...
Clinical  signs      Atypical  scrapie   sporadic  prion  disease
Bovine  spongiform encephalopathy
Clinical  signs  of  BSE                    Abnormal  gait   Changes  in  behavior   Tremors Hyper-responsiveness  to  cer...